ES2154470T3 - Derivados de tetrahidroisoquinolina y su uso farmaceutico. - Google Patents
Derivados de tetrahidroisoquinolina y su uso farmaceutico.Info
- Publication number
- ES2154470T3 ES2154470T3 ES97940074T ES97940074T ES2154470T3 ES 2154470 T3 ES2154470 T3 ES 2154470T3 ES 97940074 T ES97940074 T ES 97940074T ES 97940074 T ES97940074 T ES 97940074T ES 2154470 T3 ES2154470 T3 ES 2154470T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- ring
- optionally replaced
- group
- azacicloalcan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 title 1
- -1 HYDROXY GROUP Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R 1 REPRESENTA UN SUSTITUYENTE SELECCIONADO A PARTIR DE: UN ATOMO DE HIDROGENO O HALOGENO; UN GRUPO HIDROXI, CIANO, NITRO, TRIFLUOROMETILO, TRIFLUOROMETOXI, TRIFLUOROMETANOSULFONILOXI, ALQUILO C 1-4 , ALCOXI C 1-4 , ARILALCOXI C 14 , ALQUILTIO C 1-4 , ALQUIL C 1-4 SULFONILALQUILO C S UB,14 , ARILSULFONILO, ARILSULFONILOXI, ARILSULFONILALQUILO C SUB,14 , ALQUIL C 1-4 SULFONAMIDO, ALQUIL C 1-4 AMIDO, ALQUIL C 1-4 SULFONAMIDOALQUILO C 1-4 , ALQUIL C 14 AMIDOALQUILO C 1-4 , ARILSULFONAMIDO, ARILCARBOXAMIDO, ARILSULFONAMIDOALQUILO C 1-4 , ARILCARBOXAMIDOALQUILO C SUB,1-4 , AROILO, AROILALQUILO C 1-4 O ARILALCANOILO C 1-4 ; UN GRUPO R 3 OCO(CH 2 ) P , R 3 CON(R SUP,4 )(CH 2 ) P , R 3 R 4 NCO(CH 2 ) P O R 3 R 4 NSO 2 (CH 2 ) P , DONDE R 3 Y R 4 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C 1-4 O R 3 R 4 FORMA PARTE DE UN ANILLO AZACICLOALCANO C 3-6 O C 3-6 (2 - OXO) AZACICLOALCANO Y P REPRESENTA CERO O UN ENTERODE 1 A 4; Q ES 1 O 2; O UN GRUPO AR 1 Z, DONDE AR 1 REPRESENTA UN ANILLO FENILO OPCIONALMENTE SUSTITUIDO O UN ANILLO HETEROCICLICO AROMATICO DE 5 O 6 MIEMBROS OPCIONALMENTE SUSTITUIDO Y Z REPRESENTA UN ENLACE O, S O CH 2 ; R 2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C 1-4 ; Q ES 1 O 2; AR REPRESENTA UN ANILLO FENILO, OPCIONALMENTE SUSTITUIDO O UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS, OPCIONALMENTE SUSTITUIDO; O UN SISTEMA DE ANILLOS HETEROAROMATICO O AROMATICO BICICLICO, OPCIONALMENTE SUSTITUIDO; ASI COMO LAS SALES DE DICHOS COMPUESTOS. LOS COMPUESTOS DE FORMULA (I) Y SUS SALES PRESENTAN AFINIDAD POR LOS RECEPTORES DE DOPAMINA, ESPECIALMENTE POR LOS RECEPTORES D 3 Y, POR TANTO, PODRIAN SER ADECUADOS EN EL TRATAMIE NTO DE ESTADOS EN LOS CUALES ES BENEFICIOSA LA MODULACION DEL RECEPTOR D 3 , POR EJEMPLO COMO AGENTES ANTIPSICOTICOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617079.0A GB9617079D0 (en) | 1996-08-14 | 1996-08-14 | Compounds |
| GBGB9704523.1A GB9704523D0 (en) | 1997-03-05 | 1997-03-05 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2154470T3 true ES2154470T3 (es) | 2001-04-01 |
Family
ID=26309872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97940074T Expired - Lifetime ES2154470T3 (es) | 1996-08-14 | 1997-08-08 | Derivados de tetrahidroisoquinolina y su uso farmaceutico. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6143762A (es) |
| EP (1) | EP0922035B1 (es) |
| JP (1) | JP2000517301A (es) |
| AR (1) | AR008291A1 (es) |
| AU (1) | AU4204697A (es) |
| CA (1) | CA2263284A1 (es) |
| DE (1) | DE69704060T2 (es) |
| ES (1) | ES2154470T3 (es) |
| WO (1) | WO1998006699A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708694D0 (en) * | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
| GB9708805D0 (en) * | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| IL132631A0 (en) * | 1997-05-03 | 2001-03-19 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
| GB9709303D0 (en) * | 1997-05-09 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| US5912342A (en) * | 1997-08-12 | 1999-06-15 | Heinonen; Petri | Compounds a containing a solid support |
| US6541487B1 (en) * | 1998-05-01 | 2003-04-01 | R.T. Alamo Ventures I, Llc | PDE III inhibitors for treating sexual dysfunction |
| GB9810876D0 (en) * | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| CA2346689A1 (en) * | 1998-10-08 | 2000-04-20 | Gregor James Macdonald | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| GB9821977D0 (en) | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| GB9821978D0 (en) * | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| AR022228A1 (es) * | 1999-01-12 | 2002-09-04 | Abbott Gmbh & Co Kg | Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion |
| WO2001087834A1 (fr) * | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Antagoniste de l'hormone de concentration de la melanine |
| WO2003037862A1 (fr) * | 2001-10-30 | 2003-05-08 | Nippon Shinyaku Co., Ltd. | Derives amide, et medicaments correspondants |
| MY133587A (en) | 2002-05-29 | 2007-11-30 | Glaxo Group Ltd | Aromatic sulfones and their medical use |
| JPWO2006054793A1 (ja) * | 2004-11-19 | 2008-06-05 | 財団法人新産業創造研究機構 | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| WO2010040274A1 (zh) | 2008-10-10 | 2010-04-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
| WO2018021447A1 (ja) * | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物 |
| JP6545747B2 (ja) * | 2017-05-09 | 2019-07-17 | 山田化学工業株式会社 | 色素化合物 |
| BR112020014875A2 (pt) | 2018-01-26 | 2020-12-08 | Shionogi & Co., Ltd. | Composto cíclico condensado tendo antagonismo de receptor de dopamina d3 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
| US5294621A (en) * | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
| GB9325827D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| WO1996030333A1 (en) * | 1995-03-27 | 1996-10-03 | Smithkline Beecham Plc | Bicyclic amine derivatives and their use as anti-psychotic agents |
| BR9709220A (pt) * | 1996-05-11 | 1999-08-10 | Smithkline Beecham Plc | Derivados de tetra-hidro-isoquinolina como moduladores dos receptores D3 da dopamina |
-
1997
- 1997-08-08 EP EP97940074A patent/EP0922035B1/en not_active Expired - Lifetime
- 1997-08-08 WO PCT/EP1997/004408 patent/WO1998006699A1/en active IP Right Grant
- 1997-08-08 DE DE69704060T patent/DE69704060T2/de not_active Expired - Fee Related
- 1997-08-08 ES ES97940074T patent/ES2154470T3/es not_active Expired - Lifetime
- 1997-08-08 CA CA002263284A patent/CA2263284A1/en not_active Abandoned
- 1997-08-08 JP JP10509410A patent/JP2000517301A/ja not_active Ceased
- 1997-08-08 AU AU42046/97A patent/AU4204697A/en not_active Abandoned
- 1997-08-08 US US09/242,200 patent/US6143762A/en not_active Expired - Fee Related
- 1997-08-12 AR ARP970103668A patent/AR008291A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998006699A1 (en) | 1998-02-19 |
| US6143762A (en) | 2000-11-07 |
| EP0922035A1 (en) | 1999-06-16 |
| AR008291A1 (es) | 1999-12-29 |
| EP0922035B1 (en) | 2001-02-07 |
| CA2263284A1 (en) | 1998-02-19 |
| JP2000517301A (ja) | 2000-12-26 |
| AU4204697A (en) | 1998-03-06 |
| DE69704060D1 (de) | 2001-03-15 |
| DE69704060T2 (de) | 2001-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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