ES2169709A1 - Metodo para la preparacion de citalopram - Google Patents

Metodo para la preparacion de citalopram

Info

Publication number
ES2169709A1
ES2169709A1 ES200150056A ES200150056A ES2169709A1 ES 2169709 A1 ES2169709 A1 ES 2169709A1 ES 200150056 A ES200150056 A ES 200150056A ES 200150056 A ES200150056 A ES 200150056A ES 2169709 A1 ES2169709 A1 ES 2169709A1
Authority
ES
Spain
Prior art keywords
citalopram
preparation
arylsulfonyl
alkylsulfonyl
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES200150056A
Other languages
English (en)
Inventor
Michael Harold Rock
Hans Petersen
Peter Ellegaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Priority to ES99950511T priority Critical patent/ES2229774T3/es
Priority to ES200150056A priority patent/ES2169709A1/es
Priority to CZ20012246A priority patent/CZ292992B6/cs
Priority to BR9917108-2A priority patent/BR9917108A/pt
Priority to SK924-2001A priority patent/SK287139B6/sk
Priority to AU63265/99A priority patent/AU742554B2/en
Priority to CH02004/01A priority patent/CH692298A5/de
Priority to JP2000571018A priority patent/JP3365764B2/ja
Priority to CH01179/01A priority patent/CH692421A5/de
Priority to EP99950511A priority patent/EP1228056B1/en
Priority to TR2001/01874T priority patent/TR200101874T1/xx
Priority to PCT/DK1999/000581 priority patent/WO2000012044A2/en
Priority to GB0115030A priority patent/GB2360281B/en
Priority to IT1999MI002505 priority patent/IT1314243B1/it
Priority to DK200100959A priority patent/DK200100959A/da
Priority to FI20011316A priority patent/FI118765B/fi
Priority to US09/891,874 priority patent/US6407267B1/en
Priority to NO20013185A priority patent/NO325185B1/no
Publication of ES2169709A1 publication Critical patent/ES2169709A1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un método para la preparación de citalopram, que comprende la reacción de un compuesto de fórmula (IV), en donde R es alquilo C1-6, acilo, alquil C1-6-sulfonilo o arilsulfonilo, con haluro de 3-( N,N-dimetilamino)-propilmagnesio, para preparar citalopram
ES200150056A 1999-10-25 1999-10-25 Metodo para la preparacion de citalopram Pending ES2169709A1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ES99950511T ES2229774T3 (es) 1999-10-25 1999-10-25 Metodo para la preparacion de citalopram.
ES200150056A ES2169709A1 (es) 1999-10-25 1999-10-25 Metodo para la preparacion de citalopram
CZ20012246A CZ292992B6 (cs) 1999-10-25 1999-10-25 Způsob výroby citalopramu
BR9917108-2A BR9917108A (pt) 1999-10-25 1999-10-25 Método para preparação de citalopram, método para a preparação do composto para a preparação racêmico; composição farmacêutica antidepressiva; utilização do mesmo
SK924-2001A SK287139B6 (sk) 1999-10-25 1999-10-25 Spôsob prípravy citalopramu
AU63265/99A AU742554B2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram
CH02004/01A CH692298A5 (de) 1999-10-25 1999-10-25 Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
JP2000571018A JP3365764B2 (ja) 1999-10-25 1999-10-25 シタロプラムの製造方法
CH01179/01A CH692421A5 (de) 1999-10-25 1999-10-25 Verfahren zur Herstellung von Citalopram.
EP99950511A EP1228056B1 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram
TR2001/01874T TR200101874T1 (tr) 1999-10-25 1999-10-25 Sitalopram hazırlanması için yöntem
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram
GB0115030A GB2360281B (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram
IT1999MI002505 IT1314243B1 (it) 1999-10-25 1999-12-01 Metodo per la preparazione di citalopram.
DK200100959A DK200100959A (da) 1999-10-25 2001-06-20 Fremgangsmåde til fremstilling af citalopram
FI20011316A FI118765B (fi) 1999-10-25 2001-06-20 Menetelmä sitalopraamin valmistamiseksi
US09/891,874 US6407267B1 (en) 1999-10-25 2001-06-25 Method for the preparation of citalopram
NO20013185A NO325185B1 (no) 1999-10-25 2001-06-25 Fremgangsmate ved fremstilling av citalopram

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES200150056A ES2169709A1 (es) 1999-10-25 1999-10-25 Metodo para la preparacion de citalopram
CH02004/01A CH692298A5 (de) 1999-10-25 1999-10-25 Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram
CH01179/01A CH692421A5 (de) 1999-10-25 1999-10-25 Verfahren zur Herstellung von Citalopram.

