EP0850926A3 - Dérives difluoroprostaglandines et leur application - Google Patents

Dérives difluoroprostaglandines et leur application Download PDF

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Publication number
EP0850926A3
EP0850926A3 EP97122702A EP97122702A EP0850926A3 EP 0850926 A3 EP0850926 A3 EP 0850926A3 EP 97122702 A EP97122702 A EP 97122702A EP 97122702 A EP97122702 A EP 97122702A EP 0850926 A3 EP0850926 A3 EP 0850926A3
Authority
EP
European Patent Office
Prior art keywords
group
difluoroprostaglandin
derivatives
medicine
difluoroprostaglandin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP97122702A
Other languages
German (de)
English (en)
Other versions
EP0850926B1 (fr
EP0850926A2 (fr
Inventor
Eiichi Santen Pharmaceutical Co. Ltd. Shirasawa
Masaaki Santen Pharmaceutical Co. Ltd. Kageyama
Tadashi Santen Pharmaceutical Co. Ltd. Nakajima
Takashi Asahi Glass Company Ltd. Nakano
Nobuaki Asahi Glass Company Ltd. Mori
Hideshi Asahi Glass Company Ltd. Sasakura
Yasushi Asahi Glass Company Ltd. Matsumura
Yoshitomi Asahi Glass Company Ltd. Morizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27301396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0850926(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asahi Glass Co Ltd, Santen Pharmaceutical Co Ltd filed Critical Asahi Glass Co Ltd
Publication of EP0850926A2 publication Critical patent/EP0850926A2/fr
Publication of EP0850926A3 publication Critical patent/EP0850926A3/fr
Application granted granted Critical
Publication of EP0850926B1 publication Critical patent/EP0850926B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP97122702A 1996-12-26 1997-12-22 Dérives difluoroprostaglandines et leur application Expired - Lifetime EP0850926B1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP34861496 1996-12-26
JP348614/96 1996-12-26
JP34861496 1996-12-26
JP7405497 1997-03-26
JP74054/97 1997-03-26
JP7405497 1997-03-26
JP17247797 1997-06-27
JP172477/97 1997-06-27
JP17247797 1997-06-27

Publications (3)

Publication Number Publication Date
EP0850926A2 EP0850926A2 (fr) 1998-07-01
EP0850926A3 true EP0850926A3 (fr) 1999-06-16
EP0850926B1 EP0850926B1 (fr) 2002-10-09

Family

ID=27301396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97122702A Expired - Lifetime EP0850926B1 (fr) 1996-12-26 1997-12-22 Dérives difluoroprostaglandines et leur application

Country Status (16)

Country Link
US (2) US5886035A (fr)
EP (1) EP0850926B1 (fr)
JP (2) JP3480549B2 (fr)
KR (1) KR100526282B1 (fr)
CN (1) CN1108289C (fr)
AT (1) ATE225770T1 (fr)
CA (1) CA2225761C (fr)
DE (2) DE122008000050I2 (fr)
DK (1) DK0850926T3 (fr)
ES (1) ES2187719T3 (fr)
FR (1) FR11C0020I2 (fr)
LU (1) LU91943I2 (fr)
NL (1) NL300407I2 (fr)
NO (2) NO317060B1 (fr)
PT (1) PT850926E (fr)
TW (1) TW536534B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE221048T1 (de) * 1996-09-17 2002-08-15 Asahi Glass Co Ltd Fluorierte prostaglandinderivate und medikamente
US6225348B1 (en) 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
IL134241A (en) 2000-01-27 2006-06-11 Finetech Pharmaceutical Ltd Process for the preparation of latanoprost
IL143477A (en) 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
AU2001228836A1 (en) * 2000-01-28 2001-08-07 Santen Pharmaceutical Co., Ltd. Novel difluoroprostaglandin derivative
ES2357551T3 (es) * 2000-09-13 2011-04-27 Santen Pharmaceutical Co., Ltd. Colirio.
CN100361661C (zh) * 2002-08-23 2008-01-16 参天制药株式会社 以拉坦前列素为有效成分的稳定的滴眼液
CA2707067C (fr) * 2002-09-09 2013-07-16 Santen Pharmaceutical Co., Ltd. Solution ophtalmique transparente contenant du latonoprost comme principe actif
WO2005011704A1 (fr) * 2003-07-31 2005-02-10 Santen Pharmaceutical Co., Ltd. Produit contenant de la prostaglandine
MXPA06006452A (es) * 2003-12-08 2006-08-31 Qualcomm Inc Interfase de tasa alta de datos con sincronizacion de enlace mejorada.
JP2006187602A (ja) * 2004-12-09 2006-07-20 Santen Pharmaceut Co Ltd 分子内にフッ素原子を有するプロスタグランジン含有製品
JP4753178B2 (ja) * 2004-12-24 2011-08-24 参天製薬株式会社 プロスタグランジンＦ２α誘導体含有製品
JP5100025B2 (ja) * 2005-03-31 2012-12-19 旭硝子株式会社 プロスタグランジンＦ２α誘導体を有効成分として含む網膜神経細胞保護剤
WO2006106915A1 (fr) 2005-03-31 2006-10-12 Asahi Glass Company, Limited AGENT PROTECTEUR POUR LA CELLULE NEURONALE RETINIENNE CONTENANT UN DERIVE DE PROSTAGLANDINE F2α COMME INGREDIENT ACTIF
CN101160128B (zh) 2005-04-13 2010-08-18 宇部兴产株式会社 含有吲唑衍生物作为有效成分的视网膜神经细胞保护剂
WO2007000642A1 (fr) * 2005-06-29 2007-01-04 Pfizer Inc. Derives nitres de fluoroprostaglandines
HUE034571T2 (en) * 2006-02-07 2018-02-28 Sucampo Pharma Llc A method for preparing a prostaglandin derivative
US7666912B2 (en) 2006-03-23 2010-02-23 Massachusetts Eye And Ear Infirmary Compositions and methods for reducing body fat
FR2918891B1 (fr) * 2007-07-20 2009-09-25 Thea Sa Lab Solution ophtalmique a base de prostaglandines sans conservateur
EP2127638A1 (fr) * 2008-05-30 2009-12-02 Santen Pharmaceutical Co., Ltd Procédé et composition pour traiter l'hypertension oculaire et le glaucome
CN102143753B (zh) * 2008-09-04 2013-07-03 参天制药株式会社 含有15,15-二氟前列腺素F2α衍生物作为有效成分的毛发生长促进剂
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
BR112013002584A2 (pt) 2010-08-02 2016-06-07 Pharma Patent Holding Inc composição, processo de kit para aperfeiçoamento de cabelo
US9089579B2 (en) 2011-01-19 2015-07-28 Topokine Therapeutics, Inc. Methods and compositions for treating metabolic syndrome
TW201906614A (zh) 2011-02-04 2019-02-16 日商興和股份有限公司 青光眼或高眼壓症之預防或治療用之點眼藥
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
US20150011755A1 (en) * 2012-02-07 2015-01-08 Dr. Reddys Laboratories Limited Amine salts of prostaglandin analogs
EP2857002A4 (fr) 2012-05-30 2015-12-09 Asahi Glass Co Ltd Composition pour la croissance capillaire
EP2922542A4 (fr) 2012-11-21 2016-10-05 Topokine Therapeutics Inc Méthodes et compositions pour augmenter localement la graisse corporelle
NO2753788T3 (fr) 2013-05-10 2018-06-16
WO2014186504A1 (fr) 2013-05-15 2014-11-20 Topokine Therapeutics, Inc. Procédés et compositions pour l'administration topique de prostaglandines à la graisse sous-cutanée
CN103570549B (zh) * 2013-10-11 2016-01-27 天泽恩源（天津）制药有限公司 一种合成他氟前列素的方法
CN103804195B (zh) * 2014-01-26 2016-06-15 天泽恩源（天津）制药有限公司 一种合成他氟前列素的方法
CN103819436A (zh) * 2014-02-21 2014-05-28 天泽恩源（天津）医药技术有限公司 (3aR,4R,5R,6aS)-4-((E)-3,3-二氟-4-苯氧基丁-1-烯-1-基)-2-氧代六氢-2H-环戊烷[b]呋喃-5-基苯甲酸酯的一种晶型及相应晶体的制备方法
WO2015200425A1 (fr) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Forme posologique à usage topique
KR20160116402A (ko) 2015-03-30 2016-10-10 연성정밀화학(주) 타플루프로스트의 제조방법
JP2018536017A (ja) 2015-09-22 2018-12-06 グレイバグ ビジョン インコーポレイテッド 眼障害の治療のための化合物及び組成物
CN107226790A (zh) * 2016-03-25 2017-10-03 苏州朗科生物技术有限公司 一种高纯度他氟前列素及其类似化合物的制备方法及中间体化合物
GR1009040B (el) 2016-04-19 2017-05-19 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου
WO2018033854A1 (fr) 2016-08-15 2018-02-22 Santen Pharmaceutical Co., Ltd. Composition ophtalmique et procédé de traitement de l'hypertension oculaire et du glaucome
CN108299192A (zh) * 2017-01-10 2018-07-20 江苏恒瑞医药股份有限公司 一种他氟前列素酸的金属盐化合物结晶形式及其制备方法
CN106986766B (zh) * 2017-05-08 2021-01-12 扬子江药业集团有限公司 他氟前列素的制备方法
CN112457277B (zh) * 2020-12-16 2022-06-28 西安国康瑞金制药有限公司 一种他氟前列腺素的制备方法
CN115385793A (zh) * 2021-01-27 2022-11-25 Ａｇｃ株式会社 他氟前列素的纯化方法
CN112832150B (zh) * 2021-01-27 2022-06-24 中交第三公路工程局有限公司 一种涵洞通道等立面垂直凿毛装置
CN116120268A (zh) * 2023-03-06 2023-05-16 南京华威医药科技集团有限公司 一种他氟前列素中间体杂质及其制备方法
CN116425707A (zh) * 2023-03-31 2023-07-14 南京华威医药科技集团有限公司 一种他氟前列素中间体异构体杂质及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0770054A (ja) * 1993-08-30 1995-03-14 R Tec Ueno:Kk 生化学的拮抗および疾患処置剤
WO1998012175A1 (fr) * 1996-09-17 1998-03-26 Asahi Glass Company Ltd. Derives de prostaglandine fluores et medicaments
WO1998021181A2 (fr) * 1996-11-12 1998-05-22 Alcon Laboratories, Inc. 15-fluoro prostaglandines utilisees en tant qu'hypotenseurs oculaires

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US5166178B1 (en) * 1987-09-18 1998-07-21 R Tech Ueno Ltd Ocular hypotensive agents
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JPH0770054A (ja) * 1993-08-30 1995-03-14 R Tec Ueno:Kk 生化学的拮抗および疾患処置剤
WO1998012175A1 (fr) * 1996-09-17 1998-03-26 Asahi Glass Company Ltd. Derives de prostaglandine fluores et medicaments
WO1998021181A2 (fr) * 1996-11-12 1998-05-22 Alcon Laboratories, Inc. 15-fluoro prostaglandines utilisees en tant qu'hypotenseurs oculaires

Non-Patent Citations (2)

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Title
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; LAKIN, K. M. ET AL: "Effects of fluorinated prostaglandins on platelet aggregation", XP002100897 *
EKSP. KLIN. FARMAKOL. (1994), 57(2), 39-41 CODEN: EKFAE9;ISSN: 0869-2092 *

Also Published As

Publication number Publication date
TW536534B (en) 2003-06-11
ATE225770T1 (de) 2002-10-15
PT850926E (pt) 2003-02-28
LU91943I2 (fr) 2012-04-16
ES2187719T3 (es) 2003-06-16
DE69716226T2 (de) 2003-06-05
CN1187486A (zh) 1998-07-15
DE69716226D1 (de) 2002-11-14
KR19980064718A (ko) 1998-10-07
US5886035A (en) 1999-03-23
JP3994074B2 (ja) 2007-10-17
NL300407I1 (nl) 2009-11-02
JPH1171344A (ja) 1999-03-16
NO976085D0 (no) 1997-12-23
NO976085L (no) 1998-06-29
FR11C0020I2 (fr) 2012-03-16
CA2225761C (fr) 2009-04-21
EP0850926B1 (fr) 2002-10-09
DE122008000050I2 (de) 2011-06-16
NO2009006I1 (no) 2009-03-16
EP0850926A2 (fr) 1998-07-01
CA2225761A1 (fr) 1998-06-26
KR100526282B1 (ko) 2006-05-17
US5985920A (en) 1999-11-16
CN1108289C (zh) 2003-05-14
NL300407I2 (nl) 2010-03-01
DE122008000050I1 (de) 2009-01-29
JP2004002462A (ja) 2004-01-08
JP3480549B2 (ja) 2003-12-22
NO2009006I2 (no) 2012-03-05
NO317060B1 (no) 2004-08-02
DK0850926T3 (da) 2003-02-17
FR11C0020I1 (fr) 2011-07-29

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