ATE255106T1 - Bicyclische, heterocyclische sulfonamide und sulfonsäureester - Google Patents
Bicyclische, heterocyclische sulfonamide und sulfonsäureesterInfo
- Publication number
- ATE255106T1 ATE255106T1 AT94926372T AT94926372T ATE255106T1 AT E255106 T1 ATE255106 T1 AT E255106T1 AT 94926372 T AT94926372 T AT 94926372T AT 94926372 T AT94926372 T AT 94926372T AT E255106 T1 ATE255106 T1 AT E255106T1
- Authority
- AT
- Austria
- Prior art keywords
- ring
- nitrogen
- optionally substituted
- bicyclic
- sulfonic acid
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 150000003459 sulfonic acid esters Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- -1 bicyclic heterocyclic sulfonamide Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24861493 | 1993-09-10 | ||
| PCT/JP1994/001487 WO1995007276A1 (en) | 1993-09-10 | 1994-09-08 | Bicyclic heterocyclic sulfonamide and sulfonic ester derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255106T1 true ATE255106T1 (de) | 2003-12-15 |
Family
ID=17180741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94926372T ATE255106T1 (de) | 1993-09-10 | 1994-09-08 | Bicyclische, heterocyclische sulfonamide und sulfonsäureester |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5767283A (de) |
| EP (1) | EP0673937B1 (de) |
| KR (2) | KR0174752B1 (de) |
| CN (2) | CN1221533C (de) |
| AT (1) | ATE255106T1 (de) |
| AU (2) | AU683492B2 (de) |
| CA (1) | CA2146961C (de) |
| DE (1) | DE69433353T2 (de) |
| DK (1) | DK0673937T3 (de) |
| ES (1) | ES2206469T3 (de) |
| HU (1) | HU224069B1 (de) |
| NO (1) | NO303778B1 (de) |
| NZ (1) | NZ273073A (de) |
| PT (1) | PT673937E (de) |
| RU (2) | RU2121997C1 (de) |
| WO (1) | WO1995007276A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9405488A (pt) * | 1993-06-25 | 1999-06-01 | Kumiai Chemical Industry Co | Derivado de indazolsulfoniluréia seu uso e intermediário para sua produção |
| AU5348396A (en) * | 1995-05-01 | 1996-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors |
| JP4130700B2 (ja) * | 1996-02-26 | 2008-08-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗腫瘍剤含有組成物 |
| ATE271385T1 (de) * | 1996-10-15 | 2004-08-15 | Searle Llc | Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und verbeugung von neoplasia |
| JP4516942B2 (ja) * | 1999-02-26 | 2010-08-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有インドール化合物 |
| JP2000247949A (ja) * | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| US6521658B1 (en) | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| ES2246922T3 (es) * | 1999-12-28 | 2006-03-01 | Eisai Co., Ltd. | Compuestos heterociclicos que tienen grupos de sulfonamida. |
| DE60141889D1 (de) * | 2000-02-03 | 2010-06-02 | Eisai R&D Man Co Ltd | Inhibitoren der integrinexpression |
| KR100767002B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
| TWI283575B (en) * | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| AU2409602A (en) | 2000-11-24 | 2002-06-03 | Eisai C0 Ltd | Method of testing anticancer agent-sensitivity of tumor cells |
| KR20030080013A (ko) * | 2001-02-21 | 2003-10-10 | 에자이 가부시키가이샤 | 인테그린 발현 억제를 통한 혈관 신생 억제제의 효과를검정하는 방법 |
| WO2002070478A1 (en) * | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
| CN1551766A (zh) * | 2001-09-05 | 2004-12-01 | ������������ʽ���� | 淋巴细胞活化抑制剂和自身免疫性疾病治疗剂 |
| WO2004026867A2 (en) | 2002-09-19 | 2004-04-01 | Schering Corporation | Imidazopyridines as cyclin dependent kinase inhibitors |
| WO2006030941A1 (ja) | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| RU2383533C2 (ru) * | 2004-10-04 | 2010-03-10 | Ф.Хоффманн-Ля Рош Аг | Алкилированные производные пиридина в качестве ингибиторов 11-бета при диабете |
| EP1813602A4 (de) * | 2004-11-17 | 2009-08-05 | Eisai R&D Man Co Ltd | Kristall einer heterocyclischen sulfonamidverbindung mit zwei ringen |
| PL1859793T3 (pl) | 2005-02-28 | 2011-09-30 | Eisai R&D Man Co Ltd | Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej |
| US8957070B2 (en) | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
| ES2493466T3 (es) * | 2005-05-12 | 2014-09-11 | Abbvie Bahamas Ltd. | Promotores de la apoptosis |
| EP2015070A4 (de) | 2006-04-20 | 2010-04-21 | Eisai R&D Man Co Ltd | Neuer marker für empfindlichkeit gegenüber einer sulfonamidverbindung |
| CN101573357B (zh) * | 2006-10-19 | 2013-01-23 | 武田药品工业株式会社 | 吲哚化合物 |
| KR101511074B1 (ko) | 2007-04-16 | 2015-04-13 | 애브비 인코포레이티드 | 7-치환된 인돌 Ｍｃｌ-1 억제제 |
| EP2178870B1 (de) * | 2007-08-17 | 2018-09-19 | LG Chem, Ltd. | Indol- und indazolverbindungen als hemmer von zellnekrose |
| KR101098583B1 (ko) | 2008-01-04 | 2011-12-26 | 주식회사 엘지생명과학 | 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체 |
| EP2229929B1 (de) | 2009-03-18 | 2017-06-14 | DENTSPLY DETREY GmbH | Dispersion zur vorübergehenden Versiegelung einer Zahnwurzel |
| TWI410408B (zh) * | 2010-03-16 | 2013-10-01 | Purzer Pharmaceutical Co Ltd | 苯磺醯胺衍生物及其醫藥組合物 |
| CN102199148A (zh) * | 2010-03-25 | 2011-09-28 | 瑞安大药厂股份有限公司 | 苯磺酰胺衍生物及其医药组合物 |
| WO2012056319A1 (en) * | 2010-10-27 | 2012-05-03 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
| CN102875549B (zh) * | 2012-09-14 | 2015-11-04 | 浙江大学 | 7-芳（甲）胺基-5-胺基-6-氮杂吲哚衍生物及制备与用途 |
| EP3037412B1 (de) | 2013-08-22 | 2020-09-30 | LG Chem, Ltd. | Indolamidverbindung als nekrosehemmer |
| JP6315853B2 (ja) | 2013-08-22 | 2018-04-25 | エルジー・ケム・リミテッド | 細胞壊死阻害剤としてのインドール化合物 |
| US20220162193A1 (en) * | 2019-04-10 | 2022-05-26 | Peloton Therapeutics, Inc. | Pyrazolesulfonamides as antitumor agents |
| KR102397752B1 (ko) | 2019-06-19 | 2022-05-16 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| WO2020256429A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| EP3971183B1 (de) | 2019-06-19 | 2026-07-29 | LG Chem, Ltd. | Verfahren zur herstellung von indol- oder indazolverbindungen |
| KR102389717B1 (ko) | 2019-06-19 | 2022-04-25 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| EP4404929A2 (de) * | 2021-09-21 | 2024-07-31 | The Trustees of Princeton University | Inhibitoren des mtdh-snd1-proteinkomplexes zur krebstherapie |
| MA54773B1 (fr) * | 2021-10-29 | 2023-10-31 | Univ Euro Mediterraneenne De Fes Uemf | Nouvelles familles de composés à base de sulfonamides pour le traitement du cancer du sein triple négatif |
| US20240092770A1 (en) * | 2022-08-15 | 2024-03-21 | Recursion Pharmaceuticals, Inc. | Heterocycle RMB39 Modulators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU509046A1 (ru) * | 1975-02-21 | 1984-06-23 | Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе | Производные 2-карбэтокси-3-аминоиндола,про вл ющие противовоспалительную активность, и способ их получени |
| JPS539256A (en) * | 1976-07-14 | 1978-01-27 | Hitachi Kiden Kogyo Kk | Two hook type club |
| DE3105850A1 (de) * | 1981-02-18 | 1982-08-19 | Horst, Hans Jörg, Priv.Doz.Dr., 2057 Reinbek | Mittel zum behandeln von tumoren |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4610981A (en) * | 1985-02-11 | 1986-09-09 | American Cyanamid Company | N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)-alkyl]benzenesulfonamides and thromboxane synthetase/antihypertensive compositions |
| EP0215200B1 (de) * | 1985-06-24 | 1992-09-09 | Merck & Co. Inc. | Verwendung von sulfanilamido Quinoxalinen zur Behandlung von neoplastischen Krankheiten |
| US4849563A (en) * | 1986-01-21 | 1989-07-18 | Yale University | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
| US4942263A (en) * | 1989-04-13 | 1990-07-17 | Eastman Kodak Company | Preparation of aldehydes |
| ATE167473T1 (de) * | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
| JP2790926B2 (ja) * | 1990-08-20 | 1998-08-27 | エーザイ株式会社 | スルホンアミド誘導体 |
| LU87814A1 (fr) * | 1990-09-27 | 1992-05-25 | Oreal | Composition cosmetique comportant une dispersion de vesicules lipidiques ainsi que des pigments melaniques,et son utilisation |
-
1994
- 1994-09-08 RU RU96119782A patent/RU2121997C1/ru not_active IP Right Cessation
- 1994-09-08 KR KR1019950701862A patent/KR0174752B1/ko not_active Expired - Fee Related
- 1994-09-08 CN CNB011194561A patent/CN1221533C/zh not_active Expired - Fee Related
- 1994-09-08 ES ES94926372T patent/ES2206469T3/es not_active Expired - Lifetime
- 1994-09-08 DK DK94926372T patent/DK0673937T3/da active
- 1994-09-08 CA CA002146961A patent/CA2146961C/en not_active Expired - Fee Related
- 1994-09-08 RU RU95112848A patent/RU2128648C1/ru not_active IP Right Cessation
- 1994-09-08 AU AU76237/94A patent/AU683492B2/en not_active Ceased
- 1994-09-08 EP EP94926372A patent/EP0673937B1/de not_active Expired - Lifetime
- 1994-09-08 AT AT94926372T patent/ATE255106T1/de active
- 1994-09-08 CN CN94190672A patent/CN1079097C/zh not_active Expired - Fee Related
- 1994-09-08 PT PT94926372T patent/PT673937E/pt unknown
- 1994-09-08 DE DE69433353T patent/DE69433353T2/de not_active Expired - Lifetime
- 1994-09-08 WO PCT/JP1994/001487 patent/WO1995007276A1/ja not_active Ceased
- 1994-09-08 NZ NZ273073A patent/NZ273073A/en not_active IP Right Cessation
- 1994-09-08 HU HU9501363A patent/HU224069B1/hu not_active IP Right Cessation
-
1995
- 1995-05-09 NO NO19951813A patent/NO303778B1/no not_active IP Right Cessation
-
1997
- 1997-01-17 US US08/785,610 patent/US5767283A/en not_active Expired - Lifetime
- 1997-04-09 AU AU17785/97A patent/AU711438B2/en not_active Ceased
-
1998
- 1998-09-07 KR KR1019980707044A patent/KR100188846B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2128648C1 (ru) | 1999-04-10 |
| DE69433353T2 (de) | 2004-09-09 |
| EP0673937A4 (de) | 1996-01-17 |
| CN1079097C (zh) | 2002-02-13 |
| HUT71551A (en) | 1995-12-28 |
| RU2121997C1 (ru) | 1998-11-20 |
| AU7623794A (en) | 1995-03-27 |
| KR0174752B1 (ko) | 1999-02-01 |
| HU224069B1 (hu) | 2005-05-30 |
| NO951813D0 (no) | 1995-05-09 |
| DE69433353D1 (de) | 2004-01-08 |
| PT673937E (pt) | 2004-04-30 |
| CN1114506A (zh) | 1996-01-03 |
| US5767283A (en) | 1998-06-16 |
| NO303778B1 (no) | 1998-08-31 |
| WO1995007276A1 (en) | 1995-03-16 |
| ES2206469T3 (es) | 2004-05-16 |
| CA2146961A1 (en) | 1995-03-16 |
| AU683492B2 (en) | 1997-11-13 |
| HU9501363D0 (en) | 1995-06-28 |
| CN1221533C (zh) | 2005-10-05 |
| RU95112848A (ru) | 1997-03-20 |
| AU1778597A (en) | 1997-08-14 |
| EP0673937A1 (de) | 1995-09-27 |
| CN1491941A (zh) | 2004-04-28 |
| NO951813L (no) | 1995-05-09 |
| NZ273073A (en) | 1996-09-25 |
| AU711438B2 (en) | 1999-10-14 |
| KR950704304A (ko) | 1995-11-17 |
| CA2146961C (en) | 2006-11-07 |
| KR100188846B1 (en) | 1999-06-01 |
| EP0673937B1 (de) | 2003-11-26 |
| DK0673937T3 (da) | 2004-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69433353D1 (de) | Bicyclische, heterocyclische sulfonamide und sulfonsäureester | |
| AU624405B2 (en) | Heterocyclic bisphosphonic acid derivatives | |
| EP1103552A4 (de) | Benzothiepin-derivate, verfahren zu ihrer herstellung und ihre verwendungen | |
| AU6876894A (en) | New compositions of matter | |
| FI951416A0 (fi) | Trisykliset heterosykliset sulfonamidi- ja sulfoniesterijohdannaiset | |
| AU4216993A (en) | Novel arylglycinamide derivatives and preparative processes therefor | |
| IL86381A0 (en) | Oxetanocins and pharmaceutical compositions containing the same | |
| AU2124992A (en) | Pharmaceutically useful indole derivatives | |
| EP0878196A4 (de) | Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate | |
| ATE148128T1 (de) | Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung | |
| HUT75647A (en) | Imidazolidinone derivatives and pharmaceutical compositions containing them, which are suitable for treament of senile dementia | |
| AU3255989A (en) | Heterotetracyclic lactam derivatives | |
| HUT61967A (en) | Process for producing new alkyl aminoalkyl amine- and -ether derivatives and pharmaceutical compositions comprising such compounds | |
| NO920619L (no) | Oxazinobenzazolforbindelser | |
| AU8591991A (en) | Piperazine derivatives | |
| AU1093692A (en) | Disubstituted ureas and thioureas derivatives | |
| HRP20050617A2 (en) | Imidazol derivatives having affinity for alpha 2 receptors activity | |
| EP1433479B8 (de) | Mittel zur anregung des appetits und mittel zur behandlung von anorexie | |
| DE3867202D1 (de) | Sulfamoyl-2-benzofurancarbonsaeure-derivate, ihre herstellung und ihre verwendung. | |
| AU2001225466A1 (en) | Pyrimidine derivatives having antitumor effect |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0673937 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner |