CA2238723A1 - Arylethenesulfonamide derivatives and drug composition containing the same - Google Patents
Arylethenesulfonamide derivatives and drug composition containing the sameInfo
- Publication number
- CA2238723A1 CA2238723A1 CA002238723A CA2238723A CA2238723A1 CA 2238723 A1 CA2238723 A1 CA 2238723A1 CA 002238723 A CA002238723 A CA 002238723A CA 2238723 A CA2238723 A CA 2238723A CA 2238723 A1 CA2238723 A1 CA 2238723A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- atom
- substituted
- optionally substituted
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
(see formula I) Novel arylethenesulfonamide derivative having a high affinity for drugs, especially endoserine receptors, and represented by general formula (I); pharmaceutically acceptable salts thereof; and drugs comprising the same as the active ingredient, especially endoserine receptor antagonist, wherein Ar: optionally substituted aryl group or optionally substituted five- to six-membered heteroaryl group;
X: oxygen atom, sulfur atom or a group represented by a formula -NH-;
Y: oxygen atom or sulfur atom;
R1: hydrogen atom, optionally halogen-substituted lower alkyl group, cycloalkyl group, optionally substituted aryl group or optionally substituted five- to six-membered heteroaryl group;
R2: lower alkyl group, lower alkenyl group or lower alkynyl group where each of which may be substituted with one to three substituent(s) selected from a group consisting of hydroxyl group, lower alkoxy group, cycloalkyl group, halogen atom, carboxyl group and lower alkoxycarbonyl group;
R3: phenyl group which may be substituted with one to four substituent(s) selected from a group consisting of optionally halogen-substituted lower alkyl group, lower alkoxy group, halogen atom, lower alkylthio group, lower alkylsulfinyl group, lower alkanesulfonyl group, carboxyl group, lower alkoxycarbonyl group and carbamoyl group; and R4 and R5: they may be same or different and each is hydrogen atom or lower alkyl
X: oxygen atom, sulfur atom or a group represented by a formula -NH-;
Y: oxygen atom or sulfur atom;
R1: hydrogen atom, optionally halogen-substituted lower alkyl group, cycloalkyl group, optionally substituted aryl group or optionally substituted five- to six-membered heteroaryl group;
R2: lower alkyl group, lower alkenyl group or lower alkynyl group where each of which may be substituted with one to three substituent(s) selected from a group consisting of hydroxyl group, lower alkoxy group, cycloalkyl group, halogen atom, carboxyl group and lower alkoxycarbonyl group;
R3: phenyl group which may be substituted with one to four substituent(s) selected from a group consisting of optionally halogen-substituted lower alkyl group, lower alkoxy group, halogen atom, lower alkylthio group, lower alkylsulfinyl group, lower alkanesulfonyl group, carboxyl group, lower alkoxycarbonyl group and carbamoyl group; and R4 and R5: they may be same or different and each is hydrogen atom or lower alkyl
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPHEI-7-332111 | 1995-12-20 | ||
| JP33211195 | 1995-12-20 | ||
| PCT/JP1996/003701 WO1997022595A1 (en) | 1995-12-20 | 1996-12-19 | Arylethenesulfonamide derivatives and drug composition containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2238723A1 true CA2238723A1 (en) | 1997-06-26 |
| CA2238723C CA2238723C (en) | 2006-06-13 |
Family
ID=36587553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002238723A Expired - Fee Related CA2238723C (en) | 1995-12-20 | 1996-12-19 | Arylethenesulfonamide derivatives and drug composition containing the same |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2238723C (en) |
-
1996
- 1996-12-19 CA CA002238723A patent/CA2238723C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2238723C (en) | 2006-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |