ES2098947T3 - Derivados de beta,beta-dimetil-4-piperidinoetanamina como inhibidores de la biosintesis del colesterol. - Google Patents
Derivados de beta,beta-dimetil-4-piperidinoetanamina como inhibidores de la biosintesis del colesterol.Info
- Publication number
- ES2098947T3 ES2098947T3 ES94916294T ES94916294T ES2098947T3 ES 2098947 T3 ES2098947 T3 ES 2098947T3 ES 94916294 T ES94916294 T ES 94916294T ES 94916294 T ES94916294 T ES 94916294T ES 2098947 T3 ES2098947 T3 ES 2098947T3
- Authority
- ES
- Spain
- Prior art keywords
- beta
- pct
- inhibitors
- cholesterol biosynthesis
- piperidinoetanamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A LOS BE , BE -DIMETIL.-4PIPERIDINO-ETANAMINA (I) (DONDE LOS GRUPO R{SUB,1} A R{SUB,3} ESTAN DEFINIDOS COMO SE INDICA EN LA DESCRIPCION). SE REFIERE TAMBIEN A SU PROCESO DE PREPARACION Y A SU UTILIZACION COMO AGENTES INHIBIDORES DE LA BIOSINTESIS DEL COLESTEROL, PARTICULARMENTE DE LA EPOXIESCUALENO CICLASA, UTIL COMO HIPOCOLESTEROLEMINANTES, HIPOLIPEMINANTES, ANTIATEROMATOSOS Y ANTIFUNGICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9305915A FR2705343B1 (fr) | 1993-05-17 | 1993-05-17 | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2098947T3 true ES2098947T3 (es) | 1997-05-01 |
Family
ID=9447204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94916294T Expired - Lifetime ES2098947T3 (es) | 1993-05-17 | 1994-05-17 | Derivados de beta,beta-dimetil-4-piperidinoetanamina como inhibidores de la biosintesis del colesterol. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5614534A (es) |
EP (1) | EP0699187B1 (es) |
JP (1) | JPH08510726A (es) |
AT (1) | ATE148108T1 (es) |
CA (1) | CA2163001A1 (es) |
DE (1) | DE69401584T2 (es) |
ES (1) | ES2098947T3 (es) |
FR (1) | FR2705343B1 (es) |
WO (1) | WO1994026713A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4410822A1 (de) * | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
US6964974B2 (en) | 2000-09-08 | 2005-11-15 | Hoffmann-La Roche Inc. | 2,3-oxidosqualene-lanosterol cyclase inhibitors |
TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
BRPI0512410A (pt) * | 2004-06-24 | 2008-03-04 | Incyte Corp | compostos de amido e seu uso como produtos farmacêuticos |
EP1768954A4 (en) | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS |
MXPA06014574A (es) * | 2004-06-24 | 2007-03-12 | Incyte Corp | Piperidinas n-sustituidas y su uso como farmaceuticos. |
EP1773773A4 (en) * | 2004-06-24 | 2009-07-29 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
EP1758882A4 (en) * | 2004-06-24 | 2008-01-23 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
EP1778229A4 (en) * | 2004-08-10 | 2009-06-17 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
KR101368228B1 (ko) * | 2004-11-10 | 2014-02-27 | 인사이트 코포레이션 | 락탐 화합물 및 약제로서의 이의 용도 |
US8110581B2 (en) * | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
EP1824842A4 (en) * | 2004-11-18 | 2009-08-26 | Incyte Corp | INHIBITORS OF 11-HYDROXYL STEROID DEHYDROGENASE TYPE 1 AND METHOD OF USE |
WO2007038138A2 (en) * | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
NZ568446A (en) * | 2005-12-05 | 2011-12-22 | Incyte Corp | Lactam compounds and methods of using the same as modulators of 11-beta hydroxyl steroid dehydrogenase 1 |
US7998959B2 (en) * | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
EP1979318A1 (en) * | 2006-01-31 | 2008-10-15 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
WO2007101270A1 (en) * | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
EP2013163A1 (en) * | 2006-05-01 | 2009-01-14 | Incyte Corporation | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 |
CA2652375A1 (en) * | 2006-05-17 | 2007-11-29 | Incyte Corporation | Heterocyclic inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type i and methods of using the same |
CA2656732C (en) | 2006-06-23 | 2016-01-12 | Kba-Giori S.A. | Numbering device for typographic numbering |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB991509A (en) * | 1963-10-15 | 1965-05-12 | Parke Davis & Co | Aminoalkylpiperidinoalkyl-ª‡-naphthylamines |
US4248877A (en) * | 1973-06-22 | 1981-02-03 | Sandoz Ltd. | Organic compounds |
JPS5195049A (en) * | 1975-02-12 | 1976-08-20 | * **********so*****no***tsu*****************************************ni*no | |
US4473694A (en) * | 1981-04-03 | 1984-09-25 | The B. F. Goodrich Company | Process for the preparation of polysubstituted α-aminoacetamides |
US4569933A (en) * | 1984-04-13 | 1986-02-11 | Cornu Pierre Jean | Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole |
US4879300A (en) * | 1986-12-22 | 1989-11-07 | Dr. Lo. Zambeletti S.P.A. | Novel piperidine derivatives |
US4939161A (en) * | 1989-05-12 | 1990-07-03 | Boc, Inc. | Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides |
CA2025490C (en) * | 1989-09-22 | 2003-09-16 | James R. Mccarthy | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis |
NZ239023A (en) * | 1990-07-24 | 1993-12-23 | Merrell Dow Pharma | N-substituted-hydroxyalkyl piperidine derivatives and pharmaceutical |
JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
-
1993
- 1993-05-17 FR FR9305915A patent/FR2705343B1/fr not_active Expired - Fee Related
-
1994
- 1994-05-17 AT AT94916294T patent/ATE148108T1/de not_active IP Right Cessation
- 1994-05-17 ES ES94916294T patent/ES2098947T3/es not_active Expired - Lifetime
- 1994-05-17 JP JP6525084A patent/JPH08510726A/ja active Pending
- 1994-05-17 CA CA002163001A patent/CA2163001A1/en not_active Abandoned
- 1994-05-17 DE DE69401584T patent/DE69401584T2/de not_active Expired - Fee Related
- 1994-05-17 EP EP94916294A patent/EP0699187B1/fr not_active Expired - Lifetime
- 1994-05-17 WO PCT/FR1994/000584 patent/WO1994026713A1/fr active IP Right Grant
- 1994-05-17 US US08/545,626 patent/US5614534A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69401584D1 (de) | 1997-03-06 |
ATE148108T1 (de) | 1997-02-15 |
EP0699187A1 (fr) | 1996-03-06 |
WO1994026713A1 (fr) | 1994-11-24 |
DE69401584T2 (de) | 1997-05-22 |
JPH08510726A (ja) | 1996-11-12 |
FR2705343B1 (fr) | 1995-07-21 |
US5614534A (en) | 1997-03-25 |
CA2163001A1 (en) | 1994-11-24 |
EP0699187B1 (fr) | 1997-01-22 |
FR2705343A1 (fr) | 1994-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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