EA200200970A1 - Способ получения циталопрама - Google Patents
Способ получения циталопрамаInfo
- Publication number
- EA200200970A1 EA200200970A1 EA200200970A EA200200970A EA200200970A1 EA 200200970 A1 EA200200970 A1 EA 200200970A1 EA 200200970 A EA200200970 A EA 200200970A EA 200200970 A EA200200970 A EA 200200970A EA 200200970 A1 EA200200970 A1 EA 200200970A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- cyano
- cor
- iii
- hydrogen
- Prior art date
Links
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 2
- 229960001653 citalopram Drugs 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к способу получения циталопрама из соединения формулы (III), где Y представляет собой цианогруппу или группу, которая может быть преобразована в цианогруппу, R представляет собой водород, -O-R, NH, NHCHили -N(СН), где Rвыбран из водорода, алкила, алкенила, алкинила и необязательно алкилзамещенного арила или аралкила; который в любой последовательности включает i) восстановление двойной связи в боковой цепи формулы -CH=CH-COR; ii) преобразование группы -COR или его восстановленной формы в диметиламинометильную группу; и iii) если Y не является циано, преобразование группы Y в цианогруппу; с последующим выделением циталопрамового основания или его фармацевтически приемлемой соли добавления кислот.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200000415 | 2000-03-14 | ||
PCT/DK2001/000162 WO2001068630A1 (en) | 2000-03-14 | 2001-03-09 | Method for the preparation of citalopram |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200200970A1 true EA200200970A1 (ru) | 2003-02-27 |
EA005094B1 EA005094B1 (ru) | 2004-10-28 |
Family
ID=8159331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200970A EA005094B1 (ru) | 2000-03-14 | 2001-03-09 | Способ получения циталопрама |
Country Status (26)
Country | Link |
---|---|
US (1) | US6806376B2 (ru) |
EP (1) | EP1265882B1 (ru) |
JP (1) | JP2003527386A (ru) |
KR (1) | KR20020080476A (ru) |
CN (1) | CN1418205A (ru) |
AT (1) | ATE257832T1 (ru) |
AU (1) | AU2001239213A1 (ru) |
BG (1) | BG107051A (ru) |
BR (1) | BR0109268A (ru) |
CA (1) | CA2402557A1 (ru) |
DE (1) | DE60101786T2 (ru) |
DK (1) | DK1265882T3 (ru) |
EA (1) | EA005094B1 (ru) |
ES (1) | ES2214400T3 (ru) |
HR (1) | HRP20020740A2 (ru) |
HU (1) | HUP0300178A2 (ru) |
IL (1) | IL151488A0 (ru) |
IS (1) | IS6527A (ru) |
MX (1) | MXPA02008653A (ru) |
NO (1) | NO20024198L (ru) |
PL (1) | PL360107A1 (ru) |
PT (1) | PT1265882E (ru) |
SK (1) | SK14512002A3 (ru) |
TR (2) | TR200400611T4 (ru) |
WO (1) | WO2001068630A1 (ru) |
ZA (1) | ZA200206897B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL198024B1 (pl) * | 1999-04-14 | 2008-05-30 | Lundbeck & Co As H | Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu |
IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
EA200200968A1 (ru) | 2000-03-13 | 2003-02-27 | Х.Лундбекк А/С | Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов |
IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
TR200202166T2 (tr) | 2000-03-13 | 2002-12-23 | H. Lndbeck A/S | Sitalopramın preparasyon metodu |
AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
PE20040991A1 (es) | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | Separacion de intermediarios para la preparacion de escitalopram |
WO2004085416A1 (en) * | 2003-03-24 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
TWI339651B (en) | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1143702A (ru) | 1965-03-18 | |||
GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
US5296507A (en) | 1990-09-06 | 1994-03-22 | H.Lundbeck A/S | Treatment of cerbrovascular disorders |
DE19626659A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
DE19627697A1 (de) | 1996-07-10 | 1998-01-15 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
JP3526581B2 (ja) | 1997-07-08 | 2004-05-17 | ハー・ルンドベック・アクティーゼルスカブ | シタロプラムの製造方法 |
UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
DE69714480T2 (de) | 1997-11-11 | 2003-03-06 | Lundbeck & Co As H | Verfahren zur Herstellung von Citalopram |
WO2000023431A1 (en) | 1998-10-20 | 2000-04-27 | H. Lundbeck A/S | Method for the preparation of citalopram |
CZ300408B6 (cs) | 1998-12-23 | 2009-05-13 | H. Lundbeck A/S | Zpusob výroby 5-kyanoftalidu |
AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
PL198024B1 (pl) | 1999-04-14 | 2008-05-30 | Lundbeck & Co As H | Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu |
ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
