MX9806341A - Derivados de ergolina heterociclica. - Google Patents

Derivados de ergolina heterociclica.

Info

Publication number
MX9806341A
MX9806341A MX9806341A MX9806341A MX9806341A MX 9806341 A MX9806341 A MX 9806341A MX 9806341 A MX9806341 A MX 9806341A MX 9806341 A MX9806341 A MX 9806341A MX 9806341 A MX9806341 A MX 9806341A
Authority
MX
Mexico
Prior art keywords
hydrogen
atom
heterocyclyl
receptor ligands
chlorine
Prior art date
Application number
MX9806341A
Other languages
English (en)
Inventor
Sergio Mantegani
Tiziano Bandiera
Maurizio Meroni
Mario Varasi
Carla Caccia
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of MX9806341A publication Critical patent/MX9806341A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

El derivado ergolina que tiene la formula (I) en donde R1 es un átomo de hidrogeno o un grupo alquilo C1-4; R2 es un átomo de hidrogeno, cloro o bromo, metilo o un grupo alquiltio C1-4; n es 0.1 o 2; el substituyente a la posicion 8 en una configuracion alfa o beta, Het representa un anillo heterocíclico aromático de 5 miembros, dicho anillo tiene 3 heteroátomos, el cual es el mismo o diferente y el cual se selecciona a partir del grupo que consiste de átomos de azufre, oxígeno y nitrogeno y X es un átomo de hidrogeno, cloro, bromo o fluor, o una sal de adicion farmacéuticamente aceptable del mismo, se activa al nivel del sistema nervioso central. También se describe un proceso para su preparacion, así como sus composiciones farmacéuticas del mismo.
MX9806341A 1996-02-15 1998-08-06 Derivados de ergolina heterociclica. MX9806341A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9603226.3A GB9603226D0 (en) 1996-02-15 1996-02-15 Heterocyclyl-ergoline derivatives

Publications (1)

Publication Number Publication Date
MX9806341A true MX9806341A (es) 1998-10-31

Family

ID=10788832

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806341A MX9806341A (es) 1996-02-15 1998-08-06 Derivados de ergolina heterociclica.

Country Status (26)

Country Link
US (1) US6087371A (es)
EP (1) EP0885222B1 (es)
JP (1) JP2000504700A (es)
KR (1) KR19990082680A (es)
CN (1) CN1211253A (es)
AR (1) AR005820A1 (es)
AT (1) ATE201683T1 (es)
AU (1) AU1767797A (es)
BR (1) BR9707463A (es)
CA (1) CA2243992A1 (es)
DE (1) DE69705032T2 (es)
DK (1) DK0885222T3 (es)
EA (1) EA199800720A1 (es)
ES (1) ES2159838T3 (es)
GB (1) GB9603226D0 (es)
GR (1) GR3036390T3 (es)
HU (1) HUP9900572A3 (es)
IL (1) IL125344A0 (es)
MX (1) MX9806341A (es)
NO (1) NO983656L (es)
NZ (1) NZ331087A (es)
PL (1) PL328373A1 (es)
PT (1) PT885222E (es)
TW (1) TW360655B (es)
WO (1) WO1997030050A1 (es)
ZA (1) ZA971167B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1685838A1 (en) * 2000-08-16 2006-08-02 Pharmacia & Upjohn Company LLC Compounds for the treatment of addictive disorders
KR20030024877A (ko) * 2000-08-16 2003-03-26 파마시아 앤드 업존 캄파니 중독성 질환의 치료용 화합물
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
ES2618022T3 (es) * 2008-07-17 2017-06-20 Bayer Cropscience Ag Compuestos heterocíclicos como pesticidas
CN106866656A (zh) * 2017-02-28 2017-06-20 西南交通大学 一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU39278B (en) * 1976-12-22 1984-10-31 Lek Tovarna Farmacevtskih Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
FI76085C (fi) * 1981-07-21 1988-09-09 Erba Farmitalia Foerfarande foer framstaellning av ergolinderivat.
HU190105B (en) * 1983-06-03 1986-08-28 Gyogyszerkutato Intezet Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
EP0317269B1 (en) * 1987-11-20 1992-03-04 FARMITALIA CARLO ERBA S.r.l. Antiparkinson ergoline derivatives
DK0464178T3 (da) * 1990-01-25 1996-01-02 Pharmacia Spa Fremgangsmåde til fremstilling af ergolinderivater
JP2888648B2 (ja) * 1990-12-28 1999-05-10 出光興産株式会社 スチレン系重合体の製造方法及びその触媒

Also Published As

Publication number Publication date
CN1211253A (zh) 1999-03-17
DE69705032D1 (de) 2001-07-05
AR005820A1 (es) 1999-07-14
EP0885222A1 (en) 1998-12-23
JP2000504700A (ja) 2000-04-18
TW360655B (en) 1999-06-11
EP0885222B1 (en) 2001-05-30
PL328373A1 (en) 1999-01-18
AU1767797A (en) 1997-09-02
EA199800720A1 (ru) 1999-02-25
DE69705032T2 (de) 2001-11-22
ATE201683T1 (de) 2001-06-15
PT885222E (pt) 2001-10-31
HUP9900572A2 (hu) 1999-06-28
WO1997030050A1 (en) 1997-08-21
GB9603226D0 (en) 1996-04-17
NO983656D0 (no) 1998-08-10
ES2159838T3 (es) 2001-10-16
HUP9900572A3 (en) 2000-10-30
US6087371A (en) 2000-07-11
IL125344A0 (en) 1999-03-12
NO983656L (no) 1998-10-12
KR19990082680A (ko) 1999-11-25
DK0885222T3 (da) 2001-08-27
GR3036390T3 (en) 2001-11-30
NZ331087A (en) 1999-08-30
CA2243992A1 (en) 1997-08-21
BR9707463A (pt) 1999-07-20
ZA971167B (en) 1997-08-25

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