NO983656L - Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander - Google Patents

Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander

Info

Publication number
NO983656L
NO983656L NO983656A NO983656A NO983656L NO 983656 L NO983656 L NO 983656L NO 983656 A NO983656 A NO 983656A NO 983656 A NO983656 A NO 983656A NO 983656 L NO983656 L NO 983656L
Authority
NO
Norway
Prior art keywords
hydrogen
atom
heterocyclyl
ergoline derivatives
receptor ligands
Prior art date
Application number
NO983656A
Other languages
English (en)
Other versions
NO983656D0 (no
Inventor
Sergio Mantegani
Tiziano Bandiera
Maurizio Meroni
Mario Varasi
Carla Caccia
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NO983656D0 publication Critical patent/NO983656D0/no
Publication of NO983656L publication Critical patent/NO983656L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ergolinderivat som har formel I der Ri er et hydrogenatom eller CM alkylgruppe; R2 er hydrogen, klor eller bromatom, metyl eller CM alkyltiogruppe; n er O, l eller 2; substituenten i posisjon 8 er i a- eller B-konfigurasjon; Het representerer en aromatisk 5- leddet heterocyklisk ring, denne ringen har tre heteroatomer som er like eller forskjellige og som blir valgt fra gruppen som består av svovel, oksygen og nitrogenatom og X er hydrogen, klor eller brom eller fluoratom, eller et farmasøytisk akseptabelt syreaddisjonssalt derav er aktive i sentralnervesystem-nivå. En fremgangsmåte for deres fremstilling blir også beskrevet, og det samme gjør farmasøytiske sammensetninger som inneholder disse.
NO983656A 1996-02-15 1998-08-10 Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander NO983656L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9603226.3A GB9603226D0 (en) 1996-02-15 1996-02-15 Heterocyclyl-ergoline derivatives
PCT/EP1997/000582 WO1997030050A1 (en) 1996-02-15 1997-02-07 Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands

Publications (2)

Publication Number Publication Date
NO983656D0 NO983656D0 (no) 1998-08-10
NO983656L true NO983656L (no) 1998-10-12

Family

ID=10788832

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983656A NO983656L (no) 1996-02-15 1998-08-10 Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander

Country Status (26)

Country Link
US (1) US6087371A (no)
EP (1) EP0885222B1 (no)
JP (1) JP2000504700A (no)
KR (1) KR19990082680A (no)
CN (1) CN1211253A (no)
AR (1) AR005820A1 (no)
AT (1) ATE201683T1 (no)
AU (1) AU1767797A (no)
BR (1) BR9707463A (no)
CA (1) CA2243992A1 (no)
DE (1) DE69705032T2 (no)
DK (1) DK0885222T3 (no)
EA (1) EA199800720A1 (no)
ES (1) ES2159838T3 (no)
GB (1) GB9603226D0 (no)
GR (1) GR3036390T3 (no)
HU (1) HUP9900572A3 (no)
IL (1) IL125344A0 (no)
MX (1) MX9806341A (no)
NO (1) NO983656L (no)
NZ (1) NZ331087A (no)
PL (1) PL328373A1 (no)
PT (1) PT885222E (no)
TW (1) TW360655B (no)
WO (1) WO1997030050A1 (no)
ZA (1) ZA971167B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0112939A (pt) * 2000-08-16 2005-11-01 Upjohn Co Compostos para o tratamento de distúrbios de dependência
EP1685838A1 (en) * 2000-08-16 2006-08-02 Pharmacia & Upjohn Company LLC Compounds for the treatment of addictive disorders
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
ES2567183T3 (es) * 2008-07-17 2016-04-20 Bayer Cropscience Ag Compuestos heterocíclicos como pesticidas
CN106866656A (zh) * 2017-02-28 2017-06-20 西南交通大学 一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU39278B (en) * 1976-12-22 1984-10-31 Lek Tovarna Farmacevtskih Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
FI76085C (fi) * 1981-07-21 1988-09-09 Erba Farmitalia Foerfarande foer framstaellning av ergolinderivat.
HU190105B (en) * 1983-06-03 1986-08-28 Gyogyszerkutato Intezet Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
DE3868866D1 (de) * 1987-11-20 1992-04-09 Erba Carlo Spa Ergolinderivate mit antiparkinsonwirkung.
US5210194A (en) * 1990-01-25 1993-05-11 Farmitalia Carlo Erba S.R.L. An Italian Body Corporate Process for preparing ergoline derivatives
JP2888648B2 (ja) * 1990-12-28 1999-05-10 出光興産株式会社 スチレン系重合体の製造方法及びその触媒

Also Published As

Publication number Publication date
MX9806341A (es) 1998-10-31
PL328373A1 (en) 1999-01-18
DE69705032D1 (de) 2001-07-05
CA2243992A1 (en) 1997-08-21
EP0885222A1 (en) 1998-12-23
NZ331087A (en) 1999-08-30
IL125344A0 (en) 1999-03-12
HUP9900572A3 (en) 2000-10-30
DE69705032T2 (de) 2001-11-22
ES2159838T3 (es) 2001-10-16
GR3036390T3 (en) 2001-11-30
BR9707463A (pt) 1999-07-20
ZA971167B (en) 1997-08-25
PT885222E (pt) 2001-10-31
DK0885222T3 (da) 2001-08-27
KR19990082680A (ko) 1999-11-25
JP2000504700A (ja) 2000-04-18
GB9603226D0 (en) 1996-04-17
NO983656D0 (no) 1998-08-10
US6087371A (en) 2000-07-11
AR005820A1 (es) 1999-07-14
HUP9900572A2 (hu) 1999-06-28
ATE201683T1 (de) 2001-06-15
EA199800720A1 (ru) 1999-02-25
EP0885222B1 (en) 2001-05-30
CN1211253A (zh) 1999-03-17
WO1997030050A1 (en) 1997-08-21
AU1767797A (en) 1997-09-02
TW360655B (en) 1999-06-11

Similar Documents

Publication Publication Date Title
NO20053133L (no) Kjemiske forbindelser.
CY1117132T1 (el) Παραγωγο θειαζολιου
DE3781080T2 (de) 2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
NO20023218L (no) 2-amino-nikotinamidderivater og deres anvendelse som VEGF- reseptor tyrosinkinaseinhibitorer
ATE424393T1 (de) 3-substituierte 4-pyrimidonderivate
NO303778B1 (no) Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt
DK0958296T3 (da) Heterocykliske forbindelser, fremgangsmåde til deres fremstilling og farmaceutiske præparater, der indeholder dem, og deres anvendelse i behandlingen af diabetes og beslægtede sygdomme
AU572405B2 (en) Heterocyclic-substituted indole
FI953968A0 (fi) Antraniiliset happojohdannaiset
IL88122A0 (en) Heterocyclic derivatives and pharmaceutical compositions containing them
DE69943144D1 (de) Stickstoffenthaltende heterocyclische verbindungen
DK0622361T3 (da) Heterocykliske forbindelser som bradykininantagonister
NO983656L (no) Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander
NO20053302L (no) Imidazolderivater med affinitet for alfa 2-reseptoraktivitet.
NO933478L (no) 6-heterocyklisk-4-amino-1,2,2a,3,4,5-heksahydrobenz(CD)indoler for behandling av reisesyke og oppkast
KR940018362A (ko) 니코틴산 유도체
DE60239324D1 (de) Phenyl- und pyridyl-piperidine mit tnf-wirkung
MY104164A (en) Heterocyclic compounds.
NO944888L (no) 5-(1,2,4-triazol-1-ylmetyl)-3H-isobenzofuran-1-on derivater, deres fremstilling og anvendelse som aromataseinhibitorer