AU1952697A - Inhibitors of farnesyl-protein transferase - Google Patents
Inhibitors of farnesyl-protein transferaseInfo
- Publication number
- AU1952697A AU1952697A AU19526/97A AU1952697A AU1952697A AU 1952697 A AU1952697 A AU 1952697A AU 19526/97 A AU19526/97 A AU 19526/97A AU 1952697 A AU1952697 A AU 1952697A AU 1952697 A AU1952697 A AU 1952697A
- Authority
- AU
- Australia
- Prior art keywords
- farnesyl
- inhibitors
- protein transferase
- transferase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1108196P | 1996-01-30 | 1996-01-30 | |
US60/011081 | 1996-01-30 | ||
GB9607124 | 1996-04-04 | ||
GBGB9607124.6A GB9607124D0 (en) | 1996-04-04 | 1996-04-04 | Inhibitors of farnesyl-protein transferase |
PCT/US1997/001455 WO1997027853A1 (en) | 1996-01-30 | 1997-01-27 | Inhibitors of farnesyl-protein transferase |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1952697A true AU1952697A (en) | 1997-08-22 |
AU703988B2 AU703988B2 (en) | 1999-04-01 |
Family
ID=26309063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU19526/97A Ceased AU703988B2 (en) | 1996-01-30 | 1997-01-27 | Inhibitors of farnesyl-protein transferase |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0877610A4 (en) |
JP (1) | JP2000505797A (en) |
AU (1) | AU703988B2 (en) |
WO (1) | WO1997027853A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2243507A1 (en) * | 1996-01-30 | 1997-08-07 | Christopher J. Dinsmore | Inhibitors of farnesyl-protein transferase |
WO2000001701A1 (en) | 1998-07-02 | 2000-01-13 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
JP2002519376A (en) | 1998-07-02 | 2002-07-02 | メルク エンド カムパニー インコーポレーテッド | Prenyl protein transferase inhibitors |
US7049324B1 (en) | 1999-11-15 | 2006-05-23 | Ashis Kumar Saha | Triazoles as farnesyl transferase inhibitors |
EP1232147B1 (en) | 1999-11-15 | 2008-04-02 | Janssen Pharmaceutica N.V. | Triazoles as farnesyl transferase inhibitors |
US6380228B1 (en) | 2000-04-10 | 2002-04-30 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4749713A (en) * | 1986-03-07 | 1988-06-07 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
US5571792A (en) * | 1994-06-30 | 1996-11-05 | Warner-Lambert Company | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
US5578629A (en) * | 1995-03-29 | 1996-11-26 | Merck & Co., Inc. | Benzamide-containing inhibitors of farnesyl-protein transferase |
US5534537A (en) * | 1995-03-29 | 1996-07-09 | Merck & Co., Inc. | Prodrugs of inhibitors of farnesyl-protein transferase |
-
1997
- 1997-01-27 JP JP9527800A patent/JP2000505797A/en active Pending
- 1997-01-27 AU AU19526/97A patent/AU703988B2/en not_active Ceased
- 1997-01-27 WO PCT/US1997/001455 patent/WO1997027853A1/en not_active Application Discontinuation
- 1997-01-27 EP EP97907546A patent/EP0877610A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2000505797A (en) | 2000-05-16 |
WO1997027853A1 (en) | 1997-08-07 |
EP0877610A1 (en) | 1998-11-18 |
AU703988B2 (en) | 1999-04-01 |
EP0877610A4 (en) | 1999-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |