EA200400129A1 - Способ получения периндоприла, его аналогов и солей с использованием 2,5-диоксооксазолидиновых промежуточных соединений - Google Patents
Способ получения периндоприла, его аналогов и солей с использованием 2,5-диоксооксазолидиновых промежуточных соединенийInfo
- Publication number
- EA200400129A1 EA200400129A1 EA200400129A EA200400129A EA200400129A1 EA 200400129 A1 EA200400129 A1 EA 200400129A1 EA 200400129 A EA200400129 A EA 200400129A EA 200400129 A EA200400129 A EA 200400129A EA 200400129 A1 EA200400129 A1 EA 200400129A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- formula
- compound
- dioxooxazazolidine
- analogues
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Способ получения соединения формулы (IV), либо его сложного эфира или соли, включающий 1) взаимодействие соединения формулы (I) (где Rпредставляет собой Cалкил, Rпредставляет собой Cалкил, a Rпредставляет собой Cалкил) с соединением формулы XC=O (где каждый X независимо представляет собой уходящую группу) с образованием соединения формулы (II) (где R, Rи Rтакие же, как определено выше); и 2) взаимодействие указанного соединения формулы (II) с соединением формулы (III) (где Rпредставляет собой водород или защитную группу), а также способ получения соединения формулы (I).Отчет о международном поиске был опубликован 2003.08.28.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01500197 | 2001-07-24 | ||
PCT/EP2002/008223 WO2003010142A2 (en) | 2001-07-24 | 2002-07-23 | A process for the preparation of perindopril, its analgous compounds and salts thereof using 2,5 -dioxo-oxazolidine intermediate compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200400129A1 true EA200400129A1 (ru) | 2004-08-26 |
EA007000B1 EA007000B1 (ru) | 2006-06-30 |
Family
ID=8183486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400129A EA007000B1 (ru) | 2001-07-24 | 2002-07-23 | Способ получения периндоприла, его аналогов и солей с использованием 2,5-диоксо-оксазолидиновых промежуточных соединений |
Country Status (24)
Country | Link |
---|---|
US (1) | US20040248814A1 (ru) |
EP (1) | EP1279665B1 (ru) |
JP (1) | JP4083118B2 (ru) |
KR (1) | KR100694528B1 (ru) |
CN (1) | CN100503568C (ru) |
AR (1) | AR036187A1 (ru) |
AT (1) | ATE386717T1 (ru) |
AU (1) | AU2002328954B2 (ru) |
BR (1) | BR0211422A (ru) |
CY (1) | CY1107403T1 (ru) |
DE (1) | DE60225092T2 (ru) |
DK (1) | DK1279665T3 (ru) |
EA (1) | EA007000B1 (ru) |
ES (1) | ES2300402T3 (ru) |
HK (1) | HK1067129A1 (ru) |
HU (1) | HUP0202414A3 (ru) |
MX (1) | MXPA04000649A (ru) |
NO (1) | NO20040278L (ru) |
NZ (1) | NZ530578A (ru) |
PL (1) | PL355161A1 (ru) |
PT (1) | PT1279665E (ru) |
SI (1) | SI1279665T1 (ru) |
WO (1) | WO2003010142A2 (ru) |
ZA (1) | ZA200400323B (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60220877T2 (de) | 2002-01-30 | 2008-04-10 | Les Laboratoires Servier | Verfahren zur Herstellung von hochreinem Perindopril und Zwischenverbindungen nützlich in der Synthese |
DK1603558T3 (da) | 2003-02-28 | 2008-09-01 | Servier S A Lab | Fremgangsmåde til fremstilling af perindopril og salte deraf |
JP4733023B2 (ja) | 2003-04-16 | 2011-07-27 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎ウイルスの大環状イソキノリンペプチド阻害剤 |
SI21506A (sl) * | 2003-05-08 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo perindoprila |
SI21507A (sl) | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
WO2005019173A1 (en) * | 2003-08-21 | 2005-03-03 | Hetero Drugs Limited | Process for pure perindopril tert-butylamine salt |
SI1675827T1 (sl) * | 2003-10-21 | 2010-04-30 | Servier Lab | Nov postopek za pripravo kristaliniŽŤnega perindopril erbumina |
SI21703A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia |
SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
ES2255872B1 (es) * | 2004-12-31 | 2007-08-16 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de perindopril erbumina. |
US7291745B2 (en) | 2005-03-21 | 2007-11-06 | Glenmark Pharmaceuticals Limited | Process for the preparation of perindopril |
JP2006290825A (ja) * | 2005-04-13 | 2006-10-26 | Shiono Chemical Co Ltd | アルファ型ペリンドプリルエルブミンの製造法 |
WO2006137082A1 (en) * | 2005-06-23 | 2006-12-28 | Ramesh Babu Potluri | Process for industrially viable preparation of perindopril erbumine |
FR2894825B1 (fr) * | 2005-12-21 | 2010-12-03 | Servier Lab | Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent |
KR101396899B1 (ko) * | 2006-05-12 | 2014-05-19 | 에지스 지오기스제르기아르 니일바노산 무코도 레스즈베니타르사사그 | Ace-억제제의 합성에서의 약학적 중간체 및 이의 용도 |
JP2008019214A (ja) * | 2006-07-13 | 2008-01-31 | Shiono Chemical Co Ltd | ペリンドプリルまたはその誘導体の製造方法 |
ATE551328T1 (de) | 2007-06-06 | 2012-04-15 | Dsm Sinochem Pharm Nl Bv | Neuartige 5-substituierte hydantoine |
FR2985512B1 (fr) * | 2012-01-05 | 2014-06-20 | Servier Lab | Procede de preparation du sel de l-arginine du perindopril |
FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
CN111116709B (zh) * | 2019-12-31 | 2022-06-24 | 北京鑫开元医药科技有限公司 | 一种培哚普利制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US4508729A (en) * | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
ZA817261B (en) * | 1980-10-23 | 1982-09-29 | Schering Corp | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
DE19575012I2 (de) * | 1980-10-23 | 2002-01-24 | Schering Corp | Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US4558038A (en) * | 1981-03-30 | 1985-12-10 | Usv Pharmaceutical Corp. | N-Substituted-amindo-amino acids |
US4496542A (en) * | 1981-03-30 | 1985-01-29 | Usv Pharmaceutical Corporation | N-substituted-amido-amino acids |
US4686295A (en) * | 1982-03-10 | 1987-08-11 | Usv Pharmaceutical Corporation | N-carboxy anhydride intermediates |
US4885293A (en) * | 1984-09-24 | 1989-12-05 | Schering Corporation | Antiglaucoma agents |
JPS6248696A (ja) * | 1985-08-27 | 1987-03-03 | Kanegafuchi Chem Ind Co Ltd | N−〔1(s)−エトキシカルボニル−3−フエニルプロピル〕−l−アラニル−l−プロリンの製造法 |
ES2004804A6 (es) | 1987-08-13 | 1989-02-01 | Pharma Investi S A | Un procedimiento para preparar derivados de carboxialquildipeptidos |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
FR2620699B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides |
FR2620700B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
FR2620703B1 (fr) * | 1987-09-17 | 1991-10-04 | Adir | Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides |
US5258525A (en) * | 1991-03-27 | 1993-11-02 | Mcneilab, Inc. | Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters |
SI9200213A (en) * | 1992-09-16 | 1994-03-31 | Krka | Process for preparing alkyl-l-alanil-l-proline derivates |
IN184759B (ru) | 1997-07-22 | 2000-09-23 | Kaneka Corp | |
SE0000382D0 (sv) * | 2000-02-07 | 2000-02-07 | Astrazeneca Ab | New process |
-
2002
- 2002-07-22 AR ARP020102743A patent/AR036187A1/es not_active Application Discontinuation
- 2002-07-23 BR BR0211422-4A patent/BR0211422A/pt not_active IP Right Cessation
- 2002-07-23 NZ NZ530578A patent/NZ530578A/en not_active IP Right Cessation
- 2002-07-23 ES ES02016262T patent/ES2300402T3/es not_active Expired - Lifetime
- 2002-07-23 AT AT02016262T patent/ATE386717T1/de active
- 2002-07-23 EA EA200400129A patent/EA007000B1/ru not_active IP Right Cessation
- 2002-07-23 KR KR1020047001019A patent/KR100694528B1/ko not_active IP Right Cessation
- 2002-07-23 JP JP2003515501A patent/JP4083118B2/ja not_active Expired - Fee Related
- 2002-07-23 PL PL02355161A patent/PL355161A1/xx not_active Application Discontinuation
- 2002-07-23 DE DE60225092T patent/DE60225092T2/de not_active Revoked
- 2002-07-23 WO PCT/EP2002/008223 patent/WO2003010142A2/en active Application Filing
- 2002-07-23 HU HU0202414A patent/HUP0202414A3/hu unknown
- 2002-07-23 DK DK02016262T patent/DK1279665T3/da active
- 2002-07-23 MX MXPA04000649A patent/MXPA04000649A/es active IP Right Grant
- 2002-07-23 CN CNB028143221A patent/CN100503568C/zh not_active Expired - Fee Related
- 2002-07-23 PT PT02016262T patent/PT1279665E/pt unknown
- 2002-07-23 AU AU2002328954A patent/AU2002328954B2/en not_active Ceased
- 2002-07-23 SI SI200230668T patent/SI1279665T1/sl unknown
- 2002-07-23 EP EP02016262A patent/EP1279665B1/en not_active Revoked
- 2002-07-23 US US10/484,672 patent/US20040248814A1/en not_active Abandoned
-
2004
- 2004-01-15 ZA ZA2004/00323A patent/ZA200400323B/en unknown
- 2004-01-21 NO NO20040278A patent/NO20040278L/no not_active Application Discontinuation
-
2005
- 2005-01-19 HK HK05100509.9A patent/HK1067129A1/xx unknown
-
2008
- 2008-04-21 CY CY20081100440T patent/CY1107403T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR20040029378A (ko) | 2004-04-06 |
AU2002328954B2 (en) | 2007-10-04 |
NO20040278L (no) | 2004-01-21 |
WO2003010142A3 (en) | 2003-08-28 |
CY1107403T1 (el) | 2012-12-19 |
JP2005501829A (ja) | 2005-01-20 |
EP1279665B1 (en) | 2008-02-20 |
SI1279665T1 (sl) | 2008-06-30 |
AR036187A1 (es) | 2004-08-18 |
HK1067129A1 (en) | 2005-04-01 |
DK1279665T3 (da) | 2008-06-23 |
JP4083118B2 (ja) | 2008-04-30 |
ZA200400323B (en) | 2005-03-30 |
EP1279665A3 (en) | 2003-03-12 |
US20040248814A1 (en) | 2004-12-09 |
MXPA04000649A (es) | 2004-10-27 |
EP1279665A2 (en) | 2003-01-29 |
HUP0202414A3 (en) | 2003-05-28 |
PT1279665E (pt) | 2008-03-28 |
CN100503568C (zh) | 2009-06-24 |
DE60225092T2 (de) | 2009-02-19 |
WO2003010142A2 (en) | 2003-02-06 |
ATE386717T1 (de) | 2008-03-15 |
HUP0202414A2 (hu) | 2003-02-28 |
HU0202414D0 (ru) | 2002-09-28 |
DE60225092D1 (de) | 2008-04-03 |
EA007000B1 (ru) | 2006-06-30 |
KR100694528B1 (ko) | 2007-03-13 |
NZ530578A (en) | 2007-02-23 |
BR0211422A (pt) | 2004-08-17 |
ES2300402T3 (es) | 2008-06-16 |
CN1529694A (zh) | 2004-09-15 |
PL355161A1 (en) | 2003-01-13 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |