BR0212495A - Método para a preparação de tetraidrobenzotiepinas cristalinas - Google Patents

Método para a preparação de tetraidrobenzotiepinas cristalinas

Info

Publication number
BR0212495A
BR0212495A BR0212495-5A BR0212495A BR0212495A BR 0212495 A BR0212495 A BR 0212495A BR 0212495 A BR0212495 A BR 0212495A BR 0212495 A BR0212495 A BR 0212495A
Authority
BR
Brazil
Prior art keywords
preparation
provides
compounds
tetrahydrobenzothiepine
tetrahydrobenzothiepines
Prior art date
Application number
BR0212495-5A
Other languages
English (en)
Inventor
Partha S Mudipalli
Mark J Pozzo
Jung Min Park
Original Assignee
Searle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle Llc filed Critical Searle Llc
Publication of BR0212495A publication Critical patent/BR0212495A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"MéTODO PARA A PREPARAçãO DE TETRAIDROBENZOTIEPINAS CRISTALINAS". Dentre suas várias modalidades, a presente invenção fornece um processo aperfeiçoado para a preparação de compostos de 1,1-dióxido de tetraidrobenzotiepina; fornece um processo para preparar uma mistura diastereoisomérica de compostos de 1,1-dióxido de tetraidrobenzotiepina a partir de um único diastereoisómero destes compostos; fornece um processo para a preparação de compostos de propionaldeído 3-bromo-2-substituídos; fornece um processo para a preparação de compostos de propionaldeído 3-tio-2-substituìdos; e fornece um processo para a preparação de monocristais de inibidores do transportador apical de ácidos biliares co-dependente de sódio (ASBT), que têm alta pureza e baixos níveis de impurezas de solventes.
BR0212495-5A 2001-09-12 2002-08-23 Método para a preparação de tetraidrobenzotiepinas cristalinas BR0212495A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31833401P 2001-09-12 2001-09-12
PCT/US2002/026877 WO2003022804A2 (en) 2001-09-12 2002-08-23 Method for the preparation of crystalline tetrahydrobenzothiepines

Publications (1)

Publication Number Publication Date
BR0212495A true BR0212495A (pt) 2004-08-24

Family

ID=23237734

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212495-5A BR0212495A (pt) 2001-09-12 2002-08-23 Método para a preparação de tetraidrobenzotiepinas cristalinas

Country Status (8)

Country Link
US (1) US20030199515A1 (pt)
EP (1) EP1425279A4 (pt)
JP (1) JP2005502702A (pt)
AU (1) AU2002332638A1 (pt)
BR (1) BR0212495A (pt)
CA (1) CA2460330A1 (pt)
MX (1) MXPA04002455A (pt)
WO (1) WO2003022804A2 (pt)

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US8015725B2 (en) * 2004-09-21 2011-09-13 Dos-I Solutions, S.L. Method and machine for the sintering and/or drying of powder materials using infrared radiation
ES2586931T3 (es) 2010-11-08 2016-10-19 Albireo Ab Inhibidores de IBAT para el tratamiento de enfermedades hepáticas
RU2619215C2 (ru) 2010-11-08 2017-05-12 Альбирео Аб Фармацевтическая комбинация, включающая ibat-ингибитор и связующее желчной кислоты
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
US10709755B2 (en) 2014-06-25 2020-07-14 Elobix Ab Solid formulation and method for preventing or reducing coloration thereof
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
CN108601745B (zh) 2016-02-09 2021-12-07 阿尔比里奥公司 口服考来烯胺制剂及其用途
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
CA3011565C (en) 2016-02-09 2024-01-02 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
CA3071182A1 (en) 2017-08-09 2019-02-14 Albireo Ab Cholestyramine pellets, oral cholestyramine formulations and use thereof
WO2019032026A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CN112449637B (zh) 2018-06-05 2024-03-19 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP7448490B2 (ja) 2018-06-20 2024-03-12 アルビレオ・アクチボラグ オデビキシバットの医薬製剤
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
JP2023504647A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
FI4069360T3 (fi) 2019-12-04 2024-02-20 Albireo Ab Bentsotia(di)atsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina
JP2023504643A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CA3158184A1 (en) 2019-12-04 2021-08-10 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
JP2023537285A (ja) 2020-08-03 2023-08-31 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
EP4243831A1 (en) 2020-11-12 2023-09-20 Albireo AB Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
CN116583504A (zh) 2020-12-04 2023-08-11 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642268B2 (en) * 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Also Published As

Publication number Publication date
US20030199515A1 (en) 2003-10-23
EP1425279A2 (en) 2004-06-09
WO2003022804A9 (en) 2003-12-18
MXPA04002455A (es) 2004-06-29
CA2460330A1 (en) 2003-03-20
EP1425279A4 (en) 2005-10-26
WO2003022804A2 (en) 2003-03-20
AU2002332638A1 (en) 2003-03-24
JP2005502702A (ja) 2005-01-27
WO2003022804A3 (en) 2003-11-20

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired