EA200200939A1 - Способ получения циталопрама - Google Patents
Способ получения циталопрамаInfo
- Publication number
- EA200200939A1 EA200200939A1 EA200200939A EA200200939A EA200200939A1 EA 200200939 A1 EA200200939 A1 EA 200200939A1 EA 200200939 A EA200200939 A EA 200200939A EA 200200939 A EA200200939 A EA 200200939A EA 200200939 A1 EA200200939 A1 EA 200200939A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- halogen
- formula
- citalopram
- followed
- defined above
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Настоящее изобретение относится к способу получения циталопрама, который включает взаимодействие соединения формулы (II) с соединением, имеющим формулу (III), где R представляет собой галоген или -O-SO-X, где Х представляет собой алкил, алкенил, алкинил или необязательно алкилзамещенный арил или аралкил и Rпредставляет собой диметиламино, галоген или -O-SO-X, где Х такой, как определен выше, при условии, что R не является галогеном, когда Rпредставляет собой диметиламино; и если Rпредставляет собой диметиламино, с последующим выделением основания циталопрама или его фармацевтически приемлемой соли добавления кислот, и если Rпредставляет собой галоген или -O-SO-X, где Х такой, как определен выше, с последующим преобразованием полученного соединения формулы, где Rпредставляет собой галоген или группу формулы -O-SO-X, где Х такой как определен выше, в циталопрам, с последующим выделением основания циталопрама или его фармацевтически приемлемой соли добавления кислот.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000353 | 2000-03-03 | ||
| PCT/DK2001/000140 WO2001051478A1 (en) | 2000-03-03 | 2001-03-01 | Method for the preparation of citalopram |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200939A1 true EA200200939A1 (ru) | 2003-02-27 |
| EA005491B1 EA005491B1 (ru) | 2005-02-24 |
Family
ID=8159277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200939A EA005491B1 (ru) | 2000-03-03 | 2001-03-01 | Способ получения циталопрама |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6768011B2 (ru) |
| EP (1) | EP1263750A1 (ru) |
| JP (1) | JP2003519692A (ru) |
| KR (1) | KR20020080450A (ru) |
| CN (1) | CN1411454A (ru) |
| AR (1) | AR027559A1 (ru) |
| AU (1) | AU2001240469A1 (ru) |
| BE (1) | BE1011481A6 (ru) |
| BG (1) | BG107050A (ru) |
| BR (1) | BR0109022A (ru) |
| CA (1) | CA2401374A1 (ru) |
| EA (1) | EA005491B1 (ru) |
| FR (1) | FR2805814A1 (ru) |
| GR (1) | GR1003795B (ru) |
| HR (1) | HRP20020742A2 (ru) |
| HU (1) | HUP0300060A3 (ru) |
| IE (1) | IES20010157A2 (ru) |
| IL (1) | IL151467A0 (ru) |
| IS (1) | IS6526A (ru) |
| IT (1) | ITMI20010444A1 (ru) |
| MX (1) | MXPA02008634A (ru) |
| NL (1) | NL1017417C1 (ru) |
| NO (1) | NO20024180D0 (ru) |
| NZ (1) | NZ521200A (ru) |
| PL (1) | PL358543A1 (ru) |
| SK (1) | SK14152002A3 (ru) |
| TR (1) | TR200202096T2 (ru) |
| WO (1) | WO2001051478A1 (ru) |
| ZA (1) | ZA200206846B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE237604T1 (de) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
| CN1429219A (zh) | 2000-03-13 | 2003-07-09 | H·隆德贝克有限公司 | 制备西酞普兰的方法 |
| IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| CA2402553A1 (en) | 2000-03-13 | 2001-09-20 | H. Lundbeck A/S | Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| ATE257832T1 (de) | 2000-03-14 | 2004-01-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
| EP1446396A1 (en) * | 2001-11-08 | 2004-08-18 | Sepracor, Inc. | Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram |
| TWI306846B (en) | 2002-08-12 | 2009-03-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050154052A1 (en) * | 2003-03-24 | 2005-07-14 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| TWI339651B (en) | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| GB0601286D0 (en) | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1143703A (ru) | 1965-03-18 | |||
| GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| US5296507A (en) | 1990-09-06 | 1994-03-22 | H.Lundbeck A/S | Treatment of cerbrovascular disorders |
| DE19626659A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
| DE19627697A1 (de) | 1996-07-10 | 1998-01-15 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
| DK1015416T3 (da) | 1997-07-08 | 2001-11-05 | Lundbeck & Co As H | Fremgangsmåde til fremstilling af citalopram |
| UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
| EA002770B1 (ru) | 1997-11-11 | 2002-08-29 | Х.Лундбекк А/С | Способ получения циталопрама |
| KR100411505B1 (ko) | 1998-10-20 | 2003-12-18 | 하. 룬트벡 아크티에 셀스카브 | 시탈로프람의 제조방법 |
| CA2356188C (en) | 1998-12-23 | 2006-05-23 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
| AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
| ATE237604T1 (de) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991486A1 (it) | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
| ES2229774T3 (es) | 1999-10-25 | 2005-04-16 | H. Lundbeck A/S | Metodo para la preparacion de citalopram. |
| AR026063A1 (es) | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
| US6310222B1 (en) | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
| SI1246812T1 (en) | 1999-12-28 | 2004-08-31 | H. Lundbeck A/S | Method for the preparation of citalopram |
| HUP0203840A3 (en) | 1999-12-30 | 2005-02-28 | Lundbeck & Co As H | Method for the preparation of citalopram |
| IL150561A0 (en) | 2000-01-14 | 2003-02-12 | Lundbeck & Co As H | Method for the preparation of 5-cyanophthalide |
| IT1317729B1 (it) | 2000-01-18 | 2003-07-15 | Norpharma S P A | Procedimento per la preparazione della 5-carbossiftalide. |
| US6433196B1 (en) | 2000-02-17 | 2002-08-13 | Sumika Fine Chemicals Co., Ltd. | Production method of citalopram, intermediate therefor and production method of the intermediate |
| IES20010143A2 (en) | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
| NL1017415C1 (nl) * | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
| IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| CN1429219A (zh) | 2000-03-13 | 2003-07-09 | H·隆德贝克有限公司 | 制备西酞普兰的方法 |
| GB2357762B (en) | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| CA2402553A1 (en) | 2000-03-13 | 2001-09-20 | H. Lundbeck A/S | Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| ATE257832T1 (de) | 2000-03-14 | 2004-01-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| TR200202168T2 (tr) | 2000-03-16 | 2002-12-23 | H. Lundbeck A/S | 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu |
| AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
| AU2001272368A1 (en) | 2000-07-06 | 2002-01-21 | H. Lundbeck, A/S | Method for the preparation of citalopram |
| FI20011621A (fi) | 2000-08-18 | 2002-02-19 | Lundbeck & Co As H | Menetelmä sitalopraamin valmistamiseksi |
| EA003581B1 (ru) | 2000-12-22 | 2003-06-26 | Х.Лундбекк А/С | Способ получения чистого циталопрама |
| EA003459B1 (ru) | 2000-12-28 | 2003-06-26 | Х.Лундбекк А/С | Способ получения чистого циталопрама |
-
2001
- 2001-02-21 IE IE20010157A patent/IES20010157A2/en not_active IP Right Cessation
- 2001-02-21 NL NL1017417A patent/NL1017417C1/nl not_active IP Right Cessation
- 2001-02-27 AR ARP010100886A patent/AR027559A1/es unknown
- 2001-03-01 HU HU0300060A patent/HUP0300060A3/hu unknown
- 2001-03-01 EP EP01911454A patent/EP1263750A1/en not_active Withdrawn
- 2001-03-01 CN CN01806029A patent/CN1411454A/zh active Pending
- 2001-03-01 SK SK1415-2002A patent/SK14152002A3/sk unknown
- 2001-03-01 MX MXPA02008634A patent/MXPA02008634A/es not_active Application Discontinuation
- 2001-03-01 PL PL01358543A patent/PL358543A1/xx not_active Application Discontinuation
- 2001-03-01 AU AU2001240469A patent/AU2001240469A1/en not_active Abandoned
- 2001-03-01 BR BR0109022-4A patent/BR0109022A/pt not_active IP Right Cessation
- 2001-03-01 NZ NZ521200A patent/NZ521200A/en unknown
- 2001-03-01 WO PCT/DK2001/000140 patent/WO2001051478A1/en not_active Application Discontinuation
- 2001-03-01 JP JP2001551860A patent/JP2003519692A/ja not_active Withdrawn
- 2001-03-01 IL IL15146701A patent/IL151467A0/xx unknown
- 2001-03-01 CA CA002401374A patent/CA2401374A1/en not_active Abandoned
- 2001-03-01 TR TR2002/02096T patent/TR200202096T2/xx unknown
- 2001-03-01 KR KR1020027011336A patent/KR20020080450A/ko not_active Application Discontinuation
