DE69401584T2 - Beta,beta-dimethyl-4-piperidinethanamin-derivate als inhibitoren der cholesterin-biosynthese - Google Patents
Beta,beta-dimethyl-4-piperidinethanamin-derivate als inhibitoren der cholesterin-biosyntheseInfo
- Publication number
- DE69401584T2 DE69401584T2 DE69401584T DE69401584T DE69401584T2 DE 69401584 T2 DE69401584 T2 DE 69401584T2 DE 69401584 T DE69401584 T DE 69401584T DE 69401584 T DE69401584 T DE 69401584T DE 69401584 T2 DE69401584 T2 DE 69401584T2
- Authority
- DE
- Germany
- Prior art keywords
- beta
- inhibitors
- pct
- dimethyl
- biosynthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9305915A FR2705343B1 (fr) | 1993-05-17 | 1993-05-17 | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
PCT/FR1994/000584 WO1994026713A1 (fr) | 1993-05-17 | 1994-05-17 | Derives de beta, beta-dimethyl-4-piperidineethanamine comme inhibiteurs de la biosynthese du cholesterol |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69401584D1 DE69401584D1 (de) | 1997-03-06 |
DE69401584T2 true DE69401584T2 (de) | 1997-05-22 |
Family
ID=9447204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69401584T Expired - Fee Related DE69401584T2 (de) | 1993-05-17 | 1994-05-17 | Beta,beta-dimethyl-4-piperidinethanamin-derivate als inhibitoren der cholesterin-biosynthese |
Country Status (9)
Country | Link |
---|---|
US (1) | US5614534A (de) |
EP (1) | EP0699187B1 (de) |
JP (1) | JPH08510726A (de) |
AT (1) | ATE148108T1 (de) |
CA (1) | CA2163001A1 (de) |
DE (1) | DE69401584T2 (de) |
ES (1) | ES2098947T3 (de) |
FR (1) | FR2705343B1 (de) |
WO (1) | WO1994026713A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4410822A1 (de) * | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
US6964974B2 (en) * | 2000-09-08 | 2005-11-15 | Hoffmann-La Roche Inc. | 2,3-oxidosqualene-lanosterol cyclase inhibitors |
TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
US7687665B2 (en) | 2004-06-24 | 2010-03-30 | Incyte Corporation | 2-methylprop anamides and their use as pharmaceuticals |
AU2005267331A1 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
US20060009471A1 (en) * | 2004-06-24 | 2006-01-12 | Wenqing Yao | Amido compounds and their use as pharmaceuticals |
US20060009491A1 (en) * | 2004-06-24 | 2006-01-12 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
EP1758580A4 (de) * | 2004-06-24 | 2008-01-16 | Incyte Corp | N-substituierte piperidine und ihre verwendung als arzneimittel |
MX2007001540A (es) * | 2004-08-10 | 2007-04-23 | Incyte Corp | Compuestos amido y sus usos como farmaceuticos. |
US8110581B2 (en) * | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
ES2547724T3 (es) * | 2004-11-10 | 2015-10-08 | Incyte Corporation | Compuestos de lactama y su uso como productos farmacéuticos |
JP2008520700A (ja) * | 2004-11-18 | 2008-06-19 | インサイト・コーポレイション | 11−βヒドロキシルステロイドデヒドロゲナーゼタイプIの阻害剤およびその使用方法 |
WO2007038138A2 (en) * | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
KR101415861B1 (ko) * | 2005-12-05 | 2014-07-04 | 인사이트 코포레이션 | 락탐 화합물 및 이를 사용하는 방법 |
US7998959B2 (en) * | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
CA2635814A1 (en) * | 2006-01-31 | 2007-08-09 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
US20070213311A1 (en) * | 2006-03-02 | 2007-09-13 | Yun-Long Li | Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
JP2009535420A (ja) * | 2006-05-01 | 2009-10-01 | インサイト・コーポレイション | 11−βヒドロキシルステロイドデヒドロゲナーゼタイプ1のモジュレーターとしてのテトラ置換ウレア |
US7838544B2 (en) * | 2006-05-17 | 2010-11-23 | Incyte Corporation | Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same |
PT2032364E (pt) | 2006-06-23 | 2011-03-17 | Kba Giori Sa | Dispositivo de numeração para executar numeração tipográfica |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB991509A (en) * | 1963-10-15 | 1965-05-12 | Parke Davis & Co | Aminoalkylpiperidinoalkyl-ª‡-naphthylamines |
US4248877A (en) * | 1973-06-22 | 1981-02-03 | Sandoz Ltd. | Organic compounds |
JPS5195049A (en) * | 1975-02-12 | 1976-08-20 | * **********so*****no***tsu*****************************************ni*no | |
US4473694A (en) * | 1981-04-03 | 1984-09-25 | The B. F. Goodrich Company | Process for the preparation of polysubstituted α-aminoacetamides |
US4569933A (en) * | 1984-04-13 | 1986-02-11 | Cornu Pierre Jean | Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole |
DK674487A (da) * | 1986-12-22 | 1988-06-23 | Zambeletti Spa L | Piperidinderivater |
US4939161A (en) * | 1989-05-12 | 1990-07-03 | Boc, Inc. | Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides |
CA2025490C (en) * | 1989-09-22 | 2003-09-16 | James R. Mccarthy | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis |
ZA915660B (en) * | 1990-07-24 | 1992-05-27 | Merrell Dow Pharma | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis |
JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
-
1993
- 1993-05-17 FR FR9305915A patent/FR2705343B1/fr not_active Expired - Fee Related
-
1994
- 1994-05-17 AT AT94916294T patent/ATE148108T1/de not_active IP Right Cessation
- 1994-05-17 DE DE69401584T patent/DE69401584T2/de not_active Expired - Fee Related
- 1994-05-17 JP JP6525084A patent/JPH08510726A/ja active Pending
- 1994-05-17 WO PCT/FR1994/000584 patent/WO1994026713A1/fr active IP Right Grant
- 1994-05-17 CA CA002163001A patent/CA2163001A1/en not_active Abandoned
- 1994-05-17 ES ES94916294T patent/ES2098947T3/es not_active Expired - Lifetime
- 1994-05-17 EP EP94916294A patent/EP0699187B1/de not_active Expired - Lifetime
- 1994-05-17 US US08/545,626 patent/US5614534A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2705343B1 (fr) | 1995-07-21 |
EP0699187A1 (de) | 1996-03-06 |
ES2098947T3 (es) | 1997-05-01 |
EP0699187B1 (de) | 1997-01-22 |
WO1994026713A1 (fr) | 1994-11-24 |
FR2705343A1 (fr) | 1994-11-25 |
CA2163001A1 (en) | 1994-11-24 |
ATE148108T1 (de) | 1997-02-15 |
DE69401584D1 (de) | 1997-03-06 |
US5614534A (en) | 1997-03-25 |
JPH08510726A (ja) | 1996-11-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |