TR200202168T2 - 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu - Google Patents

5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu

Info

Publication number
TR200202168T2
TR200202168T2 TR2002/02168T TR200202168T TR200202168T2 TR 200202168 T2 TR200202168 T2 TR 200202168T2 TR 2002/02168 T TR2002/02168 T TR 2002/02168T TR 200202168 T TR200202168 T TR 200202168T TR 200202168 T2 TR200202168 T2 TR 200202168T2
Authority
TR
Turkey
Prior art keywords
fluorophenyl
cyano
preparation
dihydroisobenzofurans
dihydroisobenzofuran
Prior art date
Application number
TR2002/02168T
Other languages
English (en)
Inventor
Petersen Hans
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of TR200202168T2 publication Critical patent/TR200202168T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuran'in, bir 5-ikame edilmis 1(4-florofenil)-1,3-dihidro-izobenzofuran türevinin dönüstürülmesini kapsayan preparasyon metodu.
TR2002/02168T 2000-03-16 2001-03-16 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu TR200202168T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200000437 2000-03-16

Publications (1)

Publication Number Publication Date
TR200202168T2 true TR200202168T2 (tr) 2002-12-23

Family

ID=8159344

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/02168T TR200202168T2 (tr) 2000-03-16 2001-03-16 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu

Country Status (27)

Country Link
US (1) US20030060640A1 (tr)
EP (1) EP1274699A1 (tr)
JP (1) JP2003527388A (tr)
KR (1) KR20020080483A (tr)
CN (1) CN1418206A (tr)
AT (1) AT5093U1 (tr)
AU (1) AU2001244086A1 (tr)
BG (1) BG107049A (tr)
BR (1) BR0109180A (tr)
CA (1) CA2402869A1 (tr)
CH (1) CH692148A5 (tr)
CZ (1) CZ20023406A3 (tr)
DE (1) DE10190485T1 (tr)
EA (1) EA200200982A1 (tr)
ES (1) ES2159271B1 (tr)
HR (1) HRP20020757A2 (tr)
HU (1) HUP0300134A2 (tr)
IL (1) IL151487A0 (tr)
IS (1) IS6522A (tr)
MX (1) MXPA02008652A (tr)
NO (1) NO20024197L (tr)
NZ (1) NZ521059A (tr)
PL (1) PL360115A1 (tr)
SK (1) SK14812002A3 (tr)
TR (1) TR200202168T2 (tr)
WO (1) WO2001068632A1 (tr)
ZA (1) ZA200206802B (tr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL198024B1 (pl) * 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
EA200200968A1 (ru) 2000-03-13 2003-02-27 Х.Лундбекк А/С Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
CA2402557A1 (en) 2000-03-14 2001-09-20 Hans Petersen Method for the preparation of citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1797060A2 (en) 2004-08-23 2007-06-20 Sun Pharmaceutical Industries Limited "process for preparation of citalopram and enantiomers"
JP2006176490A (ja) * 2004-11-29 2006-07-06 Sumitomo Chemical Co Ltd ５−フタランカルボニトリル及びシタロプラムの製造方法
CN102190641A (zh) * 2011-03-23 2011-09-21 四川科伦药物研究有限公司 一种制备西酞普兰和艾司西酞普兰关键中间体的方法
CN105037304B (zh) * 2015-06-11 2018-12-04 福州大学 一种合成3-卤亚甲基-2,3-二氢苯并呋喃类化合物的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (tr) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
EP0613720A1 (en) * 1993-03-05 1994-09-07 Duphar International Research B.V Nickel catalyst for the cyanation of aromatic halides
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja) * 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE69714480T2 (de) * 1997-11-11 2003-03-06 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
CZ300408B6 (cs) * 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) * 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
TR200101874T1 (tr) * 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EA200200332A1 (ru) * 2000-07-06 2002-06-27 Х.Лундбекк А/С Способ получения циталопрама
CA2354880C (en) * 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
KR100439329B1 (ko) * 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
AU3920201A (en) * 2000-12-28 2001-07-09 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
EP1274699A1 (en) 2003-01-15
DE10190485T1 (de) 2002-03-21
US20030060640A1 (en) 2003-03-27
CA2402869A1 (en) 2001-09-20
ZA200206802B (en) 2003-11-26
WO2001068632A1 (en) 2001-09-20
HUP0300134A2 (en) 2003-05-28
JP2003527388A (ja) 2003-09-16
IS6522A (is) 2002-08-23
CN1418206A (zh) 2003-05-14
MXPA02008652A (es) 2003-02-24
ES2159271A1 (es) 2001-09-16
NO20024197D0 (no) 2002-09-03
BG107049A (en) 2003-05-30
IL151487A0 (en) 2003-04-10
AT5093U1 (de) 2002-03-25
BR0109180A (pt) 2003-05-27
HRP20020757A2 (en) 2004-12-31
SK14812002A3 (sk) 2003-02-04
CH692148A5 (de) 2002-02-28
PL360115A1 (en) 2004-09-06
ES2159271B1 (es) 2002-05-01
KR20020080483A (ko) 2002-10-23
AU2001244086A1 (en) 2001-09-24
NZ521059A (en) 2004-04-30
CZ20023406A3 (cs) 2003-01-15
NO20024197L (no) 2002-09-03
EA200200982A1 (ru) 2003-02-27

Similar Documents

Publication Publication Date Title
TR200202168T2 (tr) 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
ES2195554T3 (es) Metodo para la preparacion de citalopram.
NO2005009I2 (no) Emselex-darifenacin. Iupac-navn: (S)-2-ä1-Ä2-(2,3 -dihydrobenzofuran-5-yl)etylÜ-3-pyrrolidinylü-2,2-difenylacetamid
DE60018372D1 (de) Oralzusammensetzung als mikroemulsion von silybin
IT1316928B1 (it) Perfezionamento ad un attacco per protesi dentarie.
AR029598A1 (es) Metodo para la preparacion de citalopram
TR200202166T2 (tr) Sitalopramın preparasyon metodu
TR200201688T2 (tr) Sitalopram hazırlama yöntemi.
DK1326609T3 (da) Stabil, oral formulering, der indeholder benzimidazolderivat
TR200202195T2 (tr) 5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi
ATE255105T1 (de) Serotonerge benzofurane
DK1163231T3 (da) Perfluoralkylamider, deres fremstilling og deres anvendelse inden for diagnostikken
DE60001366D1 (de) Orale zusammensetzung enthaltend perlit
DK1177191T3 (da) Substituerede benzimidazoler, fremstilling og anvendelse deraf som midler til bekæmpelse af parasitiske protozoer
IT1317821B1 (it) Protesi cotiloidea.
NO20021429L (no) 1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner
IT247382Y1 (it) Impianto dentale endosseo.
ATA156199A (de) Hochgoldhaltige, gelbe dentallegierung
IT1299702B1 (it) Implantoprotesi dentarie flangiate.
ES1045685Y (es) Pieza prefabricada de chapas de madera.
IT249092Y1 (it) Frese diamantate per preparazione dentale protesica per turbina.
ES1044111Y (es) Batidor de escayola de doble eje.
ITTO20010527A0 (it) Staffa implantare per protesi dentaria.