EP0891349A4 - Inhibitors of farnesyl-protein transferase - Google Patents

Inhibitors of farnesyl-protein transferase

Info

Publication number
EP0891349A4
EP0891349A4 EP97917599A EP97917599A EP0891349A4 EP 0891349 A4 EP0891349 A4 EP 0891349A4 EP 97917599 A EP97917599 A EP 97917599A EP 97917599 A EP97917599 A EP 97917599A EP 0891349 A4 EP0891349 A4 EP 0891349A4
Authority
EP
European Patent Office
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97917599A
Other languages
German (de)
French (fr)
Other versions
EP0891349A1 (en
Inventor
Christopher J Dinsmore
Theresa M Williams
Jeffrey Bergman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9613461.4A external-priority patent/GB9613461D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0891349A1 publication Critical patent/EP0891349A1/en
Publication of EP0891349A4 publication Critical patent/EP0891349A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
EP97917599A 1996-04-03 1997-03-27 Inhibitors of farnesyl-protein transferase Withdrawn EP0891349A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1458796P 1996-04-03 1996-04-03
US14587P 1996-04-03
GB9613461 1996-06-27
GBGB9613461.4A GB9613461D0 (en) 1996-06-27 1996-06-27 Inhibitors of farnesyl-protein transferase
PCT/US1997/004711 WO1997036888A1 (en) 1996-04-03 1997-03-27 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
EP0891349A1 EP0891349A1 (en) 1999-01-20
EP0891349A4 true EP0891349A4 (en) 2001-01-24

Family

ID=26309576

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97917599A Withdrawn EP0891349A4 (en) 1996-04-03 1997-03-27 Inhibitors of farnesyl-protein transferase

Country Status (5)

Country Link
EP (1) EP0891349A4 (en)
JP (1) JP2000507576A (en)
AU (1) AU715667B2 (en)
CA (1) CA2249604A1 (en)
WO (1) WO1997036888A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1090012A4 (en) 1998-07-02 2005-04-06 Merck & Co Inc Inhibitors of prenyl-protein transferase
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
CA2774959C (en) 2000-08-04 2016-05-31 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
US6967202B2 (en) 2000-08-04 2005-11-22 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
AU2003244455A1 (en) 2002-02-08 2003-09-02 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
PT2537524T (en) 2003-05-15 2016-09-05 Ampio Pharmaceuticals Inc Treatment of t-cell mediated diseases
WO2009146320A1 (en) 2008-05-27 2009-12-03 Dmi Life Sciences, Inc. Therapeutic methods and compounds
EP2613786A4 (en) 2010-09-07 2013-10-23 Dmi Acquisition Corp Treatment of diseases
MY167804A (en) 2011-10-10 2018-09-26 Ampio Pharmaceuticals Inc Treatment of degenerative joint disease
EP2765968A4 (en) 2011-10-10 2015-01-21 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
JP6231484B2 (en) 2011-10-28 2017-11-15 アンピオ ファーマシューティカルズ，インコーポレイテッド Rhinitis treatment
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
JP6723222B2 (en) 2014-08-18 2020-07-15 アンピオ ファーマシューティカルズ，インコーポレイテッド Treatment of joint pathology
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
WO2021195265A1 (en) 2020-03-24 2021-09-30 Ampio Pharmaceuticals, Inc. Methods for treating diseases associated with respiratory viruses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54106481A (en) * 1978-02-08 1979-08-21 Toyama Chem Co Ltd Novel 2,3-dioxopiperazine derivative and its preparation
JPS61233675A (en) * 1985-03-26 1986-10-17 Fujisawa Pharmaceut Co Ltd Piperazine compound
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0670314A1 (en) * 1993-09-22 1995-09-06 Kyowa Hakko Kogyo Co., Ltd. Farnesyltransferase inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287195A (en) * 1978-07-14 1981-09-01 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
US4456605A (en) * 1981-05-07 1984-06-26 Janssen Pharmaceutica N.V. Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54106481A (en) * 1978-02-08 1979-08-21 Toyama Chem Co Ltd Novel 2,3-dioxopiperazine derivative and its preparation
JPS61233675A (en) * 1985-03-26 1986-10-17 Fujisawa Pharmaceut Co Ltd Piperazine compound
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0670314A1 (en) * 1993-09-22 1995-09-06 Kyowa Hakko Kogyo Co., Ltd. Farnesyltransferase inhibitor

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
B. H. CHASE, A. M. DOWNES: "The Synthesis of (14)C-Labelled Diethylcarbamazine, 1-Diethylcarbamyl-4-methylpiperazine ("Hetrazan")", J. CHEM. SOC., 1953, pages 3874 - 3877, XP000943297 *
N. SHIMAZAKI ET AL.: "Diketopiperazine derivatives, a new synthesis of platelet-activating factor inhibitors", CHEM. PHARM. BULL., vol. 35, no. 8, 1987, pages 3527 - 3530, XP000941477 *
PATENT ABSTRACTS OF JAPAN vol. 003, no. 128 24 October 1979 (1979-10-24) *
PATENT ABSTRACTS OF JAPAN vol. 011, no. 080 11 March 1998 (1998-03-11) *
See also references of WO9736888A1 *
T. D. HARRIS ET AL.: "An Improved Synthesis of 1-Methyl-2,5-piperazinedione", J. HETEROCYCL. CHEM., vol. 18, no. 1, 1981, pages 423 - 424, XP000943271 *
T. FUKUYAMA ET AL.: "Total synthesis of gliotoxin, dehydrogliotoxin and hyalodendrin", TETRAHEDRON, vol. 37, 1981, pages 2045 - 2078, XP000941476 *
T. M. WILLIAMS ET AL.: "2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase", J. MED. CHEM., vol. 39, no. 7, 1996, pages 1345 - 1348, XP002152726 *

Also Published As

Publication number Publication date
AU715667B2 (en) 2000-02-10
WO1997036888A1 (en) 1997-10-09
CA2249604A1 (en) 1997-10-09
JP2000507576A (en) 2000-06-20
EP0891349A1 (en) 1999-01-20
AU2587597A (en) 1997-10-22

Similar Documents

Publication Publication Date Title
EP0891350A4 (en) Inhibitors of farnesyl-protein transferase
EP1011669A4 (en) Inhibitors of farnesyl-protein transferase
GB9604311D0 (en) Inhibitors of farnesyl-protein transferase
EP0891360A4 (en) Inhibitors of farnesyl-protein transferase
EP1045844A4 (en) Inhibitors of farnesyl-protein transferase
EP0904080A4 (en) Inhibitors of farnesyl-protein transferase
EP0880320A4 (en) Inhibitors of farnesyl-protein transferase
EP0891349A4 (en) Inhibitors of farnesyl-protein transferase
EP0891352A4 (en) Inhibitors of farnesyl-protein transferase
EP1035850A4 (en) Inhibitors of farnesyl-protein transferase
EP1035852A4 (en) Inhibitors of farnesyl-protein transferase
EP0891335A4 (en) Inhibitors of farnesyl-protein transferase
EP0891353A4 (en) Inhibitors of farnesyl-protein transferase
EP0959883A4 (en) Inhibitors of farnesyl-protein transferase
EP1035849A4 (en) Inhibitors of farnesyl-protein transferase
EP0877610A4 (en) Inhibitors of farnesyl-protein transferase
EP1023270A4 (en) Inhibitors of farnesyl-protein transferase
EP0900081A4 (en) Inhibitors of farnesyl-protein transferase
GB9721000D0 (en) Inhibitors of farnesyl-protein transferase
GB9613460D0 (en) Inhibitors of farnesyl-protein transferase
GB9617257D0 (en) Inhibitors of farnesyl-protein transferase
GB9610338D0 (en) Inhibitors of farnesyl-protein transferase
GB9610654D0 (en) Inhibitors of farnesyl-protein transferase
GB9612291D0 (en) Inhibitors of farnesyl-protein transferase
GB9609666D0 (en) Inhibitors of farnesyl-protein transferase

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19981103

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20001206

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20011001