HUP0004238A2 - Farnezil-transzferáz inhibitor hatású imidazolszármazékok és eljárás előállításukra, valamint a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Farnezil-transzferáz inhibitor hatású imidazolszármazékok és eljárás előállításukra, valamint a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0004238A2 HUP0004238A2 HU0004238A HUP0004238A HUP0004238A2 HU P0004238 A2 HUP0004238 A2 HU P0004238A2 HU 0004238 A HU0004238 A HU 0004238A HU P0004238 A HUP0004238 A HU P0004238A HU P0004238 A2 HUP0004238 A2 HU P0004238A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- inhibitory activity
- imidazole derivatives
- formula
- preparation
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000007317 Farnesyltranstransferase Human genes 0.000 title 1
- 108010007508 Farnesyltranstransferase Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
A találmány tárgya az (1) általános képletű, új imidazolszármazékok,amelyek inhibitor-aktivitást mutatnak a famezil-transzferázzalszemben: ahol A jelentése többek között hidrogénatom, alkilcsoport,cikloalkilcsoport, piperidinil-csoport vagy adott esetbenszubsztituált fenilcsoport; Y jelentése többek között szubsztituáltpirrolil-, imidazolil-, pirazolil-, axazolil- vagy tiazolilcsoport;vagy gyógyszerészetileg elfogadható sóik vagy izomerjeik. A találmánytárgyához tartozik egy eljárás az (1) általános képletű vegyületekelőállítására; köztitermékek, amelyeket az (1) általános képletűvegyület előállításához használnak; és gyógyszerkészítmények, amelyekaz (1) általános képletű vegyületeket tartalmazzák hatóanyagként. Atalálmány szerinti gyógyszerkészítmények elsősorban a rákbetegség, aresztenózis, az ateroszklerózis és vírusbetegségek megelőzésére éskezelésére használhatók. Ó
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19970063858 | 1997-11-28 | ||
KR1019980011359A KR19990066679A (ko) | 1997-11-28 | 1998-03-31 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
KR1019980023698A KR20000002788A (ko) | 1998-06-23 | 1998-06-23 | 피라졸 구조를 갖는 파네실 전이효소 억제제 및그의 제조방법 |
KR1019980024423A KR19990062439A (ko) | 1997-11-28 | 1998-06-26 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
KR19980031512 | 1998-08-03 | ||
KR1019980046457A KR20000015758A (ko) | 1998-08-03 | 1998-10-30 | 피롤 구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
PCT/KR1998/000377 WO1999028315A1 (en) | 1997-11-28 | 1998-11-25 | Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0004238A2 true HUP0004238A2 (hu) | 2001-05-28 |
HUP0004238A3 HUP0004238A3 (en) | 2001-07-30 |
Family
ID=27555104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0004238A HUP0004238A3 (en) | 1997-11-28 | 1998-11-25 | Imidazole derivatives having an inhibitory activity for farnesyl transferase, process for preparation thereof and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
US (3) | US6268363B1 (hu) |
EP (1) | EP1045846B1 (hu) |
JP (2) | JP3548118B2 (hu) |
CN (1) | CN1188407C (hu) |
AR (1) | AR017700A1 (hu) |
AT (1) | ATE239014T1 (hu) |
AU (1) | AU731272B2 (hu) |
BR (1) | BR9815423A (hu) |
CA (1) | CA2310629A1 (hu) |
DE (1) | DE69814167T2 (hu) |
ES (1) | ES2193590T3 (hu) |
HU (1) | HUP0004238A3 (hu) |
ID (1) | ID24175A (hu) |
IL (1) | IL135473A0 (hu) |
NZ (1) | NZ504013A (hu) |
PL (1) | PL340729A1 (hu) |
RU (1) | RU2179975C1 (hu) |
WO (1) | WO1999028315A1 (hu) |
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DE69904302T2 (de) * | 1998-02-02 | 2003-08-14 | Lg Chemical Ltd | Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung |
KR100395300B1 (ko) * | 1999-08-11 | 2003-08-27 | 주식회사 엘지생명과학 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
ATE277039T1 (de) * | 1999-04-13 | 2004-10-15 | Lg Chem Investment Ltd | Farnesyltransferase-inhibitoren die eine pyrrolstruktur haben und verfahren zu ihrer herstellung |
FR2796943A1 (fr) * | 1999-07-30 | 2001-02-02 | Aventis Pharma Sa | Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique |
KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-{〔1-(1,3-벤조디옥솔-5-일메틸-1h-이미다졸-5-일〕메틸}-4-(1-나프틸)-1h-피롤-3-일〕(4-메틸-1-피페라지닐)메타논의 약학적 조성물 |
KR100412334B1 (ko) * | 2000-02-22 | 2003-12-31 | 주식회사 엘지생명과학 | 4-치환된-1h-피롤-3-카복실산 에스테르의 새로운 제조방법 |
AU2001244596A1 (en) * | 2000-03-30 | 2001-10-15 | Rei Asakai | Indolylpyrrole derivatives and cell death inhibitors |
AU2003237121A1 (en) * | 2002-04-26 | 2003-11-10 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
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RU2462463C2 (ru) * | 2002-08-23 | 2012-09-27 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч | Синтез эпотилонов, их промежуточных продуктов, аналогов и их применения |
EP1539234A4 (en) * | 2002-09-05 | 2006-02-15 | Medimmune Inc | METHODS OF PREVENTING OR TREATING CELLULAR MALIGNITES BY ADMINISTERING CD2 ANTAGONISTS |
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EP2316487B1 (en) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Recombinant IL-9 antibodies & uses thereof |
JP4934426B2 (ja) | 2003-08-18 | 2012-05-16 | メディミューン,エルエルシー | 抗体のヒト化 |
US7214825B2 (en) * | 2003-10-17 | 2007-05-08 | Honeywell International Inc. | O-(3-chloropropenyl) hydroxylamine free base |
US7183305B2 (en) | 2003-11-11 | 2007-02-27 | Allergan, Inc. | Process for the synthesis of imidazoles |
US7880017B2 (en) | 2003-11-11 | 2011-02-01 | Allergan, Inc. | Process for the synthesis of imidazoles |
WO2005116001A1 (en) * | 2004-05-29 | 2005-12-08 | 7Tm Pharma A/S | Substituted thiazoleacetic as crth2 ligands |
EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
JP5153613B2 (ja) | 2005-03-18 | 2013-02-27 | メディミューン,エルエルシー | 抗体のフレームワーク・シャッフル |
KR20080025174A (ko) | 2005-06-23 | 2008-03-19 | 메디뮨 인코포레이티드 | 응집 및 단편화 프로파일이 최적화된 항체 제제 |
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DK2668210T3 (da) | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | Anti-kit antistoffer og anvendelser deraf |
CN116574185A (zh) | 2012-07-25 | 2023-08-11 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
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SG11201509982UA (hu) | 2013-06-06 | 2016-04-28 | Igenica Biotherapeutics Inc | |
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KR102614642B1 (ko) | 2014-06-04 | 2023-12-19 | 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 | 강글리오사이드 gd2에 대한 사람 단클론 항체 |
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EP0300688A1 (en) * | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
US5681795A (en) * | 1994-03-02 | 1997-10-28 | Zeneca Limited | 3-benzoyl pyrrole and pyrazole herbicides |
US5756528A (en) | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2250919C (en) | 1996-03-29 | 2008-05-13 | Therakos, Inc. | Photopheresis treatment of leukocytes |
WO1997036585A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU717298B2 (en) * | 1996-04-03 | 2000-03-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997036901A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
JP2001509131A (ja) | 1996-04-03 | 2001-07-10 | メルク エンド カンパニー インコーポレーテッド | ファルネシルプロテイントランスフェラーゼの阻害剤 |
WO1997036876A1 (en) | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
-
1998
- 1998-11-25 PL PL98340729A patent/PL340729A1/xx unknown
- 1998-11-25 AU AU15083/99A patent/AU731272B2/en not_active Ceased
- 1998-11-25 BR BR9815423-0A patent/BR9815423A/pt not_active Application Discontinuation
- 1998-11-25 RU RU2000116633/04A patent/RU2179975C1/ru not_active IP Right Cessation
- 1998-11-25 HU HU0004238A patent/HUP0004238A3/hu unknown
- 1998-11-25 IL IL13547398A patent/IL135473A0/xx unknown
- 1998-11-25 AT AT98959231T patent/ATE239014T1/de not_active IP Right Cessation
- 1998-11-25 DE DE69814167T patent/DE69814167T2/de not_active Expired - Fee Related
- 1998-11-25 ES ES98959231T patent/ES2193590T3/es not_active Expired - Lifetime
- 1998-11-25 JP JP2000523207A patent/JP3548118B2/ja not_active Expired - Fee Related
- 1998-11-25 US US09/554,646 patent/US6268363B1/en not_active Expired - Fee Related
- 1998-11-25 CA CA002310629A patent/CA2310629A1/en not_active Abandoned
- 1998-11-25 ID IDW20000933A patent/ID24175A/id unknown
- 1998-11-25 EP EP98959231A patent/EP1045846B1/en not_active Expired - Lifetime
- 1998-11-25 WO PCT/KR1998/000377 patent/WO1999028315A1/en active IP Right Grant
- 1998-11-25 CN CNB988114976A patent/CN1188407C/zh not_active Expired - Fee Related
- 1998-11-25 NZ NZ504013A patent/NZ504013A/en unknown
- 1998-11-30 AR ARP980106048A patent/AR017700A1/es not_active Application Discontinuation
-
2001
- 2001-03-20 US US09/813,437 patent/US6518429B2/en not_active Expired - Fee Related
- 2001-10-03 JP JP2001307368A patent/JP2002161092A/ja active Pending
- 2001-12-03 US US10/005,262 patent/US6472526B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HUP0004238A3 (en) | 2001-07-30 |
JP2001524550A (ja) | 2001-12-04 |
ATE239014T1 (de) | 2003-05-15 |
CA2310629A1 (en) | 1999-06-10 |
CN1279680A (zh) | 2001-01-10 |
US6472526B1 (en) | 2002-10-29 |
EP1045846A1 (en) | 2000-10-25 |
DE69814167T2 (de) | 2004-02-26 |
IL135473A0 (en) | 2001-05-20 |
AU731272B2 (en) | 2001-03-29 |
BR9815423A (pt) | 2000-10-17 |
AU1508399A (en) | 1999-06-16 |
US6518429B2 (en) | 2003-02-11 |
US6268363B1 (en) | 2001-07-31 |
DE69814167D1 (de) | 2003-06-05 |
CN1188407C (zh) | 2005-02-09 |
EP1045846B1 (en) | 2003-05-02 |
ID24175A (id) | 2000-07-13 |
NZ504013A (en) | 2002-02-01 |
RU2179975C1 (ru) | 2002-02-27 |
US20020137769A1 (en) | 2002-09-26 |
AR017700A1 (es) | 2001-09-12 |
ES2193590T3 (es) | 2003-11-01 |
JP2002161092A (ja) | 2002-06-04 |
WO1999028315A1 (en) | 1999-06-10 |
RU2000116633A (ru) | 2004-02-20 |
JP3548118B2 (ja) | 2004-07-28 |
PL340729A1 (en) | 2001-02-26 |
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