DE60117963D1 - Verfahren zu herstellung von citalopram - Google Patents

Verfahren zu herstellung von citalopram

Info

Publication number
DE60117963D1
DE60117963D1 DE60117963T DE60117963T DE60117963D1 DE 60117963 D1 DE60117963 D1 DE 60117963D1 DE 60117963 T DE60117963 T DE 60117963T DE 60117963 T DE60117963 T DE 60117963T DE 60117963 D1 DE60117963 D1 DE 60117963D1
Authority
DE
Germany
Prior art keywords
formula
sub
compound
citalopram
sup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60117963T
Other languages
English (en)
Inventor
Alan Kenneth Greenwood
Derek Mchattie
Josef Antonin Rechka
Paul Christopher Markus Hedger
Philip Gamble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Resolution Chemicals Ltd
Original Assignee
Resolution Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolution Chemicals Ltd filed Critical Resolution Chemicals Ltd
Application granted granted Critical
Publication of DE60117963D1 publication Critical patent/DE60117963D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60117963T 2000-03-07 2001-03-07 Verfahren zu herstellung von citalopram Expired - Lifetime DE60117963D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0005477.5A GB0005477D0 (en) 2000-03-07 2000-03-07 Process for the preparation of citalopram
PCT/GB2001/000994 WO2001066536A1 (en) 2000-03-07 2001-03-07 Process for the preparation of citalopram

Publications (1)

Publication Number Publication Date
DE60117963D1 true DE60117963D1 (de) 2006-05-11

Family

ID=9887136

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60117963T Expired - Lifetime DE60117963D1 (de) 2000-03-07 2001-03-07 Verfahren zu herstellung von citalopram

Country Status (13)

Country Link
US (1) US7002025B2 (de)
EP (1) EP1268461B1 (de)
CN (1) CN1216049C (de)
AT (1) ATE320424T1 (de)
AU (2) AU3759101A (de)
BR (1) BR0109048A (de)
CA (1) CA2401861A1 (de)
DE (1) DE60117963D1 (de)
GB (1) GB0005477D0 (de)
NO (1) NO20024241L (de)
NZ (1) NZ521172A (de)
WO (1) WO2001066536A1 (de)
ZA (1) ZA200206914B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ATE355268T1 (de) 1999-10-25 2006-03-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
WO2001049672A1 (en) 1999-12-30 2001-07-12 H. Lundbeck A/S Method for the preparation of citalopram
CZ20022601A3 (cs) 2000-01-14 2002-10-16 H. Lundbeck A/S Způsob výroby 5-kyanoftalidu
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EP1265883A1 (de) 2000-03-13 2002-12-18 H. Lundbeck A/S Verfahren zur herstellung von citalopram
EA200200968A1 (ru) 2000-03-13 2003-02-27 Х.Лундбекк А/С Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) * 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
ATE222899T1 (de) 2000-12-28 2002-09-15 Lundbeck & Co As H Verfahren zur herstellung von reinem citalopram
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
CN106083786A (zh) * 2016-07-07 2016-11-09 孙冉 一种酰基呋喃类医药中间体化合物的合成方法
CN106187965B (zh) * 2016-07-07 2019-02-12 上海博栋化学科技有限公司 一种药物中间体双环呋喃类化合物的合成方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607884A (en) 1969-03-11 1971-09-21 Mobil Oil Corp Preparation of 5-carboxyphthalide in liquid sodium trioxide
DE2242007A1 (de) 1972-08-26 1974-03-14 Basf Ag Verfahren zur herstellung von phthalimidinen
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
DE2630927A1 (de) 1976-07-09 1978-01-19 Basf Ag Verfahren zur herstellung von phthalidcarbonsaeure-(5)
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
HU212435B (en) 1990-06-07 1996-06-28 Sandoz Ag Herbicidal compositions containing substituted phthalides and heterocyclic phthalides as active ingredient and process for preparation of their active ingredients.
US6204284B1 (en) 1991-12-20 2001-03-20 American Cyanamid Company Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
GB9325360D0 (en) 1993-12-10 1994-02-16 Univ Bristol Organic compounds
CA2229617A1 (en) 1995-10-20 1997-05-01 Dr. Karl Thomae Gmbh 5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE19539091A1 (de) 1995-10-20 1997-04-24 Thomae Gmbh Dr K 5-gliedrige Heterocyclen, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zur ihrer Herstellung
US5691362A (en) 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
EP1015416B1 (de) 1997-07-08 2001-09-19 H. Lundbeck A/S Verfahren zur herstellung von citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
JP3827530B2 (ja) 1998-12-16 2006-09-27 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 置換アリール誘導体及び置換ヘテロアリール誘導体、それらの調製及び薬物としてのそれらの使用
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
CA2385749A1 (en) 1999-09-28 2001-04-05 H. Lundbeck A/S Melt granulated composition and modified release dosage form prepared from said composition
AU1130901A (en) 1999-11-01 2001-05-14 H. Lundbeck A/S Method for the preparation of 5-carboxyphthalide
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
JP2003517481A (ja) 1999-12-17 2003-05-27 ブリストルーマイヤーズ スクイブ カンパニー 抗精神病複素環式化合物
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
WO2001049672A1 (en) 1999-12-30 2001-07-12 H. Lundbeck A/S Method for the preparation of citalopram
CZ20022601A3 (cs) 2000-01-14 2002-10-16 H. Lundbeck A/S Způsob výroby 5-kyanoftalidu
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.

Also Published As

Publication number Publication date
AU2001237591B2 (en) 2005-05-19
EP1268461B1 (de) 2006-03-15
NZ521172A (en) 2004-05-28
GB0005477D0 (en) 2000-04-26
ZA200206914B (en) 2004-11-29
EP1268461A1 (de) 2003-01-02
US20040014997A1 (en) 2004-01-22
ATE320424T1 (de) 2006-04-15
BR0109048A (pt) 2003-06-03
US7002025B2 (en) 2006-02-21
WO2001066536A1 (en) 2001-09-13
NO20024241D0 (no) 2002-09-05
AU3759101A (en) 2001-09-17
CN1427834A (zh) 2003-07-02
NO20024241L (no) 2002-11-07
CN1216049C (zh) 2005-08-24
CA2401861A1 (en) 2001-09-13

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Legal Events

Date Code Title Description
8332 No legal effect for de