BR0109048A - Processo para a sìntese de citalopram - Google Patents

Processo para a sìntese de citalopram

Info

Publication number
BR0109048A
BR0109048A BR0109048-8A BR0109048A BR0109048A BR 0109048 A BR0109048 A BR 0109048A BR 0109048 A BR0109048 A BR 0109048A BR 0109048 A BR0109048 A BR 0109048A
Authority
BR
Brazil
Prior art keywords
formula
sub
compound
citalopram
sup
Prior art date
Application number
BR0109048-8A
Other languages
English (en)
Inventor
Alan Kenneth Greenwood
Derek Mchattie
Josef Antonin Rechka
Paul Christopher Markus Hedger
Mark Philip Gamble
Original Assignee
Resolution Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolution Chemicals Ltd filed Critical Resolution Chemicals Ltd
Publication of BR0109048A publication Critical patent/BR0109048A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"PROCESSO PARA A SìNTESE DE CITALOPRAM". A preparação de citalopram compreende as etapas de: (a) converter o composto de Fórmula (I) em um composto de Fórmula (II), em que R na Fórmula (I) representa um grupo alquileno de 2 a 5 átomos de carbono, que pode ser substituído ou não substituído, e R^ 1^ nos compostos de Fórmula (II) representa um grupo de ácido carboxílico ou um éster dele; e (b) converter o composto de Fórmula (II) para formar citalopram ou um sal farmaceuticamente aceitável dele, ou uma conversão direta do composto de Fórmula (I) em citalopram.
BR0109048-8A 2000-03-07 2001-03-07 Processo para a sìntese de citalopram BR0109048A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0005477.5A GB0005477D0 (en) 2000-03-07 2000-03-07 Process for the preparation of citalopram
PCT/GB2001/000994 WO2001066536A1 (en) 2000-03-07 2001-03-07 Process for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BR0109048A true BR0109048A (pt) 2003-06-03

Family

ID=9887136

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109048-8A BR0109048A (pt) 2000-03-07 2001-03-07 Processo para a sìntese de citalopram

Country Status (13)

Country Link
US (1) US7002025B2 (pt)
EP (1) EP1268461B1 (pt)
CN (1) CN1216049C (pt)
AT (1) ATE320424T1 (pt)
AU (2) AU3759101A (pt)
BR (1) BR0109048A (pt)
CA (1) CA2401861A1 (pt)
DE (1) DE60117963D1 (pt)
GB (1) GB0005477D0 (pt)
NO (1) NO20024241L (pt)
NZ (1) NZ521172A (pt)
WO (1) WO2001066536A1 (pt)
ZA (1) ZA200206914B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CA2291133C (en) 1999-10-25 2003-06-17 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
IL150367A0 (en) 1999-12-30 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
WO2001068629A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
TR200400611T4 (tr) 2000-03-14 2004-04-21 H.Lundbeck A/S Sitalopramın preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) * 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
CN106083786A (zh) * 2016-07-07 2016-11-09 孙冉 一种酰基呋喃类医药中间体化合物的合成方法
CN106187965B (zh) * 2016-07-07 2019-02-12 上海博栋化学科技有限公司 一种药物中间体双环呋喃类化合物的合成方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607884A (en) 1969-03-11 1971-09-21 Mobil Oil Corp Preparation of 5-carboxyphthalide in liquid sodium trioxide
DE2242007A1 (de) 1972-08-26 1974-03-14 Basf Ag Verfahren zur herstellung von phthalimidinen
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
DE2630927A1 (de) 1976-07-09 1978-01-19 Basf Ag Verfahren zur herstellung von phthalidcarbonsaeure-(5)
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
HU212435B (en) 1990-06-07 1996-06-28 Sandoz Ag Herbicidal compositions containing substituted phthalides and heterocyclic phthalides as active ingredient and process for preparation of their active ingredients.
US6204284B1 (en) 1991-12-20 2001-03-20 American Cyanamid Company Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
GB9325360D0 (en) 1993-12-10 1994-02-16 Univ Bristol Organic compounds
EP0858457A1 (de) 1995-10-20 1998-08-19 Dr. Karl Thomae GmbH 5-gliedrige heterocyclen, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung
DE19539091A1 (de) 1995-10-20 1997-04-24 Thomae Gmbh Dr K 5-gliedrige Heterocyclen, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zur ihrer Herstellung
US5691362A (en) 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
CZ291440B6 (cs) * 1997-07-08 2003-03-12 H. Lundbeck A/S Způsob výroby citalopramu
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
SK285719B6 (sk) 1998-10-20 2007-07-06 H. Lundbeck A/S Spôsob prípravy citalopramu a medziprodukty
US6479524B1 (en) 1998-12-16 2002-11-12 Boehringer Ingelheim Pharma Kg Substituted aryl and heteroaryl derivatives, their production and their use as medicines
EA004033B1 (ru) 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
EP1220658A1 (en) 1999-09-28 2002-07-10 H. Lundbeck A/S Melt granulated composition and modified release dosage form prepared from said composition
AU1130901A (en) 1999-11-01 2001-05-14 H. Lundbeck A/S Method for the preparation of 5-carboxyphthalide
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
CA2394548A1 (en) 1999-12-17 2001-06-21 Joseph P. Yevich Antipsychotic heterocycle compounds
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
IL150367A0 (en) 1999-12-30 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram

Also Published As

Publication number Publication date
US20040014997A1 (en) 2004-01-22
GB0005477D0 (en) 2000-04-26
US7002025B2 (en) 2006-02-21
EP1268461B1 (en) 2006-03-15
NO20024241L (no) 2002-11-07
NZ521172A (en) 2004-05-28
CA2401861A1 (en) 2001-09-13
AU3759101A (en) 2001-09-17
WO2001066536A1 (en) 2001-09-13
AU2001237591B2 (en) 2005-05-19
CN1216049C (zh) 2005-08-24
ZA200206914B (en) 2004-11-29
NO20024241D0 (no) 2002-09-05
DE60117963D1 (de) 2006-05-11
CN1427834A (zh) 2003-07-02
EP1268461A1 (en) 2003-01-02
ATE320424T1 (de) 2006-04-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009