- 2001-03-01 EA EA200200939A patent/EA005491B1/ru not_active IP Right Cessation
- 2001-03-02 BE BE2001/0143A patent/BE1011481A6/fr not_active IP Right Cessation
- 2001-03-02 FR FR0102896A patent/FR2805814A1/fr active Pending
- 2001-03-05 IT IT2001MI000444A patent/ITMI20010444A1/it unknown
- 2001-03-05 GR GR20010100106A patent/GR1003795B/el unknown
-
2002
- 2002-08-27 IS IS6526A patent/IS6526A/is unknown
- 2002-08-27 ZA ZA200206846A patent/ZA200206846B/en unknown
- 2002-08-29 US US10/232,994 patent/US6768011B2/en not_active Expired - Fee Related
- 2002-09-02 BG BG107050A patent/BG107050A/xx unknown
- 2002-09-02 NO NO20024180A patent/NO20024180D0/no not_active Application Discontinuation
- 2002-09-10 HR HR20020742A patent/HRP20020742A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL151467A0 (en) | 2003-04-10 |
| NZ521200A (en) | 2004-03-26 |
| ITMI20010444A1 (it) | 2002-09-05 |
| EA005491B1 (ru) | 2005-02-24 |
| WO2001051478A1 (en) | 2001-07-19 |
| BG107050A (en) | 2003-05-30 |
| BR0109022A (pt) | 2003-06-03 |
| PL358543A1 (en) | 2004-08-09 |
| BE1011481A6 (fr) | 2001-07-03 |
| GR1003795B (el) | 2002-02-08 |
| CN1411454A (zh) | 2003-04-16 |
| EP1263750A1 (en) | 2002-12-11 |
| IS6526A (is) | 2002-08-27 |
| HUP0300060A3 (en) | 2005-02-28 |
| NL1017417C1 (nl) | 2001-03-16 |
| HUP0300060A2 (en) | 2003-05-28 |
| JP2003519692A (ja) | 2003-06-24 |
| US6768011B2 (en) | 2004-07-27 |
| FR2805814A1 (fr) | 2001-09-07 |
| KR20020080450A (ko) | 2002-10-23 |
| US20030092761A1 (en) | 2003-05-15 |
| NO20024180L (no) | 2002-09-02 |
| SK14152002A3 (sk) | 2003-03-04 |
| NO20024180D0 (no) | 2002-09-02 |
| CA2401374A1 (en) | 2001-07-19 |
| ZA200206846B (en) | 2003-08-27 |
| MXPA02008634A (es) | 2003-02-24 |
| AU2001240469A1 (en) | 2001-07-24 |
| TR200202096T2 (tr) | 2003-01-21 |
| IES20010157A2 (en) | 2002-03-06 |
| AR027559A1 (es) | 2003-04-02 |
| HRP20020742A2 (en) | 2004-02-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GR20010100097A (el) | Μεθοδος παρασκευης της σιταλοπραμης | |
| SI1781683T1 (sl) | Postopek za pripravo 17-vinil-triflatov kot intermediatov | |
| EA200200898A1 (ru) | Способ получения циталопрама | |
| EA200101081A1 (ru) | Способ получения циталопрама | |
| EA200200939A1 (ru) | Способ получения циталопрама | |
| IS6859A (is) | Kristölluð form atorvastatíns | |
| EA200200481A1 (ru) | Способ получения производных 4-трифторметилсульфинилпиразола | |
| EA200201071A1 (ru) | Циклопентилзамещенные производные глутарамида в качестве ингибиторов нейтральной эндопептидазы | |
| EA200400129A1 (ru) | Способ получения периндоприла, его аналогов и солей с использованием 2,5-диоксооксазолидиновых промежуточных соединений | |
| BR0109048A (pt) | Processo para a sìntese de citalopram | |
| EA200200719A1 (ru) | Способ получения циталопрама | |
| EA200000094A1 (ru) | Способ получения замещенного пергидроизоиндола | |
| EA199800792A1 (ru) | Способы получения промежуточных соединений для пестицидов | |
| HUP0300856A2 (hu) | Eljárás szubsztituált fenil-acetonitrilek elżállítására | |
| NO20002589D0 (no) | Bifenylamidinderivater | |
| EA200200970A1 (ru) | Способ получения циталопрама | |
| EA200100213A1 (ru) | Способ синтеза производных (1h)-бензо[c]хинолизин-3-онов | |
| EA200100593A1 (ru) | Способ получения циталопрама | |
| EA200000924A2 (ru) | СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОН-3-ПИРИДИЛСУЛЬФОНИЛЬНЫХ СОЕДИНЕНИЙ И ИХ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ | |
| EA200200971A1 (ru) | Способ получения циталопрама | |
| NO20033049L (no) | Fremgangsmåte for fremstilling av (+/-) trans-4-p-fluorfenyl- 3-hydroksymetyl-1-metylpiperidin | |
| MXPA03011647A (es) | Procedimiento de resolucion para el acido ( r ) - (-) - 2-hidroxi - 2- (2 - clorofenil) acetico. | |
| EA200500032A1 (ru) | Производные ацилоксипирролидина и их применение в качестве лигандов v1b или v1b и v1a рецепторов | |
| TW200503701A (en) | Novel intermediate for the preparation of therapeutically active imidazopyridines | |
| DK1320527T3 (da) | Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |