NO303778B1 - Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt - Google Patents
Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomproduktInfo
- Publication number
- NO303778B1 NO303778B1 NO19951813A NO951813A NO303778B1 NO 303778 B1 NO303778 B1 NO 303778B1 NO 19951813 A NO19951813 A NO 19951813A NO 951813 A NO951813 A NO 951813A NO 303778 B1 NO303778 B1 NO 303778B1
- Authority
- NO
- Norway
- Prior art keywords
- derivative
- ring
- nitrogen
- optionally substituted
- sulfonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24861493 | 1993-09-10 | ||
| PCT/JP1994/001487 WO1995007276A1 (fr) | 1993-09-10 | 1994-09-08 | Derives bicycliques heterocycliques d'ester sulfonique et de sulfonamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951813D0 NO951813D0 (no) | 1995-05-09 |
| NO951813L NO951813L (no) | 1995-05-09 |
| NO303778B1 true NO303778B1 (no) | 1998-08-31 |
Family
ID=17180741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19951813A NO303778B1 (no) | 1993-09-10 | 1995-05-09 | Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5767283A (no) |
| EP (1) | EP0673937B1 (no) |
| KR (2) | KR0174752B1 (no) |
| CN (2) | CN1221533C (no) |
| AT (1) | ATE255106T1 (no) |
| AU (2) | AU683492B2 (no) |
| CA (1) | CA2146961C (no) |
| DE (1) | DE69433353T2 (no) |
| DK (1) | DK0673937T3 (no) |
| ES (1) | ES2206469T3 (no) |
| HU (1) | HU224069B1 (no) |
| NO (1) | NO303778B1 (no) |
| NZ (1) | NZ273073A (no) |
| PT (1) | PT673937E (no) |
| RU (2) | RU2128648C1 (no) |
| WO (1) | WO1995007276A1 (no) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU674240B2 (en) * | 1993-06-25 | 1996-12-12 | Ihara Chemical Industry Co. Ltd. | Indazolesulfonylurea derivative, use thereof, and intermediate for production thereof |
| JPH11505524A (ja) * | 1995-05-01 | 1999-05-21 | 藤沢薬品工業株式会社 | イミダゾ１，２−ａピリジンおよびイミダゾ１，２−ａピリデジン誘導体、および骨吸収阻害剤としてのその用途 |
| EP0923932B1 (en) * | 1996-02-26 | 2011-06-29 | Eisai R&D Management Co., Ltd. | Composition containing antitumor agent |
| JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| JP4516942B2 (ja) * | 1999-02-26 | 2010-08-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有インドール化合物 |
| US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| US6521658B1 (en) | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| NZ520299A (en) * | 2000-02-03 | 2004-05-28 | Eisai Co Ltd | Integrin expression inhibitors containing sulphonamide derivatives |
| KR100767002B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
| TWI283575B (en) * | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| KR100857735B1 (ko) * | 2000-11-24 | 2008-09-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항암제에 대한 종양 세포의 감수성을 검정하는 방법 |
| CN100384482C (zh) * | 2001-02-21 | 2008-04-30 | 卫材R&D管理有限公司 | 测定通过抑制整联蛋白表达所介导的血管生成抑制剂的作用的方法 |
| WO2002070478A1 (en) * | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
| US20040235866A1 (en) * | 2001-09-05 | 2004-11-25 | Takahisa Hanada | Lymphocytic activation inhibitor and remedial agent for autoimmune disease |
| DE60317529T2 (de) | 2002-09-19 | 2008-09-25 | Schering Corp. | Imidazopyridine als hemmstoffe cyclin abhängiger kinasen |
| EP1797877A4 (en) | 2004-09-13 | 2010-12-15 | Eisai Co Ltd | JOINT USE OF A SULFONAMIDE-BASED COMPOUND AND AN ANGIOGENESIS INHIBITOR |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| JPWO2006054456A1 (ja) * | 2004-11-17 | 2008-05-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 二環式へテロ環含有スルホンアミド化合物の結晶 |
| ME01222B (me) * | 2005-02-28 | 2013-06-20 | Eisai R&D Man Co Ltd | Nova kombinovana upotreba jedinjenja sulfonamida u liječenju kancera |
| JP5094394B2 (ja) * | 2005-04-20 | 2012-12-12 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| NZ561609A (en) * | 2005-05-12 | 2010-03-26 | Abbott Lab | 3-((trifluoromethyl)sulfonyl)benzenesulfonamide and 3-((chloro(difluoro)methyl)sulfonyl)benzenesulfonamide apoptosis promoters |
| JPWO2007123274A1 (ja) | 2006-04-20 | 2009-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規感受性マーカー |
| BRPI0717722A2 (pt) | 2006-10-19 | 2013-10-29 | Takeda Pharmaceutical | Composto ou um sal do mesmo, pró-droga, ativador de glicoquinase, agente farmacêutico, métodos para ativar uma glicoquinase em um mamífero e para a profilaxia ou o tratamento de diabetes ou obesidade em um mamífero, e, uso do composto ou uma pró-droga do mesmo |
| US8445679B2 (en) * | 2007-04-16 | 2013-05-21 | Abbvie Inc. | 7-substituted indole MCL-1 inhibitors |
| US8222414B2 (en) | 2007-08-17 | 2012-07-17 | Lg Life Sciences Ltd. | Indole compounds as an inhibitor of cellular necrosis |
| CN101952281B (zh) | 2008-01-04 | 2014-04-02 | 株式会社Lg生命科学 | 具有细胞、组织及器官保存效果的吲哚及吲唑衍生物 |
| EP2229929B1 (en) | 2009-03-18 | 2017-06-14 | DENTSPLY DETREY GmbH | Temporary root canal sealer dispersion |
| TWI410408B (zh) * | 2010-03-16 | 2013-10-01 | Purzer Pharmaceutical Co Ltd | 苯磺醯胺衍生物及其醫藥組合物 |
| CN102199148A (zh) * | 2010-03-25 | 2011-09-28 | 瑞安大药厂股份有限公司 | 苯磺酰胺衍生物及其医药组合物 |
| WO2012056319A1 (en) * | 2010-10-27 | 2012-05-03 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
| CN102875549B (zh) * | 2012-09-14 | 2015-11-04 | 浙江大学 | 7-芳（甲）胺基-5-胺基-6-氮杂吲哚衍生物及制备与用途 |
| EP3037418B1 (en) | 2013-08-22 | 2019-10-02 | LG Chem, Ltd. | Indole compound as inhibitor of necrosis |
| CN105658625B (zh) | 2013-08-22 | 2019-05-03 | 株式会社Lg化学 | 作为细胞坏死阻碍剂的吲哚酰胺化合物 |
| US20220162193A1 (en) * | 2019-04-10 | 2022-05-26 | Peloton Therapeutics, Inc. | Pyrazolesulfonamides as antitumor agents |
| EP3971183A4 (en) | 2019-06-19 | 2022-08-10 | LG Chem, Ltd. | PROCESS FOR THE PREPARATION OF INDOLE OR INDAZOLE COMPOUNDS |
| CN114096534B (zh) | 2019-06-19 | 2024-01-02 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
| CN114080386B (zh) | 2019-06-19 | 2024-05-31 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
| WO2020256429A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| WO2023064669A2 (en) * | 2021-09-21 | 2023-04-20 | The Trustees Of Princeton University | Inhibitors of the mtdh-snd1 protein complex for cancer therapy |
| MA54773B1 (fr) * | 2021-10-29 | 2023-10-31 | Univ Euro Mediterraneenne De Fes Uemf | Nouvelles familles de composés à base de sulfonamides pour le traitement du cancer du sein triple négatif |
| US20240092770A1 (en) * | 2022-08-15 | 2024-03-21 | Recursion Pharmaceuticals, Inc. | Heterocycle RMB39 Modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS539256A (en) * | 1976-07-14 | 1978-01-27 | Hitachi Kiden Kogyo Kk | Two hook type club |
| DE3686688T2 (de) * | 1985-06-24 | 1993-03-18 | Merck & Co Inc | Verwendung von sulfanilamido quinoxalinen zur behandlung von neoplastischen krankheiten. |
| JP2790926B2 (ja) * | 1990-08-20 | 1998-08-27 | エーザイ株式会社 | スルホンアミド誘導体 |
| LU87814A1 (fr) * | 1990-09-27 | 1992-05-25 | Oreal | Composition cosmetique comportant une dispersion de vesicules lipidiques ainsi que des pigments melaniques,et son utilisation |
-
1994
- 1994-09-08 EP EP94926372A patent/EP0673937B1/en not_active Expired - Lifetime
- 1994-09-08 CN CNB011194561A patent/CN1221533C/zh not_active Expired - Fee Related
- 1994-09-08 KR KR1019950701862A patent/KR0174752B1/ko not_active IP Right Cessation
- 1994-09-08 PT PT94926372T patent/PT673937E/pt unknown
- 1994-09-08 RU RU95112848A patent/RU2128648C1/ru not_active IP Right Cessation
- 1994-09-08 AU AU76237/94A patent/AU683492B2/en not_active Ceased
- 1994-09-08 WO PCT/JP1994/001487 patent/WO1995007276A1/ja active IP Right Grant
- 1994-09-08 DK DK94926372T patent/DK0673937T3/da active
- 1994-09-08 HU HU9501363A patent/HU224069B1/hu not_active IP Right Cessation
- 1994-09-08 CA CA002146961A patent/CA2146961C/en not_active Expired - Fee Related
- 1994-09-08 AT AT94926372T patent/ATE255106T1/de active
- 1994-09-08 NZ NZ273073A patent/NZ273073A/en not_active IP Right Cessation
- 1994-09-08 RU RU96119782A patent/RU2121997C1/ru not_active IP Right Cessation
- 1994-09-08 CN CN94190672A patent/CN1079097C/zh not_active Expired - Fee Related
- 1994-09-08 DE DE69433353T patent/DE69433353T2/de not_active Expired - Lifetime
- 1994-09-08 ES ES94926372T patent/ES2206469T3/es not_active Expired - Lifetime
-
1995
- 1995-05-09 NO NO19951813A patent/NO303778B1/no not_active IP Right Cessation
-
1997
- 1997-01-17 US US08/785,610 patent/US5767283A/en not_active Expired - Lifetime
- 1997-04-09 AU AU17785/97A patent/AU711438B2/en not_active Ceased
-
1998
- 1998-09-07 KR KR1019980707044A patent/KR100188846B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU95112848A (ru) | 1997-03-20 |
| KR100188846B1 (en) | 1999-06-01 |
| NO951813D0 (no) | 1995-05-09 |
| AU683492B2 (en) | 1997-11-13 |
| CA2146961C (en) | 2006-11-07 |
| CN1221533C (zh) | 2005-10-05 |
| RU2121997C1 (ru) | 1998-11-20 |
| CN1079097C (zh) | 2002-02-13 |
| KR950704304A (ko) | 1995-11-17 |
| US5767283A (en) | 1998-06-16 |
| DK0673937T3 (da) | 2004-03-22 |
| AU711438B2 (en) | 1999-10-14 |
| CA2146961A1 (en) | 1995-03-16 |
| ATE255106T1 (de) | 2003-12-15 |
| DE69433353T2 (de) | 2004-09-09 |
| PT673937E (pt) | 2004-04-30 |
| EP0673937A4 (en) | 1996-01-17 |
| AU7623794A (en) | 1995-03-27 |
| NO951813L (no) | 1995-05-09 |
| NZ273073A (en) | 1996-09-25 |
| AU1778597A (en) | 1997-08-14 |
| CN1114506A (zh) | 1996-01-03 |
| CN1491941A (zh) | 2004-04-28 |
| KR0174752B1 (ko) | 1999-02-01 |
| HU224069B1 (hu) | 2005-05-30 |
| RU2128648C1 (ru) | 1999-04-10 |
| HUT71551A (en) | 1995-12-28 |
| EP0673937A1 (en) | 1995-09-27 |
| EP0673937B1 (en) | 2003-11-26 |
| HU9501363D0 (en) | 1995-06-28 |
| ES2206469T3 (es) | 2004-05-16 |
| WO1995007276A1 (fr) | 1995-03-16 |
| DE69433353D1 (de) | 2004-01-08 |
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