RU92016217A - Двойные ингибиторы no синтазы и циклооксигеназы, способ их получения и фармацевтическая композиция на их основе - Google Patents
Двойные ингибиторы no синтазы и циклооксигеназы, способ их получения и фармацевтическая композиция на их основеInfo
- Publication number
- RU92016217A RU92016217A RU92016217/04A RU92016217A RU92016217A RU 92016217 A RU92016217 A RU 92016217A RU 92016217/04 A RU92016217/04 A RU 92016217/04A RU 92016217 A RU92016217 A RU 92016217A RU 92016217 A RU92016217 A RU 92016217A
- Authority
- RU
- Russia
- Prior art keywords
- cyclooxygenase
- synthase
- basis
- production
- pharmaceutical composition
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 title 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000000511 arginine group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Claims (1)
- Предложены соединения общей формулы АВ, которые могут быть солями или амидами, в которых А обозначает ингибитор циклооксигеназы, имеющий доступную кислотную функциональную группу, а В обозначает L - форму аналогов аргинина формулы:
где R1, R2 и R3 являются различными заместителями, а также способ получения таких соединений и их фармацевтических композиций.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929200114A GB9200114D0 (en) | 1992-01-04 | 1992-01-04 | Dual inhibitors of no synthase and cyclooxygenase |
GB9200114.8 | 1992-01-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU92016217A true RU92016217A (ru) | 1995-05-20 |
RU2104999C1 RU2104999C1 (ru) | 1998-02-20 |
Family
ID=10708115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU92016217A RU2104999C1 (ru) | 1992-01-04 | 1992-12-31 | Двойные ингибиторы no-синтазы и циклооксигеназы, способ их получения, фармацевтическая композиция на их основе |
Country Status (34)
Country | Link |
---|---|
US (2) | US5480999A (ru) |
JP (1) | JP2984498B2 (ru) |
KR (1) | KR100287539B1 (ru) |
AT (1) | AT401054B (ru) |
AU (1) | AU664399B2 (ru) |
BE (1) | BE1006227A3 (ru) |
CA (1) | CA2085555C (ru) |
CH (1) | CH685629A5 (ru) |
DE (1) | DE4244539B4 (ru) |
DK (1) | DK157592A (ru) |
DZ (1) | DZ1657A1 (ru) |
ES (1) | ES2052452B1 (ru) |
FI (1) | FI925883A (ru) |
FR (2) | FR2685916B1 (ru) |
GB (2) | GB9200114D0 (ru) |
GR (1) | GR1001443B (ru) |
HK (1) | HK22296A (ru) |
HU (1) | HU220218B (ru) |
IE (1) | IE71675B1 (ru) |
IT (1) | IT1256761B (ru) |
LU (1) | LU88208A1 (ru) |
MA (1) | MA22753A1 (ru) |
MY (1) | MY109846A (ru) |
NL (1) | NL194889C (ru) |
NO (1) | NO302943B1 (ru) |
NZ (1) | NZ245499A (ru) |
OA (1) | OA10050A (ru) |
PL (1) | PL169432B1 (ru) |
PT (1) | PT101165B (ru) |
RU (1) | RU2104999C1 (ru) |
SE (1) | SE511568C2 (ru) |
TN (1) | TNSN93001A1 (ru) |
TW (1) | TW267152B (ru) |
ZA (1) | ZA9210080B (ru) |
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JPH10500138A (ja) * | 1994-05-07 | 1998-01-06 | アストラ・アクチエボラーグ | 酸化窒素合成酵素阻害剤としての2環アミジン誘導体 |
ATE291909T1 (de) * | 1994-05-11 | 2005-04-15 | Jes Olesen | Verwendung der no-faenger, inhibitoren oder antagonisten zur behandlung von migraene |
US6066333A (en) * | 1994-09-22 | 2000-05-23 | William Harvey Research Limited | Pharmaceutical control of inflammation |
CA2132690A1 (en) * | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
FR2727111B1 (fr) * | 1994-11-21 | 1997-01-17 | Hoechst Lab | Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments |
PT793646E (pt) | 1994-11-23 | 2002-03-28 | Biovitrum Ab | Carboxilatos de aminoguanidina destinados ao tratamento de diabetes mellitus nao-insulinodependente |
JPH08333258A (ja) | 1994-12-14 | 1996-12-17 | Japan Tobacco Inc | チアジン又はチアゼピン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤 |
ES2096524B1 (es) * | 1994-12-22 | 1997-11-16 | Sanchez Manuel Guerra | Uso de la ng-monometil-l-arginina, para aumentar la capacidad de hacer ejercicio fisico. |
FR2730930B1 (fr) * | 1995-02-27 | 1997-04-04 | Oreal | Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique |
GB9504350D0 (en) * | 1995-03-04 | 1995-04-26 | Sod Conseils Rech Applic | Arginine derivatives |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
GB9514518D0 (en) * | 1995-07-15 | 1995-09-13 | Sod Conseils Rech Applic | Guanidine salt inhibitors of NO synthase and cyclooxygenase |
TR199801731T2 (xx) * | 1996-03-05 | 1999-02-22 | Children's Hospital Medical Center | Siklooksijenaz önleyicileri olarak merkapto türevleri. |
US5955617A (en) * | 1996-05-21 | 1999-09-21 | Pharmacia & Upjohn Company | Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus |
US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US8022095B2 (en) * | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
IT1301966B1 (it) | 1998-07-30 | 2000-07-20 | Zambon Spa | Composizioni farmaceutiche ad attivita' analgesica |
US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
CA2398642A1 (en) * | 2000-01-31 | 2001-08-02 | Yuhong Zhou | Mucin synthesis inhibitors |
US7345051B2 (en) * | 2000-01-31 | 2008-03-18 | Genaera Corporation | Mucin synthesis inhibitors |
WO2004004648A2 (en) * | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
EP1542972A4 (en) * | 2002-07-29 | 2008-01-23 | Nitromed Inc | CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITION AND METHOD OF USE |
JP4616009B2 (ja) * | 2002-12-26 | 2011-01-19 | ポーゼン インコーポレイテッド | NSAIDsおよびトリプタンを含有する多層剤型 |
AU2004247076A1 (en) * | 2003-06-06 | 2004-12-23 | Glaxo Group Limited | Composition comprising triptans and NSAIDs |
CA2530058A1 (en) * | 2003-06-19 | 2004-12-29 | Genaera Corporation | Mucin synthesis inhibitors |
AU2004253159A1 (en) * | 2003-06-25 | 2005-01-06 | Vanderbilt University | COX-2-targeted imaging agents |
AU2005244770A1 (en) * | 2004-04-26 | 2005-12-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
BRPI0606515A2 (pt) * | 2005-01-04 | 2009-06-30 | Novartis Ag | estrutura de raios x de fpps humana e uso para selecionar compostos de ligação de fpps |
WO2007149456A2 (en) | 2006-06-19 | 2007-12-27 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of cox-2 |
EP2768499A4 (en) | 2011-10-17 | 2015-08-26 | Univ Vanderbilt | INDOMETACIN ANALOGUES FOR THE TREATMENT OF CANCER PROSTATE RESISTANT TO CASTRATION |
TWM469254U (zh) | 2013-08-29 | 2014-01-01 | J D Components Co Ltd | 自行車之三件式豎管 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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FR6838M (ru) * | 1967-12-08 | 1969-03-31 | ||
ES423794A1 (es) * | 1974-03-01 | 1976-05-01 | Medicinales S A Promesa Prod | Procediemiento de obtencion de una nueva sal soluble de acido acetilsalicilico. |
FR2320759A1 (fr) * | 1975-08-11 | 1977-03-11 | Union Pharma Scient Appl | Solution d'acide acetylsalicylique extemporanee injectable |
IT1127274B (it) * | 1979-12-04 | 1986-05-21 | Selvi & C Spa | Sali dell'acido 5-fluoro-2-metil-1-(p-(metilsulfinil)-benzilidene)-indene-3-acetico |
JPS5781409A (en) * | 1980-11-10 | 1982-05-21 | Toko Yakuhin Kogyo Kk | External plaster |
CA1213888A (en) * | 1983-09-28 | 1986-11-12 | Warner-Lambert Company | L-arginine isoxicamate |
US5081184A (en) * | 1985-08-02 | 1992-01-14 | General Electric Company | Solvent-resistant, compatible blends of polyphenylene ethers and linear polyesters |
JPS6393718A (ja) * | 1986-10-07 | 1988-04-25 | Green Cross Corp:The | 注射剤 |
US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
DK0424028T3 (da) * | 1989-10-17 | 1996-01-29 | Merck & Co Inc | S(+)-ibuprofen-L-aminosyre og S(+)-ibuprofen-D-aminosyre som et forbedret smertestillende middel med fremskyndet indtrædelse |
GB8929076D0 (en) * | 1989-12-22 | 1990-02-28 | Scras | Treatment of shock by blocking agents of edrf effect or formation |
US5468476A (en) * | 1994-03-16 | 1995-11-21 | Ahluwalia; Gurpreet S. | Reduction of hair growth |
-
1992
- 1992-01-04 GB GB929200114A patent/GB9200114D0/en active Pending
- 1992-12-14 NO NO924835A patent/NO302943B1/no unknown
- 1992-12-16 CA CA002085555A patent/CA2085555C/en not_active Expired - Fee Related
- 1992-12-17 NZ NZ245499A patent/NZ245499A/en unknown
- 1992-12-18 CH CH3890/92A patent/CH685629A5/fr not_active IP Right Cessation
- 1992-12-18 GR GR920100563A patent/GR1001443B/el not_active IP Right Cessation
- 1992-12-18 SE SE9203825A patent/SE511568C2/sv not_active IP Right Cessation
- 1992-12-18 TW TW081110175A patent/TW267152B/zh active
- 1992-12-18 MY MYPI92002343A patent/MY109846A/en unknown
- 1992-12-22 FR FR9215448A patent/FR2685916B1/fr not_active Expired - Fee Related
- 1992-12-22 FR FR9215447A patent/FR2685869B1/fr not_active Expired - Fee Related
- 1992-12-22 BE BE9201127A patent/BE1006227A3/fr not_active IP Right Cessation
- 1992-12-23 AT AT0256092A patent/AT401054B/de not_active IP Right Cessation
- 1992-12-23 IT ITMI922953A patent/IT1256761B/it active IP Right Grant
- 1992-12-23 US US07/995,792 patent/US5480999A/en not_active Expired - Lifetime
- 1992-12-24 GB GB9227026A patent/GB2263111B/en not_active Expired - Lifetime
- 1992-12-25 MA MA23045A patent/MA22753A1/fr unknown
- 1992-12-28 FI FI925883A patent/FI925883A/fi not_active Application Discontinuation
- 1992-12-29 LU LU88208A patent/LU88208A1/fr unknown
- 1992-12-29 ZA ZA9210080A patent/ZA9210080B/xx unknown
- 1992-12-29 ES ES09202635A patent/ES2052452B1/es not_active Expired - Fee Related
- 1992-12-29 DZ DZ920171A patent/DZ1657A1/fr active
- 1992-12-30 HU HU9204173A patent/HU220218B/hu not_active IP Right Cessation
- 1992-12-30 PT PT101165A patent/PT101165B/pt not_active IP Right Cessation
- 1992-12-30 KR KR1019920026433A patent/KR100287539B1/ko not_active IP Right Cessation
- 1992-12-30 DE DE4244539A patent/DE4244539B4/de not_active Expired - Fee Related
- 1992-12-30 PL PL92297247A patent/PL169432B1/pl not_active IP Right Cessation
- 1992-12-30 DK DK157592A patent/DK157592A/da not_active Application Discontinuation
- 1992-12-31 IE IE922954A patent/IE71675B1/en not_active IP Right Cessation
- 1992-12-31 AU AU30498/92A patent/AU664399B2/en not_active Ceased
- 1992-12-31 RU RU92016217A patent/RU2104999C1/ru not_active IP Right Cessation
- 1992-12-31 OA OA60325A patent/OA10050A/fr unknown
-
1993
- 1993-01-04 NL NL9300001A patent/NL194889C/nl not_active IP Right Cessation
- 1993-01-04 JP JP5000091A patent/JP2984498B2/ja not_active Expired - Fee Related
- 1993-01-04 TN TNTNSN93001A patent/TNSN93001A1/fr unknown
- 1993-09-29 US US08/128,908 patent/US5360925A/en not_active Expired - Lifetime
-
1996
- 1996-02-08 HK HK22296A patent/HK22296A/xx not_active IP Right Cessation
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