EA200100310A1 - Кислородсодержащие гетероциклические соединения - Google Patents
Кислородсодержащие гетероциклические соединенияInfo
- Publication number
- EA200100310A1 EA200100310A1 EA200100310A EA200100310A EA200100310A1 EA 200100310 A1 EA200100310 A1 EA 200100310A1 EA 200100310 A EA200100310 A EA 200100310A EA 200100310 A EA200100310 A EA 200100310A EA 200100310 A1 EA200100310 A1 EA 200100310A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrogen atom
- containing heterocyclic
- heterocyclic compounds
- oxygen containing
- substituted
- Prior art date
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 239000001301 oxygen Substances 0.000 title abstract 2
- 229910052760 oxygen Inorganic materials 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
Abstract
Настоящее изобретение относится к кислородсодержащим гетероциклическим соединениям, представленным следующей формулой (I)где m представляет целое число от 0 до 4; R, R, Rи Rнезависимо представляют атом водорода, замещенный или незамещенный низший алкил и т.д.; Rпредставляет замещенный или незамещенный низший алкокси и т.д.; Rпредставляет атом водорода и т.д.; и Y представляет следующую формулу (II)где Rпредставляет циано и т.д., Rпредставляет атом водорода и т.д., Rпредставляет карбокси и т.д. и Rпредставляет атом водорода и т.д., и тому подобное; или их фармацевтически приемлемым солям.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24968598 | 1998-09-03 | ||
JP8275899 | 1999-03-26 | ||
PCT/JP1999/004788 WO2000014085A1 (fr) | 1998-09-03 | 1999-09-03 | Composes heterocycliques oxygenes |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100310A1 true EA200100310A1 (ru) | 2001-10-22 |
EA004138B1 EA004138B1 (ru) | 2004-02-26 |
Family
ID=26423777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100310A EA004138B1 (ru) | 1998-09-03 | 1999-09-03 | ПРОИЗВОДНЫЕ БЕНЗО(b)ЦИКЛОДИОКСААЛКАНА |
Country Status (15)
Country | Link |
---|---|
US (1) | US6376535B2 (ru) |
EP (1) | EP1110961B1 (ru) |
JP (1) | JP3589985B2 (ru) |
KR (1) | KR20010073099A (ru) |
CN (1) | CN1109029C (ru) |
AT (1) | ATE271045T1 (ru) |
AU (1) | AU756878B2 (ru) |
BR (1) | BR9913405A (ru) |
CA (1) | CA2341890C (ru) |
DE (1) | DE69918695T2 (ru) |
EA (1) | EA004138B1 (ru) |
ES (1) | ES2224747T3 (ru) |
HU (1) | HUP0103896A3 (ru) |
MX (1) | MXPA01002102A (ru) |
WO (1) | WO2000014085A1 (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001236048A1 (en) * | 2000-03-02 | 2001-09-12 | Kyowa Hakko Kogyo Co. Ltd. | Oxygen-containing heterocyclic compounds |
CA2435801A1 (en) * | 2001-01-26 | 2002-08-01 | Shin-Ichiro Mohri | Styrene derivative and process for preparing the same |
WO2006041120A1 (ja) * | 2004-10-13 | 2006-04-20 | Kyowa Hakko Kogyo Co., Ltd. | 医薬組成物 |
CA2584169A1 (en) * | 2004-10-13 | 2006-04-20 | Kyowa Hakko Kogyo Co., Ltd. | Remedies/preventives for chronic skin disease |
WO2006123726A1 (ja) * | 2005-05-18 | 2006-11-23 | Kyowa Hakko Kogyo Co., Ltd. | 医薬組成物 |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
TW201018682A (en) * | 2008-09-25 | 2010-05-16 | Kyorin Seiyaku Kk | Heterocyclic biaryl derivative, and pde inhibitor comprising same as active ingredient |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US9051290B2 (en) | 2010-04-28 | 2015-06-09 | Leo Pharma A/S | Biaryl phosphodiesterase inhibitors |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
US10052326B1 (en) | 2017-10-12 | 2018-08-21 | King Saud University | Antihepatotoxic agents |
CN108341807B (zh) * | 2018-02-08 | 2020-07-28 | 平顶山学院 | 含苯并二噁烷骨架的哌嗪酰胺类化合物及其制备方法和应用 |
CN110698466B (zh) * | 2019-05-20 | 2022-07-22 | 暨南大学 | 一种炭皮苯酞类化合物、组合物、制备方法及其用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU521225B2 (en) | 1977-04-19 | 1982-03-25 | Delalande S.A. | Alkylenedioxy phenyl derivatives |
DE3785113T2 (de) | 1986-08-08 | 1993-11-04 | Mitsui Toatsu Chemicals | Insektizider harzfilmueberzug. |
JPS63179868A (ja) | 1987-01-21 | 1988-07-23 | Eisai Co Ltd | 1,4−ベンゾジオキサン誘導体及びその製法 |
GB9027098D0 (en) | 1990-12-13 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
US5166367A (en) | 1991-06-21 | 1992-11-24 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
JPH07242543A (ja) | 1994-03-03 | 1995-09-19 | Taiho Yakuhin Kogyo Kk | 肝疾患治療剤 |
JPH07242655A (ja) | 1994-03-03 | 1995-09-19 | Taiho Yakuhin Kogyo Kk | 1,4−ベンゾジオキサン誘導体 |
JPH10147585A (ja) * | 1996-11-19 | 1998-06-02 | Kyowa Hakko Kogyo Co Ltd | 含酸素複素環化合物 |
CN1163493C (zh) | 1995-05-19 | 2004-08-25 | 协和发酵工业株式会社 | 含氧杂环化合物 |
TR199800767T2 (xx) | 1995-10-30 | 1998-07-21 | Smithkline Beecham Corporation | Proteaz engelleyicileri. |
AU4945697A (en) | 1996-10-09 | 1998-05-05 | Novartis Ag | Solid phase synthesis of heterocyclic compounds |
DE69715769T2 (de) | 1996-11-04 | 2003-05-28 | Bayer Cropscience S.A., Lyon | 1-Polyarylpyrazole als Pestizide |
WO1998022455A1 (fr) * | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Composes heterocycliques d'oxygene |
JPH1149755A (ja) | 1997-07-30 | 1999-02-23 | Nippon Kayaku Co Ltd | 新規含窒素ヘテロ環誘導体およびそれを有効成分とする殺虫殺ダニ組成物 |
WO1999016766A1 (fr) * | 1997-10-01 | 1999-04-08 | Kyowa Hakko Kogyo Co., Ltd. | Derives de benzodioxole |
-
1999
- 1999-09-03 KR KR1020017002765A patent/KR20010073099A/ko not_active Application Discontinuation
- 1999-09-03 CA CA002341890A patent/CA2341890C/en not_active Expired - Fee Related
- 1999-09-03 CN CN99810602A patent/CN1109029C/zh not_active Expired - Fee Related
- 1999-09-03 MX MXPA01002102A patent/MXPA01002102A/es unknown
- 1999-09-03 AT AT99968667T patent/ATE271045T1/de not_active IP Right Cessation
- 1999-09-03 HU HU0103896A patent/HUP0103896A3/hu unknown
- 1999-09-03 JP JP2000568843A patent/JP3589985B2/ja not_active Expired - Fee Related
- 1999-09-03 EA EA200100310A patent/EA004138B1/ru not_active IP Right Cessation
- 1999-09-03 ES ES99968667T patent/ES2224747T3/es not_active Expired - Lifetime
- 1999-09-03 BR BR9913405-5A patent/BR9913405A/pt not_active IP Right Cessation
- 1999-09-03 EP EP99968667A patent/EP1110961B1/en not_active Expired - Lifetime
- 1999-09-03 WO PCT/JP1999/004788 patent/WO2000014085A1/ja not_active Application Discontinuation
- 1999-09-03 DE DE69918695T patent/DE69918695T2/de not_active Expired - Lifetime
- 1999-09-03 AU AU22511/00A patent/AU756878B2/en not_active Ceased
-
2001
- 2001-03-01 US US09/795,093 patent/US6376535B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2224747T3 (es) | 2005-03-01 |
CA2341890A1 (en) | 2000-03-16 |
MXPA01002102A (es) | 2003-02-24 |
KR20010073099A (ko) | 2001-07-31 |
CN1109029C (zh) | 2003-05-21 |
US6376535B2 (en) | 2002-04-23 |
DE69918695D1 (de) | 2004-08-19 |
AU756878B2 (en) | 2003-01-23 |
HUP0103896A2 (hu) | 2002-04-29 |
EA004138B1 (ru) | 2004-02-26 |
EP1110961B1 (en) | 2004-07-14 |
HUP0103896A3 (en) | 2003-01-28 |
BR9913405A (pt) | 2001-10-02 |
WO2000014085A1 (fr) | 2000-03-16 |
US20010056117A1 (en) | 2001-12-27 |
EP1110961A4 (en) | 2001-12-12 |
AU2251100A (en) | 2000-03-27 |
DE69918695T2 (de) | 2005-07-21 |
CN1317002A (zh) | 2001-10-10 |
ATE271045T1 (de) | 2004-07-15 |
CA2341890C (en) | 2006-07-18 |
JP3589985B2 (ja) | 2004-11-17 |
EP1110961A1 (en) | 2001-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |