AR037005A1 - Derivados de acidos dimetilfenilaceticos, derivados de piperidina, y proceso para la produccion de derivados de piperidina. - Google Patents
Derivados de acidos dimetilfenilaceticos, derivados de piperidina, y proceso para la produccion de derivados de piperidina.Info
- Publication number
- AR037005A1 AR037005A1 ARP020102261A ARP020102261A AR037005A1 AR 037005 A1 AR037005 A1 AR 037005A1 AR P020102261 A ARP020102261 A AR P020102261A AR P020102261 A ARP020102261 A AR P020102261A AR 037005 A1 AR037005 A1 AR 037005A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- alkyl
- carbon atoms
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Derivados de ácidos dimetilfenilacéticos que comprende el compuesto la fórmula 1 en donde alquilo es de 1-6 átomos de carbono. Derivados de piperidina, que comprenden el compuesto de la fórmula 2 en donde alquilo es de 1-6 átomos de carbono; procesos para la preparación de ciertos derivados de piperidina, incluyendo fexofenadina (F), el ingrediente activo en la antihistamina no sedante distribuida en los Estados Unidos con la designación "Allegra", que comprende el proceso: a) acilar un compuesto inicial de la fórmula 3 en donde alquilo es de 1-6 átomos de carbono, con un compuesto de la fórmula 4 bajo condiciones eficaces para producir una mezcla de regioisómeros de la fórmula 5 En donde alquilo es de 1-6 átomos de carbono; y b) recuperar de la mezcla de regioisómeros el compuesto de la fórmula 6 en donde alquilo es de 1-6 átomos de carbono; el proceso que comprende dicha provisión: a) acilar un compuesto inicial de la fórmula 3,en donde alquilo es de 1-6 átomos de carbono, con un compuesto de la fórmula 4 bajo condiciones eficaces para producir una mezcla de regioisómeros de la fórmula 5 en donde alquilo es de 1-6 átomos de carbono; y b) recuperar de la mezcla de regioisómeros el compuesto de la fórmula 6 , en donde alquilo es de 1-6 átomos de carbono; el proceso para la preparación de un compuesto de la fórmula 7 en donde alquilo es de 1-6 átomos de carbono, que comprende, a) acilar un compuesto inicial de la fórmula 3 en donde alquilo es de 1-6 átomos de carbono, con un compuesto de la fórmula 4 bajo condiciones eficaces para producir una mezcla de regioisómeros de la fórmula 5 en donde alquilo es de 1-6 átomos de carbono; y b) recuperar de la mezcla de regioisómeros el compuesto de la fórmula 1 en donde alquilo es de 1-6 átomos de carbono; c) convertir el compuesto de la etapa b) en el compuesto derivado de piperidina de la fórmula 2 en donde alquilo es de 1-6 átomos de carbono, con un compuesto de piperidina de la fórmula 8 y d) reducir el compuesto derivado de piperidina preparado en la etapa c); en donde dicha reducción en la etapa a) se lleva a cabo usando borano-metil sulfuro. Además se relaciona con intermediarios sintéticos útiles en los procesos de preparación de los derivados de piperidina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29839701P | 2001-06-15 | 2001-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037005A1 true AR037005A1 (es) | 2004-10-20 |
Family
ID=23150325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102261A AR037005A1 (es) | 2001-06-15 | 2002-06-14 | Derivados de acidos dimetilfenilaceticos, derivados de piperidina, y proceso para la produccion de derivados de piperidina. |
Country Status (23)
Country | Link |
---|---|
US (2) | US6743941B2 (es) |
EP (1) | EP1401816B1 (es) |
JP (1) | JP4344230B2 (es) |
KR (1) | KR100903285B1 (es) |
CN (1) | CN1229347C (es) |
AR (1) | AR037005A1 (es) |
AT (1) | ATE386021T1 (es) |
AU (1) | AU2002320847B2 (es) |
BR (1) | BR0210410A (es) |
CA (1) | CA2450313C (es) |
DE (1) | DE60225008T2 (es) |
DK (1) | DK1401816T3 (es) |
ES (1) | ES2298384T3 (es) |
HK (1) | HK1063795A1 (es) |
HU (1) | HUP0401125A2 (es) |
IL (2) | IL159304A0 (es) |
MX (1) | MXPA03010960A (es) |
NO (1) | NO20035572L (es) |
NZ (1) | NZ530153A (es) |
PL (1) | PL364369A1 (es) |
PT (1) | PT1401816E (es) |
WO (1) | WO2002102776A1 (es) |
ZA (1) | ZA200308697B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7498345B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
CN100453522C (zh) * | 2005-01-26 | 2009-01-21 | 中国科学技术大学 | 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法 |
WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
ITMI20061491A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
CN102070570A (zh) * | 2009-11-21 | 2011-05-25 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法 |
CN102070490B (zh) * | 2009-11-21 | 2014-07-30 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法 |
US10751332B2 (en) | 2015-06-15 | 2020-08-25 | Asana Biosciences, Llc | Heterocyclic inhibitors of ERK1 and ERK2 and their use in the treatment of cancer |
CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
CA3002425C (en) | 2015-10-22 | 2023-10-17 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of fexofenadine and of intermediates used therein |
TW202128665A (zh) | 2019-10-28 | 2021-08-01 | 美商阿沙納生物科學公司 | 使用erk1與erk2之雜環抑制劑之改良之方法、套組、組成物及給藥攝生法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2946809A1 (de) * | 1979-11-20 | 1981-06-11 | A. Nattermann & Cie GmbH, 5000 Köln | 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel |
IT1200123B (it) | 1985-09-27 | 1989-01-05 | Ind Chimica Srl | Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo |
EP0347123A3 (en) | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
IT1249684B (it) | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
EP0635004B1 (en) * | 1992-04-10 | 2002-07-17 | Merrell Pharmaceuticals Inc. | 4-diphenylmethyl piperidine derivatives and process for their preparation |
ATE254594T1 (de) | 1993-06-24 | 2003-12-15 | Albany Molecular Res Inc | Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate |
-
2002
- 2002-06-11 US US10/166,893 patent/US6743941B2/en not_active Expired - Lifetime
- 2002-06-12 IL IL15930402A patent/IL159304A0/xx unknown
- 2002-06-12 JP JP2003505319A patent/JP4344230B2/ja not_active Expired - Fee Related
- 2002-06-12 ES ES02754657T patent/ES2298384T3/es not_active Expired - Lifetime
- 2002-06-12 KR KR1020037016429A patent/KR100903285B1/ko not_active IP Right Cessation
- 2002-06-12 HU HU0401125A patent/HUP0401125A2/hu unknown
- 2002-06-12 WO PCT/EP2002/006424 patent/WO2002102776A1/en active IP Right Grant
- 2002-06-12 CN CNB028119312A patent/CN1229347C/zh not_active Expired - Fee Related
- 2002-06-12 MX MXPA03010960A patent/MXPA03010960A/es active IP Right Grant
- 2002-06-12 EP EP02754657A patent/EP1401816B1/en not_active Expired - Lifetime
- 2002-06-12 PT PT02754657T patent/PT1401816E/pt unknown
- 2002-06-12 AT AT02754657T patent/ATE386021T1/de active
- 2002-06-12 BR BR0210410-5A patent/BR0210410A/pt not_active IP Right Cessation
- 2002-06-12 AU AU2002320847A patent/AU2002320847B2/en not_active Ceased
- 2002-06-12 NZ NZ530153A patent/NZ530153A/en not_active IP Right Cessation
- 2002-06-12 CA CA2450313A patent/CA2450313C/en not_active Expired - Fee Related
- 2002-06-12 DE DE60225008T patent/DE60225008T2/de not_active Expired - Lifetime
- 2002-06-12 PL PL02364369A patent/PL364369A1/xx not_active Application Discontinuation
- 2002-06-12 DK DK02754657T patent/DK1401816T3/da active
- 2002-06-14 AR ARP020102261A patent/AR037005A1/es unknown
-
2003
- 2003-11-07 ZA ZA200308697A patent/ZA200308697B/en unknown
- 2003-12-10 IL IL159304A patent/IL159304A/en not_active IP Right Cessation
- 2003-12-12 NO NO20035572A patent/NO20035572L/no unknown
-
2004
- 2004-04-22 US US10/829,803 patent/US7235665B2/en not_active Expired - Lifetime
- 2004-09-03 HK HK04106643A patent/HK1063795A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2298384T3 (es) | 2008-05-16 |
PL364369A1 (en) | 2004-12-13 |
KR20040010720A (ko) | 2004-01-31 |
EP1401816A1 (en) | 2004-03-31 |
KR100903285B1 (ko) | 2009-06-17 |
IL159304A (en) | 2010-02-17 |
HK1063795A1 (en) | 2005-01-14 |
CA2450313C (en) | 2010-08-10 |
EP1401816B1 (en) | 2008-02-13 |
NZ530153A (en) | 2005-07-29 |
AU2002320847B2 (en) | 2007-09-20 |
US7235665B2 (en) | 2007-06-26 |
US6743941B2 (en) | 2004-06-01 |
PT1401816E (pt) | 2008-04-08 |
US20040198983A1 (en) | 2004-10-07 |
DE60225008D1 (de) | 2008-03-27 |
ATE386021T1 (de) | 2008-03-15 |
HUP0401125A2 (hu) | 2004-09-28 |
DK1401816T3 (da) | 2008-06-09 |
CN1516689A (zh) | 2004-07-28 |
WO2002102776A1 (en) | 2002-12-27 |
ZA200308697B (en) | 2004-09-03 |
DE60225008T2 (de) | 2009-01-29 |
JP4344230B2 (ja) | 2009-10-14 |
JP2005502603A (ja) | 2005-01-27 |
IL159304A0 (en) | 2004-06-01 |
NO20035572D0 (no) | 2003-12-12 |
US20030105329A1 (en) | 2003-06-05 |
NO20035572L (no) | 2004-02-16 |
CA2450313A1 (en) | 2002-12-27 |
CN1229347C (zh) | 2005-11-30 |
MXPA03010960A (es) | 2004-02-27 |
BR0210410A (pt) | 2004-08-17 |
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Legal Events
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FB | Suspension of granting procedure |