FR2088019A1 - Esters of 2 and 6-substituted nicotinic acids - with vasomotor active - Google Patents
Esters of 2 and 6-substituted nicotinic acids - with vasomotor activeInfo
- Publication number
- FR2088019A1 FR2088019A1 FR7016802A FR7016802A FR2088019A1 FR 2088019 A1 FR2088019 A1 FR 2088019A1 FR 7016802 A FR7016802 A FR 7016802A FR 7016802 A FR7016802 A FR 7016802A FR 2088019 A1 FR2088019 A1 FR 2088019A1
- Authority
- FR
- France
- Prior art keywords
- ch2
- active
- vasomotor
- esters
- nicotinic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Abstract
Cpds. are of formula: (where R is aliphatic, araliphatic, heteroaliphatic or aminoalkyl; R2 and R6 = opt. substd. 1-20C aliphatic gps., alkenylaromatic, alkenylheterocyclic, alklaromatic, alkylheterocyclic. Prefd. gps. R are -A.B where B is dimethylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino, piperazino, N-methylpiperazino; A is -CH2-CH2- or -CH2.CH2-CH2-). Cpds. have vasomotor activity, active in animals at parenteral doses of 10 mg/kg.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7016802A FR2088019B1 (en) | 1970-05-08 | 1970-05-08 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7016802A FR2088019B1 (en) | 1970-05-08 | 1970-05-08 | |
GB1249771A GB1352415A (en) | 1970-05-03 | 1971-04-30 | Esters of substituted nicotine acids |
ES71390924A ES390924A1 (en) | 1970-05-03 | 1971-05-06 | Process for the preparation of nicotinic acid derivatives. |
BE766808A BE766808A (en) | 1970-05-03 | 1971-05-06 | New esters of nicotinic acid substituted |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2088019A1 true FR2088019A1 (en) | 1972-01-07 |
FR2088019B1 FR2088019B1 (en) | 1974-08-30 |
Family
ID=9055254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7016802A Expired FR2088019B1 (en) | 1970-05-08 | 1970-05-08 |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2088019B1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2205515A1 (en) * | 1972-11-08 | 1974-05-31 | Hokuriku Pharmaceutical | |
US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US7642263B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7696191B2 (en) | 2006-12-21 | 2010-04-13 | Astrazeneca Ab | Crystalline compound |
US7700640B2 (en) | 2004-10-16 | 2010-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
US7709505B2 (en) | 2002-11-19 | 2010-05-04 | Astrazeneca Ab | Benzofuran derivatives, process for their preparation and intermediates thereof |
US7902200B2 (en) | 2006-10-23 | 2011-03-08 | Astrazeneca Ab | Chemical compounds |
US7973178B2 (en) | 2005-11-28 | 2011-07-05 | Astrazeneca Ab | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
US8071608B2 (en) * | 2009-04-09 | 2011-12-06 | Astrazeneca Ab | Therapeutic agents |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
TW200825060A (en) | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
EA201100097A1 (en) | 2008-08-04 | 2011-10-31 | Астразенека Аб | Derivatives of pyrazolo [3,4] pyrimidin-4-yl, and their use in the treatment of diabetes and obesity |
GB0902434D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
GB0902406D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
AR076220A1 (en) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Pyrazole derivatives [4,5 - e] pyrimidine |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH458344A (en) * | 1964-01-20 | 1968-06-30 | Orgamol Sa | A process for the preparation of basic esters of pyridine carboxylic acids |
JPS644086A (en) * | 1987-06-26 | 1989-01-09 | Yokogawa Electric Corp | Quantum resistance standard |
-
1970
- 1970-05-08 FR FR7016802A patent/FR2088019B1/fr not_active Expired
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH458344A (en) * | 1964-01-20 | 1968-06-30 | Orgamol Sa | A process for the preparation of basic esters of pyridine carboxylic acids |
JPS644086A (en) * | 1987-06-26 | 1989-01-09 | Yokogawa Electric Corp | Quantum resistance standard |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2205515A1 (en) * | 1972-11-08 | 1974-05-31 | Hokuriku Pharmaceutical | |
US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US7524957B2 (en) | 2001-08-17 | 2009-04-28 | Astrazeneca Ab | Compounds effecting glucokinase |
US7951830B2 (en) | 2001-08-17 | 2011-05-31 | Astrazeneca Ab | Compounds effecting glucokinase |
US7709505B2 (en) | 2002-11-19 | 2010-05-04 | Astrazeneca Ab | Benzofuran derivatives, process for their preparation and intermediates thereof |
US7700640B2 (en) | 2004-10-16 | 2010-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
US7642259B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7642263B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7977328B2 (en) | 2005-07-09 | 2011-07-12 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7973178B2 (en) | 2005-11-28 | 2011-07-05 | Astrazeneca Ab | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
US7902200B2 (en) | 2006-10-23 | 2011-03-08 | Astrazeneca Ab | Chemical compounds |
US7696191B2 (en) | 2006-12-21 | 2010-04-13 | Astrazeneca Ab | Crystalline compound |
US8071608B2 (en) * | 2009-04-09 | 2011-12-06 | Astrazeneca Ab | Therapeutic agents |
Also Published As
Publication number | Publication date |
---|---|
FR2088019B1 (en) | 1974-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |