EA200501135A1 - Способы получения алкалоидов хиназолина - Google Patents

Способы получения алкалоидов хиназолина

Info

Publication number
EA200501135A1
EA200501135A1 EA200501135A EA200501135A EA200501135A1 EA 200501135 A1 EA200501135 A1 EA 200501135A1 EA 200501135 A EA200501135 A EA 200501135A EA 200501135 A EA200501135 A EA 200501135A EA 200501135 A1 EA200501135 A1 EA 200501135A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
methods
iii
hinazoline
alkaloids
Prior art date
Application number
EA200501135A
Other languages
English (en)
Other versions
EA009047B1 (ru
Inventor
Йохим Моорманн
Ханс-Райнер Хоффман
Рудольф Матуш
Original Assignee
Хф Арцнаймиттельфоршунг Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32747532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200501135(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Хф Арцнаймиттельфоршунг Гмбх filed Critical Хф Арцнаймиттельфоршунг Гмбх
Publication of EA200501135A1 publication Critical patent/EA200501135A1/ru
Publication of EA009047B1 publication Critical patent/EA009047B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Настоящее изобретение относится к способам получения соединения, имеющего следующую формулу (I):путем преобразования соединения, имеющего формулу (II), при помощи 2-пирролидона, который используется в избыточном количестве относительно соединения (II); а также к способам получения соединения, имеющего следующую формулу (III):в ходе осуществления которых:(A) получают соединение (I);(B) осуществляют восстановительную реакцию, продуктом которой является соединение (III) в виде соли;(C) из соли высвобождают соединение (III).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200501135A 2003-02-03 2004-01-22 Способы получения алкалоидов хиназолина EA009047B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10304141A DE10304141B4 (de) 2003-02-03 2003-02-03 Verfahren zur Herstellung von Chinazolin-Alkaloiden
PCT/EP2004/000485 WO2004069836A1 (de) 2003-02-03 2004-01-22 Verfahren zur herstellung von chinazolin-alkaloiden

Publications (2)

Publication Number Publication Date
EA200501135A1 true EA200501135A1 (ru) 2006-02-24
EA009047B1 EA009047B1 (ru) 2007-10-26

Family

ID=32747532

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501135A EA009047B1 (ru) 2003-02-03 2004-01-22 Способы получения алкалоидов хиназолина

Country Status (26)

Country Link
US (1) US7495096B2 (ru)
EP (1) EP1590351B1 (ru)
JP (1) JP2006516578A (ru)
KR (1) KR20050096165A (ru)
CN (1) CN100558727C (ru)
AR (1) AR042946A1 (ru)
AT (1) ATE407135T1 (ru)
AU (1) AU2004208873B2 (ru)
BR (1) BRPI0407012A (ru)
CA (1) CA2514945A1 (ru)
DE (2) DE10304141B4 (ru)
DK (1) DK1590351T3 (ru)
EA (1) EA009047B1 (ru)
ES (1) ES2314366T3 (ru)
HK (1) HK1075898A1 (ru)
MX (1) MXPA05008179A (ru)
MY (1) MY141734A (ru)
NO (1) NO20053689L (ru)
NZ (1) NZ541101A (ru)
PL (1) PL378406A1 (ru)
PT (1) PT1590351E (ru)
SI (1) SI1590351T1 (ru)
TW (1) TW200418811A (ru)
UA (1) UA81287C2 (ru)
WO (1) WO2004069836A1 (ru)
ZA (1) ZA200505160B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004048927A1 (de) * 2004-10-06 2006-04-20 Lts Lohmann Therapie-Systeme Ag Pharmazeutische Kombination enthaltend Desoxypeganin und Cyp2D6 Inhibitoren
US11583530B2 (en) 2017-08-03 2023-02-21 Galectin Sciences, Llc Compounds for the prevention and treatment of medical disorders and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU605614A1 (ru) * 1971-10-20 1978-05-05 Ордена Трудового Красного Знамени Институт Химии Растительных Веществ Ан Узбекской Сср Антихолинэстеразное средство
JP3180464B2 (ja) * 1991-08-30 2001-06-25 新日本理化株式会社 ジアセタール化合物の製造方法
DE19530606A1 (de) * 1995-08-21 1997-02-27 Basf Ag 1-(Pyridyl)-pyrazole
JP3958452B2 (ja) * 1997-10-31 2007-08-15 大日精化工業株式会社 新規化学発光試薬及びその製造方法
DE19906979B4 (de) 1999-02-19 2004-07-08 Lts Lohmann Therapie-Systeme Ag Verwendung von Desoxypeganin zur Behandlung der Nikotinabhängigkeit
DE19906975B4 (de) 1999-02-19 2004-04-15 Lts Lohmann Therapie-Systeme Ag Arzneiform zur Behandlung von Alzheimer'scher Demenz
DE19906978B4 (de) 1999-02-19 2004-07-08 Lts Lohmann Therapie-Systeme Ag Pharmazeutische Zusammensetzung enthaltend Desoxypeganin zur Behandlung der Drogenabhängigkeit

Also Published As

Publication number Publication date
ES2314366T3 (es) 2009-03-16
AU2004208873B2 (en) 2009-12-17
US7495096B2 (en) 2009-02-24
CA2514945A1 (en) 2004-08-19
NO20053689L (no) 2005-07-29
PT1590351E (pt) 2008-11-21
DE502004007980D1 (de) 2008-10-16
AU2004208873A1 (en) 2004-08-19
CN100558727C (zh) 2009-11-11
AR042946A1 (es) 2005-07-06
DK1590351T3 (da) 2008-12-15
NZ541101A (en) 2009-03-31
SI1590351T1 (sl) 2009-02-28
KR20050096165A (ko) 2005-10-05
DE10304141B4 (de) 2006-03-09
WO2004069836A1 (de) 2004-08-19
BRPI0407012A (pt) 2006-01-10
DE10304141A1 (de) 2004-08-26
PL378406A1 (pl) 2006-04-03
MXPA05008179A (es) 2006-02-17
CN1745084A (zh) 2006-03-08
MY141734A (en) 2010-06-15
US20060084669A1 (en) 2006-04-20
EP1590351A1 (de) 2005-11-02
ZA200505160B (en) 2007-01-31
ATE407135T1 (de) 2008-09-15
EA009047B1 (ru) 2007-10-26
EP1590351B1 (de) 2008-09-03
TW200418811A (en) 2004-10-01
HK1075898A1 (en) 2005-12-30
UA81287C2 (en) 2007-12-25
JP2006516578A (ja) 2006-07-06

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU