DE122008000050I2 - Difluoroprostaglandin-Derivate und ihre Anwendung - Google Patents
Difluoroprostaglandin-Derivate und ihre AnwendungInfo
- Publication number
- DE122008000050I2 DE122008000050I2 DE122008000050C DE122008000050C DE122008000050I2 DE 122008000050 I2 DE122008000050 I2 DE 122008000050I2 DE 122008000050 C DE122008000050 C DE 122008000050C DE 122008000050 C DE122008000050 C DE 122008000050C DE 122008000050 I2 DE122008000050 I2 DE 122008000050I2
- Authority
- DE
- Germany
- Prior art keywords
- group
- medicine
- difluoroprostaglandin
- derivatives
- difluoroprostaglandin derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34861496 | 1996-12-26 | ||
JP7405497 | 1997-03-26 | ||
JP17247797 | 1997-06-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE122008000050I1 DE122008000050I1 (de) | 2009-01-29 |
DE122008000050I2 true DE122008000050I2 (de) | 2011-06-16 |
Family
ID=27301396
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122008000050C Active DE122008000050I2 (de) | 1996-12-26 | 1997-12-22 | Difluoroprostaglandin-Derivate und ihre Anwendung |
DE69716226T Expired - Lifetime DE69716226T2 (de) | 1996-12-26 | 1997-12-22 | Difluoroprostaglandin-Derivate und ihre Anwendung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69716226T Expired - Lifetime DE69716226T2 (de) | 1996-12-26 | 1997-12-22 | Difluoroprostaglandin-Derivate und ihre Anwendung |
Country Status (16)
Country | Link |
---|---|
US (2) | US5886035A (de) |
EP (1) | EP0850926B1 (de) |
JP (2) | JP3480549B2 (de) |
KR (1) | KR100526282B1 (de) |
CN (1) | CN1108289C (de) |
AT (1) | ATE225770T1 (de) |
CA (1) | CA2225761C (de) |
DE (2) | DE122008000050I2 (de) |
DK (1) | DK0850926T3 (de) |
ES (1) | ES2187719T3 (de) |
FR (1) | FR11C0020I2 (de) |
LU (1) | LU91943I2 (de) |
NL (1) | NL300407I2 (de) |
NO (2) | NO317060B1 (de) |
PT (1) | PT850926E (de) |
TW (1) | TW536534B (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE221048T1 (de) * | 1996-09-17 | 2002-08-15 | Asahi Glass Co Ltd | Fluorierte prostaglandinderivate und medikamente |
US6225348B1 (en) | 1998-08-20 | 2001-05-01 | Alfred W. Paulsen | Method of treating macular degeneration with a prostaglandin derivative |
IL134241A (en) | 2000-01-27 | 2006-06-11 | Finetech Pharmaceutical Ltd | Process for the preparation of latanoprost |
IL143477A (en) | 2001-05-31 | 2009-07-20 | Finetech Pharmaceutical Ltd | Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives |
AU2001228836A1 (en) * | 2000-01-28 | 2001-08-07 | Santen Pharmaceutical Co., Ltd. | Novel difluoroprostaglandin derivative |
ES2357551T3 (es) * | 2000-09-13 | 2011-04-27 | Santen Pharmaceutical Co., Ltd. | Colirio. |
CN100361661C (zh) * | 2002-08-23 | 2008-01-16 | 参天制药株式会社 | 以拉坦前列素为有效成分的稳定的滴眼液 |
CA2707067C (en) * | 2002-09-09 | 2013-07-16 | Santen Pharmaceutical Co., Ltd. | Clear ophthalmic solution comprising latanoprost as active ingredient |
WO2005011704A1 (ja) * | 2003-07-31 | 2005-02-10 | Santen Pharmaceutical Co., Ltd. | プロスタグランジン含有製品 |
MXPA06006452A (es) * | 2003-12-08 | 2006-08-31 | Qualcomm Inc | Interfase de tasa alta de datos con sincronizacion de enlace mejorada. |
JP2006187602A (ja) * | 2004-12-09 | 2006-07-20 | Santen Pharmaceut Co Ltd | 分子内にフッ素原子を有するプロスタグランジン含有製品 |
JP4753178B2 (ja) * | 2004-12-24 | 2011-08-24 | 参天製薬株式会社 | プロスタグランジンF2α誘導体含有製品 |
JP5100025B2 (ja) * | 2005-03-31 | 2012-12-19 | 旭硝子株式会社 | プロスタグランジンF2α誘導体を有効成分として含む網膜神経細胞保護剤 |
WO2006106915A1 (ja) | 2005-03-31 | 2006-10-12 | Asahi Glass Company, Limited | プロスタグランジンF2α誘導体を有効成分として含む網膜神経細胞保護剤 |
CN101160128B (zh) | 2005-04-13 | 2010-08-18 | 宇部兴产株式会社 | 含有吲唑衍生物作为有效成分的视网膜神经细胞保护剂 |
WO2007000642A1 (en) * | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Fluoroprostaglandins nitroderivatives |
HUE034571T2 (en) * | 2006-02-07 | 2018-02-28 | Sucampo Pharma Llc | A method for preparing a prostaglandin derivative |
US7666912B2 (en) | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
FR2918891B1 (fr) * | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
EP2127638A1 (de) * | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Verfahren und Zusammensetzung zur Behandlung von Augenhochdruck und Glaukom |
CN102143753B (zh) * | 2008-09-04 | 2013-07-03 | 参天制药株式会社 | 含有15,15-二氟前列腺素F2α衍生物作为有效成分的毛发生长促进剂 |
US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
BR112013002584A2 (pt) | 2010-08-02 | 2016-06-07 | Pharma Patent Holding Inc | composição, processo de kit para aperfeiçoamento de cabelo |
US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
TW201906614A (zh) | 2011-02-04 | 2019-02-16 | 日商興和股份有限公司 | 青光眼或高眼壓症之預防或治療用之點眼藥 |
US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
US20150011755A1 (en) * | 2012-02-07 | 2015-01-08 | Dr. Reddys Laboratories Limited | Amine salts of prostaglandin analogs |
EP2857002A4 (de) | 2012-05-30 | 2015-12-09 | Asahi Glass Co Ltd | Zusammensetzung für haarwachstum |
EP2922542A4 (de) | 2012-11-21 | 2016-10-05 | Topokine Therapeutics Inc | Verfahren und zusammensetzungen zur lokalen körperfettvermehrung |
NO2753788T3 (de) | 2013-05-10 | 2018-06-16 | ||
WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
CN103570549B (zh) * | 2013-10-11 | 2016-01-27 | 天泽恩源(天津)制药有限公司 | 一种合成他氟前列素的方法 |
CN103804195B (zh) * | 2014-01-26 | 2016-06-15 | 天泽恩源(天津)制药有限公司 | 一种合成他氟前列素的方法 |
CN103819436A (zh) * | 2014-02-21 | 2014-05-28 | 天泽恩源(天津)医药技术有限公司 | (3aR,4R,5R,6aS)-4-((E)-3,3-二氟-4-苯氧基丁-1-烯-1-基)-2-氧代六氢-2H-环戊烷[b]呋喃-5-基苯甲酸酯的一种晶型及相应晶体的制备方法 |
WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
KR20160116402A (ko) | 2015-03-30 | 2016-10-10 | 연성정밀화학(주) | 타플루프로스트의 제조방법 |
JP2018536017A (ja) | 2015-09-22 | 2018-12-06 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための化合物及び組成物 |
CN107226790A (zh) * | 2016-03-25 | 2017-10-03 | 苏州朗科生物技术有限公司 | 一种高纯度他氟前列素及其类似化合物的制备方法及中间体化合物 |
GR1009040B (el) | 2016-04-19 | 2017-05-19 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου |
WO2018033854A1 (en) | 2016-08-15 | 2018-02-22 | Santen Pharmaceutical Co., Ltd. | Ophthalmic composition and a method for treating ocular hypertension and glaucoma |
CN108299192A (zh) * | 2017-01-10 | 2018-07-20 | 江苏恒瑞医药股份有限公司 | 一种他氟前列素酸的金属盐化合物结晶形式及其制备方法 |
CN106986766B (zh) * | 2017-05-08 | 2021-01-12 | 扬子江药业集团有限公司 | 他氟前列素的制备方法 |
CN112457277B (zh) * | 2020-12-16 | 2022-06-28 | 西安国康瑞金制药有限公司 | 一种他氟前列腺素的制备方法 |
CN115385793A (zh) * | 2021-01-27 | 2022-11-25 | Agc株式会社 | 他氟前列素的纯化方法 |
CN112832150B (zh) * | 2021-01-27 | 2022-06-24 | 中交第三公路工程局有限公司 | 一种涵洞通道等立面垂直凿毛装置 |
CN116120268A (zh) * | 2023-03-06 | 2023-05-16 | 南京华威医药科技集团有限公司 | 一种他氟前列素中间体杂质及其制备方法 |
CN116425707A (zh) * | 2023-03-31 | 2023-07-14 | 南京华威医药科技集团有限公司 | 一种他氟前列素中间体异构体杂质及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166178B1 (en) * | 1987-09-18 | 1998-07-21 | R Tech Ueno Ltd | Ocular hypotensive agents |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
JPH0770054A (ja) * | 1993-08-30 | 1995-03-14 | R Tec Ueno:Kk | 生化学的拮抗および疾患処置剤 |
ATE221048T1 (de) * | 1996-09-17 | 2002-08-15 | Asahi Glass Co Ltd | Fluorierte prostaglandinderivate und medikamente |
CA2269855A1 (en) * | 1996-11-12 | 1998-05-22 | Alcon Laboratories, Inc. | 15-fluoro prostaglandins as ocular hypotensives |
-
1997
- 1997-12-12 JP JP34334397A patent/JP3480549B2/ja not_active Expired - Lifetime
- 1997-12-17 TW TW086119094A patent/TW536534B/zh not_active IP Right Cessation
- 1997-12-18 US US08/993,017 patent/US5886035A/en not_active Expired - Lifetime
- 1997-12-22 DK DK97122702T patent/DK0850926T3/da active
- 1997-12-22 AT AT97122702T patent/ATE225770T1/de active
- 1997-12-22 DE DE122008000050C patent/DE122008000050I2/de active Active
- 1997-12-22 EP EP97122702A patent/EP0850926B1/de not_active Expired - Lifetime
- 1997-12-22 ES ES97122702T patent/ES2187719T3/es not_active Expired - Lifetime
- 1997-12-22 DE DE69716226T patent/DE69716226T2/de not_active Expired - Lifetime
- 1997-12-22 PT PT97122702T patent/PT850926E/pt unknown
- 1997-12-23 CA CA002225761A patent/CA2225761C/en not_active Expired - Lifetime
- 1997-12-23 NO NO19976085A patent/NO317060B1/no not_active IP Right Cessation
- 1997-12-26 CN CN97126331A patent/CN1108289C/zh not_active Expired - Lifetime
- 1997-12-26 KR KR1019970074620A patent/KR100526282B1/ko not_active IP Right Cessation
-
1998
- 1998-08-03 US US09/127,804 patent/US5985920A/en not_active Expired - Lifetime
-
2003
- 2003-07-31 JP JP2003284134A patent/JP3994074B2/ja not_active Expired - Lifetime
-
2009
- 2009-03-06 NO NO2009006C patent/NO2009006I2/no not_active IP Right Cessation
- 2009-09-02 NL NL300407C patent/NL300407I2/nl unknown
-
2011
- 2011-06-21 FR FR11C0020C patent/FR11C0020I2/fr active Active
-
2012
- 2012-02-15 LU LU91943C patent/LU91943I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
TW536534B (en) | 2003-06-11 |
ATE225770T1 (de) | 2002-10-15 |
PT850926E (pt) | 2003-02-28 |
LU91943I2 (fr) | 2012-04-16 |
ES2187719T3 (es) | 2003-06-16 |
DE69716226T2 (de) | 2003-06-05 |
CN1187486A (zh) | 1998-07-15 |
DE69716226D1 (de) | 2002-11-14 |
KR19980064718A (ko) | 1998-10-07 |
US5886035A (en) | 1999-03-23 |
JP3994074B2 (ja) | 2007-10-17 |
NL300407I1 (nl) | 2009-11-02 |
JPH1171344A (ja) | 1999-03-16 |
NO976085D0 (no) | 1997-12-23 |
NO976085L (no) | 1998-06-29 |
FR11C0020I2 (fr) | 2012-03-16 |
CA2225761C (en) | 2009-04-21 |
EP0850926A3 (de) | 1999-06-16 |
EP0850926B1 (de) | 2002-10-09 |
NO2009006I1 (no) | 2009-03-16 |
EP0850926A2 (de) | 1998-07-01 |
CA2225761A1 (en) | 1998-06-26 |
KR100526282B1 (ko) | 2006-05-17 |
US5985920A (en) | 1999-11-16 |
CN1108289C (zh) | 2003-05-14 |
NL300407I2 (nl) | 2010-03-01 |
DE122008000050I1 (de) | 2009-01-29 |
JP2004002462A (ja) | 2004-01-08 |
JP3480549B2 (ja) | 2003-12-22 |
NO2009006I2 (no) | 2012-03-05 |
NO317060B1 (no) | 2004-08-02 |
DK0850926T3 (da) | 2003-02-17 |
FR11C0020I1 (de) | 2011-07-29 |
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