FR2088019A1 - Esters of 2 and 6-substituted nicotinic acids - with vasomotor active - Google Patents
Esters of 2 and 6-substituted nicotinic acids - with vasomotor activeInfo
- Publication number
- FR2088019A1 FR2088019A1 FR7016802A FR7016802A FR2088019A1 FR 2088019 A1 FR2088019 A1 FR 2088019A1 FR 7016802 A FR7016802 A FR 7016802A FR 7016802 A FR7016802 A FR 7016802A FR 2088019 A1 FR2088019 A1 FR 2088019A1
- Authority
- FR
- France
- Prior art keywords
- active
- vasomotor
- esters
- nicotinic acids
- substituted nicotinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Abstract
Cpds. are of formula: (where R is aliphatic, araliphatic, heteroaliphatic or aminoalkyl; R2 and R6 = opt. substd. 1-20C aliphatic gps., alkenylaromatic, alkenylheterocyclic, alklaromatic, alkylheterocyclic. Prefd. gps. R are -A.B where B is dimethylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino, piperazino, N-methylpiperazino; A is -CH2-CH2- or -CH2.CH2-CH2-). Cpds. have vasomotor activity, active in animals at parenteral doses of 10 mg/kg.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7016802A FR2088019A1 (en) | 1970-05-08 | 1970-05-08 | Esters of 2 and 6-substituted nicotinic acids - with vasomotor active |
GB1249771A GB1352415A (en) | 1970-05-03 | 1971-04-30 | Esters of substituted nicotine acids |
BE766808A BE766808A (en) | 1970-05-03 | 1971-05-06 | NEW ESTERS OF SUBSTITUTE NICOTINIC ACID |
ES71390924A ES390924A1 (en) | 1970-05-03 | 1971-05-06 | Esters of substituted nicotine acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7016802A FR2088019A1 (en) | 1970-05-08 | 1970-05-08 | Esters of 2 and 6-substituted nicotinic acids - with vasomotor active |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2088019A1 true FR2088019A1 (en) | 1972-01-07 |
FR2088019B1 FR2088019B1 (en) | 1974-08-30 |
Family
ID=9055254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7016802A Granted FR2088019A1 (en) | 1970-05-03 | 1970-05-08 | Esters of 2 and 6-substituted nicotinic acids - with vasomotor active |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2088019A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2205515A1 (en) * | 1972-11-08 | 1974-05-31 | Hokuriku Pharmaceutical | |
US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US7642259B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7696191B2 (en) | 2006-12-21 | 2010-04-13 | Astrazeneca Ab | Crystalline compound |
US7700640B2 (en) | 2004-10-16 | 2010-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
US7709505B2 (en) | 2002-11-19 | 2010-05-04 | Astrazeneca Ab | Benzofuran derivatives, process for their preparation and intermediates thereof |
US7902200B2 (en) | 2006-10-23 | 2011-03-08 | Astrazeneca Ab | Chemical compounds |
US7973178B2 (en) | 2005-11-28 | 2011-07-05 | Astrazeneca Ab | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
US8071608B2 (en) * | 2009-04-09 | 2011-12-06 | Astrazeneca Ab | Therapeutic agents |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
SA07280576B1 (en) | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators |
MX2011001333A (en) | 2008-08-04 | 2011-03-15 | Astrazeneca Ab | Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity. |
GB0902406D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH458344A (en) * | 1964-01-20 | 1968-06-30 | Orgamol Sa | Process for the preparation of basic esters of pyridine carboxylic acids |
JPS644086A (en) * | 1987-06-26 | 1989-01-09 | Yokogawa Electric Corp | Quantum resistance standard |
-
1970
- 1970-05-08 FR FR7016802A patent/FR2088019A1/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH458344A (en) * | 1964-01-20 | 1968-06-30 | Orgamol Sa | Process for the preparation of basic esters of pyridine carboxylic acids |
JPS644086A (en) * | 1987-06-26 | 1989-01-09 | Yokogawa Electric Corp | Quantum resistance standard |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2205515A1 (en) * | 1972-11-08 | 1974-05-31 | Hokuriku Pharmaceutical | |
US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US7524957B2 (en) | 2001-08-17 | 2009-04-28 | Astrazeneca Ab | Compounds effecting glucokinase |
US7951830B2 (en) | 2001-08-17 | 2011-05-31 | Astrazeneca Ab | Compounds effecting glucokinase |
US7709505B2 (en) | 2002-11-19 | 2010-05-04 | Astrazeneca Ab | Benzofuran derivatives, process for their preparation and intermediates thereof |
US7700640B2 (en) | 2004-10-16 | 2010-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
US7642259B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7642263B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7977328B2 (en) | 2005-07-09 | 2011-07-12 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7973178B2 (en) | 2005-11-28 | 2011-07-05 | Astrazeneca Ab | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
US7902200B2 (en) | 2006-10-23 | 2011-03-08 | Astrazeneca Ab | Chemical compounds |
US7696191B2 (en) | 2006-12-21 | 2010-04-13 | Astrazeneca Ab | Crystalline compound |
US8071608B2 (en) * | 2009-04-09 | 2011-12-06 | Astrazeneca Ab | Therapeutic agents |
Also Published As
Publication number | Publication date |
---|---|
FR2088019B1 (en) | 1974-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2088019A1 (en) | Esters of 2 and 6-substituted nicotinic acids - with vasomotor active | |
ES406084A2 (en) | Derivatives of 5-cinnamoyl benzofuran | |
CA1016414A (en) | Fluidized bed furnace having fuel air supply lance and a fuel air supply lance construction | |
GB1380219A (en) | Latch needle for knitting machines | |
GB1251282A (en) | ||
GB1294343A (en) | A patterning mechanism in a multi-feed circular knitting machine | |
PH10188A (en) | 6-(l-3-acylamidoacetamido)-penicillanic acids,their pharmaceutically acceptable salts and their medicinal uses | |
FR2088020A1 (en) | Aminoalkyl esters of diacetylgentisic acid - with analgesic activity | |
FR2166101A1 (en) | 1,4-di (morpholino,piperidino or pyrrolidino)-7-substd - -pyrido (3,4-d)-pyridazines - as diuretics | |
FR2100973A1 (en) | 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity | |
GB1457005A (en) | 2-substituted-3-aminoquinoxalines | |
FR2088018A1 (en) | Vasodilatory, substd nicotinic acid amino ester derivs | |
FR2073427A1 (en) | 4-methyl-5-ethyl-n-heterocyclic thiazoles - with antianoxic activity | |
GB1396465A (en) | 1-arylideneamino-4-2-oxo-3-phenyl-3-benzofuryl piperazines | |
GB1389186A (en) | Chromone derivatives processes for their manufacture | |
FR2154082A5 (en) | Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn | |
ES385522A1 (en) | Azamorphinan compounds | |
FR2085647A1 (en) | 6-amino-2-methyl-2-heptanols - with cardiovascular analeptic analgesic and spasmolytic activity | |
GB1344104A (en) | Cams for knitting machines | |
FR2068430A1 (en) | 3-dialkylaminoalkoxy coumarilonitriles vasodilatory spasmolytic | |
FR2182886A1 (en) | 5-aminoalkyl-tetrahydro-1,5-benzoxazepines - as cns-depressants from tetrahydrobenzo xazepines via 5-chloroacyl-derivs with amines | |
FR2150240A2 (en) | 5-cinnamoyl-4,7-dimethoxy-6-tertiary amino alkyl - -benzofurans - vasodilators,hypotensives,diuretics,spasmolytics,analg | |
USD232090S (en) | Portable hydrant | |
FR2192807A2 (en) | 5-cinnamoyl-4,7-dimethoxy-6-tertiary amino alkyl - -benzofurans - vasodilators,hypotensives,diuretics,spasmolytics,analg | |
YU263971A (en) | Improvement in a head for final treatment of deep cylindrical openings by simultaneously turning and rolling |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |