EA200602169A1 - Способ получения производных 2-оксо-1-пирролидина внутримолекулярным аллилированием - Google Patents
Способ получения производных 2-оксо-1-пирролидина внутримолекулярным аллилированиемInfo
- Publication number
- EA200602169A1 EA200602169A1 EA200602169A EA200602169A EA200602169A1 EA 200602169 A1 EA200602169 A1 EA 200602169A1 EA 200602169 A EA200602169 A EA 200602169A EA 200602169 A EA200602169 A EA 200602169A EA 200602169 A1 EA200602169 A1 EA 200602169A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- allylation
- oxy
- intracellular
- producing
- pyrrolidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
Настоящее изобретение относится к новому способу получения производных 2-оксо-1-пирролидина общей формулы (I), включающему циклизацию промежуточного соединения общей формулы (II), в котором заместители имеют значения, определенные в настоящем описании.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04013715 | 2004-06-11 | ||
PCT/EP2005/005689 WO2005121082A1 (en) | 2004-06-11 | 2005-05-26 | Process for preparing 2-oxo-1-pyrrolidine derivatives by intramolecular allylation |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200602169A1 true EA200602169A1 (ru) | 2007-06-29 |
EA010912B1 EA010912B1 (ru) | 2008-12-30 |
Family
ID=34925330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200602169A EA010912B1 (ru) | 2004-06-11 | 2005-05-26 | Способ получения производных 2-оксо-1-пирролидина внутримолекулярным аллилированием |
Country Status (15)
Country | Link |
---|---|
US (1) | US7612215B2 (ru) |
EP (1) | EP1758855B1 (ru) |
JP (1) | JP4866352B2 (ru) |
KR (1) | KR101159870B1 (ru) |
CN (1) | CN1964942A (ru) |
AU (1) | AU2005251884B2 (ru) |
BR (1) | BRPI0511956A (ru) |
CA (1) | CA2568700A1 (ru) |
DE (1) | DE602005003472T2 (ru) |
EA (1) | EA010912B1 (ru) |
ES (1) | ES2296177T3 (ru) |
IL (1) | IL179650A0 (ru) |
MX (1) | MXPA06014201A (ru) |
WO (1) | WO2005121082A1 (ru) |
ZA (1) | ZA200610274B (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1993998B1 (en) * | 2005-12-07 | 2013-08-21 | UCB Pharma, S.A. | 3-carboxy- 2-oxo-1 -pyrrolidine derivatives and their uses |
US8338621B2 (en) | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
WO2009109547A1 (en) * | 2008-03-03 | 2009-09-11 | Ucb Pharma, S.A. | Pharmaceutical solutions, process of preparation and therapeutic uses |
DK3260118T3 (da) | 2008-10-16 | 2021-04-19 | Univ Johns Hopkins | Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
DK3431106T3 (da) | 2014-01-21 | 2021-03-15 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
WO2016191288A1 (en) | 2015-05-22 | 2016-12-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
CN115141134A (zh) * | 2021-03-31 | 2022-10-04 | 江西同和药业股份有限公司 | 一种化合物及其制备方法和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
-
2005
- 2005-05-26 US US11/570,143 patent/US7612215B2/en not_active Expired - Fee Related
- 2005-05-26 BR BRPI0511956-1A patent/BRPI0511956A/pt not_active IP Right Cessation
- 2005-05-26 AU AU2005251884A patent/AU2005251884B2/en not_active Ceased
- 2005-05-26 EP EP05746202A patent/EP1758855B1/en active Active
- 2005-05-26 CN CNA2005800189559A patent/CN1964942A/zh active Pending
- 2005-05-26 EA EA200602169A patent/EA010912B1/ru not_active IP Right Cessation
- 2005-05-26 CA CA002568700A patent/CA2568700A1/en not_active Abandoned
- 2005-05-26 DE DE602005003472T patent/DE602005003472T2/de active Active
- 2005-05-26 ES ES05746202T patent/ES2296177T3/es active Active
- 2005-05-26 KR KR1020077000546A patent/KR101159870B1/ko not_active IP Right Cessation
- 2005-05-26 JP JP2007526239A patent/JP4866352B2/ja not_active Expired - Fee Related
- 2005-05-26 ZA ZA200610274A patent/ZA200610274B/en unknown
- 2005-05-26 WO PCT/EP2005/005689 patent/WO2005121082A1/en active IP Right Grant
- 2005-05-26 MX MXPA06014201A patent/MXPA06014201A/es active IP Right Grant
-
2006
- 2006-11-28 IL IL179650A patent/IL179650A0/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2568700A1 (en) | 2005-12-22 |
ZA200610274B (en) | 2008-06-25 |
CN1964942A (zh) | 2007-05-16 |
AU2005251884B2 (en) | 2011-03-24 |
US20080125598A1 (en) | 2008-05-29 |
DE602005003472D1 (de) | 2008-01-03 |
US7612215B2 (en) | 2009-11-03 |
MXPA06014201A (es) | 2007-03-12 |
EP1758855B1 (en) | 2007-11-21 |
EP1758855A1 (en) | 2007-03-07 |
AU2005251884A1 (en) | 2005-12-22 |
BRPI0511956A (pt) | 2008-01-22 |
ES2296177T3 (es) | 2008-04-16 |
EA010912B1 (ru) | 2008-12-30 |
WO2005121082A1 (en) | 2005-12-22 |
DE602005003472T2 (de) | 2008-09-25 |
JP2008501740A (ja) | 2008-01-24 |
JP4866352B2 (ja) | 2012-02-01 |
KR20070026794A (ko) | 2007-03-08 |
KR101159870B1 (ko) | 2012-06-25 |
IL179650A0 (en) | 2007-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC4A | Registration of transfer of a eurasian patent by assignment | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |