EA199800720A1 - Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора - Google Patents

Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора

Info

Publication number
EA199800720A1
EA199800720A1 EA199800720A EA199800720A EA199800720A1 EA 199800720 A1 EA199800720 A1 EA 199800720A1 EA 199800720 A EA199800720 A EA 199800720A EA 199800720 A EA199800720 A EA 199800720A EA 199800720 A1 EA199800720 A1 EA 199800720A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ergoline
hydrogen
heterocyclic derivatives
bromine
chlorine
Prior art date
Application number
EA199800720A
Other languages
English (en)
Inventor
Серджио Мантегани
Тициано Бандьера
Маурицио Мерони
Марио Варази
Карла Качча
Original Assignee
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон С.П.А. filed Critical Фармация Энд Апджон С.П.А.
Publication of EA199800720A1 publication Critical patent/EA199800720A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Производное эрголина, имеющее формулу (I), в которой Rявляется атомом водорода или Салкильной группой; Rявляется атомом водорода, хлора или брома, метильной или C-алкилтиогруппой; n равно 0, 1 или 2; заместитель в положении 8 имеет α- или β-конфигурацию; Het представляет собой ароматическое 5-членное гетероциклическое кольцо, упомянутое кольцо имеет три гетероатома, которые являются одинаковыми или разными и которые выбирают из группы, состоящей из атома серы, кислорода и азота, и Х является атомом водорода, хлора или брома или фтора, или его фармацевтически приемлемая соль с кислотой являются активными в отношении центральной нервной системы. Описан также способ их получения и содержащие их лекарственные препараты.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800720A 1996-02-15 1997-02-07 Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора EA199800720A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9603226.3A GB9603226D0 (en) 1996-02-15 1996-02-15 Heterocyclyl-ergoline derivatives
PCT/EP1997/000582 WO1997030050A1 (en) 1996-02-15 1997-02-07 Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands

Publications (1)

Publication Number Publication Date
EA199800720A1 true EA199800720A1 (ru) 1999-02-25

Family

ID=10788832

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800720A EA199800720A1 (ru) 1996-02-15 1997-02-07 Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора

Country Status (26)

Country Link
US (1) US6087371A (ru)
EP (1) EP0885222B1 (ru)
JP (1) JP2000504700A (ru)
KR (1) KR19990082680A (ru)
CN (1) CN1211253A (ru)
AR (1) AR005820A1 (ru)
AT (1) ATE201683T1 (ru)
AU (1) AU1767797A (ru)
BR (1) BR9707463A (ru)
CA (1) CA2243992A1 (ru)
DE (1) DE69705032T2 (ru)
DK (1) DK0885222T3 (ru)
EA (1) EA199800720A1 (ru)
ES (1) ES2159838T3 (ru)
GB (1) GB9603226D0 (ru)
GR (1) GR3036390T3 (ru)
HU (1) HUP9900572A3 (ru)
IL (1) IL125344A0 (ru)
MX (1) MX9806341A (ru)
NO (1) NO983656L (ru)
NZ (1) NZ331087A (ru)
PL (1) PL328373A1 (ru)
PT (1) PT885222E (ru)
TW (1) TW360655B (ru)
WO (1) WO1997030050A1 (ru)
ZA (1) ZA971167B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1685838A1 (en) * 2000-08-16 2006-08-02 Pharmacia & Upjohn Company LLC Compounds for the treatment of addictive disorders
EP1363634A2 (en) * 2000-08-16 2003-11-26 PHARMACIA & UPJOHN COMPANY Compounds for the treatment of addictive disorders
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
EP2586311B1 (de) * 2008-07-17 2016-12-14 Bayer CropScience AG Heterocyclische Verbindungen als Schädlingsbekämpfungsmittel
CN106866656A (zh) * 2017-02-28 2017-06-20 西南交通大学 一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU39278B (en) * 1976-12-22 1984-10-31 Lek Tovarna Farmacevtskih Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
AU553809B2 (en) * 1981-07-21 1986-07-31 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
HU190105B (en) * 1983-06-03 1986-08-28 Gyogyszerkutato Intezet Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
DE3868866D1 (de) * 1987-11-20 1992-04-09 Erba Carlo Spa Ergolinderivate mit antiparkinsonwirkung.
DK0464178T3 (da) * 1990-01-25 1996-01-02 Pharmacia Spa Fremgangsmåde til fremstilling af ergolinderivater
JP2888648B2 (ja) * 1990-12-28 1999-05-10 出光興産株式会社 スチレン系重合体の製造方法及びその触媒

Also Published As

Publication number Publication date
ZA971167B (en) 1997-08-25
MX9806341A (es) 1998-10-31
ES2159838T3 (es) 2001-10-16
WO1997030050A1 (en) 1997-08-21
HUP9900572A2 (hu) 1999-06-28
DE69705032D1 (de) 2001-07-05
DE69705032T2 (de) 2001-11-22
KR19990082680A (ko) 1999-11-25
EP0885222B1 (en) 2001-05-30
GB9603226D0 (en) 1996-04-17
AR005820A1 (es) 1999-07-14
CN1211253A (zh) 1999-03-17
ATE201683T1 (de) 2001-06-15
IL125344A0 (en) 1999-03-12
NO983656L (no) 1998-10-12
JP2000504700A (ja) 2000-04-18
HUP9900572A3 (en) 2000-10-30
NZ331087A (en) 1999-08-30
GR3036390T3 (en) 2001-11-30
US6087371A (en) 2000-07-11
CA2243992A1 (en) 1997-08-21
AU1767797A (en) 1997-09-02
EP0885222A1 (en) 1998-12-23
PT885222E (pt) 2001-10-31
DK0885222T3 (da) 2001-08-27
NO983656D0 (no) 1998-08-10
TW360655B (en) 1999-06-11
BR9707463A (pt) 1999-07-20
PL328373A1 (en) 1999-01-18

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