DE69904302D1 - Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung - Google Patents
Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellungInfo
- Publication number
- DE69904302D1 DE69904302D1 DE69904302T DE69904302T DE69904302D1 DE 69904302 D1 DE69904302 D1 DE 69904302D1 DE 69904302 T DE69904302 T DE 69904302T DE 69904302 T DE69904302 T DE 69904302T DE 69904302 D1 DE69904302 D1 DE 69904302D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- farnesyl transferase
- piperid
- production
- transferase inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019980002777A KR100388789B1 (ko) | 1998-02-02 | 1998-02-02 | 피롤구조를갖는파네실전이효소억제제및그의제조방법 |
KR19980002776 | 1998-02-02 | ||
KR1019980028340A KR100388792B1 (ko) | 1998-02-02 | 1998-07-14 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
KR10-1998-0032150A KR100388794B1 (ko) | 1998-08-07 | 1998-08-07 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
PCT/KR1999/000051 WO1999038862A1 (en) | 1998-02-02 | 1999-02-01 | Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69904302D1 true DE69904302D1 (de) | 2003-01-16 |
DE69904302T2 DE69904302T2 (de) | 2003-08-14 |
Family
ID=27483262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69904302T Expired - Fee Related DE69904302T2 (de) | 1998-02-02 | 1999-02-01 | Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung |
Country Status (12)
Country | Link |
---|---|
US (1) | US6436960B1 (de) |
EP (1) | EP1058683B1 (de) |
JP (1) | JP3283032B2 (de) |
CN (1) | CN1158277C (de) |
AT (1) | ATE229017T1 (de) |
AU (1) | AU745855B2 (de) |
BR (1) | BR9908545A (de) |
CA (1) | CA2320233C (de) |
DE (1) | DE69904302T2 (de) |
ES (1) | ES2185307T3 (de) |
PT (1) | PT1058683E (de) |
WO (1) | WO1999038862A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100388792B1 (ko) * | 1998-02-02 | 2003-09-22 | 주식회사 엘지생명과학 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
KR100388794B1 (ko) * | 1998-08-07 | 2003-10-10 | 주식회사 엘지생명과학 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
US6511978B1 (en) * | 1999-04-13 | 2003-01-28 | Lg Life Sciences, Ltd. | Pyrrole derivatives useful for farnesyl transferase inhibitors and their preparations |
KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-{〔1-(1,3-벤조디옥솔-5-일메틸-1h-이미다졸-5-일〕메틸}-4-(1-나프틸)-1h-피롤-3-일〕(4-메틸-1-피페라지닐)메타논의 약학적 조성물 |
US7035932B1 (en) * | 2000-10-27 | 2006-04-25 | Eric Morgan Dowling | Federated multiprotocol communication |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
NZ540148A (en) | 2002-12-20 | 2007-11-30 | Glaxo Group Ltd | Benzazepine derivatives for the treatment of neurological disorders |
KR20120035234A (ko) | 2003-04-11 | 2012-04-13 | 메디뮨 엘엘씨 | 재조합 il?9 항체 및 그의 용도 |
WO2005042743A2 (en) | 2003-08-18 | 2005-05-12 | Medimmune, Inc. | Humanization of antibodies |
KR20060101488A (ko) * | 2003-10-17 | 2006-09-25 | 인사이트 코포레이션 | 매트릭스 메탈로프로테이나제의 억제제로서의 치환된시클릭 히드록사메이트 |
AU2005299355A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
JP5153613B2 (ja) | 2005-03-18 | 2013-02-27 | メディミューン,エルエルシー | 抗体のフレームワーク・シャッフル |
CA2613512A1 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
MY162024A (en) | 2006-08-28 | 2017-05-31 | La Jolla Inst Allergy & Immunology | Antagonistic human light-specific human monoclonal antibodies |
EP2068923A4 (de) | 2007-03-30 | 2010-11-24 | Medimmune Llc | Antikörper mit verminderten deamidierungsprofilen |
EP2668210B1 (de) | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anti-kit-antikörper und ihre verwendungen |
GB201107985D0 (en) | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
BR112015001459B1 (pt) | 2012-07-25 | 2023-02-14 | Celldex Therapeutics, Inc | Anticorpo isolado ou fragmento do mesmo, conjugado, usos dos mesmos, composição farmacêutica, polinucleotídeo, vetor, célula hospedeira, célula isolada, kit, método in vitro para inibir atividade da kit, método para produzir um anticorpo |
WO2014059028A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
EP3003390B1 (de) | 2013-06-06 | 2021-07-07 | Pierre Fabre Médicament | Anti-c10orf54-antikörper und verwendungen davon |
RU2699289C2 (ru) | 2013-08-26 | 2019-09-04 | Байонтек Рисерч Энд Дивелопмент, Инк. | НУКЛЕИНОВЫЕ КИСЛОТЫ, КОДИРУЮЩИЕ АНТИТЕЛА ПРОТИВ СИАЛИРОВАННОГО АНТИГЕНА ЛЬЮИСАа ЧЕЛОВЕКА |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
AU2015271685B2 (en) | 2014-06-04 | 2021-02-18 | Biontech Research And Development, Inc. | Human monoclonal antibodies to ganglioside GD2 |
US10766959B2 (en) | 2014-12-11 | 2020-09-08 | Pierre Fabre Medicament | Anti-C10ORF54 antibodies and uses thereof |
CN114504652A (zh) | 2015-03-03 | 2022-05-17 | 科马布有限公司 | 抗体、用途和方法 |
EP3383908A1 (de) | 2015-12-02 | 2018-10-10 | Stsciences, Inc. | Spezifische antikörper gegen glykosylierten btla (b- und t-lymphozyt-attenuator) |
EP3909983A1 (de) | 2015-12-02 | 2021-11-17 | STCube & Co. Inc. | Antikörper und moleküle, die immunspezifisch an btn1a1 binden, und therapeutische verwendungen davon |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
JP2020522512A (ja) | 2017-05-31 | 2020-07-30 | ストキューブ アンド シーオー., インコーポレイテッド | Btn1a1に免疫特異的に結合する抗体及び分子を用いて癌を治療する方法 |
JP7369038B2 (ja) | 2017-05-31 | 2023-10-25 | ストキューブ アンド シーオー., インコーポレイテッド | Btn1a1に免疫特異的に結合する抗体及び分子並びにその治療的使用 |
JP2020522562A (ja) | 2017-06-06 | 2020-07-30 | ストキューブ アンド シーオー., インコーポレイテッド | Btn1a1又はbtn1a1リガンドに結合する抗体及び分子を用いて癌を治療する方法 |
US11707522B2 (en) | 2017-10-13 | 2023-07-25 | Boehringer Ingelheim International Gmbh | Human antibodies to Tn antigen |
AU2019306165A1 (en) | 2018-07-20 | 2021-02-25 | Pierre Fabre Medicament | Receptor for vista |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
CZ229594A3 (en) * | 1992-03-25 | 1995-04-12 | Pfizer | Peptides, process of their preparation, their use and pharmaceutical compositions based thereon |
GB9312806D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
EP0891351A1 (de) * | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibitoren von farnesylprotein-transferase |
JP2000504023A (ja) * | 1996-04-03 | 2000-04-04 | メルク エンド カンパニー インコーポレーテッド | 癌治療方法 |
AU716153B2 (en) * | 1996-04-03 | 2000-02-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997036900A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997038665A2 (en) * | 1996-04-03 | 1997-10-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CN1188407C (zh) * | 1997-11-28 | 2005-02-09 | Lg化学株式会社 | 具有法尼基转移酶抑制活性的咪唑衍生物及其制备方法 |
-
1999
- 1999-02-01 AT AT99901979T patent/ATE229017T1/de not_active IP Right Cessation
- 1999-02-01 DE DE69904302T patent/DE69904302T2/de not_active Expired - Fee Related
- 1999-02-01 PT PT99901979T patent/PT1058683E/pt unknown
- 1999-02-01 US US09/601,426 patent/US6436960B1/en not_active Expired - Fee Related
- 1999-02-01 CN CNB99802581XA patent/CN1158277C/zh not_active Expired - Fee Related
- 1999-02-01 CA CA002320233A patent/CA2320233C/en not_active Expired - Fee Related
- 1999-02-01 BR BR9908545-3A patent/BR9908545A/pt not_active Application Discontinuation
- 1999-02-01 ES ES99901979T patent/ES2185307T3/es not_active Expired - Lifetime
- 1999-02-01 AU AU21886/99A patent/AU745855B2/en not_active Ceased
- 1999-02-01 JP JP2000529330A patent/JP3283032B2/ja not_active Expired - Fee Related
- 1999-02-01 EP EP99901979A patent/EP1058683B1/de not_active Expired - Lifetime
- 1999-02-01 WO PCT/KR1999/000051 patent/WO1999038862A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
PT1058683E (pt) | 2003-04-30 |
JP2002501918A (ja) | 2002-01-22 |
AU2188699A (en) | 1999-08-16 |
DE69904302T2 (de) | 2003-08-14 |
AU745855B2 (en) | 2002-04-11 |
EP1058683B1 (de) | 2002-12-04 |
WO1999038862A1 (en) | 1999-08-05 |
CA2320233C (en) | 2004-07-27 |
ATE229017T1 (de) | 2002-12-15 |
CA2320233A1 (en) | 1999-08-05 |
JP3283032B2 (ja) | 2002-05-20 |
BR9908545A (pt) | 2001-10-02 |
ES2185307T3 (es) | 2003-04-16 |
CN1289331A (zh) | 2001-03-28 |
EP1058683A1 (de) | 2000-12-13 |
CN1158277C (zh) | 2004-07-21 |
US6436960B1 (en) | 2002-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |