EA200500032A1 - Производные ацилоксипирролидина и их применение в качестве лигандов v1b или v1b и v1a рецепторов - Google Patents

Производные ацилоксипирролидина и их применение в качестве лигандов v1b или v1b и v1a рецепторов

Info

Publication number
EA200500032A1
EA200500032A1 EA200500032A EA200500032A EA200500032A1 EA 200500032 A1 EA200500032 A1 EA 200500032A1 EA 200500032 A EA200500032 A EA 200500032A EA 200500032 A EA200500032 A EA 200500032A EA 200500032 A1 EA200500032 A1 EA 200500032A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
acyloxypyrrolidine
application
receptors ligands
alkyl
Prior art date
Application number
EA200500032A
Other languages
English (en)
Other versions
EA008444B1 (ru
Inventor
Ален Оломбар
Жорж Гарсия
Антуан Праден
Клодин Серрадей-Ле Галь
Жан Ваньон
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA200500032A1 publication Critical patent/EA200500032A1/ru
Publication of EA008444B1 publication Critical patent/EA008444B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Изобретение касается производных ацилоксипирролидина общей формулы (I), где Rпредставляет собой атом водорода, (C-C)алкил, (C-C)циклоалкил, группу -CHCHCOOH или группу -NRR; каждый из Rи Rнезависимо представляет собой атом водорода или (C-C)алкил. Изобретение также касается способа получения указанных производных и их терапевтического применения.Отчет о международном поиске был опубликован 2004.05.06.
EA200500032A 2002-07-19 2003-07-17 Производные ацилоксипирролидина и их применение в качестве лигандов vили vи vрецепторов EA008444B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0209242A FR2842527B1 (fr) 2002-07-19 2002-07-19 Derives d'acyloxypyrolidine, leur preparation et leur application en therapeutique
PCT/FR2003/002262 WO2004009585A2 (fr) 2002-07-19 2003-07-17 Derives d'acyloxypyrrolidine et leur utilisation en tant que ligands des recepteurs v1b et v1a de avp

Publications (2)

Publication Number Publication Date
EA200500032A1 true EA200500032A1 (ru) 2005-08-25
EA008444B1 EA008444B1 (ru) 2007-06-29

Family

ID=29797610

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500032A EA008444B1 (ru) 2002-07-19 2003-07-17 Производные ацилоксипирролидина и их применение в качестве лигандов vили vи vрецепторов

Country Status (28)

Country Link
US (1) US7202267B2 (ru)
EP (1) EP1525198B1 (ru)
JP (1) JP4264414B2 (ru)
CN (1) CN100425608C (ru)
AR (1) AR040571A1 (ru)
AT (1) ATE312092T1 (ru)
AU (1) AU2003271815B8 (ru)
BR (1) BR0312800A (ru)
CA (1) CA2492224A1 (ru)
DE (1) DE60302670T2 (ru)
DK (1) DK1525198T3 (ru)
EA (1) EA008444B1 (ru)
ES (1) ES2254962T3 (ru)
FR (1) FR2842527B1 (ru)
HK (1) HK1074444A1 (ru)
HR (1) HRP20041231A2 (ru)
IL (1) IL165942A (ru)
IS (1) IS2487B (ru)
ME (1) MEP12408A (ru)
MX (1) MXPA05000822A (ru)
NO (1) NO20050292L (ru)
NZ (1) NZ537615A (ru)
PL (1) PL375309A1 (ru)
RS (1) RS20050018A (ru)
TW (1) TWI274751B (ru)
UA (1) UA78805C2 (ru)
WO (1) WO2004009585A2 (ru)
ZA (1) ZA200500478B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4618127B2 (ja) 2003-08-28 2011-01-26 大正製薬株式会社 １，３−ジヒドロ−２ｈ−インドール−２−オン誘導体
TW200643015A (en) 2005-03-11 2006-12-16 Akzo Nobel Nv 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
DE102005015957A1 (de) * 2005-03-31 2006-10-05 Abbott Gmbh & Co. Kg Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
WO2006133242A2 (en) 2005-06-07 2006-12-14 Pharmacopeia, Inc. Azinone and diazinone v3 inhibitors for depression and stress disorders
US7820649B2 (en) 2006-09-11 2010-10-26 N.V. Organon Quinazolinone and isoquinolinone acetamide derivatives
CN103864658B (zh) * 2014-03-06 2016-06-15 南京工业大学 氮杂环丁酮衍生物及其制备方法与应用
CN104447489B (zh) * 2014-12-29 2017-01-11 南京工业大学 3,4-二芳基马来酰亚胺衍生物及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804114B1 (fr) * 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
NZ537615A (en) 2006-11-30
US7202267B2 (en) 2007-04-10
AU2003271815B2 (en) 2009-03-12
AU2003271815B8 (en) 2009-04-30
DE60302670T2 (de) 2006-09-07
TW200410957A (en) 2004-07-01
UA78805C2 (en) 2007-04-25
HK1074444A1 (en) 2005-11-11
IS2487B (is) 2008-12-15
EP1525198A2 (fr) 2005-04-27
HRP20041231A2 (en) 2005-02-28
IL165942A0 (en) 2006-01-15
WO2004009585A2 (fr) 2004-01-29
CN1681806A (zh) 2005-10-12
WO2004009585A3 (fr) 2004-05-06
ATE312092T1 (de) 2005-12-15
FR2842527B1 (fr) 2005-01-28
PL375309A1 (en) 2005-11-28
CA2492224A1 (en) 2004-01-29
AU2003271815A1 (en) 2004-02-09
IS7641A (is) 2005-01-12
DK1525198T3 (da) 2006-04-18
US20050192335A1 (en) 2005-09-01
CN100425608C (zh) 2008-10-15
IL165942A (en) 2010-04-15
RS20050018A (en) 2007-06-04
EP1525198B1 (fr) 2005-12-07
FR2842527A1 (fr) 2004-01-23
JP4264414B2 (ja) 2009-05-20
MEP12408A (en) 2010-06-10
JP2005537271A (ja) 2005-12-08
ZA200500478B (en) 2006-07-26
BR0312800A (pt) 2005-04-19
AR040571A1 (es) 2005-04-13
ES2254962T3 (es) 2006-06-16
EA008444B1 (ru) 2007-06-29
TWI274751B (en) 2007-03-01
DE60302670D1 (de) 2006-01-12
NO20050292L (no) 2005-04-19
MXPA05000822A (es) 2005-08-29

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU