EA200000826A1 - Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы - Google Patents

Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы

Info

Publication number
EA200000826A1
EA200000826A1 EA200000826A EA200000826A EA200000826A1 EA 200000826 A1 EA200000826 A1 EA 200000826A1 EA 200000826 A EA200000826 A EA 200000826A EA 200000826 A EA200000826 A EA 200000826A EA 200000826 A1 EA200000826 A1 EA 200000826A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
halidated
amidinomomino
synthase inhibitors
acids applicable
Prior art date
Application number
EA200000826A
Other languages
English (en)
Inventor
Энн Э. Халлинан
Барнетт С. Питцел
Дейл П. Спенглер
Арийя А. Бергманис
Тимоти Дж. Хейген
Софья Цимбалов
Михали В. Тот
Кит Р. Уэббер
Доналд У. мл. Хансен
Алик К. Авасти
Original Assignee
Дж.Д.Сирл Энд Ко.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дж.Д.Сирл Энд Ко. filed Critical Дж.Д.Сирл Энд Ко.
Publication of EA200000826A1 publication Critical patent/EA200000826A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Галоидированные производные амидиноаминокислот формулы (I), в которых все заместители указаны в описании, применимые в качестве ингибиторов NO-синтазы.Отчет о международном поиске был опубликован 1999.11.11.
EA200000826A 1998-03-11 1999-03-04 Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы EA200000826A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3828498A 1998-03-11 1998-03-11
PCT/US1999/003728 WO1999046240A2 (en) 1998-03-11 1999-03-04 Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
EA200000826A1 true EA200000826A1 (ru) 2001-04-23

Family

ID=21899068

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000826A EA200000826A1 (ru) 1998-03-11 1999-03-04 Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы

Country Status (35)

Country Link
US (1) US6344483B1 (ru)
EP (2) EP1415982A1 (ru)
JP (1) JP2002506056A (ru)
KR (1) KR20010034598A (ru)
CN (1) CN1171861C (ru)
AP (1) AP2000001900A0 (ru)
AR (1) AR018159A1 (ru)
AT (1) ATE277894T1 (ru)
AU (1) AU746235B2 (ru)
BG (1) BG104766A (ru)
BR (1) BR9908702A (ru)
CA (1) CA2322873A1 (ru)
CU (1) CU23047A3 (ru)
DE (1) DE69920670T2 (ru)
EA (1) EA200000826A1 (ru)
EE (1) EE200000519A (ru)
ES (1) ES2239839T3 (ru)
GE (1) GEP20043179B (ru)
HR (1) HRP20000595A2 (ru)
HU (1) HUP0101467A3 (ru)
ID (1) ID26208A (ru)
IL (1) IL137654A0 (ru)
IS (1) IS5583A (ru)
NO (1) NO20004531L (ru)
NZ (1) NZ506721A (ru)
OA (1) OA11901A (ru)
PL (1) PL343380A1 (ru)
PT (1) PT1062201E (ru)
SI (1) SI1062201T1 (ru)
SK (1) SK13012000A3 (ru)
TR (1) TR200002605T2 (ru)
UA (1) UA67767C2 (ru)
WO (1) WO1999046240A2 (ru)
YU (1) YU52200A (ru)
ZA (1) ZA991894B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2256223T3 (es) 2000-03-24 2006-07-16 Pharmacia Corporation Amidinocompuestos utiles como inhibidores de oxido nitrico sintasa.
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6956131B2 (en) * 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
AR032318A1 (es) 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
AR031609A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
AR031129A1 (es) 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR035585A1 (es) * 2000-09-15 2004-06-16 Pharmacia Corp Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
GB0031179D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US6582387B2 (en) * 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
CA2484654A1 (en) * 2002-05-16 2003-11-27 Pharmacia Corporation A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases
DK2399893T3 (en) * 2004-12-22 2018-10-08 Ambrx Inc COMPOSITIONS CONTAINING, INVOLVING PROCEDURES, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
AU2006223482A1 (en) * 2005-03-14 2006-09-21 Janssen Pharmaceutica, N.V. Process for the preparation of opioid modulators
ATE500215T1 (de) 2005-11-08 2011-03-15 Ambrx Inc Beschleuniger für die modifikation nichtnatürlicher aminosäuren und nichtnatürlicher aminosäurepolypeptide
CN101448512B (zh) 2005-12-14 2015-11-25 Ambrx公司 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及非天然氨基酸和多肽的用途
KR101103720B1 (ko) * 2011-06-02 2012-01-11 한국건설기술연구원 자연환기에 의한 중공층의 온도제어가 가능한 일체형 다중유리 복합창짝
EP3656391A1 (en) 2013-09-09 2020-05-27 CanImGuide Therapeutics AB Immune system modulators
US10881709B2 (en) 2015-03-06 2021-01-05 Canimguide Therapeutics Ab Immune system modulators and compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
AU692892B2 (en) * 1994-06-15 1998-06-18 Wellcome Foundation Limited, The Enzyme inhibitors
GB9425701D0 (en) 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors

Also Published As

Publication number Publication date
PT1062201E (pt) 2005-02-28
UA67767C2 (ru) 2004-07-15
HUP0101467A3 (en) 2003-03-28
SK13012000A3 (sk) 2001-06-11
KR20010034598A (ko) 2001-04-25
AP2000001900A0 (en) 2000-09-30
IS5583A (is) 2000-08-04
WO1999046240A3 (en) 1999-11-11
BR9908702A (pt) 2000-11-21
DE69920670T2 (de) 2006-02-16
ATE277894T1 (de) 2004-10-15
DE69920670D1 (de) 2004-11-04
CU23047A3 (es) 2005-04-26
JP2002506056A (ja) 2002-02-26
OA11901A (en) 2006-04-10
IL137654A0 (en) 2001-10-31
ID26208A (id) 2000-11-07
ZA991894B (en) 1999-09-27
US6344483B1 (en) 2002-02-05
AU2778699A (en) 1999-09-27
SI1062201T1 (en) 2005-10-31
EP1062201B1 (en) 2004-09-29
TR200002605T2 (tr) 2000-12-21
ES2239839T3 (es) 2005-10-01
HUP0101467A2 (hu) 2001-08-28
NO20004531D0 (no) 2000-09-11
YU52200A (sh) 2002-09-19
HRP20000595A2 (en) 2001-04-30
BG104766A (bg) 2001-03-30
WO1999046240A2 (en) 1999-09-16
EP1415982A1 (en) 2004-05-06
CN1292779A (zh) 2001-04-25
EP1062201A2 (en) 2000-12-27
GEP20043179B (en) 2004-02-25
CN1171861C (zh) 2004-10-20
PL343380A1 (en) 2001-08-13
AU746235B2 (en) 2002-04-18
NZ506721A (en) 2003-07-25
CA2322873A1 (en) 1999-09-16
NO20004531L (no) 2000-10-30
EE200000519A (et) 2002-02-15
AR018159A1 (es) 2001-10-31

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