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FR2088019A1 - Esters of 2 and 6-substituted nicotinic acids - with vasomotor active - Google Patents

Esters of 2 and 6-substituted nicotinic acids - with vasomotor active

Info

Publication number
FR2088019A1
FR2088019A1 FR7016802A FR7016802A FR2088019A1 FR 2088019 A1 FR2088019 A1 FR 2088019A1 FR 7016802 A FR7016802 A FR 7016802A FR 7016802 A FR7016802 A FR 7016802A FR 2088019 A1 FR2088019 A1 FR 2088019A1
Authority
FR
Grant status
Application
Patent type
Prior art keywords
vasomotor
gps
aliphatic
cpds
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7016802A
Other versions
FR2088019B1 (en )
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DAVID RABOT ETS FR
RABOT ETS DAVID
Original Assignee
DAVID RABOT ETS,FR
RABOT ETS DAVID
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3

Abstract

Cpds. are of formula: (where R is aliphatic, araliphatic, heteroaliphatic or aminoalkyl; R2 and R6 = opt. substd. 1-20C aliphatic gps., alkenylaromatic, alkenylheterocyclic, alklaromatic, alkylheterocyclic. Prefd. gps. R are -A.B where B is dimethylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino, piperazino, N-methylpiperazino; A is -CH2-CH2- or -CH2.CH2-CH2-). Cpds. have vasomotor activity, active in animals at parenteral doses of 10 mg/kg.
FR7016802A 1970-05-08 1970-05-08 Expired FR2088019B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7016802A FR2088019B1 (en) 1970-05-08 1970-05-08

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR7016802A FR2088019B1 (en) 1970-05-08 1970-05-08
GB1249771A GB1352415A (en) 1970-05-03 1971-04-30 Esters of substituted nicotine acids
ES390924A ES390924A1 (en) 1970-05-03 1971-05-06 Process for the preparation of nicotinic acid derivatives.
BE766808A BE766808A (en) 1970-05-03 1971-05-06 New esters of nicotinic acid substituted

Publications (2)

Publication Number Publication Date
FR2088019A1 true true FR2088019A1 (en) 1972-01-07
FR2088019B1 FR2088019B1 (en) 1974-08-30

Family

ID=9055254

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7016802A Expired FR2088019B1 (en) 1970-05-08 1970-05-08

Country Status (1)

Country Link
FR (1) FR2088019B1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2205515A1 (en) * 1972-11-08 1974-05-31 Hokuriku Pharmaceutical
US7199140B2 (en) 2001-06-26 2007-04-03 Astrazeneca Ab Vinyl phenyl derivatives as GLK activators
US7390908B2 (en) 2001-08-17 2008-06-24 Astrazeneca Ab Compounds effecting glucokinase
US7642263B2 (en) 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7696191B2 (en) 2006-12-21 2010-04-13 Astrazeneca Ab Crystalline compound
US7700640B2 (en) 2004-10-16 2010-04-20 Astrazeneca Ab Process for making phenoxy benzamide compounds
US7709505B2 (en) 2002-11-19 2010-05-04 Astrazeneca Ab Benzofuran derivatives, process for their preparation and intermediates thereof
US7902200B2 (en) 2006-10-23 2011-03-08 Astrazeneca Ab Chemical compounds
US7973178B2 (en) 2005-11-28 2011-07-05 Astrazeneca Ab Chemical process for the preparation of an amido-phenoxybenzoic acid compound
US8071608B2 (en) * 2009-04-09 2011-12-06 Astrazeneca Ab Therapeutic agents

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992623A1 (en) 2004-06-05 2008-11-19 Astra Zeneca AB Heteroaryl benzamide derivative for use as GLK activator in the treatment of diabetes
EP1891058A1 (en) 2005-05-27 2008-02-27 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
CN101805299A (en) 2006-10-26 2010-08-18 阿斯利康(瑞典)有限公司 Benzoyl amino heterocyclyl compounds as glucokinase (glk) activators
JP2011529955A (en) 2008-08-04 2011-12-15 アストラゼネカ アクチボラグ Therapeutic agent 414
GB0902434D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS644086A (en) * 1987-06-26 1989-01-09 Yokogawa Electric Corp Quantum resistance standard

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS644086A (en) * 1987-06-26 1989-01-09 Yokogawa Electric Corp Quantum resistance standard

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2205515A1 (en) * 1972-11-08 1974-05-31 Hokuriku Pharmaceutical
US7199140B2 (en) 2001-06-26 2007-04-03 Astrazeneca Ab Vinyl phenyl derivatives as GLK activators
US7390908B2 (en) 2001-08-17 2008-06-24 Astrazeneca Ab Compounds effecting glucokinase
US7524957B2 (en) 2001-08-17 2009-04-28 Astrazeneca Ab Compounds effecting glucokinase
US7951830B2 (en) 2001-08-17 2011-05-31 Astrazeneca Ab Compounds effecting glucokinase
US7709505B2 (en) 2002-11-19 2010-05-04 Astrazeneca Ab Benzofuran derivatives, process for their preparation and intermediates thereof
US7700640B2 (en) 2004-10-16 2010-04-20 Astrazeneca Ab Process for making phenoxy benzamide compounds
US7642259B2 (en) 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7642263B2 (en) 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7977328B2 (en) 2005-07-09 2011-07-12 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7973178B2 (en) 2005-11-28 2011-07-05 Astrazeneca Ab Chemical process for the preparation of an amido-phenoxybenzoic acid compound
US7902200B2 (en) 2006-10-23 2011-03-08 Astrazeneca Ab Chemical compounds
US7696191B2 (en) 2006-12-21 2010-04-13 Astrazeneca Ab Crystalline compound
US8071608B2 (en) * 2009-04-09 2011-12-06 Astrazeneca Ab Therapeutic agents

Also Published As

Publication number Publication date Type
FR2088019B1 (en) 1974-08-30 grant

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