Publications (1)

Publication Number Publication Date
ES2169709A1 true ES2169709A1 (es) 2002-07-01

Family

ID=27429871

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99950511T Expired - Lifetime ES2229774T3 (es) 1999-10-25 1999-10-25 Metodo para la preparacion de citalopram.
ES200150056A Pending ES2169709A1 (es) 1999-10-25 1999-10-25 Metodo para la preparacion de citalopram

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99950511T Expired - Lifetime ES2229774T3 (es) 1999-10-25 1999-10-25 Metodo para la preparacion de citalopram.

Country Status (11)

Country Link
US (1) US6407267B1 (es)
EP (1) EP1228056B1 (es)
AU (1) AU742554B2 (es)
CH (2) CH692298A5 (es)
DK (1) DK200100959A (es)
ES (2) ES2229774T3 (es)
GB (1) GB2360281B (es)
NO (1) NO325185B1 (es)
SK (1) SK287139B6 (es)
TR (1) TR200101874T1 (es)
WO (1) WO2000012044A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582780B2 (en) 2004-02-12 2009-09-01 H. Lundbeck A/S Method for the separation of intermediates which may be used for the preparation of escitalopram

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
WO2001047909A1 (en) 1999-12-28 2001-07-05 H. Lundbeck A/S Method for the preparation of citalopram
PL198803B1 (pl) 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
ES2206177T3 (es) 2000-01-14 2004-05-16 H. Lundbeck A/S Metodo para la preparacion de 5-cianoftalida.
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2402553A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
EP1274699A1 (en) * 2000-03-16 2003-01-15 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
CA2435925A1 (en) 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
GB0601286D0 (en) * 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
EP0171943A1 (en) * 1984-08-06 1986-02-19 H. Lundbeck A/S Novel intermediate and method for its preparation
EP0347066A1 (en) * 1988-06-14 1989-12-20 H. Lundbeck A/S New enantiomers and their isolation
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (es) 1965-03-18
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
JP4025501B2 (ja) 2000-03-03 2007-12-19 株式会社ソニー・コンピュータエンタテインメント 楽音発生装置
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
EP0171943A1 (en) * 1984-08-06 1986-02-19 H. Lundbeck A/S Novel intermediate and method for its preparation
EP0347066A1 (en) * 1988-06-14 1989-12-20 H. Lundbeck A/S New enantiomers and their isolation
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582780B2 (en) 2004-02-12 2009-09-01 H. Lundbeck A/S Method for the separation of intermediates which may be used for the preparation of escitalopram

Also Published As

Publication number Publication date
GB0115030D0 (en) 2001-08-08
SK287139B6 (sk) 2010-01-07
EP1228056B1 (en) 2004-09-22
TR200101874T1 (tr) 2002-02-21
GB2360281B (en) 2002-01-16
EP1228056A2 (en) 2002-08-07
NO325185B1 (no) 2008-02-11
AU6326599A (en) 2000-03-21
US6407267B1 (en) 2002-06-18
SK9242001A3 (en) 2001-12-03
CH692421A5 (de) 2002-06-14
DK200100959A (da) 2001-07-11
NO20013185L (no) 2001-08-24
CH692298A5 (de) 2002-04-30
NO20013185D0 (no) 2001-06-25
US20020035277A1 (en) 2002-03-21
GB2360281A (en) 2001-09-19
AU742554B2 (en) 2002-01-03
ES2229774T3 (es) 2005-04-16
WO2000012044A3 (en) 2000-08-03
WO2000012044A2 (en) 2000-03-09

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