ATE386021T1 - Verfahren zur herstellung des piperidinderivats fexofenadin - Google Patents
Verfahren zur herstellung des piperidinderivats fexofenadinInfo
- Publication number
- ATE386021T1 ATE386021T1 AT02754657T AT02754657T ATE386021T1 AT E386021 T1 ATE386021 T1 AT E386021T1 AT 02754657 T AT02754657 T AT 02754657T AT 02754657 T AT02754657 T AT 02754657T AT E386021 T1 ATE386021 T1 AT E386021T1
- Authority
- AT
- Austria
- Prior art keywords
- fexofenadine
- producing
- piperidine derivative
- piperidine
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29839701P | 2001-06-15 | 2001-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE386021T1 true ATE386021T1 (de) | 2008-03-15 |
Family
ID=23150325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02754657T ATE386021T1 (de) | 2001-06-15 | 2002-06-12 | Verfahren zur herstellung des piperidinderivats fexofenadin |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6743941B2 (de) |
| EP (1) | EP1401816B1 (de) |
| JP (1) | JP4344230B2 (de) |
| KR (1) | KR100903285B1 (de) |
| CN (1) | CN1229347C (de) |
| AR (1) | AR037005A1 (de) |
| AT (1) | ATE386021T1 (de) |
| AU (1) | AU2002320847B2 (de) |
| BR (1) | BR0210410A (de) |
| CA (1) | CA2450313C (de) |
| DE (1) | DE60225008T2 (de) |
| DK (1) | DK1401816T3 (de) |
| ES (1) | ES2298384T3 (de) |
| HK (1) | HK1063795A1 (de) |
| HU (1) | HUP0401125A2 (de) |
| IL (2) | IL159304A0 (de) |
| MX (1) | MXPA03010960A (de) |
| NO (1) | NO20035572L (de) |
| NZ (1) | NZ530153A (de) |
| PL (1) | PL364369A1 (de) |
| PT (1) | PT1401816E (de) |
| WO (1) | WO2002102776A1 (de) |
| ZA (1) | ZA200308697B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7498345B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
| CN100453522C (zh) * | 2005-01-26 | 2009-01-21 | 中国科学技术大学 | 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法 |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| ITMI20061491A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| CN102070490B (zh) * | 2009-11-21 | 2014-07-30 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法 |
| CN102070570A (zh) * | 2009-11-21 | 2011-05-25 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法 |
| RU2017139727A (ru) | 2015-06-15 | 2019-07-16 | АСАНА БАЙОСАЙЕНСИЗ, ЭлЭлСи | Гетероциклические ингибиторы erk1 и erk2 и их применение для лечения злокачественного новообразования |
| CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
| DK3365327T3 (da) | 2015-10-22 | 2020-02-24 | Sanofi Aventis Deutschland | Fremgangsmåde til fremstilling af fexofenadin og mellemprodukter, der anvendes deri |
| US20230027072A1 (en) | 2019-10-28 | 2023-01-26 | Asana Biosciences, Llc | Improved methods, kits, compositions and dosing regimens for the use of heterocyclic inhibitors of erk1 and erk2 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2946809A1 (de) * | 1979-11-20 | 1981-06-11 | A. Nattermann & Cie GmbH, 5000 Köln | 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| IT1200123B (it) | 1985-09-27 | 1989-01-05 | Ind Chimica Srl | Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo |
| EP0347123A3 (de) | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl-, -cycloheptyl- und -oxepinylamine mit antihistaminischer Aktivität |
| IT1249684B (it) | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
