FR11C0020I2 - Dérives difluoroprostaglandines et leur application - Google Patents

Dérives difluoroprostaglandines et leur application

Info

Publication number
FR11C0020I2
FR11C0020I2 FR11C0020C FR11C0020C FR11C0020I2 FR 11C0020 I2 FR11C0020 I2 FR 11C0020I2 FR 11C0020 C FR11C0020 C FR 11C0020C FR 11C0020 C FR11C0020 C FR 11C0020C FR 11C0020 I2 FR11C0020 I2 FR 11C0020I2
Authority
FR
France
Prior art keywords
application
difluoroprostaglandin
derivatives
difluoroprostaglandin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR11C0020C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27301396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR11C0020(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Publication of FR11C0020I1 publication Critical patent/FR11C0020I1/fr
Application granted granted Critical
Publication of FR11C0020I2 publication Critical patent/FR11C0020I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR11C0020C 1996-12-26 2011-06-21 Dérives difluoroprostaglandines et leur application Active FR11C0020I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34861496 1996-12-26
JP7405497 1997-03-26
JP17247797 1997-06-27

Publications (2)

Publication Number Publication Date
FR11C0020I1 FR11C0020I1 (fr) 2011-07-29
FR11C0020I2 true FR11C0020I2 (fr) 2012-03-16

Family

ID=27301396

Family Applications (1)

Application Number Title Priority Date Filing Date
FR11C0020C Active FR11C0020I2 (fr) 1996-12-26 2011-06-21 Dérives difluoroprostaglandines et leur application

Country Status (16)

Country Link
US (2) US5886035A (fr)
EP (1) EP0850926B1 (fr)
JP (2) JP3480549B2 (fr)
KR (1) KR100526282B1 (fr)
CN (1) CN1108289C (fr)
AT (1) ATE225770T1 (fr)
CA (1) CA2225761C (fr)
DE (2) DE69716226T2 (fr)
DK (1) DK0850926T3 (fr)
ES (1) ES2187719T3 (fr)
FR (1) FR11C0020I2 (fr)
LU (1) LU91943I2 (fr)
NL (1) NL300407I2 (fr)
NO (2) NO317060B1 (fr)
PT (1) PT850926E (fr)
TW (1) TW536534B (fr)

Families Citing this family (47)

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EP0930296B2 (fr) * 1996-09-17 2005-11-02 Asahi Glass Company Ltd. Derives de prostaglandine fluores et medicaments
US6225348B1 (en) 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
IL143477A (en) 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
IL134241A (en) 2000-01-27 2006-06-11 Finetech Pharmaceutical Ltd Process for the preparation of latanoprost
AU2001228836A1 (en) * 2000-01-28 2001-08-07 Santen Pharmaceutical Co., Ltd. Novel difluoroprostaglandin derivative
EP1321144B1 (fr) * 2000-09-13 2010-12-08 Santen Pharmaceutical Co., Ltd. Collyre
CN100591333C (zh) * 2002-08-23 2010-02-24 参天制药株式会社 以拉坦前列素为有效成分的稳定的滴眼液
AU2003261981A1 (en) * 2002-09-09 2004-03-29 Santen Pharmaceutical Co., Ltd. Transparent eye drops containing latanoprost
ATE450264T1 (de) * 2003-07-31 2009-12-15 Santen Pharmaceutical Co Ltd Prostaglandin enthaltendes produkt
CA2731265A1 (fr) * 2003-12-08 2005-06-23 Qualcomm Incorporated Interface haut debit de donnees a synchronisation de liaisons amelioree
JP2006187602A (ja) * 2004-12-09 2006-07-20 Santen Pharmaceut Co Ltd 分子内にフッ素原子を有するプロスタグランジン含有製品
JP4753178B2 (ja) * 2004-12-24 2011-08-24 参天製薬株式会社 プロスタグランジンＦ２α誘導体含有製品
US20090234005A1 (en) * 2005-03-31 2009-09-17 Naruhiro Ishida Protective agent for retinal neuronal cell containing prostaglandin f2alpha derivative as active ingredient
JP5100025B2 (ja) * 2005-03-31 2012-12-19 旭硝子株式会社 プロスタグランジンＦ２α誘導体を有効成分として含む網膜神経細胞保護剤
KR20070119726A (ko) 2005-04-13 2007-12-20 우베 고산 가부시키가이샤 인다졸 유도체를 유효 성분으로서 함유하는 망막신경세포보호제
JP2009500315A (ja) * 2005-06-29 2009-01-08 ファイザー・インク フルオロプロスタグランジンのニトロ誘導体
CN102391237B (zh) * 2006-02-07 2014-07-16 株式会社·R-技术上野 用于制备前列腺素衍生物的方法
WO2007111806A2 (fr) 2006-03-23 2007-10-04 Massachusetts Eye And Ear Infirmary Compositions et procedes pour la reduction des tissus adipeux de l'organisme
FR2918891B1 (fr) * 2007-07-20 2009-09-25 Thea Sa Lab Solution ophtalmique a base de prostaglandines sans conservateur
EP2127638A1 (fr) 2008-05-30 2009-12-02 Santen Pharmaceutical Co., Ltd Procédé et composition pour traiter l'hypertension oculaire et le glaucome
CA2735825C (fr) * 2008-09-04 2016-06-21 Santen Pharmaceutical Co., Ltd. Agent favorisant la pousse des cheveux contenant un derive de la 15,15-difluoroprostaglandine f2.alpha. en tant qu'ingredient actif
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
AU2010358560B2 (en) 2010-08-02 2015-02-12 Ac Patent Holding Inc. Composition, method and kit for enhancing hair
ES2687494T3 (es) 2011-01-19 2018-10-25 Topokine Therapeutics, Inc. Métodos y composiciones para reducir la grasa corporal
ES2684351T3 (es) 2011-02-04 2018-10-02 Kowa Co., Ltd. Terapia farmacológica para prevenir o tratar glaucoma
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
US20150011755A1 (en) * 2012-02-07 2015-01-08 Dr. Reddys Laboratories Limited Amine salts of prostaglandin analogs
EP2857002A4 (fr) 2012-05-30 2015-12-09 Asahi Glass Co Ltd Composition pour la croissance capillaire
CA2869676C (fr) 2012-11-21 2015-06-23 Topokine Therapeutics, Inc. Utilisations et compositions comprenant de la thiazolidinedione et de l'acide oleique pour augmenter localement la graisse sous-cutanee
NO2753788T3 (fr) 2013-05-10 2018-06-16
WO2014186504A1 (fr) 2013-05-15 2014-11-20 Topokine Therapeutics, Inc. Procédés et compositions pour l'administration topique de prostaglandines à la graisse sous-cutanée
CN103570549B (zh) * 2013-10-11 2016-01-27 天泽恩源（天津）制药有限公司 一种合成他氟前列素的方法
CN103804195B (zh) * 2014-01-26 2016-06-15 天泽恩源（天津）制药有限公司 一种合成他氟前列素的方法
CN103819436A (zh) * 2014-02-21 2014-05-28 天泽恩源（天津）医药技术有限公司 (3aR,4R,5R,6aS)-4-((E)-3,3-二氟-4-苯氧基丁-1-烯-1-基)-2-氧代六氢-2H-环戊烷[b]呋喃-5-基苯甲酸酯的一种晶型及相应晶体的制备方法
WO2015200425A1 (fr) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Forme posologique à usage topique
KR20160116402A (ko) 2015-03-30 2016-10-10 연성정밀화학(주) 타플루프로스트의 제조방법
BR112018005589A2 (pt) 2015-09-22 2018-10-09 Graybug Vision Inc “composto, composição farmaceuticamente aceitável, e, uso de um composto”
CN107226790A (zh) * 2016-03-25 2017-10-03 苏州朗科生物技术有限公司 一种高纯度他氟前列素及其类似化合物的制备方法及中间体化合物
GR1009040B (el) 2016-04-19 2017-05-19 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου
WO2018033854A1 (fr) 2016-08-15 2018-02-22 Santen Pharmaceutical Co., Ltd. Composition ophtalmique et procédé de traitement de l'hypertension oculaire et du glaucome
CN108299192A (zh) * 2017-01-10 2018-07-20 江苏恒瑞医药股份有限公司 一种他氟前列素酸的金属盐化合物结晶形式及其制备方法
CN106986766B (zh) * 2017-05-08 2021-01-12 扬子江药业集团有限公司 他氟前列素的制备方法
CN112457277B (zh) * 2020-12-16 2022-06-28 西安国康瑞金制药有限公司 一种他氟前列腺素的制备方法
CN112832150B (zh) * 2021-01-27 2022-06-24 中交第三公路工程局有限公司 一种涵洞通道等立面垂直凿毛装置
CN115322095A (zh) * 2021-01-27 2022-11-11 Ａｇｃ株式会社 他氟前列素的纯化方法
CN116120268A (zh) * 2023-03-06 2023-05-16 南京华威医药科技集团有限公司 一种他氟前列素中间体杂质及其制备方法
CN116425707A (zh) * 2023-03-31 2023-07-14 南京华威医药科技集团有限公司 一种他氟前列素中间体异构体杂质及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166178B1 (en) * 1987-09-18 1998-07-21 R Tech Ueno Ltd Ocular hypotensive agents
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
JPH0770054A (ja) * 1993-08-30 1995-03-14 R Tec Ueno:Kk 生化学的拮抗および疾患処置剤
EP0930296B2 (fr) * 1996-09-17 2005-11-02 Asahi Glass Company Ltd. Derives de prostaglandine fluores et medicaments
JP4248022B2 (ja) * 1996-11-12 2009-04-02 アルコン ラボラトリーズ，インコーポレイテッド 眼圧降下剤としての１５―フルオロプロスタグランジン

Also Published As

Publication number Publication date
ES2187719T3 (es) 2003-06-16
NL300407I2 (nl) 2010-03-01
US5886035A (en) 1999-03-23
DK0850926T3 (da) 2003-02-17
JP3994074B2 (ja) 2007-10-17
NO976085L (no) 1998-06-29
ATE225770T1 (de) 2002-10-15
DE69716226D1 (de) 2002-11-14
JPH1171344A (ja) 1999-03-16
CA2225761A1 (fr) 1998-06-26
FR11C0020I1 (fr) 2011-07-29
NO976085D0 (no) 1997-12-23
KR100526282B1 (ko) 2006-05-17
DE69716226T2 (de) 2003-06-05
US5985920A (en) 1999-11-16
CA2225761C (fr) 2009-04-21
EP0850926B1 (fr) 2002-10-09
NO2009006I1 (no) 2009-03-16
TW536534B (en) 2003-06-11
PT850926E (pt) 2003-02-28
JP2004002462A (ja) 2004-01-08
EP0850926A2 (fr) 1998-07-01
CN1187486A (zh) 1998-07-15
NO317060B1 (no) 2004-08-02
LU91943I2 (fr) 2012-04-16
DE122008000050I1 (de) 2009-01-29
KR19980064718A (ko) 1998-10-07
CN1108289C (zh) 2003-05-14
JP3480549B2 (ja) 2003-12-22
DE122008000050I2 (de) 2011-06-16
NO2009006I2 (no) 2012-03-05
EP0850926A3 (fr) 1999-06-16
NL300407I1 (nl) 2009-11-02

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