HUP0303891A2 - Gyógyhatású piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Gyógyhatású piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0303891A2
HUP0303891A2 HU0303891A HUP0303891A HUP0303891A2 HU P0303891 A2 HUP0303891 A2 HU P0303891A2 HU 0303891 A HU0303891 A HU 0303891A HU P0303891 A HUP0303891 A HU P0303891A HU P0303891 A2 HUP0303891 A2 HU P0303891A2
Authority
HU
Hungary
Prior art keywords
group
alkyl group
compounds
preparation
pharmaceutical compositions
Prior art date
Application number
HU0303891A
Other languages
English (en)
Inventor
Terence D. Butters
Raymond A. Dwek
George Fleet
Michael Glen Orchard
Frances Mary Platt
Original Assignee
Oxford Glycosciences (Uk) Ltd.
The Chancellor, Masters And Scholars Of The University Of Oxford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Glycosciences (Uk) Ltd., The Chancellor, Masters And Scholars Of The University Of Oxford filed Critical Oxford Glycosciences (Uk) Ltd.
Publication of HUP0303891A2 publication Critical patent/HUP0303891A2/hu
Publication of HUP0303891A3 publication Critical patent/HUP0303891A3/hu
Publication of HU229428B1 publication Critical patent/HU229428B1/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/12Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)

Abstract

A találmány az (I) általános képletű vegyületekre, gyógyászatilagelfogadható sóikra és prodrugjaikra vonatkozik. Az (I) általánosképletben R jelentése alkilcsoport, amely adott esetbencikloalkilcsoporttal helyettesített és adott esetben egy oxigénatommalvan megszakítva; vagy jelentése alkilaril-csoport, amely adott esetbenegy vagy több helyettesítőt, mégpedig fluor-, klór- vagy brómatomot,trifluormetil-, trifluormetoxicsoportot, -OR1 általános képletűcsoportot vagy alkilcsoportot tartalmaz és R1 jelentése hidrogénatomvagy alkilcsoport. A találmány kiterjed fenti vegyületekelőállítására, valamint az ilyen vegyületeket tartalmazó,glükozilceramid szintáz inhibitor hatású gyógyszerkészítményre,amelyek többek között glikolipidtárolási betegségek, rákosmegbetegedések, rendellenes glikolipid szintézissel kapcsolatosbetegségek és hasonlók kezelésére alkalmasak. Ó
HU0303891A 2001-01-12 2002-01-11 Pharmaceutically active piridine derivatives, process for their preparation and pharmaceutical compositions containing them HU229428B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0100889.5A GB0100889D0 (en) 2001-01-12 2001-01-12 Compounds
PCT/GB2002/000106 WO2002055498A1 (en) 2001-01-12 2002-01-11 Pharmaceutically active piperidine derivatives

Publications (3)

Publication Number Publication Date
HUP0303891A2 true HUP0303891A2 (hu) 2004-03-29
HUP0303891A3 HUP0303891A3 (en) 2010-01-28
HU229428B1 HU229428B1 (en) 2013-12-30

Family

ID=9906757

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303891A HU229428B1 (en) 2001-01-12 2002-01-11 Pharmaceutically active piridine derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (3) US20040097551A1 (hu)
EP (1) EP1362031B1 (hu)
JP (1) JP4313572B2 (hu)
KR (1) KR100879651B1 (hu)
CN (1) CN1267420C (hu)
AT (1) ATE389635T1 (hu)
AU (1) AU2002219363B2 (hu)
BR (1) BRPI0206433B8 (hu)
CA (1) CA2433675C (hu)
DE (1) DE60225671T2 (hu)
ES (1) ES2304439T3 (hu)
GB (1) GB0100889D0 (hu)
HU (1) HU229428B1 (hu)
IL (1) IL156873A0 (hu)
MX (1) MXPA03006185A (hu)
PT (1) PT1362031E (hu)
RU (1) RU2279425C2 (hu)
WO (1) WO2002055498A1 (hu)
ZA (1) ZA200305118B (hu)

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US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
CN1655777A (zh) 2002-03-13 2005-08-17 尤尼特尔药品公司 雄性避孕的非激素方法
CA2492410C (en) 2002-07-17 2011-09-13 Oxford Glycosciences (Uk) Ltd Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
JP4575156B2 (ja) 2002-07-17 2010-11-04 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
GB0313678D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
GB0313677D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0400812D0 (en) 2004-01-14 2004-02-18 Celltech R&D Ltd Novel compounds

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RU2003124756A (ru) 2005-01-10
HU229428B1 (en) 2013-12-30
PT1362031E (pt) 2008-06-12
KR20030081383A (ko) 2003-10-17
BRPI0206433B1 (pt) 2020-01-07
EP1362031A1 (en) 2003-11-19
KR100879651B1 (ko) 2009-01-20
US20040097551A1 (en) 2004-05-20
CN1496351A (zh) 2004-05-12
US20060074107A1 (en) 2006-04-06
CA2433675A1 (en) 2002-07-18
BRPI0206433B8 (pt) 2021-05-25
CA2433675C (en) 2011-03-22
ATE389635T1 (de) 2008-04-15
EP1362031B1 (en) 2008-03-19
GB0100889D0 (en) 2001-02-21
US8729099B2 (en) 2014-05-20
DE60225671D1 (de) 2008-04-30
US20140303208A1 (en) 2014-10-09
US9199935B2 (en) 2015-12-01
ES2304439T3 (es) 2008-10-16
IL156873A0 (en) 2004-02-08
WO2002055498A1 (en) 2002-07-18
CN1267420C (zh) 2006-08-02
HUP0303891A3 (en) 2010-01-28
JP2004517869A (ja) 2004-06-17
JP4313572B2 (ja) 2009-08-12
DE60225671T2 (de) 2009-04-16
ZA200305118B (en) 2004-10-01
AU2002219363B2 (en) 2007-11-01
BR0206433A (pt) 2003-12-30
RU2279425C2 (ru) 2006-07-10
MXPA03006185A (es) 2004-12-03

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