TR200101874T1 (tr) | 1999-10-25 | 2002-02-21 | H. Lundbeck A/S | Sitalopram hazırlanması için yöntem |
AR026063A1 (es) | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
US6310222B1 (en) | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
ATE261953T1 (de) | 1999-12-28 | 2004-04-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
TR200201688T2 (tr) | 1999-12-30 | 2002-11-21 | H. Lundbeck A/S | Sitalopram hazırlama yöntemi. |
EA005134B1 (ru) | 2000-01-14 | 2004-12-30 | Х.Лундбекк А/С | Способ получения 5-цианофталида |
US6433196B1 (en) | 2000-02-17 | 2002-08-13 | Sumika Fine Chemicals Co., Ltd. | Production method of citalopram, intermediate therefor and production method of the intermediate |
IES20010143A2 (en) | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
NL1017415C1 (nl) | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
TR200202166T2 (tr) | 2000-03-13 | 2002-12-23 | H. Lndbeck A/S | Sitalopramın preparasyon metodu |
CA2402869A1 (en) | 2000-03-16 | 2001-09-20 | Hans Petersen | Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
EA200200332A1 (ru) | 2000-07-06 | 2002-06-27 | Х.Лундбекк А/С | Способ получения циталопрама |
CA2354880C (en) | 2000-08-18 | 2003-06-03 | H. Lundbeck A/S | Method for the preparation of citalopram |
KR100439329B1 (ko) | 2000-12-22 | 2004-07-07 | 하. 룬트벡 아크티에 셀스카브 | 순수한 시탈로프람의 제조방법 |
AU3920201A (en) | 2000-12-28 | 2001-07-09 | H. Lundbeck A/S | Process for the preparation of pure citalopram |
-
2001
- 2001-03-09 CA CA002402557A patent/CA2402557A1/en not_active Abandoned
- 2001-03-09 PL PL36010701A patent/PL360107A1/xx not_active Application Discontinuation
- 2001-03-09 HU HU0300178A patent/HUP0300178A2/hu unknown
- 2001-03-09 ES ES01913738T patent/ES2214400T3/es not_active Expired - Lifetime
- 2001-03-09 SK SK1451-2002A patent/SK14512002A3/sk unknown
- 2001-03-09 KR KR1020027011729A patent/KR20020080476A/ko not_active Application Discontinuation
- 2001-03-09 PT PT01913738T patent/PT1265882E/pt unknown
- 2001-03-09 JP JP2001567722A patent/JP2003527386A/ja not_active Withdrawn
- 2001-03-09 BR BR0109268-5A patent/BR0109268A/pt not_active IP Right Cessation
- 2001-03-09 AU AU2001239213A patent/AU2001239213A1/en not_active Abandoned
- 2001-03-09 DK DK01913738T patent/DK1265882T3/da active
- 2001-03-09 TR TR2004/00611T patent/TR200400611T4/xx unknown
- 2001-03-09 CN CN01806482A patent/CN1418205A/zh active Pending
- 2001-03-09 MX MXPA02008653A patent/MXPA02008653A/es not_active Application Discontinuation
- 2001-03-09 EA EA200200970A patent/EA005094B1/ru not_active IP Right Cessation
- 2001-03-09 WO PCT/DK2001/000162 patent/WO2001068630A1/en not_active Application Discontinuation
- 2001-03-09 DE DE60101786T patent/DE60101786T2/de not_active Expired - Fee Related
- 2001-03-09 IL IL15148801A patent/IL151488A0/xx unknown
- 2001-03-09 EP EP01913738A patent/EP1265882B1/en not_active Expired - Lifetime
- 2001-03-09 AT AT01913738T patent/ATE257832T1/de not_active IP Right Cessation
- 2001-03-09 TR TR2002/02155T patent/TR200202155T2/xx unknown
-
2002
- 2002-08-27 IS IS6527A patent/IS6527A/is unknown
- 2002-08-28 ZA ZA200206897A patent/ZA200206897B/en unknown
- 2002-09-02 BG BG107051A patent/BG107051A/xx unknown
- 2002-09-03 NO NO20024198A patent/NO20024198L/no not_active Application Discontinuation
- 2002-09-06 US US10/238,907 patent/US6806376B2/en not_active Expired - Fee Related
- 2002-09-10 HR HRP20020740 patent/HRP20020740A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20020080476A (ko) | 2002-10-23 |
DK1265882T3 (da) | 2004-06-01 |
JP2003527386A (ja) | 2003-09-16 |
CA2402557A1 (en) | 2001-09-20 |
IL151488A0 (en) | 2003-04-10 |
IS6527A (is) | 2002-08-27 |
PL360107A1 (en) | 2004-09-06 |
DE60101786D1 (de) | 2004-02-19 |
BR0109268A (pt) | 2002-12-03 |
ES2214400T3 (es) | 2004-09-16 |
NO20024198D0 (no) | 2002-09-03 |
ZA200206897B (en) | 2003-08-28 |
MXPA02008653A (es) | 2003-02-24 |
NO20024198L (no) | 2002-09-03 |
WO2001068630A1 (en) | 2001-09-20 |
HRP20020740A2 (en) | 2004-12-31 |
AU2001239213A1 (en) | 2001-09-24 |
PT1265882E (pt) | 2004-06-30 |
ATE257832T1 (de) | 2004-01-15 |
BG107051A (en) | 2003-05-30 |
US6806376B2 (en) | 2004-10-19 |
DE60101786T2 (de) | 2004-07-15 |
EA005094B1 (ru) | 2004-10-28 |
SK14512002A3 (sk) | 2003-03-04 |
CN1418205A (zh) | 2003-05-14 |
EP1265882A1 (en) | 2002-12-18 |
TR200400611T4 (tr) | 2004-04-21 |
US20030050484A1 (en) | 2003-03-13 |
EP1265882B1 (en) | 2004-01-14 |
TR200202155T2 (tr) | 2002-12-23 |
HUP0300178A2 (en) | 2003-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |