BRPI0418212A - composto ou um sal deste farmaceuticamente aceitável, ativador da glicocinase, e, medicamentos para a terapia e/ou prevenção da diabete, e da obesidade - Google Patents
composto ou um sal deste farmaceuticamente aceitável, ativador da glicocinase, e, medicamentos para a terapia e/ou prevenção da diabete, e da obesidadeInfo
- Publication number
- BRPI0418212A BRPI0418212A BRPI0418212-0A BRPI0418212A BRPI0418212A BR PI0418212 A BRPI0418212 A BR PI0418212A BR PI0418212 A BRPI0418212 A BR PI0418212A BR PI0418212 A BRPI0418212 A BR PI0418212A
- Authority
- BR
- Brazil
- Prior art keywords
- obesity
- diabetes
- pharmaceutically acceptable
- salt
- nitrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO OU UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL, ATIVADOR DA GLICOCINASE, E, MEDICAMENTOS PARA A TERAPIA E/OU PREVENçãO DA DIABETE, E DA OBESIDADE". Um ativador da glicocinase; um agente terapêutico e/ou preventivo para a diabete ou um agente terapêutico e/ou preventivo para as complicações da diabete, tais como retinopatia, nefropatia, neurose, doença cardíaca isquêmica e arteriosclerose; e um agente terapêutico e/ou preventivo para a obesidade. O ativador da glicocinase é caracterizado por conter um derivado de benzimidazol substituído por 2-heteroarila representado pela fórmula geral (I-0): ¢em que X representa carbono ou nitrogênio; X~ 1~, X~ 2~, X~ 3~ e X~ 4~ cada um independentemente representa carbono ou nitrogênio; o anel A representa, por exemplo, um heterociclo aromático nitrogenado de 5 ou 6 membros representado pela fórmula (II): (em que X representa carbono ou nitrogênio); R¬ 1¬ representa arila, etc.; R¬ 2¬ representa hidróxi, etc.; R¬ 3¬ representa -(alquila C~ 1-6~), etc.; R¬ 4¬ representa -(alquila C~ 1-6~), etc.; X~ 5~ representa -O-, etc.; a é 1, 2, ou 3; q é um número inteiro de 0 a 2; e m é um número inteiro de O a 2! ou um sal farmaceuticamente aceitável do derivado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003436992 | 2003-12-29 | ||
JP2004235696 | 2004-08-13 | ||
PCT/JP2004/019843 WO2005063738A1 (ja) | 2003-12-29 | 2004-12-28 | 新規2-へテロアリール置換ベンズイミダゾール誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0418212A true BRPI0418212A (pt) | 2007-04-27 |
Family
ID=34742165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0418212-0A BRPI0418212A (pt) | 2003-12-29 | 2004-12-28 | composto ou um sal deste farmaceuticamente aceitável, ativador da glicocinase, e, medicamentos para a terapia e/ou prevenção da diabete, e da obesidade |
Country Status (15)
Country | Link |
---|---|
US (1) | US7728025B2 (pt) |
EP (1) | EP1702919B1 (pt) |
JP (1) | JP4707560B2 (pt) |
KR (1) | KR20060105872A (pt) |
AU (1) | AU2004309287B2 (pt) |
BR (1) | BRPI0418212A (pt) |
CA (1) | CA2553160C (pt) |
EC (1) | ECSP066682A (pt) |
IL (1) | IL176451A0 (pt) |
IS (1) | IS8509A (pt) |
MA (1) | MA28336A1 (pt) |
NO (1) | NO20063475L (pt) |
NZ (1) | NZ548128A (pt) |
RU (1) | RU2329261C2 (pt) |
WO (1) | WO2005063738A1 (pt) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
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SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
JP2008516935A (ja) | 2004-10-16 | 2008-05-22 | アストラゼネカ アクチボラグ | フェノキシベンズアミド化合物の製造方法 |
KR20070083939A (ko) | 2004-11-02 | 2007-08-24 | 반유 세이야꾸 가부시끼가이샤 | 아릴옥시 치환된 벤즈이미다졸 유도체 |
TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
CA2614746C (en) | 2005-07-09 | 2011-05-10 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
US7994331B2 (en) * | 2005-07-13 | 2011-08-09 | Msd K.K. | Heterocycle-substituted benzimidazole derivative |
JP2007063225A (ja) * | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
EP1928874A1 (en) * | 2005-09-16 | 2008-06-11 | AstraZeneca AB | Heterobicyclic compounds as glucokinase activators |
CA2624102A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
US7625890B2 (en) | 2005-11-10 | 2009-12-01 | Smithkline Beecham Corp. | Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors |
US20070197532A1 (en) * | 2005-11-18 | 2007-08-23 | Cao Sheldon X | Glucokinase activators |
TW200738621A (en) | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
WO2007068894A2 (en) * | 2005-12-15 | 2007-06-21 | Astrazeneca Ab | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
WO2007087276A1 (en) * | 2006-01-23 | 2007-08-02 | Amgen Inc. | Aurora kinase modulators and method of use |
MX2008013427A (es) | 2006-04-19 | 2008-11-04 | Novartis Ag | Compuestos de benzoxazole y benzotiazole sustituidos-6-0 y metodos para inhibir la señalizacion csf-1r. |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
TW200825063A (en) | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
CL2007003061A1 (es) | 2006-10-26 | 2008-08-01 | Astrazeneca Ab | Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2. |
UY30822A1 (es) | 2006-12-21 | 2008-07-31 | Astrazeneca Ab | Fnueva forma cristalina de 3-{[5-azetidin-1-ylcabonyl)pyrazin-2-yl]oxy}-5-[1-methylethyloxy]-n-1h-pyrazol-3-ylbenzamida, composiciones conteniéndola, procesos de preparacion y aplicaciones |
JPWO2008136428A1 (ja) * | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素5員複素環化合物 |
CA2705370C (en) | 2007-11-12 | 2015-10-13 | Banyu Pharmaceutical Co., Ltd. | Heteroaryloxy quinazoline derivatives |
PL2239253T3 (pl) * | 2008-02-06 | 2013-11-29 | Daiichi Sankyo Co Ltd | Nowe pochodne fenylopirolowe |
CN105622580B (zh) | 2008-04-28 | 2019-06-21 | 詹森药业有限公司 | 作为脯氨酰羟化酶抑制剂的苯并咪唑 |
EP2324028A2 (en) | 2008-08-04 | 2011-05-25 | AstraZeneca AB | Therapeutic agents 414 |
AU2009280579A1 (en) * | 2008-08-15 | 2010-02-18 | Banyu Pharmaceutical Co.,Ltd. | Acetyl pyrrolidinyl indole derivative |
JP2012501295A (ja) * | 2008-08-29 | 2012-01-19 | Msd株式会社 | オキソテトラヒドロフラン−2−イル−ベンズイミダゾール誘導体 |
WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
GB0902434D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
GB0902406D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
WO2010116176A1 (en) * | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
AR077328A1 (es) | 2009-07-24 | 2011-08-17 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos |
EP2498781A2 (en) | 2009-11-06 | 2012-09-19 | Vanderbilt University | Aryl and heteroaryl sulfones as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
CA2782727C (en) * | 2009-12-04 | 2017-03-14 | Taisho Pharmaceutical Co., Ltd. | 2-pyridone compounds |
BR112012014899A2 (pt) * | 2009-12-18 | 2017-03-14 | Idenix Pharmaceuticals Inc | composto, composição farmacêutica, método para tratar ou prevenir uma infecção por vírus de hepatite c em um sujeito, método para tratar , prevenir ou melhorar um ou mais sintomas de uma doença hepática ou distúrbio associado a uma infecção por vírus de hepatite c em um sujeito, método para inibir a replicação de um vírus em um hospedeiro, método para inibir a replicação de um vírus |
WO2011080176A1 (en) | 2009-12-31 | 2011-07-07 | Novartis Ag | Pyrazine derivatives and their use in the treatment of neurological disorders |
US20120302558A1 (en) | 2010-07-13 | 2012-11-29 | Sangamesh Badiger | Oxazine derivatives and their use in the treatment of neurological disorders |
EP2663559B1 (en) | 2011-01-12 | 2015-07-01 | Novartis AG | Oxazine derivatives and their use in the treatment of neurological disorders |
JP6122862B2 (ja) | 2011-10-25 | 2017-04-26 | ヤンセン ファーマシューティカ エヌ.ベー. | 1−(5,6−ジクロロ−1h−ベンゾ[d]イミダゾール−2−イル)−1h−ピラゾール−4−カルボン酸のメグルミン塩製剤 |
JP6486940B2 (ja) * | 2013-09-09 | 2019-03-20 | ペロトン セラピューティクス, インコーポレイテッド | アリールエーテルおよびその使用 |
US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
EP3267792A4 (en) | 2015-03-11 | 2018-09-26 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
US10512626B2 (en) | 2015-03-11 | 2019-12-24 | Peloton Therapeautics, Inc. | Compositions for use in treating glioblastoma |
WO2016144826A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
JP6872541B2 (ja) | 2015-11-02 | 2021-05-19 | ヤンセン ファーマシューティカ エヌ.ベー. | [1,2,4]トリアゾロ[1,5−a]ピリミジン−7−イル化合物 |
EP3535269B1 (en) | 2016-11-02 | 2020-12-09 | Janssen Pharmaceutica NV | [1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors |
ES2912264T3 (es) | 2016-11-02 | 2022-05-25 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
MY193511A (en) | 2016-11-02 | 2022-10-17 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
AU2022306297A1 (en) | 2021-07-09 | 2024-02-08 | Plexium, Inc. | Aryl compounds and pharmaceutical compositions that modulate ikzf2 |
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NL134354C (pt) * | 1963-05-23 | |||
US3536809A (en) * | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
EP0726260A1 (en) | 1995-02-08 | 1996-08-14 | American Cyanamid Company | Herbicidal (1,2,4)thiadiazoles |
PE92198A1 (es) * | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
KR20010015910A (ko) * | 1998-01-23 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법 |
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WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
DE10238002A1 (de) * | 2002-08-20 | 2004-03-04 | Merck Patent Gmbh | Benzimidazolderivate |
CA2515841C (en) * | 2003-02-13 | 2010-06-01 | Banyu Pharmaceutical Co., Ltd. | Novel 2-pyridine carboxamide derivatives |
CN101712657A (zh) * | 2003-02-26 | 2010-05-26 | 万有制药株式会社 | 杂芳基氨基甲酰基苯衍生物 |
KR20070083939A (ko) * | 2004-11-02 | 2007-08-24 | 반유 세이야꾸 가부시끼가이샤 | 아릴옥시 치환된 벤즈이미다졸 유도체 |
TW200745031A (en) * | 2005-10-13 | 2007-12-16 | Merck & Co Inc | Acyl indoles, compositions containing such compounds and methods of use |
TW200821284A (en) * | 2006-10-03 | 2008-05-16 | Merck & Co Inc | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
-
2004
- 2004-12-28 CA CA2553160A patent/CA2553160C/en not_active Expired - Fee Related
- 2004-12-28 JP JP2005516745A patent/JP4707560B2/ja not_active Expired - Fee Related
- 2004-12-28 EP EP04808192A patent/EP1702919B1/en active Active
- 2004-12-28 NZ NZ548128A patent/NZ548128A/en unknown
- 2004-12-28 RU RU2006127420/04A patent/RU2329261C2/ru not_active IP Right Cessation
- 2004-12-28 WO PCT/JP2004/019843 patent/WO2005063738A1/ja active Application Filing
- 2004-12-28 US US10/582,564 patent/US7728025B2/en active Active
- 2004-12-28 BR BRPI0418212-0A patent/BRPI0418212A/pt not_active IP Right Cessation
- 2004-12-28 KR KR1020067013089A patent/KR20060105872A/ko not_active Application Discontinuation
- 2004-12-28 AU AU2004309287A patent/AU2004309287B2/en not_active Ceased
-
2006
- 2006-06-15 IS IS8509A patent/IS8509A/xx unknown
- 2006-06-20 IL IL176451A patent/IL176451A0/en unknown
- 2006-06-28 EC EC2006006682A patent/ECSP066682A/es unknown
- 2006-07-27 MA MA29214A patent/MA28336A1/fr unknown
- 2006-07-28 NO NO20063475A patent/NO20063475L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2329261C2 (ru) | 2008-07-20 |
WO2005063738A1 (ja) | 2005-07-14 |
EP1702919A4 (en) | 2008-11-12 |
EP1702919B1 (en) | 2012-05-30 |
RU2006127420A (ru) | 2008-02-10 |
US7728025B2 (en) | 2010-06-01 |
NZ548128A (en) | 2010-05-28 |
US20080070928A1 (en) | 2008-03-20 |
CA2553160C (en) | 2010-09-28 |
JPWO2005063738A1 (ja) | 2007-07-19 |
AU2004309287A1 (en) | 2005-07-14 |
IS8509A (is) | 2006-06-15 |
CA2553160A1 (en) | 2005-07-14 |
IL176451A0 (en) | 2006-10-05 |
MA28336A1 (fr) | 2006-12-01 |
JP4707560B2 (ja) | 2011-06-22 |
EP1702919A1 (en) | 2006-09-20 |
AU2004309287B2 (en) | 2008-07-31 |
KR20060105872A (ko) | 2006-10-11 |
ECSP066682A (es) | 2006-10-25 |
NO20063475L (no) | 2006-09-28 |
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