FI953479A - 1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö - Google Patents

1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö Download PDF

Info

Publication number
FI953479A
FI953479A FI953479A FI953479A FI953479A FI 953479 A FI953479 A FI 953479A FI 953479 A FI953479 A FI 953479A FI 953479 A FI953479 A FI 953479A FI 953479 A FI953479 A FI 953479A
Authority
FI
Finland
Prior art keywords
pharmaceutical use
arylpyrimidine derivatives
arylpyrimidine
derivatives
pharmaceutical
Prior art date
Application number
FI953479A
Other languages
English (en)
Swedish (sv)
Other versions
FI953479A0 (fi
Inventor
Isobe Yoshiaki
Toshimasa Katagiri
Junko Umezawa
Yuso Goto
Masashi Sasaki
Nobuo Watanabe
Hideharu Sato
Fumihiro Obara
Original Assignee
Japan Energy Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Energy Corp filed Critical Japan Energy Corp
Publication of FI953479A0 publication Critical patent/FI953479A0/fi
Publication of FI953479A publication Critical patent/FI953479A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
FI953479A 1994-07-19 1995-07-18 1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö FI953479A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16722294 1994-07-19
JP19421994 1994-08-18

Publications (2)

Publication Number Publication Date
FI953479A0 FI953479A0 (fi) 1995-07-18
FI953479A true FI953479A (fi) 1996-01-20

Family

ID=26491330

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953479A FI953479A (fi) 1994-07-19 1995-07-18 1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö

Country Status (7)

Country Link
US (1) US5661153A (fi)
EP (1) EP0700908A1 (fi)
AU (1) AU681034B2 (fi)
CA (1) CA2154293A1 (fi)
FI (1) FI953479A (fi)
NO (1) NO952854L (fi)
NZ (1) NZ272591A (fi)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
AU716992B2 (en) * 1996-09-19 2000-03-16 Japan Energy Corporation Hydroquinone derivative and pharmaceutical use thereof
WO1998037068A1 (en) 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents
US6117878A (en) * 1998-02-24 2000-09-12 University Of Virginia 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
WO2000029389A1 (fr) * 1998-11-18 2000-05-25 Elena Alexandrovna Izaxon 6-(3-carboxymethylphenyl)-amino-uracyle ayant une action biologique
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US6670334B2 (en) 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
SG176313A1 (en) 2001-10-01 2011-12-29 Univ Virginia Patent Found 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
WO2003103665A1 (ja) * 2002-06-06 2003-12-18 株式会社医薬分子設計研究所 抗アレルギー薬
AU2003264474A1 (en) * 2002-09-20 2004-04-08 Inoue, Yoshifumi Novel uracil derivatives and medicinal use thereof
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
RU2392275C2 (ru) * 2004-02-18 2010-06-20 Астразенека Аб Бензамидные производные и их применение в качестве активирующих глюкокиназу агентов
CA2554686A1 (en) * 2004-02-18 2005-09-01 Astrazeneca Ab Compounds
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
WO2006028618A1 (en) 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7605143B2 (en) 2004-08-02 2009-10-20 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity
WO2006023272A1 (en) 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1802570A1 (en) 2004-10-16 2007-07-04 AstraZeneca AB Process for making phenoxy benzamide compounds
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1891069A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
AU2006268406C1 (en) * 2005-07-09 2011-02-24 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
WO2007007040A1 (en) * 2005-07-09 2007-01-18 Astrazeneca Ab 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
WO2007120972A2 (en) 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
SA07280576B1 (ar) * 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
EP2121666A1 (en) * 2006-12-21 2009-11-25 AstraZeneca AB Novel crystalline compound useful as glk activator
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
PE20110568A1 (es) 2008-08-04 2011-09-07 Astrazeneca Ab Agentes terapeuticos 414
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5251395A (en) * 1975-10-21 1977-04-25 Yamanouchi Pharmaceut Co Ltd Preparation of novel pteridine derivaties
JPS5283800A (en) * 1976-01-01 1977-07-12 Yamanouchi Pharmaceut Co Ltd Novel pteridine derivative
SE416810C (sv) * 1977-10-14 1982-05-11 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
US4452788A (en) * 1982-04-21 1984-06-05 Warner-Lambert Company Substituted 8-phenylxanthines
FR2531085A1 (fr) * 1982-07-28 1984-02-03 Adir Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
IT1240843B (it) * 1990-05-24 1993-12-17 Malesci Istituto Farmacobiologico Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione.
NZ238609A (en) * 1990-06-21 1993-12-23 Schering Corp Polycyclic guanine derivatives; preparation, pharmaceutical compositions,
GB9020921D0 (en) * 1990-09-26 1990-11-07 Beecham Group Plc Novel compounds
JPH05194424A (ja) 1991-10-09 1993-08-03 Nikko Kyodo Co Ltd 新規なピリミジン誘導体及び該誘導体を有効成分とする医薬
JPH06135943A (ja) 1992-09-14 1994-05-17 Japan Energy Corp 新規なウラシル誘導体及びそれを有効成分とするアレルギー疾患治療薬

Also Published As

Publication number Publication date
NZ272591A (en) 1997-05-26
EP0700908A1 (en) 1996-03-13
AU2505795A (en) 1996-02-01
US5661153A (en) 1997-08-26
NO952854L (no) 1996-01-22
AU681034B2 (en) 1997-08-14
CA2154293A1 (en) 1996-01-20
NO952854D0 (no) 1995-07-18
FI953479A0 (fi) 1995-07-18

Similar Documents

Publication Publication Date Title
FI953479A (fi) 1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
FI955051A (fi) Heterosyklisiä yhdisteitä ja niiden valmistus ja käyttö
FI942993A (fi) Organoaluminoksituote ja sen käyttö
FI973471A0 (fi) Pyratsol-4-yylibentsoyylijohdoksia ja niiden käyttö herbisideinä
DE69513671D1 (de) Arzneimittel
FI955235A (fi) Oksatsolidiinionijohdannaiset, niiden valmistus ja käyttö
FI943421A0 (fi) 1,5-bentsodiatsepiinijohdannaiset ja niiden käyttö lääkkeenä
BR9500784A (pt) Composto e formulação farmacêutica
BR9504060A (pt) Composto e formulação farmacêutica
FI952656A0 (fi) Foerfarande och anordning vid pulsmaetning av en person
DE69704060D1 (de) Tetrahydroisochinolinderivate und ihre pharmazeutische anwendung
FI933136A (fi) Antiallergiska och antiinflammatoriska n-hydroxiureaderivat
BR9509688A (pt) Composto e composição farmacêutica
FI971462A (fi) Bentsisoksatsolijohdannaisia ja niitä sisältäviä torjuntaainekoostumuksia
EE03614B1 (et) Pürasool-4-üül-bensoüüli derivaadid ja nende kasutamine herbitsiididena
FI935559A0 (fi) Foerfarande foer faestning av haordmetallstift i en borrkrona och en borrkrona
FI956251A0 (fi) 1-okso-2-(fenyylisulfonyyliamino)pentyylipiperidiinijohdannaiset, niiden valmistus ja terapeuttinen käyttö
BR9509055A (pt) Imidazoloquinoxalinona uso da mesma e composiçao farmacêutica
FI971085A (fi) Uusia PKA:ta sitovia proteiineja ja näiden käyttömuotoja
FI944556A0 (fi) Foerfarande foer producering av antracykliner och deras mellanprodukter
FI932768A (fi) Farmaceutiska mjuka gelatinkapslar innehaollande lysinklonixinat och foerfarande foer framstaellning av dessa
BR9505130A (pt) Composto e composiçao farmacêutica
FI970713A (fi) Menetelmiä hampaiden ja suun luuston kunnon ylläpitämiseksi
FI945616A0 (fi) Foerfarande och anordningar foer utnyttjande av vaogenergi
FI942533A0 (fi) Spolvaetska och droppdoseringsfoerpackning foer kontaktlinser och anvaendning av desamma