| WO1993021156A1 (en) * | 1992-04-10 | 1993-10-28 | Merrell Dow Pharmaceuticals Inc. | 4-diphenylmethyl piperidine derivatives and process for their preparation |
| AU670004B2 (en) | 1993-06-24 | 1996-06-27 | Albany Molecular Research, Inc. | Piperidine derivatives and process for their production |
-
2002
- 2002-06-11 US US10/166,893 patent/US6743941B2/en not_active Expired - Lifetime
- 2002-06-12 JP JP2003505319A patent/JP4344230B2/ja not_active Expired - Fee Related
- 2002-06-12 MX MXPA03010960A patent/MXPA03010960A/es active IP Right Grant
- 2002-06-12 CA CA2450313A patent/CA2450313C/en not_active Expired - Fee Related
- 2002-06-12 DE DE60225008T patent/DE60225008T2/de not_active Expired - Lifetime
- 2002-06-12 HU HU0401125A patent/HUP0401125A2/hu unknown
- 2002-06-12 PL PL02364369A patent/PL364369A1/xx not_active Application Discontinuation
- 2002-06-12 BR BR0210410-5A patent/BR0210410A/pt not_active IP Right Cessation
- 2002-06-12 IL IL15930402A patent/IL159304A0/xx unknown
- 2002-06-12 AT AT02754657T patent/ATE386021T1/de active
- 2002-06-12 AU AU2002320847A patent/AU2002320847B2/en not_active Ceased
- 2002-06-12 EP EP02754657A patent/EP1401816B1/de not_active Expired - Lifetime
- 2002-06-12 PT PT02754657T patent/PT1401816E/pt unknown
- 2002-06-12 WO PCT/EP2002/006424 patent/WO2002102776A1/en active IP Right Grant
- 2002-06-12 DK DK02754657T patent/DK1401816T3/da active
- 2002-06-12 ES ES02754657T patent/ES2298384T3/es not_active Expired - Lifetime
- 2002-06-12 CN CNB028119312A patent/CN1229347C/zh not_active Expired - Fee Related
- 2002-06-12 KR KR1020037016429A patent/KR100903285B1/ko not_active IP Right Cessation
- 2002-06-12 NZ NZ530153A patent/NZ530153A/en not_active IP Right Cessation
- 2002-06-14 AR ARP020102261A patent/AR037005A1/es unknown
-
2003
- 2003-11-07 ZA ZA200308697A patent/ZA200308697B/en unknown
- 2003-12-10 IL IL159304A patent/IL159304A/en not_active IP Right Cessation
- 2003-12-12 NO NO20035572A patent/NO20035572L/no unknown
-
2004
- 2004-04-22 US US10/829,803 patent/US7235665B2/en not_active Expired - Lifetime
- 2004-09-03 HK HK04106643A patent/HK1063795A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60225008T2 (de) | 2009-01-29 |
| BR0210410A (pt) | 2004-08-17 |
| HK1063795A1 (en) | 2005-01-14 |
| AR037005A1 (es) | 2004-10-20 |
| US20030105329A1 (en) | 2003-06-05 |
| KR100903285B1 (ko) | 2009-06-17 |
| US6743941B2 (en) | 2004-06-01 |
| KR20040010720A (ko) | 2004-01-31 |
| JP2005502603A (ja) | 2005-01-27 |
| NO20035572L (no) | 2004-02-16 |
| US20040198983A1 (en) | 2004-10-07 |
| CA2450313C (en) | 2010-08-10 |
| AU2002320847B2 (en) | 2007-09-20 |
| IL159304A0 (en) | 2004-06-01 |
| NZ530153A (en) | 2005-07-29 |
| HUP0401125A2 (hu) | 2004-09-28 |
| DK1401816T3 (da) | 2008-06-09 |
| CA2450313A1 (en) | 2002-12-27 |
| CN1229347C (zh) | 2005-11-30 |
| ES2298384T3 (es) | 2008-05-16 |
| PL364369A1 (en) | 2004-12-13 |
| DE60225008D1 (de) | 2008-03-27 |
| IL159304A (en) | 2010-02-17 |
| EP1401816A1 (de) | 2004-03-31 |
| JP4344230B2 (ja) | 2009-10-14 |
| MXPA03010960A (es) | 2004-02-27 |
| EP1401816B1 (de) | 2008-02-13 |
| US7235665B2 (en) | 2007-06-26 |
| CN1516689A (zh) | 2004-07-28 |
| WO2002102776A1 (en) | 2002-12-27 |
| NO20035572D0 (no) | 2003-12-12 |
| PT1401816E (pt) | 2008-04-08 |
| ZA200308697B (en) | 2004-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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