HUP0401125A2 - Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállítására - Google Patents
Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállításáraInfo
- Publication number
- HUP0401125A2 HUP0401125A2 HU0401125A HUP0401125A HUP0401125A2 HU P0401125 A2 HUP0401125 A2 HU P0401125A2 HU 0401125 A HU0401125 A HU 0401125A HU P0401125 A HUP0401125 A HU P0401125A HU P0401125 A2 HUP0401125 A2 HU P0401125A2
- Authority
- HU
- Hungary
- Prior art keywords
- production
- fexofenadine
- new intermediates
- hydroxyl
- group
- Prior art date
Links
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003592 fexofenadine Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940008201 allegra Drugs 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya eljárás piperedinszármazékok, többek között az (F)képletű fexofenadine előállítására, amely az Amerikai EgyesültÁllamokban <Allegra< néven forgalomban levő nem szedáló antihisztamingyógyszerkészítmény hatóanyaga. A találmány továbbá az eljárásbanalkalmazható (III), (Illa) és (VI) általános képletű újintermedierekre vonatkozik, a képletekben n értéke 0 vagy 1; R1jelentése hidrogénatom vagy hidroxilcsoport; R2 jelentése hidrogénatomvagy pedig az R1 szubsztituenssel együtt egy második kötést alkot; R3jelentése COOH, COOalkil-, adott esetben védett hidroxil-, ciano-,CONH2, CONHalkil vagy CON(alkil)2 képletű csoport; A, B és D jelentésehidrogén- vagy halogénatom, alkil-, hidroxil- vagy alkoxicsoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29839701P | 2001-06-15 | 2001-06-15 | |
| PCT/EP2002/006424 WO2002102776A1 (en) | 2001-06-15 | 2002-06-12 | Process for the production of the piperidine derivative fexofenadine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0401125A2 true HUP0401125A2 (hu) | 2004-09-28 |
Family
ID=23150325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401125A HUP0401125A2 (hu) | 2001-06-15 | 2002-06-12 | Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállítására |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6743941B2 (hu) |
| EP (1) | EP1401816B1 (hu) |
| JP (1) | JP4344230B2 (hu) |
| KR (1) | KR100903285B1 (hu) |
| CN (1) | CN1229347C (hu) |
| AR (1) | AR037005A1 (hu) |
| AT (1) | ATE386021T1 (hu) |
| AU (1) | AU2002320847B2 (hu) |
| BR (1) | BR0210410A (hu) |
| CA (1) | CA2450313C (hu) |
| DE (1) | DE60225008T2 (hu) |
| DK (1) | DK1401816T3 (hu) |
| ES (1) | ES2298384T3 (hu) |
| HK (1) | HK1063795A1 (hu) |
| HU (1) | HUP0401125A2 (hu) |
| IL (2) | IL159304A0 (hu) |
| MX (1) | MXPA03010960A (hu) |
| NO (1) | NO20035572L (hu) |
| NZ (1) | NZ530153A (hu) |
| PL (1) | PL364369A1 (hu) |
| PT (1) | PT1401816E (hu) |
| WO (1) | WO2002102776A1 (hu) |
| ZA (1) | ZA200308697B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
| US7498345B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| CN100453522C (zh) * | 2005-01-26 | 2009-01-21 | 中国科学技术大学 | 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法 |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| ITMI20061491A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| CN102070490B (zh) * | 2009-11-21 | 2014-07-30 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法 |
| CN102070570A (zh) * | 2009-11-21 | 2011-05-25 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法 |
| PL3842429T3 (pl) | 2015-06-15 | 2023-02-20 | Asana Biosciences, Llc | Heterocykliczne inhibitory ERK1 i ERK2 oraz ich zastosowanie w leczeniu nowotworu złośliwego |
| CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
| DK3365327T3 (da) | 2015-10-22 | 2020-02-24 | Sanofi Aventis Deutschland | Fremgangsmåde til fremstilling af fexofenadin og mellemprodukter, der anvendes deri |
| TW202128665A (zh) | 2019-10-28 | 2021-08-01 | 美商阿沙納生物科學公司 | 使用ｅｒｋ１與ｅｒｋ２之雜環抑制劑之改良之方法、套組、組成物及給藥攝生法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2946809A1 (de) * | 1979-11-20 | 1981-06-11 | A. Nattermann & Cie GmbH, 5000 Köln | 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| IT1200123B (it) | 1985-09-27 | 1989-01-05 | Ind Chimica Srl | Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo |
| EP0347123A3 (en) | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
| IT1249684B (it) | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
| DK0635004T3 (da) * | 1992-04-10 | 2002-11-11 | Merrell Pharma Inc | 4-Diphenylmethylpiperidinderivater og fremgangsmåde til fremstilling deraf |
| HU226559B1 (en) | 1993-06-24 | 2009-03-30 | Amr Technology | Process for the production of piperidine derivatives |
-
2002
- 2002-06-11 US US10/166,893 patent/US6743941B2/en not_active Expired - Lifetime
- 2002-06-12 KR KR1020037016429A patent/KR100903285B1/ko not_active IP Right Cessation
- 2002-06-12 WO PCT/EP2002/006424 patent/WO2002102776A1/en active IP Right Grant
- 2002-06-12 HU HU0401125A patent/HUP0401125A2/hu unknown
- 2002-06-12 MX MXPA03010960A patent/MXPA03010960A/es active IP Right Grant
- 2002-06-12 DK DK02754657T patent/DK1401816T3/da active
- 2002-06-12 AU AU2002320847A patent/AU2002320847B2/en not_active Ceased
- 2002-06-12 NZ NZ530153A patent/NZ530153A/en not_active IP Right Cessation
- 2002-06-12 IL IL15930402A patent/IL159304A0/xx unknown
- 2002-06-12 PL PL02364369A patent/PL364369A1/xx not_active Application Discontinuation
- 2002-06-12 EP EP02754657A patent/EP1401816B1/en not_active Expired - Lifetime
- 2002-06-12 ES ES02754657T patent/ES2298384T3/es not_active Expired - Lifetime
- 2002-06-12 CA CA2450313A patent/CA2450313C/en not_active Expired - Fee Related
- 2002-06-12 CN CNB028119312A patent/CN1229347C/zh not_active Expired - Fee Related
- 2002-06-12 AT AT02754657T patent/ATE386021T1/de active
- 2002-06-12 BR BR0210410-5A patent/BR0210410A/pt not_active IP Right Cessation
- 2002-06-12 PT PT02754657T patent/PT1401816E/pt unknown
- 2002-06-12 JP JP2003505319A patent/JP4344230B2/ja not_active Expired - Fee Related
- 2002-06-12 DE DE60225008T patent/DE60225008T2/de not_active Expired - Lifetime
- 2002-06-14 AR ARP020102261A patent/AR037005A1/es unknown
-
2003
- 2003-11-07 ZA ZA200308697A patent/ZA200308697B/en unknown
- 2003-12-10 IL IL159304A patent/IL159304A/en not_active IP Right Cessation
- 2003-12-12 NO NO20035572A patent/NO20035572L/no unknown
-
2004
- 2004-04-22 US US10/829,803 patent/US7235665B2/en not_active Expired - Lifetime
- 2004-09-03 HK HK04106643A patent/HK1063795A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1063795A1 (en) | 2005-01-14 |
| ATE386021T1 (de) | 2008-03-15 |
| NZ530153A (en) | 2005-07-29 |
| IL159304A (en) | 2010-02-17 |
| CA2450313A1 (en) | 2002-12-27 |
| CN1516689A (zh) | 2004-07-28 |
| MXPA03010960A (es) | 2004-02-27 |
| PL364369A1 (en) | 2004-12-13 |
| NO20035572L (no) | 2004-02-16 |
| BR0210410A (pt) | 2004-08-17 |
| WO2002102776A1 (en) | 2002-12-27 |
| CN1229347C (zh) | 2005-11-30 |
| DE60225008D1 (de) | 2008-03-27 |
| JP4344230B2 (ja) | 2009-10-14 |
| KR100903285B1 (ko) | 2009-06-17 |
| AU2002320847B2 (en) | 2007-09-20 |
| US7235665B2 (en) | 2007-06-26 |
| EP1401816A1 (en) | 2004-03-31 |
| JP2005502603A (ja) | 2005-01-27 |
| CA2450313C (en) | 2010-08-10 |
| EP1401816B1 (en) | 2008-02-13 |
| US6743941B2 (en) | 2004-06-01 |
| KR20040010720A (ko) | 2004-01-31 |
| ES2298384T3 (es) | 2008-05-16 |
| ZA200308697B (en) | 2004-09-03 |
| IL159304A0 (en) | 2004-06-01 |
| PT1401816E (pt) | 2008-04-08 |
| US20040198983A1 (en) | 2004-10-07 |
| NO20035572D0 (no) | 2003-12-12 |
| DE60225008T2 (de) | 2009-01-29 |
| AR037005A1 (es) | 2004-10-20 |
| US20030105329A1 (en) | 2003-06-05 |
| DK1401816T3 (da) | 2008-06-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0401125A2 (hu) | Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállítására | |
| HUP0300434A2 (hu) | Oxazolszármazékok és alkalmazásuk tirozin-kináz-inhibitorként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0302487A2 (hu) | Új mandulasavszármazékok és felhasználásuk trombin inhibitorokként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0203206A2 (hu) | Eljárás 4-trifluormetilszulfinilpirazol-származékok előállítására | |
| HUP0303084A2 (hu) | Gyulladásgátló hatású 17béta-karbotioát-17alfa-arilkarboniloxiloxi androsztán-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0003309A2 (hu) | Imidazolilcsoportot tartalmazó gyűrűs acetálok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
| DE69904302D1 (de) | Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung | |
| NO20051600L (no) | 1,4-disubstituerte piperidinderivater og anvendelse derav som 11-betaHSD1 inhibitorer | |
| HUP0302792A2 (hu) | Dipeptidil peptidáz ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0400704A2 (hu) | Heterociklusos éterrel szubsztituált imidazokinolinok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0302157A2 (hu) | 4-(2-Fenil-tiazol-5-il)-1,4-diazabiciklo[3.2.2]nonán-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények | |
| NO20060147L (no) | Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav | |
| HUP0401886A2 (hu) | Kemokin receptor aktivitás modulátorokként alkalmazható piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| DE69308029D1 (de) | 1,2,3,5,6,7,8,8a-OCTAHYDRO-5,5,8a-TRIMETHYL-(8aBETA)-6-ISOCHINOLINAMINE-DERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS THERAPEUTIKA | |
| WO2004048340A8 (en) | Sinomenine and sinomenine compounds, synthesis and use | |
| NO20060146L (no) | Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav | |
| HUP0303043A2 (hu) | Orrgyógyászatilag aktív vegyületek | |
| DE69401584T2 (de) | Beta,beta-dimethyl-4-piperidinethanamin-derivate als inhibitoren der cholesterin-biosynthese | |
| AR003469A1 (es) | 2-(4-sustituido)-bencilamino-2-metil-propanamidas, su uso, procedimiento para su preparación y composiciones farmaceuticas que las contienen. | |
| HUP0100684A2 (hu) | Szubsztituált krománszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| AU4397501A (en) | Process of making racemic bupivacaine's enantiomers, levobupivacaine's pharmaceutical compositions, levobupivacaine's pharmaceutical compositions formulated on its free base form or its pharmaceutical acceptable salts and use of levobupivacaine's pharmaceutical compositions formulated on its free base form | |
| DK1187803T3 (da) | Amorfe salpetersyreestere og deres farmaceutiske sammensætninger | |
| HUP0203884A2 (hu) | Kristályos oximinoalkánsav-származékok és cukorbaj elleni alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| CA2281918A1 (en) | Oxazolidines as 5-ht2a-antagonists | |
| MXPA02004441A (es) | Derivados de isoxazol como inhibidores de la fosfodiesterasa. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |