BR0109022A - Método de preparação de citalopram e sua composição farmacêutica - Google Patents
Método de preparação de citalopram e sua composição farmacêuticaInfo
- Publication number
- BR0109022A BR0109022A BR0109022-4A BR0109022A BR0109022A BR 0109022 A BR0109022 A BR 0109022A BR 0109022 A BR0109022 A BR 0109022A BR 0109022 A BR0109022 A BR 0109022A
- Authority
- BR
- Brazil
- Prior art keywords
- citalopram
- halogen
- preparation
- formula
- dimethylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"MéTODO DE PREPARAçãO DE CITALOPRAM E SUA COMPOSIçãO FARMACêUTICA". A invenção refere-se a um método para a preparação de citalopram compreendendo a reação de um composto da fórmula (II) bom um composto tendo a fórmula (III) onde R é halogênio ou -O-SO~ 2~-X, onde X é alquila, alquenila, alquinila ou opcionalmente a alquila é arila ou aralquila substituída e R^ 1^ é dimetilamina, halogênio ou -O-SO~ 2-X onde X é como definido acima, desde que R não seja halogênio quando R^ 1^ for dimetilamina; e se R^ 1^ for dimetilamina seguida pelo isolamento de base do citalopram ou sal com adição de ácido farmacêuticamente aceitável do mesmo, e se R^ 1^ for halogênio ou -OSO~ 2~-X onde X é como definido acima, seguido pela conversão do composto resultante da fórmula onde R^ 2^ é halogênio ou um grupo da fórmula -O-SO~ 2~-X onde X é como definido acima, para o citalopram seguido pelo isolamento de base do citalopram ou um sal com adição de ácido farmacêuticamente aceitável do mesmo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000353 | 2000-03-03 | ||
| PCT/DK2001/000140 WO2001051478A1 (en) | 2000-03-03 | 2001-03-01 | Method for the preparation of citalopram |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0109022A true BR0109022A (pt) | 2003-06-03 |
Family
ID=8159277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0109022-4A BR0109022A (pt) | 2000-03-03 | 2001-03-01 | Método de preparação de citalopram e sua composição farmacêutica |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6768011B2 (pt) |
| EP (1) | EP1263750A1 (pt) |
| JP (1) | JP2003519692A (pt) |
| KR (1) | KR20020080450A (pt) |
| CN (1) | CN1411454A (pt) |
| AR (1) | AR027559A1 (pt) |
| AU (1) | AU2001240469A1 (pt) |
| BE (1) | BE1011481A6 (pt) |
| BG (1) | BG107050A (pt) |
| BR (1) | BR0109022A (pt) |
| CA (1) | CA2401374A1 (pt) |
| EA (1) | EA005491B1 (pt) |
| FR (1) | FR2805814A1 (pt) |
| GR (1) | GR1003795B (pt) |
| HR (1) | HRP20020742A2 (pt) |
| HU (1) | HUP0300060A3 (pt) |
| IE (1) | IES20010157A2 (pt) |
| IL (1) | IL151467A0 (pt) |
| IS (1) | IS6526A (pt) |
| IT (1) | ITMI20010444A1 (pt) |
| MX (1) | MXPA02008634A (pt) |
| NL (1) | NL1017417C1 (pt) |
| NO (1) | NO20024180D0 (pt) |
| NZ (1) | NZ521200A (pt) |
| PL (1) | PL358543A1 (pt) |
| SK (1) | SK14152002A3 (pt) |
| TR (1) | TR200202096T2 (pt) |
| WO (1) | WO2001051478A1 (pt) |
| ZA (1) | ZA200206846B (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE237604T1 (de) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
| EP1265881A1 (en) | 2000-03-13 | 2002-12-18 | H. Lundbeck A/S | Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| IL151490A0 (en) | 2000-03-13 | 2003-04-10 | Lundbeck & Co As H | Method for the preparation of citalopram |
| KR20020080476A (ko) | 2000-03-14 | 2002-10-23 | 하. 룬트벡 아크티에 셀스카브 | 시탈로프람의 제조 방법 |
| AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
