DE69704060D1 - Tetrahydroisochinolinderivate und ihre pharmazeutische anwendung - Google Patents
Tetrahydroisochinolinderivate und ihre pharmazeutische anwendungInfo
- Publication number
- DE69704060D1 DE69704060D1 DE69704060T DE69704060T DE69704060D1 DE 69704060 D1 DE69704060 D1 DE 69704060D1 DE 69704060 T DE69704060 T DE 69704060T DE 69704060 T DE69704060 T DE 69704060T DE 69704060 D1 DE69704060 D1 DE 69704060D1
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydroisochinoline
- derivatives
- pharmaceutical application
- pharmaceutical
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617079.0A GB9617079D0 (en) | 1996-08-14 | 1996-08-14 | Compounds |
| GBGB9704523.1A GB9704523D0 (en) | 1997-03-05 | 1997-03-05 | Compounds |
| PCT/EP1997/004408 WO1998006699A1 (en) | 1996-08-14 | 1997-08-08 | Tetrahydroisoquinoline derivatives and their pharmaceutical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69704060D1 true DE69704060D1 (de) | 2001-03-15 |
| DE69704060T2 DE69704060T2 (de) | 2001-08-02 |
Family
ID=26309872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69704060T Expired - Fee Related DE69704060T2 (de) | 1996-08-14 | 1997-08-08 | Tetrahydroisochinolinderivate und ihre pharmazeutische anwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6143762A (de) |
| EP (1) | EP0922035B1 (de) |
| JP (1) | JP2000517301A (de) |
| AR (1) | AR008291A1 (de) |
| AU (1) | AU4204697A (de) |
| CA (1) | CA2263284A1 (de) |
| DE (1) | DE69704060T2 (de) |
| ES (1) | ES2154470T3 (de) |
| WO (1) | WO1998006699A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708694D0 (en) * | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| IL132631A0 (en) * | 1997-05-03 | 2001-03-19 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
| GB9709303D0 (en) * | 1997-05-09 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| US5912342A (en) * | 1997-08-12 | 1999-06-15 | Heinonen; Petri | Compounds a containing a solid support |
| US6541487B1 (en) * | 1998-05-01 | 2003-04-01 | R.T. Alamo Ventures I, Llc | PDE III inhibitors for treating sexual dysfunction |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| MA26696A1 (fr) | 1998-10-08 | 2004-12-20 | Smithkline Beecham Plc | Derives de tetrahydrobenzazepine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant |
| GB9821977D0 (en) * | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| GB9821978D0 (en) * | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| TWI274750B (en) | 1999-01-12 | 2007-03-01 | Abbott Gmbh & Co Kg | Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same |
| EP1283199A4 (de) | 2000-05-16 | 2003-12-17 | Takeda Chemical Industries Ltd | Antagonisten des melanin-konzentrierenden hormons |
| EP1452525A4 (de) * | 2001-10-30 | 2005-01-26 | Nippon Shinyaku Co Ltd | Amidderivate und arzneimittel |
| MY133587A (en) | 2002-05-29 | 2007-11-30 | Glaxo Group Ltd | Aromatic sulfones and their medical use |
| JPWO2006054793A1 (ja) * | 2004-11-19 | 2008-06-05 | 財団法人新産業創造研究機構 | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| EP2354136B1 (de) | 2008-10-10 | 2016-02-24 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | Neue dopamin-d3-rezeptorliganden, ihre herstellung und verwendung |
| WO2018021447A1 (ja) | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物 |
| JP6545747B2 (ja) * | 2017-05-09 | 2019-07-17 | 山田化学工業株式会社 | 色素化合物 |
| WO2019146739A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する縮環化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
| US5294621A (en) * | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
| GB9325827D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| DE69608551T2 (de) * | 1995-03-27 | 2001-01-18 | Smithkline Beecham P.L.C., Brentford | Bicyclische amin-derivate und ihre verwendung als antipsychotische wirkstoffe |
| TR199802284T2 (xx) * | 1996-05-11 | 2000-05-22 | Smithkline Beecham P.L.C. | Dopamin D3 resept�rlerinin mod�lat�rleri olarak tetrahidroizokuinolin t�revleri. |
-
1997
- 1997-08-08 AU AU42046/97A patent/AU4204697A/en not_active Abandoned
- 1997-08-08 US US09/242,200 patent/US6143762A/en not_active Expired - Fee Related
- 1997-08-08 JP JP10509410A patent/JP2000517301A/ja not_active Ceased
- 1997-08-08 EP EP97940074A patent/EP0922035B1/de not_active Expired - Lifetime
- 1997-08-08 WO PCT/EP1997/004408 patent/WO1998006699A1/en active IP Right Grant
- 1997-08-08 ES ES97940074T patent/ES2154470T3/es not_active Expired - Lifetime
- 1997-08-08 CA CA002263284A patent/CA2263284A1/en not_active Abandoned
- 1997-08-08 DE DE69704060T patent/DE69704060T2/de not_active Expired - Fee Related
- 1997-08-12 AR ARP970103668A patent/AR008291A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6143762A (en) | 2000-11-07 |
| ES2154470T3 (es) | 2001-04-01 |
| AU4204697A (en) | 1998-03-06 |
| WO1998006699A1 (en) | 1998-02-19 |
| EP0922035A1 (de) | 1999-06-16 |
| EP0922035B1 (de) | 2001-02-07 |
| AR008291A1 (es) | 1999-12-29 |
| DE69704060T2 (de) | 2001-08-02 |
| JP2000517301A (ja) | 2000-12-26 |
| CA2263284A1 (en) | 1998-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |