JPS5721320A - Blood sugar level depressing agent - Google Patents
Blood sugar level depressing agentInfo
- Publication number
- JPS5721320A JPS5721320A JP9385380A JP9385380A JPS5721320A JP S5721320 A JPS5721320 A JP S5721320A JP 9385380 A JP9385380 A JP 9385380A JP 9385380 A JP9385380 A JP 9385380A JP S5721320 A JPS5721320 A JP S5721320A
- Authority
- JP
- Japan
- Prior art keywords
- blood sugar
- sugar level
- compound
- formula
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To provide a blood sugar level depressing agent containing a specific benzamide derivative as an active component.
CONSTITUTION: An agent containing the compound of formula [R1 and R2 are H, alkyl, (substituted) aralkyl, or (substituted) phenyl] as an active component. The compound of formula has excellent insulin biosynthesis promoting activity and blood sugar level depressing activity. It is effective at a dose of 0.lW100mg/kg for man, and maintains the activity for ≥24hr by the administration of 0.1W100mg/kg, once a day. The compound of formula can be prepared easily e.g. by reducing the corresponding m-nitrobenzoic acid amide by conventional method.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9385380A JPS5721320A (en) | 1980-07-11 | 1980-07-11 | Blood sugar level depressing agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9385380A JPS5721320A (en) | 1980-07-11 | 1980-07-11 | Blood sugar level depressing agent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5721320A true JPS5721320A (en) | 1982-02-04 |
Family
ID=14093968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9385380A Pending JPS5721320A (en) | 1980-07-11 | 1980-07-11 | Blood sugar level depressing agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5721320A (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3305755A1 (en) * | 1983-02-19 | 1984-08-23 | Gödecke AG, 1000 Berlin | N-PHENYL-BENZAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST DISEASES OF THE IMMUNE SYSTEM |
WO1996031462A1 (en) * | 1995-04-03 | 1996-10-10 | Centaur Pharmaceuticals, Inc. | Benzamides for neurodegenerative disorder treatment |
US5914350A (en) * | 1995-04-03 | 1999-06-22 | Centaur Pharmaceuticals, Inc. | Pharmaceutical compositions of nitro- and aminobenzamide compounds for neurodegenerative disorders |
US5955506A (en) * | 1996-04-03 | 1999-09-21 | Centaur Pharmaceuticals, Inc. | Benzamides for neurodegenerative disorder treatment |
GB2316403B (en) * | 1996-08-17 | 2000-04-26 | Ciba Sc Holding Ag | Process |
US6509378B2 (en) | 1995-04-03 | 2003-01-21 | Centaur Pharmaceuticals, Inc. | Acetamidobenzamide compounds for neurodegenerative disorders |
EP1500643A4 (en) * | 2002-04-03 | 2007-03-28 | Dainippon Sumitomo Pharma Co | Benzamide derivatives |
US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
US7524957B2 (en) | 2001-08-17 | 2009-04-28 | Astrazeneca Ab | Compounds effecting glucokinase |
US7642259B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7696191B2 (en) | 2006-12-21 | 2010-04-13 | Astrazeneca Ab | Crystalline compound |
US7700640B2 (en) | 2004-10-16 | 2010-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
US7709505B2 (en) | 2002-11-19 | 2010-05-04 | Astrazeneca Ab | Benzofuran derivatives, process for their preparation and intermediates thereof |
US7902200B2 (en) | 2006-10-23 | 2011-03-08 | Astrazeneca Ab | Chemical compounds |
US7973178B2 (en) | 2005-11-28 | 2011-07-05 | Astrazeneca Ab | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
US8071608B2 (en) | 2009-04-09 | 2011-12-06 | Astrazeneca Ab | Therapeutic agents |
US10548911B2 (en) | 2014-06-16 | 2020-02-04 | University Of Rochester | Small molecule anti-scarring agents |
-
1980
- 1980-07-11 JP JP9385380A patent/JPS5721320A/en active Pending
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3305755A1 (en) * | 1983-02-19 | 1984-08-23 | Gödecke AG, 1000 Berlin | N-PHENYL-BENZAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST DISEASES OF THE IMMUNE SYSTEM |
US4816485A (en) * | 1983-02-19 | 1989-03-28 | Warner-Lambert Company | N-phenylbenzamide derivatives |
US4857662A (en) * | 1983-02-19 | 1989-08-15 | Godecke Aktiengesellschaft | N-phenylbenzamide derivatives |
WO1996031462A1 (en) * | 1995-04-03 | 1996-10-10 | Centaur Pharmaceuticals, Inc. | Benzamides for neurodegenerative disorder treatment |
US5914350A (en) * | 1995-04-03 | 1999-06-22 | Centaur Pharmaceuticals, Inc. | Pharmaceutical compositions of nitro- and aminobenzamide compounds for neurodegenerative disorders |
AU721045B2 (en) * | 1995-04-03 | 2000-06-22 | Renovis, Inc. | Benzamides for neurodegenerative disorder treatment |
US6509378B2 (en) | 1995-04-03 | 2003-01-21 | Centaur Pharmaceuticals, Inc. | Acetamidobenzamide compounds for neurodegenerative disorders |
US6759433B2 (en) | 1995-04-03 | 2004-07-06 | Renovis, Inc. | Acetamidobenzamide compounds for neurodegenerative disorders |
US7005546B2 (en) | 1995-04-03 | 2006-02-28 | Renovis, Inc. | Acetamidobenzamide compounds for neurodegenerative disorders |
US5955506A (en) * | 1996-04-03 | 1999-09-21 | Centaur Pharmaceuticals, Inc. | Benzamides for neurodegenerative disorder treatment |
GB2316403B (en) * | 1996-08-17 | 2000-04-26 | Ciba Sc Holding Ag | Process |
US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
US7524957B2 (en) | 2001-08-17 | 2009-04-28 | Astrazeneca Ab | Compounds effecting glucokinase |
US7951830B2 (en) | 2001-08-17 | 2011-05-31 | Astrazeneca Ab | Compounds effecting glucokinase |
EP1500643A4 (en) * | 2002-04-03 | 2007-03-28 | Dainippon Sumitomo Pharma Co | Benzamide derivatives |
US7709505B2 (en) | 2002-11-19 | 2010-05-04 | Astrazeneca Ab | Benzofuran derivatives, process for their preparation and intermediates thereof |
US7700640B2 (en) | 2004-10-16 | 2010-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
US7642263B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7642259B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7977328B2 (en) | 2005-07-09 | 2011-07-12 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US7973178B2 (en) | 2005-11-28 | 2011-07-05 | Astrazeneca Ab | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
US7902200B2 (en) | 2006-10-23 | 2011-03-08 | Astrazeneca Ab | Chemical compounds |
US7696191B2 (en) | 2006-12-21 | 2010-04-13 | Astrazeneca Ab | Crystalline compound |
US8071608B2 (en) | 2009-04-09 | 2011-12-06 | Astrazeneca Ab | Therapeutic agents |
US10548911B2 (en) | 2014-06-16 | 2020-02-04 | University Of Rochester | Small molecule anti-scarring agents |
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