TR200202096T2 - Sitalopram hazırlamak için yöntem - Google Patents

Sitalopram hazırlamak için yöntem

Info

Publication number
TR200202096T2
TR200202096T2 TR2002/02096T TR200202096T TR200202096T2 TR 200202096 T2 TR200202096 T2 TR 200202096T2 TR 2002/02096 T TR2002/02096 T TR 2002/02096T TR 200202096 T TR200202096 T TR 200202096T TR 200202096 T2 TR200202096 T2 TR 200202096T2
Authority
TR
Turkey
Prior art keywords
citalopram
formula
halogen
isolated
alkyl
Prior art date
Application number
TR2002/02096T
Other languages
English (en)
Inventor
Harold Rock Michael
Ahmadian Haleh
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of TR200202096T2 publication Critical patent/TR200202096T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

Bulus sitalopram hazirlamak için bir yöntemle ilgilidir ki sözkonusu yöntem bir formül (II) bilesimini bir formül (III) bilesimiyle tepkimeye sokmaktan meydana gelir, burada R halojen veya -O-SO2-X' tir, burada X alkil, alkenil veya istege bagli olarak alkille ikame edilmis aril veya aralkildir ve R1 dimetilaminodur, söz konusu tepkimeden sonra sitalopram baz veya bunun farmasötik açidan kabul edilebilir bir asit tuzu izole edilir ve eger R1 halojen veya -O-SO2-X grubu ise ki burada X yukarida tarif edildigi gibidir, tepkimeyi takiben elde edilen bilesim, burada R2 halojen veya -O-SO2-X grubu ise, burada X yukarida tarif edildigi gibidir, sitaloprama dönüstürülür ve sitalopram baz veya bunun farmasötik açidan kabul edilebilir bir asit tuzu izole edilir. (formül var)
TR2002/02096T 2000-03-03 2001-03-01 Sitalopram hazırlamak için yöntem TR200202096T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200000353 2000-03-03

Publications (1)

Publication Number Publication Date
TR200202096T2 true TR200202096T2 (tr) 2003-01-21

Family

ID=8159277

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/02096T TR200202096T2 (tr) 2000-03-03 2001-03-01 Sitalopram hazırlamak için yöntem

Country Status (29)

Country Link
US (1) US6768011B2 (tr)
EP (1) EP1263750A1 (tr)
JP (1) JP2003519692A (tr)
KR (1) KR20020080450A (tr)
CN (1) CN1411454A (tr)
AR (1) AR027559A1 (tr)
AU (1) AU2001240469A1 (tr)
BE (1) BE1011481A6 (tr)
BG (1) BG107050A (tr)
BR (1) BR0109022A (tr)
CA (1) CA2401374A1 (tr)
EA (1) EA005491B1 (tr)
FR (1) FR2805814A1 (tr)
GR (1) GR1003795B (tr)
HR (1) HRP20020742A2 (tr)
HU (1) HUP0300060A3 (tr)
IE (1) IES20010157A2 (tr)
IL (1) IL151467A0 (tr)
IS (1) IS6526A (tr)
IT (1) ITMI20010444A1 (tr)
MX (1) MXPA02008634A (tr)
NL (1) NL1017417C1 (tr)
NO (1) NO20024180L (tr)
NZ (1) NZ521200A (tr)
PL (1) PL358543A1 (tr)
SK (1) SK14152002A3 (tr)
TR (1) TR200202096T2 (tr)
WO (1) WO2001051478A1 (tr)
ZA (1) ZA200206846B (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
NZ532478A (en) * 2001-11-08 2007-02-23 Sepracor Inc Methods for treating depression and other CNS disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (tr) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
JP3813820B2 (ja) 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AU778751B2 (en) 1999-12-28 2004-12-16 H. Lundbeck A/S Method for the preparation of citalopram
ATE253568T1 (de) 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2001051477A1 (en) 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
CZ20023406A3 (cs) 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL148525A0 (en) 2000-07-06 2002-09-12 Lundbeck & Co As H Method for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
CA2360303C (en) 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
EP1181272B1 (en) 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
ITMI20010444A1 (it) 2002-09-05
FR2805814A1 (fr) 2001-09-07
EA005491B1 (ru) 2005-02-24
HUP0300060A3 (en) 2005-02-28
AR027559A1 (es) 2003-04-02
SK14152002A3 (sk) 2003-03-04
CA2401374A1 (en) 2001-07-19
CN1411454A (zh) 2003-04-16
BE1011481A6 (fr) 2001-07-03
PL358543A1 (en) 2004-08-09
ZA200206846B (en) 2003-08-27
NO20024180D0 (no) 2002-09-02
NO20024180L (no) 2002-09-02
AU2001240469A1 (en) 2001-07-24
US20030092761A1 (en) 2003-05-15
HRP20020742A2 (en) 2004-02-29
KR20020080450A (ko) 2002-10-23
EP1263750A1 (en) 2002-12-11
BG107050A (en) 2003-05-30
IES20010157A2 (en) 2002-03-06
NL1017417C1 (nl) 2001-03-16
EA200200939A1 (ru) 2003-02-27
BR0109022A (pt) 2003-06-03
HUP0300060A2 (en) 2003-05-28
JP2003519692A (ja) 2003-06-24
GR1003795B (el) 2002-02-08
NZ521200A (en) 2004-03-26
US6768011B2 (en) 2004-07-27
IL151467A0 (en) 2003-04-10
WO2001051478A1 (en) 2001-07-19
IS6526A (is) 2002-08-27
MXPA02008634A (es) 2003-02-24

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