EA200700118A1 - Амидосоединения и их применение в качестве лекарственных средств - Google Patents

Амидосоединения и их применение в качестве лекарственных средств

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Publication number
EA200700118A1
EA200700118A1 EA200700118A EA200700118A EA200700118A1 EA 200700118 A1 EA200700118 A1 EA 200700118A1 EA 200700118 A EA200700118 A EA 200700118A EA 200700118 A EA200700118 A EA 200700118A EA 200700118 A1 EA200700118 A1 EA 200700118A1
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EA
Eurasian Patent Office
Prior art keywords
amidociousness
medicines
application
hydroxylsteroid
present
Prior art date
Application number
EA200700118A
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English (en)
Inventor
Вэньцин Яо
Мэйчжун Сюй
Колин Чжан
Константинос Агриос
Брайан Меткаф
Цзиньцун Чжо
Original Assignee
Инсайт Корпорейшн
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Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA200700118A1 publication Critical patent/EA200700118A1/ru

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

Настоящее изобретение относится к ингибиторам 11-β гидроксилстероид дегидрогеназы типа 1, антагонистам минералкортикоидного рецептора (MR), а также их фармацевтическим композициям. Соединения по настоящему изобретению могут применяться при лечении различных заболеваний, связанных с экспрессией или активностью 11-β гидроксилстероид дегидрогеназы типа 1 и/или заболеваний, связанных с избытком альдостерона.
EA200700118A 2004-06-24 2005-06-23 Амидосоединения и их применение в качестве лекарственных средств EA200700118A1 (ru)

Applications Claiming Priority (3)

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US58255604P 2004-06-24 2004-06-24
US63917904P 2004-12-22 2004-12-22
PCT/US2005/022411 WO2006002349A1 (en) 2004-06-24 2005-06-23 Amido compounds and their use as pharmaceuticals

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EA200700118A1 true EA200700118A1 (ru) 2007-08-31

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US (1) US20060009471A1 (ru)
EP (1) EP1758582A4 (ru)
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