| EP1446396A1 (en) * | 2001-11-08 | 2004-08-18 | Sepracor, Inc. | Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram |
| PE20040991A1 (es) | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | Separacion de intermediarios para la preparacion de escitalopram |
| AU2003223105A1 (en) * | 2003-03-24 | 2004-10-18 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| TWI339651B (en) | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| GB0601286D0 (en) | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1143703A (pt) | 1965-03-18 | |||
| GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| US5296507A (en) | 1990-09-06 | 1994-03-22 | H.Lundbeck A/S | Treatment of cerbrovascular disorders |
| DE19626659A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
| DE19627697A1 (de) | 1996-07-10 | 1998-01-15 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
| PT1015416E (pt) | 1997-07-08 | 2002-03-28 | Lundbeck & Co As H | Metodo para a producao de citalopram |
| UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
| CA2291072C (en) | 1997-11-11 | 2002-08-20 | H. Lundbeck A/S | Method for the preparation of citalopram |
| HU228576B1 (en) | 1998-10-20 | 2013-04-29 | Lundbeck & Co As H | Method for the preparation of citalopram |
| AU764161B2 (en) | 1998-12-23 | 2003-08-14 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
| AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
| ATE237604T1 (de) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991486A1 (it) | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
| SK287139B6 (sk) | 1999-10-25 | 2010-01-07 | H. Lundbeck A/S | Spôsob prípravy citalopramu |
| AR026063A1 (es) | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
| US6310222B1 (en) | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
| WO2001047909A1 (en) | 1999-12-28 | 2001-07-05 | H. Lundbeck A/S | Method for the preparation of citalopram |
| UA73336C2 (en) | 1999-12-30 | 2005-07-15 | Lundbeck & Co As H | A method for the preparation of 5-cyano-phtalid |
| TR200201783T2 (tr) | 2000-01-14 | 2002-12-23 | H. Lundbeck A/S | 5-Siyanofatalid hazırlamak için yöntem |
| IT1317729B1 (it) | 2000-01-18 | 2003-07-15 | Norpharma S P A | Procedimento per la preparazione della 5-carbossiftalide. |
| US6433196B1 (en) | 2000-02-17 | 2002-08-13 | Sumika Fine Chemicals Co., Ltd. | Production method of citalopram, intermediate therefor and production method of the intermediate |
| NL1017415C1 (nl) * | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| IES20010143A2 (en) | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
| IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
| IL151490A0 (en) | 2000-03-13 | 2003-04-10 | Lundbeck & Co As H | Method for the preparation of citalopram |
| EP1265881A1 (en) | 2000-03-13 | 2002-12-18 | H. Lundbeck A/S | Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| GB2357762B (en) | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| KR20020080476A (ko) | 2000-03-14 | 2002-10-23 | 하. 룬트벡 아크티에 셀스카브 | 시탈로프람의 제조 방법 |
| EP1274699A1 (en) | 2000-03-16 | 2003-01-15 | H. Lundbeck A/S | Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
| SK3362002A3 (en) | 2000-07-06 | 2002-08-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| FI20011622A (fi) | 2000-08-18 | 2002-02-19 | Lundbeck & Co As H | Menetelmä sitalopraamin valmistamiseksi |
| EA003581B1 (ru) | 2000-12-22 | 2003-06-26 | Х.Лундбекк А/С | Способ получения чистого циталопрама |
| AU3920201A (en) | 2000-12-28 | 2001-07-09 | H. Lundbeck A/S | Process for the preparation of pure citalopram |
-
2001
- 2001-02-21 IE IE20010157A patent/IES20010157A2/en not_active IP Right Cessation
- 2001-02-21 NL NL1017417A patent/NL1017417C1/nl not_active IP Right Cessation
- 2001-02-27 AR ARP010100886A patent/AR027559A1/es unknown
- 2001-03-01 BR BR0109022-4A patent/BR0109022A/pt not_active IP Right Cessation
- 2001-03-01 HU HU0300060A patent/HUP0300060A3/hu unknown
- 2001-03-01 EP EP01911454A patent/EP1263750A1/en not_active Withdrawn
- 2001-03-01 JP JP2001551860A patent/JP2003519692A/ja not_active Withdrawn
- 2001-03-01 KR KR1020027011336A patent/KR20020080450A/ko not_active Application Discontinuation
- 2001-03-01 MX MXPA02008634A patent/MXPA02008634A/es not_active Application Discontinuation
- 2001-03-01 AU AU2001240469A patent/AU2001240469A1/en not_active Abandoned
- 2001-03-01 SK SK1415-2002A patent/SK14152002A3/sk unknown
- 2001-03-01 NZ NZ521200A patent/NZ521200A/en unknown
- 2001-03-01 WO PCT/DK2001/000140 patent/WO2001051478A1/en not_active Application Discontinuation
- 2001-03-01 EA EA200200939A patent/EA005491B1/ru not_active IP Right Cessation
- 2001-03-01 CA CA002401374A patent/CA2401374A1/en not_active Abandoned
- 2001-03-01 IL IL15146701A patent/IL151467A0/xx unknown
- 2001-03-01 CN CN01806029A patent/CN1411454A/zh active Pending
- 2001-03-01 TR TR2002/02096T patent/TR200202096T2/xx unknown
- 2001-03-01 PL PL01358543A patent/PL358543A1/xx not_active Application Discontinuation
- 2001-03-02 BE BE2001/0143A patent/BE1011481A6/fr not_active IP Right Cessation
- 2001-03-02 FR FR0102896A patent/FR2805814A1/fr active Pending
- 2001-03-05 IT IT2001MI000444A patent/ITMI20010444A1/it unknown
- 2001-03-05 GR GR20010100106A patent/GR1003795B/el unknown
-
2002
- 2002-08-27 ZA ZA200206846A patent/ZA200206846B/en unknown
- 2002-08-27 IS IS6526A patent/IS6526A/is unknown
- 2002-08-29 US US10/232,994 patent/US6768011B2/en not_active Expired - Fee Related
- 2002-09-02 BG BG107050A patent/BG107050A/xx unknown
- 2002-09-02 NO NO20024180A patent/NO20024180D0/no not_active Application Discontinuation
- 2002-09-10 HR HR20020742A patent/HRP20020742A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020080450A (ko) | 2002-10-23 |
| ZA200206846B (en) | 2003-08-27 |
| BG107050A (en) | 2003-05-30 |
| IS6526A (is) | 2002-08-27 |
| MXPA02008634A (es) | 2003-02-24 |
| NO20024180L (no) | 2002-09-02 |
| ITMI20010444A1 (it) | 2002-09-05 |
| EA200200939A1 (ru) | 2003-02-27 |
| AU2001240469A1 (en) | 2001-07-24 |
| EA005491B1 (ru) | 2005-02-24 |
| NL1017417C1 (nl) | 2001-03-16 |
| GR1003795B (el) | 2002-02-08 |
| AR027559A1 (es) | 2003-04-02 |
| EP1263750A1 (en) | 2002-12-11 |
| HUP0300060A2 (en) | 2003-05-28 |
| FR2805814A1 (fr) | 2001-09-07 |
| CN1411454A (zh) | 2003-04-16 |
| IES20010157A2 (en) | 2002-03-06 |
| JP2003519692A (ja) | 2003-06-24 |
| TR200202096T2 (tr) | 2003-01-21 |
| SK14152002A3 (sk) | 2003-03-04 |
| US6768011B2 (en) | 2004-07-27 |
| IL151467A0 (en) | 2003-04-10 |
| NO20024180D0 (no) | 2002-09-02 |
| HUP0300060A3 (en) | 2005-02-28 |
| BE1011481A6 (fr) | 2001-07-03 |
| HRP20020742A2 (en) | 2004-02-29 |
| US20030092761A1 (en) | 2003-05-15 |
| PL358543A1 (en) | 2004-08-09 |
| NZ521200A (en) | 2004-03-26 |
| WO2001051478A1 (en) | 2001-07-19 |
| CA2401374A1 (en) | 2001-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008. |