ATE255106T1 - Bicyclische, heterocyclische sulfonamide und sulfonsäureester - Google Patents
Bicyclische, heterocyclische sulfonamide und sulfonsäureesterInfo
- Publication number
- ATE255106T1 ATE255106T1 AT94926372T AT94926372T ATE255106T1 AT E255106 T1 ATE255106 T1 AT E255106T1 AT 94926372 T AT94926372 T AT 94926372T AT 94926372 T AT94926372 T AT 94926372T AT E255106 T1 ATE255106 T1 AT E255106T1
- Authority
- AT
- Austria
- Prior art keywords
- ring
- nitrogen
- optionally substituted
- bicyclic
- sulfonic acid
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 150000003459 sulfonic acid esters Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- -1 bicyclic heterocyclic sulfonamide Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24861493 | 1993-09-10 | ||
| PCT/JP1994/001487 WO1995007276A1 (en) | 1993-09-10 | 1994-09-08 | Bicyclic heterocyclic sulfonamide and sulfonic ester derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255106T1 true ATE255106T1 (de) | 2003-12-15 |
Family
ID=17180741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94926372T ATE255106T1 (de) | 1993-09-10 | 1994-09-08 | Bicyclische, heterocyclische sulfonamide und sulfonsäureester |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5767283A (de) |
| EP (1) | EP0673937B1 (de) |
| KR (2) | KR0174752B1 (de) |
| CN (2) | CN1221533C (de) |
| AT (1) | ATE255106T1 (de) |
| AU (2) | AU683492B2 (de) |
| CA (1) | CA2146961C (de) |
| DE (1) | DE69433353T2 (de) |
| DK (1) | DK0673937T3 (de) |
| ES (1) | ES2206469T3 (de) |
| HU (1) | HU224069B1 (de) |
| NO (1) | NO303778B1 (de) |
| NZ (1) | NZ273073A (de) |
| PT (1) | PT673937E (de) |
| RU (2) | RU2121997C1 (de) |
| WO (1) | WO1995007276A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534481A (en) * | 1993-06-25 | 1996-07-09 | Kumiai Chemical Industry Co., Ltd. | Indazolesulfonylurea derivative, its use and intermediate for its production |
| WO1996034866A1 (en) * | 1995-05-01 | 1996-11-07 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors |
| US6060498A (en) * | 1996-02-26 | 2000-05-09 | Eisai Co., Ltd. | Composition containing antitumor agent |
| DE69738815D1 (de) * | 1996-10-15 | 2008-08-14 | Searle Llc | Verwendung von Cyclooxygenase-2 Inhibitoren zur Behandlung und Vorbeugung von Neoplasia |
| JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| JP4516942B2 (ja) * | 1999-02-26 | 2010-08-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有インドール化合物 |
| US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| US6521658B1 (en) | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| JP4234344B2 (ja) * | 1999-12-28 | 2009-03-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有複素環化合物 |
| KR100767002B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
| KR100767000B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
| TWI283575B (en) * | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| KR100858644B1 (ko) * | 2000-11-24 | 2008-09-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항암제에 대한 종양 세포의 감수성을 검정하기 위한 시약 |
| CA2438427C (en) * | 2001-02-21 | 2011-04-12 | Eisai Co., Ltd. | Method for testing effect of angiogenesis inhibitor via integrin expression inhibition |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| WO2003022271A1 (fr) * | 2001-09-05 | 2003-03-20 | Eisai C0. Ltd. | Inhibiteur d'activation lymphocytaire et remede pour maladie auto-immune |
| DE60317529T2 (de) | 2002-09-19 | 2008-09-25 | Schering Corp. | Imidazopyridine als hemmstoffe cyclin abhängiger kinasen |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| WO2006030941A1 (ja) | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| WO2006037501A1 (en) * | 2004-10-04 | 2006-04-13 | F. Hoffmann-La Roche Ag | Alkil-pyridines as 11-beta inhibitors for diabetes |
| WO2006054456A1 (ja) | 2004-11-17 | 2006-05-26 | Eisai R & D Management Co., Ltd. | 二環式へテロ環含有スルホンアミド化合物の結晶 |
| PT1859793E (pt) | 2005-02-28 | 2011-07-05 | Eisai R&D Man Co Ltd | Uso combinado inovador de um composto de sulfonamida no tratamento oncológico |
| EP2308839B1 (de) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Kondensierte heterozyklische verbindungen |
| CN101175738B (zh) * | 2005-05-12 | 2010-10-27 | 雅培制药有限公司 | 细胞凋亡促进剂 |
| WO2007123274A1 (ja) | 2006-04-20 | 2007-11-01 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の新規感受性マーカー |
| MX2009003972A (es) | 2006-10-19 | 2009-04-27 | Takeda Pharmaceutical | Compuesto de indol. |
| MX2009011211A (es) | 2007-04-16 | 2009-10-30 | Abbott Lab | Indoles sustituidos en la posicion 7 inhibidores de mci-1. |
| EP2178870B1 (de) * | 2007-08-17 | 2018-09-19 | LG Chem, Ltd. | Indol- und indazolverbindungen als hemmer von zellnekrose |
| KR101098583B1 (ko) | 2008-01-04 | 2011-12-26 | 주식회사 엘지생명과학 | 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체 |
| EP2229929B1 (de) | 2009-03-18 | 2017-06-14 | DENTSPLY DETREY GmbH | Dispersion zur vorübergehenden Versiegelung einer Zahnwurzel |
| TWI410408B (zh) * | 2010-03-16 | 2013-10-01 | Purzer Pharmaceutical Co Ltd | 苯磺醯胺衍生物及其醫藥組合物 |
| CN102199148A (zh) * | 2010-03-25 | 2011-09-28 | 瑞安大药厂股份有限公司 | 苯磺酰胺衍生物及其医药组合物 |
| EP2632920A1 (de) | 2010-10-27 | 2013-09-04 | Dynamix Pharmaceuticals Ltd. | Sulfonamide zur modulation von pkm2 |
| CN102875549B (zh) * | 2012-09-14 | 2015-11-04 | 浙江大学 | 7-芳（甲）胺基-5-胺基-6-氮杂吲哚衍生物及制备与用途 |
| JP6315853B2 (ja) | 2013-08-22 | 2018-04-25 | エルジー・ケム・リミテッド | 細胞壊死阻害剤としてのインドール化合物 |
| ES2835851T3 (es) | 2013-08-22 | 2021-06-23 | Lg Chemical Ltd | Compuesto de indol amida como inhibidor de necrosis |
| US20220162193A1 (en) * | 2019-04-10 | 2022-05-26 | Peloton Therapeutics, Inc. | Pyrazolesulfonamides as antitumor agents |
| EP3971186B1 (de) | 2019-06-19 | 2023-08-02 | LG Chem, Ltd. | Verfahren zur herstellung von indol- oder indazolverbindungen |
| EP3971185B1 (de) | 2019-06-19 | 2024-04-17 | LG Chem, Ltd. | Verfahren zur herstellung von indol- oder indazolverbindung |
| CN114080383B (zh) | 2019-06-19 | 2024-07-23 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
| CN114080382B (zh) | 2019-06-19 | 2024-05-24 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
| US20240398767A1 (en) * | 2021-09-21 | 2024-12-05 | The Trustees Of Princeton University | Inhibitors of the mtdh-snd1 protein complex for cancer therapy |
| MA54773B1 (fr) * | 2021-10-29 | 2023-10-31 | Univ Euro Mediterraneenne De Fes Uemf | Nouvelles familles de composés à base de sulfonamides pour le traitement du cancer du sein triple négatif |
| KR20250048008A (ko) * | 2022-08-15 | 2025-04-07 | 리커전 파마슈티컬스, 인크. | 헤테로사이클 rbm39 조절제 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU509046A1 (ru) * | 1975-02-21 | 1984-06-23 | Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе | Производные 2-карбэтокси-3-аминоиндола,про вл ющие противовоспалительную активность, и способ их получени |
| JPS539256A (en) * | 1976-07-14 | 1978-01-27 | Hitachi Kiden Kogyo Kk | Two hook type club |
| DE3105850A1 (de) * | 1981-02-18 | 1982-08-19 | Horst, Hans Jörg, Priv.Doz.Dr., 2057 Reinbek | Mittel zum behandeln von tumoren |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4610981A (en) * | 1985-02-11 | 1986-09-09 | American Cyanamid Company | N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)-alkyl]benzenesulfonamides and thromboxane synthetase/antihypertensive compositions |
| EP0215200B1 (de) * | 1985-06-24 | 1992-09-09 | Merck & Co. Inc. | Verwendung von sulfanilamido Quinoxalinen zur Behandlung von neoplastischen Krankheiten |
| US4849563A (en) * | 1986-01-21 | 1989-07-18 | Yale University | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
| US4942263A (en) * | 1989-04-13 | 1990-07-17 | Eastman Kodak Company | Preparation of aldehydes |
| JP2790926B2 (ja) * | 1990-08-20 | 1998-08-27 | エーザイ株式会社 | スルホンアミド誘導体 |
| ATE167473T1 (de) * | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
| LU87814A1 (fr) * | 1990-09-27 | 1992-05-25 | Oreal | Composition cosmetique comportant une dispersion de vesicules lipidiques ainsi que des pigments melaniques,et son utilisation |
-
1994
- 1994-09-08 CN CNB011194561A patent/CN1221533C/zh not_active Expired - Fee Related
- 1994-09-08 NZ NZ273073A patent/NZ273073A/en not_active IP Right Cessation
- 1994-09-08 ES ES94926372T patent/ES2206469T3/es not_active Expired - Lifetime
- 1994-09-08 CA CA002146961A patent/CA2146961C/en not_active Expired - Fee Related
- 1994-09-08 RU RU96119782A patent/RU2121997C1/ru not_active IP Right Cessation
- 1994-09-08 KR KR1019950701862A patent/KR0174752B1/ko not_active Expired - Fee Related
- 1994-09-08 HU HU9501363A patent/HU224069B1/hu not_active IP Right Cessation
- 1994-09-08 WO PCT/JP1994/001487 patent/WO1995007276A1/ja not_active Ceased
- 1994-09-08 PT PT94926372T patent/PT673937E/pt unknown
- 1994-09-08 DE DE69433353T patent/DE69433353T2/de not_active Expired - Lifetime
- 1994-09-08 AT AT94926372T patent/ATE255106T1/de active
- 1994-09-08 DK DK94926372T patent/DK0673937T3/da active
- 1994-09-08 AU AU76237/94A patent/AU683492B2/en not_active Ceased
- 1994-09-08 CN CN94190672A patent/CN1079097C/zh not_active Expired - Fee Related
- 1994-09-08 EP EP94926372A patent/EP0673937B1/de not_active Expired - Lifetime
- 1994-09-08 RU RU95112848A patent/RU2128648C1/ru not_active IP Right Cessation
-
1995
- 1995-05-09 NO NO19951813A patent/NO303778B1/no not_active IP Right Cessation
-
1997
- 1997-01-17 US US08/785,610 patent/US5767283A/en not_active Expired - Lifetime
- 1997-04-09 AU AU17785/97A patent/AU711438B2/en not_active Ceased
-
1998
- 1998-09-07 KR KR1019980707044A patent/KR100188846B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2128648C1 (ru) | 1999-04-10 |
| PT673937E (pt) | 2004-04-30 |
| EP0673937B1 (de) | 2003-11-26 |
| KR0174752B1 (ko) | 1999-02-01 |
| AU711438B2 (en) | 1999-10-14 |
| RU95112848A (ru) | 1997-03-20 |
| DE69433353D1 (de) | 2004-01-08 |
| EP0673937A4 (de) | 1996-01-17 |
| AU683492B2 (en) | 1997-11-13 |
| RU2121997C1 (ru) | 1998-11-20 |
| HU9501363D0 (en) | 1995-06-28 |
| CA2146961C (en) | 2006-11-07 |
| DE69433353T2 (de) | 2004-09-09 |
| CA2146961A1 (en) | 1995-03-16 |
| ES2206469T3 (es) | 2004-05-16 |
| NO951813L (no) | 1995-05-09 |
| NZ273073A (en) | 1996-09-25 |
| AU7623794A (en) | 1995-03-27 |
| HU224069B1 (hu) | 2005-05-30 |
| CN1221533C (zh) | 2005-10-05 |
| NO951813D0 (no) | 1995-05-09 |
| CN1491941A (zh) | 2004-04-28 |
| KR100188846B1 (en) | 1999-06-01 |
| NO303778B1 (no) | 1998-08-31 |
| DK0673937T3 (da) | 2004-03-22 |
| US5767283A (en) | 1998-06-16 |
| HUT71551A (en) | 1995-12-28 |
| EP0673937A1 (de) | 1995-09-27 |
| CN1114506A (zh) | 1996-01-03 |
| AU1778597A (en) | 1997-08-14 |
| KR950704304A (ko) | 1995-11-17 |
| CN1079097C (zh) | 2002-02-13 |
| WO1995007276A1 (en) | 1995-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69433353D1 (de) | Bicyclische, heterocyclische sulfonamide und sulfonsäureester | |
| AU624405B2 (en) | Heterocyclic bisphosphonic acid derivatives | |
| EP1103552A4 (de) | Benzothiepin-derivate, verfahren zu ihrer herstellung und ihre verwendungen | |
| AU6876894A (en) | New compositions of matter | |
| FI951416A0 (fi) | Trisykliset heterosykliset sulfonamidi- ja sulfoniesterijohdannaiset | |
| AU4216993A (en) | Novel arylglycinamide derivatives and preparative processes therefor | |
| HUT52915A (en) | Fungicide and insecticide compositions containing acrylic acid ester derivatives as active components and process for producing the active components | |
| AU2124992A (en) | Pharmaceutically useful indole derivatives | |
| EP0878196A4 (de) | Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate | |
| ATE148128T1 (de) | Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung | |
| HUT75647A (en) | Imidazolidinone derivatives and pharmaceutical compositions containing them, which are suitable for treament of senile dementia | |
| AU3255989A (en) | Heterotetracyclic lactam derivatives | |
| AU8591991A (en) | Piperazine derivatives | |
| AU1093692A (en) | Disubstituted ureas and thioureas derivatives | |
| NO920619L (no) | Oxazinobenzazolforbindelser | |
| HRP20050617A2 (en) | Imidazol derivatives having affinity for alpha 2 receptors activity | |
| EP1433479B8 (de) | Mittel zur anregung des appetits und mittel zur behandlung von anorexie | |
| DE3867202D1 (de) | Sulfamoyl-2-benzofurancarbonsaeure-derivate, ihre herstellung und ihre verwendung. | |
| AU2001225466A1 (en) | Pyrimidine derivatives having antitumor effect |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0673937 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner |