AR076221A1 - Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad - Google Patents

Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad

Info

Publication number
AR076221A1
AR076221A1 ARP100101164A ARP100101164A AR076221A1 AR 076221 A1 AR076221 A1 AR 076221A1 AR P100101164 A ARP100101164 A AR P100101164A AR P100101164 A ARP100101164 A AR P100101164A AR 076221 A1 AR076221 A1 AR 076221A1
Authority
AR
Argentina
Prior art keywords
pirazol
obesity
pyrimidine
derived
treat diabetes
Prior art date
Application number
ARP100101164A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR076221A1 publication Critical patent/AR076221A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

(2S)-2-[1-(2-cloro-6-ciano-fenil)pirazol[4,5-e]pirimidin-4-il]oxi-3-[(1R)-2-hidroxi-1-metil-etoxi]-N-(5-metilpirazin-2-il)propanamida o una sal farmacéuticamente aceptable del mismo, para el tratamiento o la prevencion de una enfermedad o afeccion médica mediada por la glucoquinasa (GLK o GK), que conduce a un umbral de glucosa disminuido para la secrecion de insulina.
ARP100101164A 2009-04-09 2010-04-07 Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad AR076221A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16804809P 2009-04-09 2009-04-09

Publications (1)

Publication Number Publication Date
AR076221A1 true AR076221A1 (es) 2011-05-26

Family

ID=42122852

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101164A AR076221A1 (es) 2009-04-09 2010-04-07 Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad

Country Status (5)

Country Link
US (1) US8071608B2 (es)
AR (1) AR076221A1 (es)
TW (1) TW201040189A (es)
UY (1) UY32552A (es)
WO (1) WO2010116176A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
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CL2007003061A1 (es) * 2006-10-26 2008-08-01 Astrazeneca Ab Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2.

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CN101595104A (zh) * 2006-12-21 2009-12-02 阿斯利康(瑞典)有限公司 作为glk活化剂的新的晶态化合物
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US8071608B2 (en) 2011-12-06

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