UY32552A - (2s)-2-[1-(2-cloro-6-ciano-fenil) pirazolo[4,5-e]pirimidin-4-il]oxi-3-[(1r)-2-hidroxi-1-metil-etoxi]-n-(5-metilpirazin-2-il)propanamida. - Google Patents

(2s)-2-[1-(2-cloro-6-ciano-fenil) pirazolo[4,5-e]pirimidin-4-il]oxi-3-[(1r)-2-hidroxi-1-metil-etoxi]-n-(5-metilpirazin-2-il)propanamida.

Info

Publication number
UY32552A
UY32552A UY0001032552A UY32552A UY32552A UY 32552 A UY32552 A UY 32552A UY 0001032552 A UY0001032552 A UY 0001032552A UY 32552 A UY32552 A UY 32552A UY 32552 A UY32552 A UY 32552A
Authority
UY
Uruguay
Prior art keywords
propanamide
pyrimidin
cyano
chloro
phenyl
Prior art date
Application number
UY0001032552A
Other languages
English (en)
Inventor
Rolf Peter Walker
Bennett Stuart Norman Lile
Waring Michael James
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY32552A publication Critical patent/UY32552A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

(2S)-2-[1-(2-cloro-6-ciano-fenil) pirazolo[4,5-e]pirimidin-4-il]oxi-3-[(1R)-2-hidroxi-1-metil-etoxi]-N-(5-metilpirazin-2-il)propanamida o una sal farmacéuticamente aceptable del mismo, útil en el tratamiento o prevención de una enfermedad o afección medica mediada por glucocinasa (GLK o GK), que lleva a un umbral de glucosa disminuido para la secreción de insulina.
UY0001032552A 2009-04-09 2010-04-08 (2s)-2-[1-(2-cloro-6-ciano-fenil) pirazolo[4,5-e]pirimidin-4-il]oxi-3-[(1r)-2-hidroxi-1-metil-etoxi]-n-(5-metilpirazin-2-il)propanamida. UY32552A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16804809P 2009-04-09 2009-04-09

Publications (1)

Publication Number Publication Date
UY32552A true UY32552A (es) 2010-11-30

Family

ID=42122852

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032552A UY32552A (es) 2009-04-09 2010-04-08 (2s)-2-[1-(2-cloro-6-ciano-fenil) pirazolo[4,5-e]pirimidin-4-il]oxi-3-[(1r)-2-hidroxi-1-metil-etoxi]-n-(5-metilpirazin-2-il)propanamida.

Country Status (5)

Country Link
US (1) US8071608B2 (es)
AR (1) AR076221A1 (es)
TW (1) TW201040189A (es)
UY (1) UY32552A (es)
WO (1) WO2010116176A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
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AR076221A1 (es) 2011-05-26
TW201040189A (en) 2010-11-16

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