AU2002230665A1 - 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands - Google Patents

4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands

Info

Publication number
AU2002230665A1
AU2002230665A1 AU2002230665A AU3066502A AU2002230665A1 AU 2002230665 A1 AU2002230665 A1 AU 2002230665A1 AU 2002230665 A AU2002230665 A AU 2002230665A AU 3066502 A AU3066502 A AU 3066502A AU 2002230665 A1 AU2002230665 A1 AU 2002230665A1
Authority
AU
Australia
Prior art keywords
norepinephrine
serotonin
dopamine
ligands
disubstituted piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002230665A
Inventor
Michael Z. Hoemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of AU2002230665A1 publication Critical patent/AU2002230665A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002230665A 2000-12-06 2001-12-04 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands Abandoned AU2002230665A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25165100P 2000-12-06 2000-12-06
US60/251,651 2000-12-06
PCT/US2001/047036 WO2002046156A2 (en) 2000-12-06 2001-12-04 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands

Publications (1)

Publication Number Publication Date
AU2002230665A1 true AU2002230665A1 (en) 2002-06-18

Family

ID=22952850

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002230665A Abandoned AU2002230665A1 (en) 2000-12-06 2001-12-04 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands

Country Status (3)

Country Link
US (3) US6656953B2 (en)
AU (1) AU2002230665A1 (en)
WO (1) WO2002046156A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR033287A1 (en) * 2001-05-09 2003-12-10 Lundbeck & Co As H ADHD TREATMENT
WO2003049736A1 (en) * 2001-12-11 2003-06-19 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
CN100381070C (en) * 2002-01-08 2008-04-16 Can科技公司 Encapsulation by coating with a mixture of lipids and hydrophobic, high melting point compounds
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
JP2008504280A (en) 2004-06-24 2008-02-14 インサイト・コーポレイション 2-methylpropanamide and its pharmaceutical use
AU2005258248A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
GB0423356D0 (en) * 2004-10-21 2004-11-24 Merck Sharp & Dohme Therapeutic agents
JP2008521821A (en) * 2004-11-29 2008-06-26 バーテックス ファーマシューティカルズ インコーポレイテッド Muscarinic receptor modulators
EP1863490A2 (en) * 2005-03-28 2007-12-12 Vertex Pharmaceuticals Incorporated Muscarinic modulators
WO2011112166A1 (en) * 2010-03-12 2011-09-15 Scott Cordray Method of treatment

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2538107A (en) 1946-07-30 1951-01-16 Sterling Drug Inc 4 aryl-4-aminomethylpiperidine derivatives and their preparation
US2966491A (en) * 1955-08-16 1960-12-27 Merck & Co Inc Nu-para substituted-phenylethyl-4-phenyl-4-carbalkoxy piperidines
GB888657A (en) 1958-07-14 1962-01-31 J F Macfarlan & Co Ltd Piperidine carbinols
FR1477152A (en) 1965-04-23 1967-04-14 Yoshitomi Pharmaceutical Process for the preparation of indole derivatives
DE1936452C3 (en) * 1969-07-17 1975-06-19 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Process for the preparation of 4,4-diphenylpiperidines
US4485109A (en) * 1982-05-07 1984-11-27 E. I. Du Pont De Nemours And Company 4-Aryl-4-piperidinecarbinols
CA1337418C (en) 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
KR940003491B1 (en) 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-disubstitted piperidine derivatives processe for the prepation therefor
ZA908641B (en) * 1989-10-27 1992-06-24 Du Pont (n-phthalimidoalkyl)piperidines
DE69327541T2 (en) 1992-10-28 2000-08-10 Merck Sharp & Dohme 4-ARYLMETHYLOXYMETHYL PIPERIDINE AS TACHYKININ ANTAGONISTS
US6211198B1 (en) * 1993-04-05 2001-04-03 Synaptic Pharmaceutical Corporation Dihydropyridines and new uses thereof
EP0739336B1 (en) 1994-01-13 1998-08-26 MERCK SHARP & DOHME LTD. Gem-disubstituted azacyclic tachykinin antagonists
GB9520444D0 (en) 1995-10-06 1995-12-06 Pharmacia Spa Disubstituted piperidine derivatives
GB9521781D0 (en) 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
JP3298799B2 (en) * 1995-11-22 2002-07-08 ルーセント テクノロジーズ インコーポレイテッド Cladding pump fiber and its manufacturing method
FR2745811B1 (en) 1996-03-07 1998-05-22 Sanofi Sa DISSUBSTITUTED GLUTARIMIDE PROCESS FOR ITS PREPARATION, AND ITS USE
US6124319A (en) 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6159990A (en) * 1997-06-18 2000-12-12 Synaptic Pharmaceutical Corporation Oxazolidinones as α1A receptor antagonists
GB9712882D0 (en) * 1997-06-18 1997-08-20 Pfizer Ltd Quaternary ammonium compounds
JP2002510327A (en) 1997-07-25 2002-04-02 メルク エンド カンパニー インコーポレーテッド Cyclic amine chemokine receptor activity modulator
HUP0102071A3 (en) 1998-05-11 2002-06-28 Novo Nordisk As 3,3- and 4,4-disubstituted piperidine derivatives with growth hormone releasing properties and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO2002046156A2 (en) 2002-06-13
US20070225331A1 (en) 2007-09-27
US7217823B2 (en) 2007-05-15
US20040142974A1 (en) 2004-07-22
US20020177607A1 (en) 2002-11-28
US6656953B2 (en) 2003-12-02
WO2002046156A3 (en) 2003-04-03

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