NO952854L - 1-arylpyrimidin-derivater - Google Patents

1-arylpyrimidin-derivater

Info

Publication number
NO952854L
NO952854L NO952854A NO952854A NO952854L NO 952854 L NO952854 L NO 952854L NO 952854 A NO952854 A NO 952854A NO 952854 A NO952854 A NO 952854A NO 952854 L NO952854 L NO 952854L
Authority
NO
Norway
Prior art keywords
oxo
together form
substituted
methylcyclohexyl
pyran
Prior art date
Application number
NO952854A
Other languages
English (en)
Other versions
NO952854D0 (no
Inventor
Yoshiaki Isobe
Junko Umezawa
Yuso Goto
Masashi Sasaki
Nobuo Watanabe
Hideharu Sato
Fumihiro Obara
Toshimasa Katagiri
Original Assignee
Japan Energy Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Energy Corp filed Critical Japan Energy Corp
Publication of NO952854D0 publication Critical patent/NO952854D0/no
Publication of NO952854L publication Critical patent/NO952854L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelse vedrører 1-arylpyrimidin- derivater representert ved den generelle formel (I): d) Ar R6 ., R5 hvori Rj^ er H, alkyl eller aralkyl; Ar er 1-naftyl, eller en substituert eller usubstituert fenylgruppe; R4 er en substituert fenyl, en substituert styryl, 1- metylcykloheksyl, 4-metylcykloheksyl, 4-okso-4H-pyran-2- yl eller 2-okso-2H-pyran-5-yl-gruppe; R5 °9 Re nver uavhengig er H eller alkyl; R3 er H, og R7 og R8 utgjør sammen okso, eller R3 og R7 utgjør sammen en direkte binding, og R5 og R8 utgjør sammen en annen direkte binding, eller farmasøytisk akseptable salter derav; og anvendelser av slike forbindelser som midler for behandling av allergiske sykdommer.
NO952854A 1994-07-19 1995-07-18 1-arylpyrimidin-derivater NO952854L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16722294 1994-07-19
JP19421994 1994-08-18

Publications (2)

Publication Number Publication Date
NO952854D0 NO952854D0 (no) 1995-07-18
NO952854L true NO952854L (no) 1996-01-22

Family

ID=26491330

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952854A NO952854L (no) 1994-07-19 1995-07-18 1-arylpyrimidin-derivater

Country Status (7)

Country Link
US (1) US5661153A (no)
EP (1) EP0700908A1 (no)
AU (1) AU681034B2 (no)
CA (1) CA2154293A1 (no)
FI (1) FI953479A (no)
NO (1) NO952854L (no)
NZ (1) NZ272591A (no)

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US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US6670334B2 (en) 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
NZ556354A (en) 2001-10-01 2008-10-31 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
EP1514544A4 (en) * 2002-06-06 2009-01-07 Inst Med Molecular Design Inc HYPO-ALLERGENIC
JPWO2004026842A1 (ja) * 2002-09-20 2006-01-12 住友製薬株式会社 新規ウラシル誘導体及びその医薬用途
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
BRPI0507734A (pt) * 2004-02-18 2007-07-10 Astrazeneca Ab composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto
US20080280872A1 (en) * 2004-02-18 2008-11-13 Craig Johnstone Benzamide Derivatives and Their Use as Glucokinase Activating Agents
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
US7576069B2 (en) 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
WO2006023272A1 (en) 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
EP1778712B1 (en) 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
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GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
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TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
JP4651714B2 (ja) * 2005-07-09 2011-03-16 アストラゼネカ アクチボラグ 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
WO2007007040A1 (en) * 2005-07-09 2007-01-18 Astrazeneca Ab 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
WO2007120972A2 (en) 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
CA2671535A1 (en) * 2006-12-21 2008-06-26 Astrazeneca Ab Novel crystalline compound useful as glk activator
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
CN102171213A (zh) 2008-08-04 2011-08-31 阿斯利康(瑞典)有限公司 吡唑并[3，4]嘧啶-4-基衍生物及其治疗糖尿病和肥胖症的用途
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
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Also Published As

Publication number Publication date
US5661153A (en) 1997-08-26
NO952854D0 (no) 1995-07-18
AU681034B2 (en) 1997-08-14
FI953479A0 (fi) 1995-07-18
NZ272591A (en) 1997-05-26
EP0700908A1 (en) 1996-03-13
FI953479A (fi) 1996-01-20
CA2154293A1 (en) 1996-01-20
AU2505795A (en) 1996-02-01

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