FR2100973A1 - 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity - Google Patents

5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity

Info

Publication number
FR2100973A1
FR2100973A1 FR7128105A FR7128105A FR2100973A1 FR 2100973 A1 FR2100973 A1 FR 2100973A1 FR 7128105 A FR7128105 A FR 7128105A FR 7128105 A FR7128105 A FR 7128105A FR 2100973 A1 FR2100973 A1 FR 2100973A1
Authority
FR
France
Prior art keywords
antiinflammatory
analgesic
aminopyrazoles
muscle relaxant
relaxant activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7128105A
Other languages
French (fr)
Other versions
FR2100973B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to FR7128105A priority Critical patent/FR2100973A1/en
Publication of FR2100973A1 publication Critical patent/FR2100973A1/en
Application granted granted Critical
Publication of FR2100973B1 publication Critical patent/FR2100973B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Antiinflammatory, analgesic and spasmolytic agents of formula: are claimed with their acid addition salts. In formula, Y= =NH, =O or =NOH; R1= allyl, 1-3C alkyl; R2,R3=H, allyl, 1-3C alkyl, benzyl, ethoxycarbonyl or the gp. R5CO- where R5 is H, Me or Et; or R2 + R3 and the attached N-atom is pyrrolidino, piperidino, morpholino, 4-methyl-1-piperazinyl, 4-methyl-1-homopiperazinyl, 4-(2-hydroxy-ethyl)-1-piperazinyl; or R1 and R2 together form a -CH2CH2- gp; R4=H, Me, Et; X1,X2=H, halogen, Me, -PMe or CF3. Daily adult dose is 150-450 mg.
FR7128105A 1970-07-30 1971-07-30 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity Granted FR2100973A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7128105A FR2100973A1 (en) 1970-07-30 1971-07-30 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6707470 1970-07-30
FR7128105A FR2100973A1 (en) 1970-07-30 1971-07-30 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity

Publications (2)

Publication Number Publication Date
FR2100973A1 true FR2100973A1 (en) 1972-03-24
FR2100973B1 FR2100973B1 (en) 1975-02-07

Family

ID=26216548

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7128105A Granted FR2100973A1 (en) 1970-07-30 1971-07-30 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity

Country Status (1)

Country Link
FR (1) FR2100973A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068806A2 (en) * 1981-06-26 1983-01-05 Warner-Lambert Company Basic acyl amides of (5-amino-1,3-dialkylpyrazol-4-yl)(aryl)methanones, processes for their production, and pharmaceutical compositions containing such compounds
US6316466B1 (en) 1998-05-05 2001-11-13 Syntex (U.S.A.) Llc Pyrazole derivatives P-38 MAP kinase inhibitors
US6376527B1 (en) 1998-05-05 2002-04-23 Syntex (U.S.A.) Llc Pyrazole derivatives-p38 map kinase inhibitors
US6979693B2 (en) 1998-05-05 2005-12-27 Syntex (U.S.A.) Llc Pyrazole derivatives-p38 MAP kinase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989537A (en) * 1958-05-30 1961-06-20 Ciba Pharm Prod Inc Pyrazolo [2, 3-alpha] imidazolidines
FR2023474A1 (en) * 1968-11-16 1970-08-21 Bayer Ag

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989537A (en) * 1958-05-30 1961-06-20 Ciba Pharm Prod Inc Pyrazolo [2, 3-alpha] imidazolidines
FR2023474A1 (en) * 1968-11-16 1970-08-21 Bayer Ag

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068806A2 (en) * 1981-06-26 1983-01-05 Warner-Lambert Company Basic acyl amides of (5-amino-1,3-dialkylpyrazol-4-yl)(aryl)methanones, processes for their production, and pharmaceutical compositions containing such compounds
EP0068806A3 (en) * 1981-06-26 1983-08-10 Warner-Lambert Company Basic acyl amides of (5-amino-1,3-dialkylpyrazol-4-yl)(aryl)methanones, processes for their production, and pharmaceutical compositions containing such compounds
US6316466B1 (en) 1998-05-05 2001-11-13 Syntex (U.S.A.) Llc Pyrazole derivatives P-38 MAP kinase inhibitors
US6376527B1 (en) 1998-05-05 2002-04-23 Syntex (U.S.A.) Llc Pyrazole derivatives-p38 map kinase inhibitors
US6979693B2 (en) 1998-05-05 2005-12-27 Syntex (U.S.A.) Llc Pyrazole derivatives-p38 MAP kinase inhibitors

Also Published As

Publication number Publication date
FR2100973B1 (en) 1975-02-07

Similar Documents

Publication Publication Date Title
ES448646A1 (en) N-Substituted 2-methoxybenzenesulphonamides and medicaments containing them
FR2100973A1 (en) 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity
FR1604106A (en) 1- % aroylalkyl -piperidinecarboxylic acid cpds
ES412702A1 (en) N-phosphoryl and n-phosphonyl amidines
DK195384A (en) triazine
FR2138488A1 (en) 1-(5-indanyl)-omega-aminoalkanes - with tranquillizing activity
ES392093A1 (en) 2-amino-5-chloro-thiazole derivatives
GB1096351A (en) Improvements in or relating to piperazine derivatives
ES396390A1 (en) 2-chloro-7-hydroxy-11-(1-piperazinyl)dibenz(b f)(1 4)oxazepines
ES394969A1 (en) 5-(2-amino-alkoxy-phenoxy-methyl)-3-alkyl-isoxazoles - useful as hypotensives and sedatives
FR2073427A1 (en) 4-methyl-5-ethyl-n-heterocyclic thiazoles - with antianoxic activity
ES468585A1 (en) 2-Methyl-6-alkyl-11-aminoalkyl-6,11-dihydro-5H-pyrido(2,3-B)(1,5)benzodiazepin-5-ones and salts thereof
ES394968A1 (en) 5-(2-amino-alkoxy-phenoxy-methyl)-3-alkyl-isoxazoles - useful as hypotensives and sedatives
FR2142809A1 (en) 3-hydroxy-3-methyl-2-methylene pyrrolidinium iodides - with vasodilator, hypotensive and analgesic activity
FR2142648A1 (en) 4,7-dimethoxy benzofurant derivs - diuretics vasodilators hypotensives spasmolytics bradycardiants and antiulcer agents
FR2294705A1 (en) Hypotensive benzene-1,3-disulphonamides - 4-substd. by 4-alkyl-1-piperazinyl and 6-substd. by amino (BE160676)
FR2164520A2 (en) 2-(n-heterocyclic amino)thiazolin-4-ones - with respiratory analeptic activity
FR2150594A1 (en) Omega-amino-1,2-diphenyl-1-alkanones - with analgesic antiinflammatory anti-ulcer,bronchodilator,spasmolytic and hypotensive
FR2235687A2 (en) 1-Trimethoxy phenyl-3-carboxamido indoles - anti-inflammatories, sedatives, vasodilators, hypotensives, analgesics, anticholinergics, anti-ulcer agents etc.
FR2068430A1 (en) 3-dialkylaminoalkoxy coumarilonitriles vasodilatory spasmolytic
FR2207719A2 (en) Triazolobenzodiazepine prepns - with antidepressant and anxiolytic activity
FR2247213A1 (en) 3-Aminocarbonylmethyl-5-methyl-1,2,4-oxadiazoles - with diuretic, sedative, antihistaminic analgesic and antiulcer activity
ES345691A1 (en) 2-aminomethyl benzofuran derivatives
BE807752A (en) Triazolobenzodiazepine prepns - with antidepressant and anxiolytic activity
ES361018A1 (en) Procedure for obtaining salts from biosintetic and semi-synthetic penicillins with N-substituted derivatives of aminocetil-2-metoxifenol. (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
ST Notification of lapse