EP0877610A4 - Inhibitors of farnesyl-protein transferase - Google Patents

Inhibitors of farnesyl-protein transferase

Info

Publication number
EP0877610A4
EP0877610A4 EP97907546A EP97907546A EP0877610A4 EP 0877610 A4 EP0877610 A4 EP 0877610A4 EP 97907546 A EP97907546 A EP 97907546A EP 97907546 A EP97907546 A EP 97907546A EP 0877610 A4 EP0877610 A4 EP 0877610A4
Authority
EP
European Patent Office
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97907546A
Other languages
German (de)
French (fr)
Other versions
EP0877610A1 (en
Inventor
Christopher J Dinsmore
George D Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607124.6A external-priority patent/GB9607124D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0877610A1 publication Critical patent/EP0877610A1/en
Publication of EP0877610A4 publication Critical patent/EP0877610A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP97907546A 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase Withdrawn EP0877610A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1108196P 1996-01-30 1996-01-30
US11081P 1996-01-30
GBGB9607124.6A GB9607124D0 (en) 1996-04-04 1996-04-04 Inhibitors of farnesyl-protein transferase
GB9607124 1996-04-04
PCT/US1997/001455 WO1997027853A1 (en) 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
EP0877610A1 EP0877610A1 (en) 1998-11-18
EP0877610A4 true EP0877610A4 (en) 1999-09-15

Family

ID=26309063

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97907546A Withdrawn EP0877610A4 (en) 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase

Country Status (4)

Country Link
EP (1) EP0877610A4 (en)
JP (1) JP2000505797A (en)
AU (1) AU703988B2 (en)
WO (1) WO1997027853A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2243507A1 (en) * 1996-01-30 1997-08-07 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US6410534B1 (en) 1998-07-02 2002-06-25 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
EP1091736A4 (en) 1998-07-02 2001-10-24 Merck & Co Inc Inhibitors of prenyl-protein transferase
WO2001036395A1 (en) * 1999-11-15 2001-05-25 Janssen Pharmaceutica N.V. Triazoles as farnesyl transferase inhibitors
US7049324B1 (en) 1999-11-15 2006-05-23 Ashis Kumar Saha Triazoles as farnesyl transferase inhibitors
WO2001076694A1 (en) 2000-04-10 2001-10-18 Merck & Co., Inc. Inhibitors of prenyl-protein transferase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236940A2 (en) * 1986-03-07 1987-09-16 Ciba-Geigy Ag Alpha-heterocycle substituted tolunitriles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
US5534537A (en) * 1995-03-29 1996-07-09 Merck & Co., Inc. Prodrugs of inhibitors of farnesyl-protein transferase
US5578629A (en) * 1995-03-29 1996-11-26 Merck & Co., Inc. Benzamide-containing inhibitors of farnesyl-protein transferase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236940A2 (en) * 1986-03-07 1987-09-16 Ciba-Geigy Ag Alpha-heterocycle substituted tolunitriles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9727853A1 *

Also Published As

Publication number Publication date
EP0877610A1 (en) 1998-11-18
JP2000505797A (en) 2000-05-16
AU1952697A (en) 1997-08-22
AU703988B2 (en) 1999-04-01
WO1997027853A1 (en) 1997-08-07

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20020222