IL135473A0 - Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof - Google Patents

Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

Info

Publication number
IL135473A0
IL135473A0 IL13547398A IL13547398A IL135473A0 IL 135473 A0 IL135473 A0 IL 135473A0 IL 13547398 A IL13547398 A IL 13547398A IL 13547398 A IL13547398 A IL 13547398A IL 135473 A0 IL135473 A0 IL 135473A0
Authority
IL
Israel
Prior art keywords
preparation
inhibitory activity
imidazole derivatives
farnesyl transferase
farnesyl
Prior art date
Application number
IL13547398A
Other languages
English (en)
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019980011359A external-priority patent/KR19990066679A/ko
Priority claimed from KR1019980023698A external-priority patent/KR20000002788A/ko
Priority claimed from KR1019980046457A external-priority patent/KR20000015758A/ko
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of IL135473A0 publication Critical patent/IL135473A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
IL13547398A 1997-11-28 1998-11-25 Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof IL135473A0 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR19970063858 1997-11-28
KR1019980011359A KR19990066679A (ko) 1997-11-28 1998-03-31 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법
KR1019980023698A KR20000002788A (ko) 1998-06-23 1998-06-23 피라졸 구조를 갖는 파네실 전이효소 억제제 및그의 제조방법
KR1019980024423A KR19990062439A (ko) 1997-11-28 1998-06-26 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법
KR19980031512 1998-08-03
KR1019980046457A KR20000015758A (ko) 1998-08-03 1998-10-30 피롤 구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법
PCT/KR1998/000377 WO1999028315A1 (en) 1997-11-28 1998-11-25 Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

Publications (1)

Publication Number Publication Date
IL135473A0 true IL135473A0 (en) 2001-05-20

Family

ID=27555104

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13547398A IL135473A0 (en) 1997-11-28 1998-11-25 Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

Country Status (18)

Country Link
US (3) US6268363B1 (hu)
EP (1) EP1045846B1 (hu)
JP (2) JP3548118B2 (hu)
CN (1) CN1188407C (hu)
AR (1) AR017700A1 (hu)
AT (1) ATE239014T1 (hu)
AU (1) AU731272B2 (hu)
BR (1) BR9815423A (hu)
CA (1) CA2310629A1 (hu)
DE (1) DE69814167T2 (hu)
ES (1) ES2193590T3 (hu)
HU (1) HUP0004238A3 (hu)
ID (1) ID24175A (hu)
IL (1) IL135473A0 (hu)
NZ (1) NZ504013A (hu)
PL (1) PL340729A1 (hu)
RU (1) RU2179975C1 (hu)
WO (1) WO1999028315A1 (hu)

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KR100395300B1 (ko) * 1999-08-11 2003-08-27 주식회사 엘지생명과학 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법
WO2000064891A1 (en) * 1999-04-13 2000-11-02 Lg Chem Investment Ltd. Farnesyl transferase inhibitors having a pyrrole structure and process for preparation thereof
FR2796943A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique
KR20010063274A (ko) * 1999-12-22 2001-07-09 성재갑 〔1-｛〔1-（1,3-벤조디옥솔-5-일메틸-1ｈ-이미다졸-5-일〕메틸｝-4-(1-나프틸)-1ｈ-피롤-3-일〕（4-메틸-1-피페라지닐）메타논의 약학적 조성물
KR100412334B1 (ko) * 2000-02-22 2003-12-31 주식회사 엘지생명과학 4-치환된-1ｈ-피롤-3-카복실산 에스테르의 새로운 제조방법
AU2001244596A1 (en) * 2000-03-30 2001-10-15 Rei Asakai Indolylpyrrole derivatives and cell death inhibitors
US7304061B2 (en) * 2002-04-26 2007-12-04 Vertex Pharmaceuticals Incorporated Heterocyclic inhibitors of ERK2 and uses thereof
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US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
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CA2497628A1 (en) * 2002-09-05 2004-03-18 Medimmune, Inc. Methods of preventing or treating cell malignancies by administering cd2 antagonists
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
CA2511321A1 (en) * 2002-12-23 2004-07-08 Aventis Pharma Deutschland Gmbh Pyrazole-derivatives as factor xa inhibitors
EP2316487B1 (en) 2003-04-11 2014-06-11 MedImmune, LLC Recombinant IL-9 antibodies & uses thereof
WO2005042743A2 (en) 2003-08-18 2005-05-12 Medimmune, Inc. Humanization of antibodies
US7214825B2 (en) * 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
US7880017B2 (en) 2003-11-11 2011-02-01 Allergan, Inc. Process for the synthesis of imidazoles
US7183305B2 (en) 2003-11-11 2007-02-27 Allergan, Inc. Process for the synthesis of imidazoles
EA200602288A1 (ru) * 2004-05-29 2007-10-26 7ТиЭм ФАРМА А/С Замещённые тиазолуксусные кислоты в качестве лигандов crth2
US20060121042A1 (en) 2004-10-27 2006-06-08 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
AU2006227377B2 (en) 2005-03-18 2013-01-31 Medimmune, Llc Framework-shuffling of antibodies
WO2007002543A2 (en) 2005-06-23 2007-01-04 Medimmune, Inc. Antibody formulations having optimized aggregation and fragmentation profiles
EP2051977A2 (en) * 2006-07-20 2009-04-29 Amgen Inc. SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1
NZ575163A (en) 2006-08-28 2011-12-22 Jolla Inst Allergy Immunolog Antagonistic human light-specific human monoclonal antibodies
MX2009010389A (es) 2007-03-30 2010-01-20 Medimmune Llc Formulacion de anticuerpos.
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
EP2215246B1 (en) 2007-10-31 2015-01-07 MedImmune, LLC Protein scaffolds
EP2095819A1 (en) * 2008-02-28 2009-09-02 Maastricht University N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
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AU2013329311A1 (en) 2012-10-09 2015-04-30 Igenica Biotherapeutics, Inc. Anti-C16orf54 antibodies and methods of use thereof
ES2891755T3 (es) 2013-06-06 2022-01-31 Pf Medicament Anticuerpos anti-C10orf54 y utilizaciones de los mismos
KR102553717B1 (ko) 2013-08-26 2023-07-11 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 시알릴-루이스 ａ에 대한 사람 항체 코드화 핵산
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
JP6626461B2 (ja) 2014-06-04 2019-12-25 バイオエヌテック リサーチ アンド デベロップメント， インコーポレイテッド ガングリオシドｇｄ２に対するヒトモノクローナル抗体
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Also Published As

Publication number Publication date
US6268363B1 (en) 2001-07-31
AR017700A1 (es) 2001-09-12
CN1279680A (zh) 2001-01-10
CA2310629A1 (en) 1999-06-10
ATE239014T1 (de) 2003-05-15
AU731272B2 (en) 2001-03-29
AU1508399A (en) 1999-06-16
BR9815423A (pt) 2000-10-17
ID24175A (id) 2000-07-13
HUP0004238A3 (en) 2001-07-30
CN1188407C (zh) 2005-02-09
NZ504013A (en) 2002-02-01
PL340729A1 (en) 2001-02-26
JP3548118B2 (ja) 2004-07-28
HUP0004238A2 (hu) 2001-05-28
DE69814167T2 (de) 2004-02-26
JP2002161092A (ja) 2002-06-04
EP1045846A1 (en) 2000-10-25
EP1045846B1 (en) 2003-05-02
US20020137769A1 (en) 2002-09-26
RU2000116633A (ru) 2004-02-20
ES2193590T3 (es) 2003-11-01
DE69814167D1 (de) 2003-06-05
US6472526B1 (en) 2002-10-29
RU2179975C1 (ru) 2002-02-27
WO1999028315A1 (en) 1999-06-10
JP2001524550A (ja) 2001-12-04
US6518429B2 (en) 2003-02-11

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