DE69814167D1 - Imidazolderivate mit farnesyltransferase hemmenden eigenschaften und verfahren zu ihrer herstellung - Google Patents
Imidazolderivate mit farnesyltransferase hemmenden eigenschaften und verfahren zu ihrer herstellungInfo
- Publication number
- DE69814167D1 DE69814167D1 DE69814167T DE69814167T DE69814167D1 DE 69814167 D1 DE69814167 D1 DE 69814167D1 DE 69814167 T DE69814167 T DE 69814167T DE 69814167 T DE69814167 T DE 69814167T DE 69814167 D1 DE69814167 D1 DE 69814167D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- imidazole derivatives
- farnesyl transferase
- inhibiting properties
- transferase inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR9763858 | 1997-11-28 | ||
| KR19970063858 | 1997-11-28 | ||
| KR1019980011359A KR19990066679A (ko) | 1997-11-28 | 1998-03-31 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| KR9811359 | 1998-03-31 | ||
| KR1019980023698A KR20000002788A (ko) | 1998-06-23 | 1998-06-23 | 피라졸 구조를 갖는 파네실 전이효소 억제제 및그의 제조방법 |
| KR9823698 | 1998-06-23 | ||
| KR9824423 | 1998-06-26 | ||
| KR1019980024423A KR19990062439A (ko) | 1997-11-28 | 1998-06-26 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| KR19980031512 | 1998-08-03 | ||
| KR9831512 | 1998-08-03 | ||
| KR9846457 | 1998-10-30 | ||
| KR1019980046457A KR20000015758A (ko) | 1998-08-03 | 1998-10-30 | 피롤 구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| PCT/KR1998/000377 WO1999028315A1 (en) | 1997-11-28 | 1998-11-25 | Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69814167D1 true DE69814167D1 (de) | 2003-06-05 |
| DE69814167T2 DE69814167T2 (de) | 2004-02-26 |
Family
ID=27555104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69814167T Expired - Fee Related DE69814167T2 (de) | 1997-11-28 | 1998-11-25 | Imidazolderivate mit farnesyltransferase hemmenden eigenschaften und verfahren zu ihrer herstellung |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6268363B1 (de) |
| EP (1) | EP1045846B1 (de) |
| JP (2) | JP3548118B2 (de) |
| CN (1) | CN1188407C (de) |
| AR (1) | AR017700A1 (de) |
| AT (1) | ATE239014T1 (de) |
| AU (1) | AU731272B2 (de) |
| BR (1) | BR9815423A (de) |
| CA (1) | CA2310629A1 (de) |
| DE (1) | DE69814167T2 (de) |
| ES (1) | ES2193590T3 (de) |
| HU (1) | HUP0004238A3 (de) |
| ID (1) | ID24175A (de) |
| IL (1) | IL135473A0 (de) |
| NZ (1) | NZ504013A (de) |
| PL (1) | PL340729A1 (de) |
| RU (1) | RU2179975C1 (de) |
| WO (1) | WO1999028315A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158277C (zh) * | 1998-02-02 | 2004-07-21 | Lg化学株式会社 | 具有哌啶结构的法尼转移酶抑制剂及其制备方法 |
| KR100395300B1 (ko) * | 1999-08-11 | 2003-08-27 | 주식회사 엘지생명과학 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| WO2000064891A1 (en) * | 1999-04-13 | 2000-11-02 | Lg Chem Investment Ltd. | Farnesyl transferase inhibitors having a pyrrole structure and process for preparation thereof |
| FR2796943A1 (fr) * | 1999-07-30 | 2001-02-02 | Aventis Pharma Sa | Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique |
| KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-｛〔1-（1,3-벤조디옥솔-5-일메틸-1ｈ-이미다졸-5-일〕메틸｝-4-(1-나프틸)-1ｈ-피롤-3-일〕（4-메틸-1-피페라지닐）메타논의 약학적 조성물 |
| KR100412334B1 (ko) * | 2000-02-22 | 2003-12-31 | 주식회사 엘지생명과학 | 4-치환된-1ｈ-피롤-3-카복실산 에스테르의 새로운 제조방법 |
| AU2001244596A1 (en) * | 2000-03-30 | 2001-10-15 | Rei Asakai | Indolylpyrrole derivatives and cell death inhibitors |
| US7304061B2 (en) * | 2002-04-26 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic inhibitors of ERK2 and uses thereof |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| RU2462463C2 (ru) * | 2002-08-23 | 2012-09-27 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч | Синтез эпотилонов, их промежуточных продуктов, аналогов и их применения |
| CA2497628A1 (en) * | 2002-09-05 | 2004-03-18 | Medimmune, Inc. | Methods of preventing or treating cell malignancies by administering cd2 antagonists |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| CA2511321A1 (en) * | 2002-12-23 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Pyrazole-derivatives as factor xa inhibitors |
| EP2316487B1 (de) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Rekombinante IL-9 Antikörper und ihre Verwendung |
| WO2005042743A2 (en) | 2003-08-18 | 2005-05-12 | Medimmune, Inc. | Humanization of antibodies |
| US7214825B2 (en) * | 2003-10-17 | 2007-05-08 | Honeywell International Inc. | O-(3-chloropropenyl) hydroxylamine free base |
| US7880017B2 (en) | 2003-11-11 | 2011-02-01 | Allergan, Inc. | Process for the synthesis of imidazoles |
| US7183305B2 (en) | 2003-11-11 | 2007-02-27 | Allergan, Inc. | Process for the synthesis of imidazoles |
| EA200602288A1 (ru) * | 2004-05-29 | 2007-10-26 | 7ТиЭм ФАРМА А/С | Замещённые тиазолуксусные кислоты в качестве лигандов crth2 |
| US20060121042A1 (en) | 2004-10-27 | 2006-06-08 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| AU2006227377B2 (en) | 2005-03-18 | 2013-01-31 | Medimmune, Llc | Framework-shuffling of antibodies |
| WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
| EP2051977A2 (de) * | 2006-07-20 | 2009-04-29 | Amgen Inc. | SUBSTITUIERTE AROMATISCHE AZOL-HETEROCYCLEN ALS LLbeta-HSD-1-HEMMER |
| NZ575163A (en) | 2006-08-28 | 2011-12-22 | Jolla Inst Allergy Immunolog | Antagonistic human light-specific human monoclonal antibodies |
| MX2009010389A (es) | 2007-03-30 | 2010-01-20 | Medimmune Llc | Formulacion de anticuerpos. |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| EP2215246B1 (de) | 2007-10-31 | 2015-01-07 | MedImmune, LLC | Proteingerüste |
| EP2095819A1 (de) * | 2008-02-28 | 2009-09-02 | Maastricht University | N-Benzyl-Imidazolderivate und deren Verwendung als Aldosteronsynthaseinhibitoren |
| EP2668210B1 (de) | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anti-kit-antikörper und ihre verwendungen |
| SG11201500489YA (en) | 2012-07-25 | 2015-02-27 | Kolltan Pharmaceuticals Inc | Anti-kit antibodies and uses thereof |
| AU2013329311A1 (en) | 2012-10-09 | 2015-04-30 | Igenica Biotherapeutics, Inc. | Anti-C16orf54 antibodies and methods of use thereof |
| ES2891755T3 (es) | 2013-06-06 | 2022-01-31 | Pf Medicament | Anticuerpos anti-C10orf54 y utilizaciones de los mismos |
| KR102553717B1 (ko) | 2013-08-26 | 2023-07-11 | 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 | 시알릴-루이스 ａ에 대한 사람 항체 코드화 핵산 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| JP6626461B2 (ja) | 2014-06-04 | 2019-12-25 | バイオエヌテック リサーチ アンド デベロップメント， インコーポレイテッド | ガングリオシドｇｄ２に対するヒトモノクローナル抗体 |
| WO2016094837A2 (en) | 2014-12-11 | 2016-06-16 | Igenica Biotherapeutics, Inc. | Anti-c10orf54 antibodies and uses thereof |
| BR112017015880A2 (pt) | 2015-03-03 | 2018-07-31 | Kymab Ltd | anticorpos, usos e métodos |
| KR20180100122A (ko) | 2015-12-02 | 2018-09-07 | 주식회사 에스티사이언스 | 당화된 btla(b- 및 t-림프구 약화인자)에 특이적인 항체 |
| WO2017096051A1 (en) | 2015-12-02 | 2017-06-08 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
| BR112019006448A2 (pt) | 2016-09-29 | 2019-06-25 | Bayer Cropscience Ag | novos derivados de 5-imidazol substituídos |
| EP3534947A1 (de) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antikörper, kombinationen mit antikörpern, biomarker, verwendungen und verfahren |
| AU2018277838A1 (en) | 2017-05-31 | 2019-12-19 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof |
| AU2018277545A1 (en) | 2017-05-31 | 2019-12-19 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 |
| JP2020522562A (ja) | 2017-06-06 | 2020-07-30 | ストキューブ アンド シーオー．， インコーポレイテッド | Ｂｔｎ１ａ１又はｂｔｎ１ａ１リガンドに結合する抗体及び分子を用いて癌を治療する方法 |
| EP3694889A1 (de) | 2017-10-13 | 2020-08-19 | Boehringer Ingelheim International GmbH | Humane antikörper gegen thomsen-nouvelle (tn)-antigen |
| CA3106418A1 (en) | 2018-07-20 | 2020-01-23 | Pierre Fabre Medicament | Receptor for vista |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300688A1 (de) * | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrol-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammenstellungen, die sie enthalten |
| US5681795A (en) * | 1994-03-02 | 1997-10-28 | Zeneca Limited | 3-benzoyl pyrrole and pyrazole herbicides |
| US5756528A (en) * | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP2000510101A (ja) | 1996-03-29 | 2000-08-08 | セラコス・インコーポレーテツド | 白血球のフォトフェレーシス処置 |
| WO1997036891A1 (en) | 1996-04-03 | 1997-10-09 | Merk & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP2000507590A (ja) | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
| JP2000507956A (ja) * | 1996-04-03 | 2000-06-27 | メルク エンド カンパニー インコーポレーテッド | ファルネシル−タンパク質トランスフェラーゼ阻害剤 |
| JP2001509131A (ja) | 1996-04-03 | 2001-07-10 | メルク エンド カンパニー インコーポレーテッド | ファルネシルプロテイントランスフェラーゼの阻害剤 |
| JP2000507955A (ja) | 1996-04-03 | 2000-06-27 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質転移酵素の阻害剤 |
-
1998
- 1998-11-25 HU HU0004238A patent/HUP0004238A3/hu unknown
- 1998-11-25 WO PCT/KR1998/000377 patent/WO1999028315A1/en active IP Right Grant
- 1998-11-25 BR BR9815423-0A patent/BR9815423A/pt not_active Application Discontinuation
- 1998-11-25 AU AU15083/99A patent/AU731272B2/en not_active Ceased
- 1998-11-25 PL PL98340729A patent/PL340729A1/xx unknown
- 1998-11-25 RU RU2000116633/04A patent/RU2179975C1/ru not_active IP Right Cessation
- 1998-11-25 NZ NZ504013A patent/NZ504013A/en unknown
- 1998-11-25 US US09/554,646 patent/US6268363B1/en not_active Expired - Fee Related
- 1998-11-25 EP EP98959231A patent/EP1045846B1/de not_active Expired - Lifetime
- 1998-11-25 IL IL13547398A patent/IL135473A0/xx unknown
- 1998-11-25 AT AT98959231T patent/ATE239014T1/de not_active IP Right Cessation
- 1998-11-25 ID IDW20000933A patent/ID24175A/id unknown
- 1998-11-25 CN CNB988114976A patent/CN1188407C/zh not_active Expired - Fee Related
- 1998-11-25 CA CA002310629A patent/CA2310629A1/en not_active Abandoned
- 1998-11-25 ES ES98959231T patent/ES2193590T3/es not_active Expired - Lifetime
- 1998-11-25 JP JP2000523207A patent/JP3548118B2/ja not_active Expired - Fee Related
- 1998-11-25 DE DE69814167T patent/DE69814167T2/de not_active Expired - Fee Related
- 1998-11-30 AR ARP980106048A patent/AR017700A1/es not_active Application Discontinuation
-
2001
- 2001-03-20 US US09/813,437 patent/US6518429B2/en not_active Expired - Fee Related
- 2001-10-03 JP JP2001307368A patent/JP2002161092A/ja active Pending
- 2001-12-03 US US10/005,262 patent/US6472526B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6268363B1 (en) | 2001-07-31 |
| AR017700A1 (es) | 2001-09-12 |
| CN1279680A (zh) | 2001-01-10 |
| CA2310629A1 (en) | 1999-06-10 |
| ATE239014T1 (de) | 2003-05-15 |
| AU731272B2 (en) | 2001-03-29 |
| AU1508399A (en) | 1999-06-16 |
| BR9815423A (pt) | 2000-10-17 |
| ID24175A (id) | 2000-07-13 |
| HUP0004238A3 (en) | 2001-07-30 |
| CN1188407C (zh) | 2005-02-09 |
| NZ504013A (en) | 2002-02-01 |
| PL340729A1 (en) | 2001-02-26 |
| JP3548118B2 (ja) | 2004-07-28 |
| HUP0004238A2 (hu) | 2001-05-28 |
| DE69814167T2 (de) | 2004-02-26 |
| JP2002161092A (ja) | 2002-06-04 |
| EP1045846A1 (de) | 2000-10-25 |
| EP1045846B1 (de) | 2003-05-02 |
| IL135473A0 (en) | 2001-05-20 |
| US20020137769A1 (en) | 2002-09-26 |
| RU2000116633A (ru) | 2004-02-20 |
| ES2193590T3 (es) | 2003-11-01 |
| US6472526B1 (en) | 2002-10-29 |
| RU2179975C1 (ru) | 2002-02-27 |
| WO1999028315A1 (en) | 1999-06-10 |
| JP2001524550A (ja) | 2001-12-04 |
| US6518429B2 (en) | 2003-02-11 |
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