BR0212495A - Método para a preparação de tetraidrobenzotiepinas cristalinas - Google Patents

Método para a preparação de tetraidrobenzotiepinas cristalinas

Info

Publication number
BR0212495A
BR0212495A BR0212495-5A BR0212495A BR0212495A BR 0212495 A BR0212495 A BR 0212495A BR 0212495 A BR0212495 A BR 0212495A BR 0212495 A BR0212495 A BR 0212495A
Authority
BR
Brazil
Prior art keywords
preparation
provides
compounds
tetrahydrobenzothiepine
tetrahydrobenzothiepines
Prior art date
Application number
BR0212495-5A
Other languages
English (en)
Inventor
Partha S Mudipalli
Mark J Pozzo
Jung Min Park
Original Assignee
Searle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle Llc filed Critical Searle Llc
Publication of BR0212495A publication Critical patent/BR0212495A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"MéTODO PARA A PREPARAçãO DE TETRAIDROBENZOTIEPINAS CRISTALINAS". Dentre suas várias modalidades, a presente invenção fornece um processo aperfeiçoado para a preparação de compostos de 1,1-dióxido de tetraidrobenzotiepina; fornece um processo para preparar uma mistura diastereoisomérica de compostos de 1,1-dióxido de tetraidrobenzotiepina a partir de um único diastereoisómero destes compostos; fornece um processo para a preparação de compostos de propionaldeído 3-bromo-2-substituídos; fornece um processo para a preparação de compostos de propionaldeído 3-tio-2-substituìdos; e fornece um processo para a preparação de monocristais de inibidores do transportador apical de ácidos biliares co-dependente de sódio (ASBT), que têm alta pureza e baixos níveis de impurezas de solventes.
BR0212495-5A 2001-09-12 2002-08-23 Método para a preparação de tetraidrobenzotiepinas cristalinas BR0212495A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31833401P 2001-09-12 2001-09-12
PCT/US2002/026877 WO2003022804A2 (en) 2001-09-12 2002-08-23 Method for the preparation of crystalline tetrahydrobenzothiepines

Publications (1)

Publication Number Publication Date
BR0212495A true BR0212495A (pt) 2004-08-24

Family

ID=23237734

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212495-5A BR0212495A (pt) 2001-09-12 2002-08-23 Método para a preparação de tetraidrobenzotiepinas cristalinas

Country Status (8)

Country Link
US (1) US20030199515A1 (pt)
EP (1) EP1425279A4 (pt)
JP (1) JP2005502702A (pt)
AU (1) AU2002332638A1 (pt)
BR (1) BR0212495A (pt)
CA (1) CA2460330A1 (pt)
MX (1) MXPA04002455A (pt)
WO (1) WO2003022804A2 (pt)

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ES2378233T3 (es) * 2004-09-21 2012-04-10 G & I Irtech S.L. Proceso y máquina para la aglomeración y/o secado de materiales en polvo usando radiación infrarroja
SG190029A1 (en) 2010-11-08 2013-06-28 Albireo Ab Ibat inhibitors for the treatment of liver diseases
CN105287604B (zh) 2010-11-08 2019-07-09 阿尔比里奥公司 含ibat抑制剂和胆汁酸结合剂的药物组合
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
WO2015199147A1 (ja) 2014-06-25 2015-12-30 味の素株式会社 固形製剤及びその着色防止又は着色低減方法
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
EP3413878B1 (en) 2016-02-09 2021-04-14 Albireo AB Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
RU2750944C2 (ru) 2016-02-09 2021-07-06 Альбирео Аб Пероральный состав холестирамина и его применение
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
EP3664782A1 (en) 2017-08-09 2020-06-17 Albireo AB Cholestyramine pellets, oral cholestyramine formulations and use thereof
CA3071285A1 (en) 2017-08-09 2019-02-14 Albireo Ab Cholestyramine granules, oral cholestyramine formulations and use thereof
TW202015699A (zh) 2018-06-05 2020-05-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2019245449A1 (en) 2018-06-20 2019-12-26 Albireo Ab Pharmaceutical formulation of odevixibat
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
EP4069361B1 (en) 2019-12-04 2024-01-03 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
JP2023504647A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
EP4069247A1 (en) 2019-12-04 2022-10-12 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
FI4069360T3 (fi) 2019-12-04 2024-02-20 Albireo Ab Bentsotia(di)atsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina
CN116157389A (zh) 2020-08-03 2023-05-23 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
CA3196488A1 (en) 2020-11-12 2022-05-19 Albireo Ab Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
JP2024500309A (ja) 2020-12-04 2024-01-09 アルビレオ エービー ベンゾチア（ジ）アゼピン化合物および胆汁酸モジュレータとしてのその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) * 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors

Also Published As

Publication number Publication date
JP2005502702A (ja) 2005-01-27
MXPA04002455A (es) 2004-06-29
WO2003022804A9 (en) 2003-12-18
CA2460330A1 (en) 2003-03-20
US20030199515A1 (en) 2003-10-23
EP1425279A4 (en) 2005-10-26
WO2003022804A3 (en) 2003-11-20
WO2003022804A2 (en) 2003-03-20
EP1425279A2 (en) 2004-06-09
AU2002332638A1 (en) 2003-03-24

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired